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Amyloid Proteins and Peripheral Neuropathy.

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature-deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. He

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… Updated Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota (1970–2011) ACG 2014 Ann. Sci. Meet. 2014 15 10 10.1016/j.cgh.2016.10.039 PMC5429988 27856364 64. Garcia-Cabo C. Moris G. … Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989 Blood 1992 79 1817 1822 10.1182/blood.V79.7.1817.1817 1558973 103. Schonland S.O. Hegenbart U. Bochtler T. Mangatter A. Hansberg M. Ho A.D. Lohse P. Rocken C. …

Е-постеры.

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Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… University of Kansas Clinical and Translational Science Institute • University of Kentucky—UL1TR001998: UK Center for Clinical and Translational Science • University of Massachusetts Medical School Worcester—UL1TR001453: The UMass Center for Clinical and Translational Science (UMCCTS) • University of Minnesota—UL1TR002494 …

Secondary Impact of the Coronavirus Disease 19 Pandemic on Patients and the Cellular Therapy Healthcare Ecosystem.

The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has significantly impacted global health and healthcare delivery systems. To characterize the secondary effects of the COVID-19 pandemic and mitigation strategies used in the delivery of hematopoietic stem cell transplantation (HSCT) care, we performed a comprehensive literature search encompassing changes in specific donor collection, processing practices, patient outcomes, and patient-related concerns specific to HSCT and HSCT-related healthcare delivery. In this review,

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… Email: rita.jakubowski@mountsinai.org Mark Juckett, MD; Division of Hematology, Oncology, and Transplantation; Department of Medicine; University of Minnesota. …

Cancer risks in rheumatoid arthritis patients who received immunosuppressive therapies: Will immunosuppressants work?

BACKGROUND: Exploring the cancer risks of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARDs) can help detect, evaluate, and treat malignancies at an early stage for these patients. Thus, a comprehensive analysis was conducted to determine the cancer risk of RA patients using different types of DMARDs and analyze their relationship with tumor mutational burdens (TMBs) reflecting immunogenicity. METHODS: A thorough search of PubMed, EMBASE, Web of Science, and Medline was conducted up to 20 August 2022. Standardized incidence ratios (SIRs) were constructed w

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… : results from Olmsted county, Minnesota, 1955-2007 . Arthritis Rheum ( 2010 ) 62 : 1576–82 . doi: 10.1002/art.27425 PMC2929692 20191579 52 Wilsher M Voight L Milne D Teh M Good N Kolbe J . Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis . …

The Amyloidosis Forum: a public private partnership to advance drug development in AL amyloidosis.

BACKGROUND: Immunoglobulin light chain (AL) amyloidosis is a rare, multi-systemic disorder characterized by two disease processes: an underlying plasma cell dyscrasia that provides the source of pathologic light chains, and the resulting organ dysfunction caused by deposition of amyloid light chain fibrils. There are no FDA approved treatments for AL amyloidosis; regimens developed for multiple myeloma are used off-label to treat the plasma cell disorder and no therapies are directed at organ deposition. Thus, an unmet medical need persists despite advances in disease management. A public-priv

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… Kyle RA Larson DR Kurtin PJ Kumar S Cerhan JR Therneau TM Incidence of AL amyloidosis in Olmsted County, Minnesota, 1990 through 2015 Mayo Clin Proc 2019 94 3 465 471 10.1016/j.mayocp.2019.01.023 30713046 PMC6401262 3. …

Current Status and Perspectives of Irradiation-Based Conditioning Regimens for Patients with Acute Leukemia Undergoing Hematopoietic Stem Cell Transplantation.

Acute myeloid leukemia and acute lymphoblastic leukemia are the most common indications for allogeneic hematopoietic stem cell transplantation. Total body irradiation (TBI) is an important part of conditioning regimens. TBI-based regimens offer advantages in sanctuary sites but are associated with significant risks of early and late side effects, including pulmonary toxicity, growth retardation, and second malignancy. TBI is also associated with technical problems, such as dose heterogeneity. With evolving techniques in radiation oncology, it is possible to focus the dose to the entire skeleto

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… /busulfan: a phase I study Biol Blood Marrow Transplant 2014 20 12 2034 41 10.1016/j.bbmt.2014.09.005 25234438 [56] Hui SK Verneris MR Higgins P Gerbi B Weigel B Baker SK Fraser C Tomblyn M Dusenbery K Helical tomotherapy targeting total bone marrow - first clinical experience at the University of Minnesota …

Pathogenesis and kidney prognosis of renal amyloidosis.

