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Impact of Lower-Limb Muscle Fatigue on Dynamic Postural Control During Stair Descent: A Study Using Stair-Embedded Force Plates.

This study used stair-embedded force plates to investigate the effects of lower-limb muscle fatigue on dynamic postural control during stair descent in young adults. Twenty-five healthy male adults (age = 19.2 ± 1.5 years) were tested for stair descent gait in pre-fatigue and post-fatigue conditions. To induce fatigue, participants performed a sit-to-stand task. The kinematic and kinetic data were collected synchronously, and gait parameters were analyzed. Data were analyzed using one-dimensional statistical parametric mapping (SPM1d) and paired t-tests in SPSS. After fatigue, the right knee f…

Mapping cerebral blood flow in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and orthostatic intolerance: insights from a systematic review.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating condition with a large proportion of patients that experience orthostatic intolerance (OI). This systematic review aimed to assess whether cerebral blood flow (CBF) is reduced in ME/CFS and OI, and whether the presence of both conditions leads to an additional decline in CBF. METHODS: PubMed (from 1943), MEDLINE (from 1946), EMBASE (from 1947) and Cochrane were searched from inception to February 14th, 2025, using terms including "chronic fatigue syndrome", "myalgic encephalomyelitis", "ortho…

The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19.

BACKGROUND: Fatigue is often accompanied by comorbid sleep disturbance and psychiatric distress following the COVID-19 infection. However, identifying individuals at risk for developing post-COVID fatigue remains challenging. This study aimed to identify the neurobiological markers underlying fatigue susceptibility and further investigate their effect on COVID-19-related neuropsychiatric symptoms. METHODS: Individuals following a mild SARS-CoV-2 infection (COV+) underwent neuropsychiatric measurements (n = 335) and MRI scans (n = 271) within 1 month (baseline), and 191 (70.5 %) of the individ…

Postexertional Symptom Exacerbation after Submaximal Exercise in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of COVID-19.

PURPOSE: In individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and postacute sequelae of SARS-CoV-2 infection (PASC), physical activity can exacerbate symptoms for days to weeks, referred to as postexertional symptom exacerbation (PESE). This study characterized the trajectory of PESE symptoms before and for 7 d after a submaximal exercise task in individuals with ME/CFS or PASC. METHODS: Individuals with ME/CFS ( n = 30) or PASC ( n = 30) and matched controls ( n = 30) were recruited from a university hospital and the community setting. Participants completed a 25-m…

Fatigue Severity, Cognitive Strain, and Psychological Health in Long COVID: Untangling the Interconnected Aftermath from a Dedicated Long COVID Clinic.

Post-acute sequelae of SARS-CoV-2 infection (PASC) frequently includes persistent fatigue and cognitive dysfunction, but the relationship between these symptoms remains poorly defined. In this prospective observational study at the Henry Ford St. John Long COVID Clinic (LCC) from July 2023 to March 2025, we assessed fatigue severity using the Fatigue Assessment Scale (FAS) and examined its relationship with depression and cognitive symptoms. New patients completed demographic and clinical questionnaires, Patient Health Questionnaire (PHQ)-9, and Montreal Cognitive Assessment (MoCA) at their fi…

Motor control performance-related modulation of beta-band EEG-sEMG coherence differs between general and local muscular exercise-induced fatigue.

PURPOSE: Exercise-induced fatigue can reduce motor control performance and increase the risk of sporting injuries, which are related to functional coupling within the corticomotoneuronal pathway. However, the differences in functional coupling caused by general and local muscular exercise-induced fatigue are unknown. This study aimed to investigate the effects of exercise-induced fatigue on the beta-band (16-30 Hz) functional coupling between the sensorimotor cortex (SM1) and muscles of the dominant lower limb under different fatigue protocols. METHODS: Twenty-four healthy male participants w…

Impact of Preseason Training Camps on Fitness, Fatigue, and Performance in Professional Football Players: Mildaltitude Camp Versus Sea-Level Camp.

PURPOSE: Preseason in football is crucial for optimizing physical fitness, team cohesion, and tactical readiness. This study investigated th … vide valuable insights for designing preseason programs to balance cardiovascular fitness gains and fatigue mitigation.

