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[A serious complication due to liquid silicone injection in the legs for cosmetic purpose].

Liquid injectable silicone has been used to increase volume in determined cutaneous districts, particularly in aesthetical reconstructive surgery. Although considered biologically inert for a long time this substance produced various complications as granulomatous foreign body reaction (siliconomas), secondary limphedema, tissue destruction and lethal embolism. A 35-year-old Caucasian woman came to our department with erithema and edema on the right leg, fever and chills. A thorough examination of the patient's history revealed injection of liquid silicone 7 years before for cosmetic volume in

2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors.

With the aim of identifying novel lead compounds active against emergent human infectious diseases, a series of 2,3-dihydro-4H-pyridinone de … 00 μm; EC(50) = 14 μm), compounds 4c cis and 6a showed a significant activity against Flaviviruses (Yellow Fever Virus) (CC(50) > 100 μm; EC(50) = 18μm, CC(50) > 100 μm; EC(50) = 10 μm). Among these, compound 6a displayed great inhibitory activity against Hepaciviruses (hepatitis C virus) in replicon assay [CC(50) > 100 μm; EC(50) (1b) = 4 μm]. In vitro inhibi …

Структурная основа для преференциального признания незрелых ароматизаторов антителом с синтезом.

Флавивирусы представляют собой группу человеческих патогенов, вызывающих сильные энцефалитные или геморрагические заболевания, включая вирусы Западного Нила, денге и желтой лихорадки. Здесь, с помощью рентгеновской кристаллографии, мы определили структуру реактивного антитела Е53 флавивируса, который включает высокоохранную синтезированную петлю гликпротеина вируса Западного Нила. Используя крио-электронную микроскопию, мы также установили, что E53 Fab связывается преимущественно с пиками неинфекционных, незрелых ароматов, но не может значительно связаться со зрелыми вирионами, что соответству

Совпадение в аннотации оригинала
Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X-ray crystallography we have defined the structure of the flavivirus cross-reactive antibody E53 that engages the highly conserved fusion loop of the West Nile virus envelope glycoprotein. Using…

Пептид, похожий на инсулина, регулирует созревание яиц и метаболизм в комаре Aedes aegypti.

Поглощение позвоночной крови имеет важное значение для созревания яиц и передачи паразитов, вызывающих заболевания, женскими комарами. Предварительные исследования с желтой лихорадкой комаров Эйдес аегипти показали, что кормление крови стимулирует производство яиц путем высвобождения гормонов из медиальных нейросекретарских клеток в мозге комаров. Способность говяжьего инсулина стимулировать аналогичную реакцию также свидетельствует о том, что этот спусковой механизм представляет собой эндогенный инсулиновый песптид (ИЛП). A. aegypti кодирует восемь прогнозируемых ILP. Здесь мы сообщаем, что с

Совпадение в аннотации оригинала
Ingestion of vertebrate blood is essential for egg maturation and transmission of disease-causing parasites by female mosquitoes. Prior studies with the yellow fever mosquito, Aedes aegypti, indicated blood feeding stimulates egg production by triggering the release of hormones from medial neurosecretory cells in the mosquito brain. The ability of bovine ins…

Mitochondrial DNA polymorphism and heteroplasmy in populations of Aedes aegypti in Brazil.

The tropical mosquito Aedes aegypti (Diptera: Culicidae) is the most important domestic vector of urban yellow fever and dengue viruses. Ae. aegypti originated from Africa and was probably introduced into Brazil during the colonial period through embarkations, and dengue epidemics soon followed. Genetic analysis of 12 Ae. aegypti populations from five states in Brazil was conducted based on two mitochondrial DNA fragments: cytochrome oxidase I and NADH dehydrogenase subunit 4. Analyses comparing individual haplotypes indicated the existence of two well-defined clades, probably representing two…

Evidence of multiple zoonotic agents in a wild rodent community in the eastern Sierra Nevada.

This study aimed to describe the occurrence of Yersinia pestis, Rickettsia rickettsii, Anaplasma phagocytophilum, and ectoparasites in a wild rodent community in the eastern Sierra Nevada. From May to September 2006, rodents were live-trapped, examined for ectoparasites, and blood was collected. All rodents were serologically tested for antibodies to Y. pestis, R. rickettsii, and A. phagocytophilum; in addition, blood samples and ectoparasites were tested by PCR to detect the presence of these zoonotic agents. Overall, 89 rodents, 46 fleas, and four ticks were collected. Antibody prevalence ra

Application of enzyme immunoassay on infected cells (EIA-IC) for arboviruses.

Comparative titrations of alpha-, flavi- and Bunyamwera viruses were made by EIA-IC and according to cytopathic effect (CPE). Specific enzymatic reactions appeared earlier and in higher titres than CPE. The titres of dengue type 1, Mayaro, Powassan and Langat viruses measured by EIA-IC were comparable to those measured by intracerebral inoculation of mice. The cross-reactivity testing of EIA-IC among alphaviruses (Chikungunya, Sindbis and Mayaro), flaviviruses (Japanese encephalitis, Murray valley encephalitis, Kunjin, West Nile, yellow fever and louping ill, Powassan, Langat) and Bunyamwera a…

Бактериальная общинная структура и разнообразие распространенных видов комаров в Чэнду: Отчёты по секвенированию третьего поколения в Пакбио и последствия для здоровья населения.