Light chain (AL), serum amyloid A (AA), transthyretin (ATTR), leukocyte cell derived chemotaxin 2 (ALECT2), and fibrinogen Aa (AFib) amyloidosis are some of the most common types of protein-deposition disorders involving the kidney. Each amyloidogenic protein differs in its origin and little is known about the exact mechanisms that govern renal tropism and tissue injury for each amyloid subtype. While amyloidogenic precursor protein is different in each subtype of amyloidosis, its aggregation into fibrils depositing in target organs and leading to disruption of tissue architecture and progress

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… Kyle R Linos A Beard C Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989 [see comments] Blood 1992 79 7 1817 1822 10.1182/blood.V79.7.1817.1817 1558973 Kyle R, Linos A, Beard C et al (1992) Incidence and natural history of primary systemic amyloidosis … in Olmsted County, Minnesota, 1950 through 1989 [see comments]. …

2020 ACVIM Forum On Demand Research Abstract Program.

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… dysplasia is associated with a PLA2G4F variant in the Labrador Retriever Kathryn Meurs 1 ; Sandy Tou 2 ; Teresa DeFrancesco 1 ; Bruce Keene 1 ; John Bonagura 1 ; Steven Friedenberg 3 1 North Carolina State University; 2 College of Veterinary Medicine, North Carolina State University; 3 University of Minnesota … Adin 1 ; Clarke Atkins 2 ; Steven Friedenberg 3 ; Joshua Stern 4 ; Kathryn Meurs 2 1 University of Florida; 2 North Carolina State University; 3 University of Minnesota; 4 University of California, Davis The angiotensin‐converting enzyme (ACE) gene intronic polymorphism at canine chromosome 9:11507816 …

Development and validation of a multiparametric MRI-based radiomics nomogram for the tripartite discrimination of primary benign, primary malignant, and metastatic lumbar spinal tumors.

ObjectiveTo develop and validate a multiparametric magnetic resonance imaging-based radiomics nomogram for the non-invasive preoperative differentiation of primary benign, primary malignant, and metastatic lumbar spinal tumors.MethodologyThis retrospective study enrolled 100 patients with pathologically confirmed lumbar tumors. Radiomics features were extracted from T1-weighted, T2-weighted, and fat-suppressed T2-weighted sequences. A radiomics signature was constructed using a two-step feature selection method comprising minimum redundancy maximum relevance and least absolute shrinkage and se

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… Edited by: Yoichi Watanabe , University of Minnesota Twin Cities, United States Reviewed by: Mirza Pojskic , University Hospital of Giessen and Marburg, Germany Jiri Chmelik , Brno University of Technology, Czechia AUC, Area Under the Curve; ALP, Alkaline Phosphatase; CI, Confidence Interval; DCA, …

A bibliometric and knowledge-map analysis of bispecific antibodies in cancer immunotherapy from 2000 to 2023.

BackgroundBispecific antibody (BsAb)-based cancer immunotherapy has provided new avenues for the treatment of various malignancies. The approval of Blinatumomab has encouraged further investigation into these treatments, and a series of preclinical and clinical trials have been conducted, together with the publication of numerous articles. Here, the knowledge structure of BsAb-based cancer immunotherapy is summarized using bibliometric analysis to provide in-depth insight into current research trends and foci.MethodsThe studies included in the bibliometric analysis of BsAbs in cancer immunothe

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… The top three institutions with the highest TC values were the Memorial Sloan Kettering Cancer Center (3769), Minnesota University (3348), and the German Cancer Research Center (2306). No institutions had BC values > 0.1. …

Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial.

Amyloid light-chain (AL) amyloidosis is a rare, typically fatal disease characterized by the accumulation of misfolded immunoglobulin light chains (LCs). Birtamimab is an investigational humanized monoclonal antibody designed to neutralize toxic LC aggregates and deplete insoluble organ-deposited amyloid via macrophage-induced phagocytosis. VITAL was a phase 3 randomized, double-blind, placebo-controlled clinical trial assessing the efficacy and safety of birtamimab + standard of care (SOC) in 260 newly diagnosed, treatment-naive patients with AL amyloidosis. Patients received 24 mg/kg IV birt

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… References 1 Kyle RA Gertz MA Primary systemic amyloidosis: clinical and laboratory features in 474 cases Semin Hematol 32 1 1995 45 59 7878478 2 Kyle RA Linos A Beard CM Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989 Blood 79 7 1992 1817 …

The feasibility of web surveys for obtaining patient-reported outcomes from cancer survivors: a randomized experiment comparing survey modes and brochure enclosures.

BackgroundCentral cancer registries are often used to survey population-based samples of cancer survivors. These surveys are typically administered via paper or telephone. In most populations, web surveys obtain much lower response rates than paper surveys. This study assessed the feasibility of web surveys for collecting patient-reported outcomes via a central cancer registry.MethodsPotential participants were sampled from Utah Cancer Registry records. Sample members were randomly assigned to receive a web or paper survey, and then randomized to either receive or not receive an informative br

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… The impact of survey mode on the response rate in a survey of the factors that influence Minnesota physicians’ disclosure practices. BMC Med Res Methodol. 2019;19(1):73. doi: 10.1186/s12874-019-0719-7. 60. Ritter P, Lorig K, Laurent D, Matthews K. …

Management of keratinocyte carcinoma - Special considerations in the elderly.