Dexamethasone for 12 weeks for reducing fatigue in patients receiving palliative chemotherapy: A Phase 3, Placebo-Controlled, Randomized Controlled Trial.

PURPOSE: Cancer-associated fatigue is a prevalent and distressing symptom in patients receiving palliative chemotherapy. While short-term steroid use has been employed to alleviate fatigue, its long-term efficacy and safety remain unclear. METHODS: This phase III open-label, placebo-controlled randomized trial evaluated the efficacy and safety of dexamethasone (4 mg once daily for 12 weeks) versus placebo (once daily for 12 weeks) in patients with solid malignancies undergoing palliative chemotherapy. Fatigue was assessed using the Symbolic Assessment of Fatigue Extent (SAFE) and EORTC FA-12 …

Plasma hepcidin level is elevated by water immersion-induced central fatigue via hepatic inflammatory response in male and female rats.

Fatigue is a subjective phenomenon caused by physical or mental overexertion; however, its objective biomarkers specific to the types of fatigue remain unclear. Here, we examined whether plasma hepcidin levels, which are regulated by inflammation or iron metabolism, are elevated by peripheral and central fatigue in male and female rats. Eight-week-old Wistar rats were divided into three groups: peripheral fatigue, central fatigue, and sedentary control groups. Peripheral fatigue was induced by moderate-intensity aerobic treadmill running, and central fatigue was induced by keeping rats in a ca…

Cost-effectiveness of cognitive behavioural therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injury.

OBJECTIVE: Evaluate cost, effectiveness and cost-effectiveness of cognitive behavioural therapy for sleep and fatigue (CBT-SF) vs health education (HE) and of CBT-SF vs treatment as usual (TAU) for sleep disturbance and fatigue in acquired brain injury. DESIGN: Economic evaluation from Australian health system and societal perspectives based on data from a June 2017 to October 2023 randomized controlled trial. SUBJECTS: Community-dwelling Australian adults with sleep disturbance and fatigue following acquired brain injury (n = 126). METHODS: Incremental health system costs based on cost of …

Differences in frontal cortical brain function between individuals suffering from pathological mental fatigue following acquired brain injury and healthy individuals.

Pathological mental fatigue (PMF) is a common health concern after acquired brain injuries, with tens of millions affected globally each year. Neuroimaging methods show promising results for establishing associations between PMF and brain function. The aim of this study was to investigate whether and how neural functional activity and connectivity differ during rest and cognitive tasks between people with PMF and healthy controls. Twenty participants suffering from PMF after an acquired brain injury (ABI; stroke or traumatic brain injury) and 19 healthy controls were recruited and underwent co…

Music listening for fatigue after acquired brain injury: A scoping review project with patient, carer and public involvement (PCPI) data.

Fifty percent of Acquired Brain Injury (ABI) survivors experience fatigue. Symptom management in post-acute rehabilitation, where rehabilitation adherence is essential, is lacking. Research suggests that music listening interventions could help by addressing related symptoms including pain, mood and arousal. Our objective was to explore how music listening has been used for post-ABI fatigue and whether findings, together with interview data from a post-acute ward, could inform on its use for this purpose. Synthesized data included: intervention characteristics, study design and outcomes. Joann…

Strain-Controlled Thermal-Mechanical Fatigue Behavior and Microstructural Evolution Mechanism of the Novel Cr-Mo-V Hot-Work Die Steel.

In response to the intensifying competition in the mold market and the increasingly stringent specifications of die forgings, the existing 55NiCrMoV7 (MES 1 steel) material can no longer meet the elevated demands of customers. Consequently, this study systematically optimizes the alloy composition of MES 1 steel by precisely adjusting the molybdenum (Mo) and vanadium (V) contents. The primary objective is to significantly enhance the microstructure and thermal-mechanical fatigue performance of the steel, thereby developing a high-performance, long-life hot working die steel designated as MES 2…

Crankshaft high cycle bending fatigue test method based on the combined extended Kalman filtering algorithm and different failure criterion parameters.

In this paper, an accelerated bending fatigue test method for the crankshaft was proposed based on the combination of the extended Kalman filtering algorithm method (EKF) and different failure criterion parameters. First the intrinsic frequency of the system and the fatigue crack depth were chosen to be the failure criterion parameters based on the test regulation and the theory of fracture mechanics. Then the extended Kalman filtering method was adopted in predicting the remaining high cycle fatigue life of the crankshaft during the experiment process. Finally the predicted fatigue life was s…

Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence.

BACKGROUND: Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in excessive sodium and calcium overload in skeletal muscles of ME/CFS patients to cause mitochondrial damage. Since then, experimental evidence has been provided that supports this concept. METHODS: We collect, summarize and discuss the current state of knowledge for the key role of skeletal muscle pathophysiology. …

Cancer-related fatigue in children during treatment: a 5-year cohort study of daily patient-reported outcomes with clinical implications.

BACKGROUND: Cancer-related fatigue is one of the most common and distressing symptoms in pediatric oncology, yet its assessment and management remain insufficient. This study aimed to characterize trajectories of cancer-related fatigue in children and adolescents undergoing cancer treatment and to identify diagnosis- and therapy-specific fatigue predictors for personalized supportive care. METHODS: In this prospective single-center cohort study, 104 pediatric cancer patients receiving chemotherapy (0-18 years) were enrolled at the Medical University of Innsbruck between May 1, 2020 and Decemb…

Elevated Plasma BDNF in Early Primary Biliary Cholangitis: Associations with Liver Fibrosis, IL-6, IL-18, Fatigue, and Cognitive Impairment.

BACKGROUND AND AIMS: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease frequently associated with fatigue and mild cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays key roles in neuroplasticity, immune regulation, and metabolism. This study aimed to evaluate plasma BDNF levels in early-stage PBC and examine their clinical and biochemical associations. METHODS: In this observational study, plasma BDNF, IL-6, and IL-18 concentrations were measured by ELISA in 45 patients with early-stage PBC and 31 age- and sex-matched healthy controls (mean age 60.5 yea…

Учебная подготовка по ограничению потока крови повышает силу, усталость и функциональность у взрослых средних лет с множественным склерозом: случайное контролируемое испытание.

ЦЕЛИ: ОЦЕНКА ВОЗДЕЙСТВИЯ ПРОВЕДЕНИЯ 12-недельной учебной программы по ограничению потока крови с низкой нагрузкой на физическую функцию, мышечную силу, усталость, физическую активность и ручной разъем у лиц среднего возраста с множественным склерозом (МС). DESIGN: Это исследование было задумано как случайное контролируемое клиническое испытание. МЕТОДЫ: Шестьдесят пять взрослых в возрасте 40-65 лет, имеющих MS (расширенная шкала инвалидности <7) были случайными (32 экспериментальных, 33 контрольных). Все участники в течение последних шести месяцев не занимались структурированными учениями и со

Совпадение в аннотации оригинала
OBJECTIVES: To evaluate the effects of a 12-week low-load blood flow restriction (BFR) training program on physical function, muscle strength, fatigue, physical activity, and manual dexterity in middle-aged individuals with multiple sclerosis (MS). DESIGN: This study was designed as a randomized controlled clinical trial. METHODS: Sixty-five adults aged 40…

Non-Physician Healthcare Workers During COVID-19 Pandemic and Association Between Work-Related Factors, Perceived Stress, Depressive Symptoms, and Fatigue.

OBJECTIVE: The purpose of this study is to examine the national impact of workplace factors during the SARS-CoV-2 pandemic on mental health … that occurred during the pandemic were associated with moderate to high levels of perceived stress, fatigue, and higher risk of developing depression. In particular, concerns about exposing others, experiencing discrimination related to their jobs, and caring for patients who died from COVID-19 were associated with increased perceived stress, depression, …

The Mediating Role of Self-efficacy in Acute Myocardial Infarction Patients between Post-PCI Fatigue and Post-traumatic Stress Disorder.

OBJECTIVE: This study aims to investigate the prevalence of post-traumatic stress disorder (PTSD) in patients with acute myocardial infarcti … to conduct a questionnaire survey and analyzed the correlation between self-efficacy, postoperative fatigue, and PTSD using Pearson. Additionally, we established a structural equation model (SEM) using Amos 21.0 software and conducted a mediation effect test. RESULTS: (1) The PTSD score of 268 AMI patients in this study after PCI was (36.62 ± 4.62), the …