Keratinocyte carcinomas (KCs) are now an epidemic in The United States of America, especially in elderly patients. KCs, including basal cell carcinoma and squamous cell carcinoma, can lead to disfigurement and occasionally death. However, the lower mortality rate associated with KC compared with melanoma allows for increased flexibility in the selection of treatment. Flexibility in treatment is particularly important in the elderly given that this patient population often has medical comorbidities that should be considered. These patients may have multiple KCs, higher risk tolerance to recurre

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… Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: A population-based study in Olmsted County, Minnesota, 2000 to 2019. Mayo Clin Proc. 2017;92(6):890–898. doi: 10.1016/j.mayocp.2017.02.015. Neville J.A., Welch E., Leffell D.J. …

Emerging Roles of Osteoclasts in the Modulation of Bone Microenvironment and Immune Suppression in Multiple Myeloma.

Multiple myeloma (MM) is one of the most common forms of hematologic malignancy resulting from cancerous proliferation of mature malignant plasma cells (MPCs). But despite the real improvement in therapeutics in the past years, it remains largely incurable. MM is the most frequent cancer to involve bone due to the stimulation of osteoclast (OCL) differentiation and activity. OCLs have a unique capacity to resorb bone. However, recent studies reveal that they are not restrained to this sole function. They participate in the control of angiogenesis, medullary niches, and immune responses, includ

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… Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades . Cancer ( 2004 ) 101 : 2667 – 74 . 10.1002/cncr.20652 15481060 29 Durie BG Salmon SE . High speed scintillation autoradiography . …

References

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… Transmission of Babesia microti in Minnesota through four blood donations from the same donor over a 6-month period. Transfusion. 2002;42:1154–1158. doi: 10.1046/j.1537-2995.2002.00189.x. 110. Kain KC, Jassoum SB, Fong IW, Hannach B. …

The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session (O010-O173).

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Patient Perspectives on Palliative Care Outreach to Adults Living With Homelessness.

ImportancePeople experiencing homelessness face higher rates of early mortality, multimorbidity, and unmet needs at the end of life, but despite these risks, they often encounter systemic barriers to accessing palliative care. Outreach-based models have emerged to address this gap, yet little is known about how these models are perceived by those receiving care.ObjectiveTo evaluate a palliative care outreach intervention, the Palliative Education and Care for the Homeless (PEACH) program, from the perspective of patients living with homelessness and life-limiting illness.Design, setting, and p

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… Trends in trimorbidity among adults experiencing homelessness in Minnesota, 2000-2018. Med Care. 2021;59(suppl 2):S220-S227. doi: 10.1097/MLR.0000000000001435 6. de Veer AJE, Stringer B, van Meijel B, Verkaik R, Francke AL. …

Patient perspectives on symptoms, health-related quality of life, and treatment experience associated with relapsed/refractory multiple myeloma.

Abstract Purpose This study aimed to better understand the patient perspective and treatment experience of relapsed and/or refractory multiple myeloma (RRMM). Methods This qualitative study enrolled adult RRMM patients from 6 US clinics who had ≥ 3 months of life expectancy, ≤ 6 prior lines of therapy, and ≥ 1 treatment regimen with a proteasome inhibitor and immunomodulator, or a CD38 monoclonal antibody or an alkylating agent, and a steroid. In-person semi-structured qualitative interviews were conducted to capture concepts that were relevant and important to patients. Topics included RRMM s

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… Minnesota Cancer 101(11):2667–2674. 10.1002/cncr.20652 10.1002/cncr.20652 15481060 6. Zhou L Yu Q Wei G Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019 BMC Cancer 2021 21 1 606 10.1186/s12885-021-08280-y 34034700 PMC8152089 7. …

Oncolytic Viruses for Cancer Therapy in Dogs.

Cancer remains the leading cause of death in domestic dogs. Conventional therapeutic approaches, including surgery, chemotherapy, and radiotherapy, frequently fail to achieve sustained remission or stabilization. Oncolytic virotherapy, a rapidly advancing therapeutic modality in human oncology, is emerging as a novel strategy in veterinary medicine. This systematic review summarizes current knowledge on the application of oncolytic viruses (OVs) in canine cancer treatment, focusing on their mechanisms of action, safety profiles, and clinical efficacy. We evaluate diverse OV platforms, includin

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… Efficacy was compared to two control cohorts: one comprising dogs from the University of Minnesota Veterinary Medical Center (UMN VMC), receiving standard surgical therapy and adjuvant carboplatin chemotherapy, and another consisting of 157 dogs receiving protocols designed by the National Cancer Institute …