Москито, как критические векторы таких заболеваний, как японский энцефалит, лихорадка денге и желтая лихорадка, создают значительную опасность для здоровья населения в Ченду, субтропическом городе на юго-западе Китая. В настоящем исследовании проводится экологическое наблюдение и последовательность третьего поколения PacBio для характеристики симбиотической микробиоты четырех доминирующих видов комаров (Aedes albopictus, Culex pipiens qinquefasciatus, Culex tretaeniorhynchus и Armigeres subalbatus) в городских и сельских средах обитания. В период с 2020 по 2024 год в ходе мониторинга плотности

Совпадение в аннотации оригинала
Mosquitoes, as critical vectors of diseases such as Japanese encephalitis, dengue fever, and yellow fever, pose significant public health risks in Chengdu, a subtropical city in southwestern China. The present study ecological surveillance and PacBio third-generation sequencing to characterize the symbiotic microbiota of four dominant mosquito species (Aedes…

Effectiveness of natural predators, microbial bioinsecticides, and plant-based bioinsecticides to reduce mosquito-borne disease burden: a systematic review.

Mosquito-borne diseases are a major public health burden given the limited pharmacological options. While the adverse effects of synthetic i … indicators of chikungunya, dengue, Zika, lymphatic filariasis, West Nile virus, Rift Valley fever, yellow fever, malaria, or Japanese encephalitis, were eligible. Due to outcome heterogeneity, a narrative synthesis was performed instead of a meta-analysis. Eighteen studies from Asia, Africa, Central America, and South America, assessing bacterial larvicides, …

Antibody cross-reactivity and evidence of susceptibility to emerging Flaviviruses in the dengue-endemic Brazilian Amazon.

OBJECTIVES: Several Flaviviruses can co-circulate. Pre-existing immunity to one virus can modulate the response to a heterologous virus; how … and the DENV seropositivity ranged between 84.8% and 91.0%, as determined by HIA. About 93% had antiyellow fever virus 17D-reactive antibodies, whereas 80.5% reacted to wild-type yellow fever virus. Zika virus (ZIKV) had the lowest seropositivity percentage (52.6%) compared with other Flaviviruses. Individuals who were DENV-positive with high antibody titers b …

The epidemiology of Aedes-borne arboviral diseases in Zhejiang, Southeast China: a 20 years population-based surveillance study.

OBJECTIVE: Aedes-borne arboviral diseases were important public health problems in Zhejiang before the coronavirus disease 2019 (COVID-19) p … during 2003-2012 to 44 during 2013-2019. CONCLUSION: Dengue, chikungunya fever, zika disease, and yellow fever are not endemic in Zhejiang but will be important public health problems for the province in the post-COVID-19 era.

Host-Feeding Patterns of the Mosquito Assemblage at Lomas Barbudal Biological Reserve, Guanacaste, Costa Rica.

Mosquito-borne pathogens have spread throughout tropical regions of the Western Hemisphere causing increased burden of disease in the region. Outbreaks of dengue fever, yellow fever, chikungunya, West Nile, and Zika have occurred over the past several years. Mosquito blood-feeding patterns need to be assayed to assist in determining which vertebrates could act as hosts of these mosquito-borne pathogens and which mosquito species could act as vectors. We conducted bloodmeal analyses of mosquitoes collected at Lomas Barbudal Biological Reserve, a dry tropical forest reserve in Costa Rica. Mosqui…

Potential Benefits of Antiviral African Medicinal Plants in the Management of Viral Infections: Systematic Review.

Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medi … (2 plants). Feline herpesvirus (FHV-1), Enterovirus, Dengue virus, Ebola virus, Chikungunya virus, Yellow fever virus, Respiratory syncytial virus, Rift Valley fever virus, Human cytomegalovirus each showed sensitivities to one plant. Conclusion: The current study provided a list of African medicinal plants which demonstrated antiviral activities and could po …

Nocturnal Mosquitoes of Pará State in the Brazilian Amazon: Species Composition, Habitat Segregation, and Seasonal Variation.

Mosquitoes (Diptera: Culicidae) are one of the most important disease vector species in the world. Many species have a high degree of anthro … (Theobald), and Culex (Culex) quinquefasciatus which are the main transmitters of dengue, malaria, yellow fever, mayaro, and oropouche fever, respectively. As inventories of disease-carrying mosquitoes in the region are very scarce, mainly in residential environments, our results suggest high potential for mosquito-borne disease transmission in Pará State.

Larvicidal activity of lignans and alkaloid identified in Zanthoxylum piperitum bark toward insecticide-susceptible and wild Culex pipiens pallens and Aedes aegypti.

BACKGROUND: The yellow fever mosquito, Aedes aegypti, and the common house mosquito, Culex pipiens pallens, transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity of the three lignans (-)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (XDA), and the alkaloid pellitorine from Zanthoxylum piperitum (Rutaceae) bark to third-instar larvae from insecticide-susceptible C. pipiens pallens and Ae. aegypti as well as wild C. pipiens pallens resistant to deltamethrin, cyfluthrin, fenthion, and temephos. METHODS: The toxicities …

δ-Cadinene, Calarene and .δ-4-Carene from Kadsura heteroclita Essential Oil as Novel Larvicides Against Malaria, Dengue and Filariasis Mosquitoes.

Mosquitoes (Diptera: Culicidae) are major vectors of important pathogens and parasites. Malaria, dengue fever, yellow fever, filariasis, schistosomiasis and Japanese encephalitis cause millions of deaths every year. Mosquito control is being challenging due to the development of pesticide resistance and negative environmental concerns. In this scenario, plants employed in traditional Asian medicine may be alternative sources of newer and effective mosquitocides. In this research, we evaluated the larvicidal activity of Kadsura heteroclita leaf essential oil (EO) and its major chemical constitu…

A multiplex ELISA-based protein array for screening diagnostic antigens and diagnosis of Flaviviridae infection.

Assays with the ability to detect multiple antibodies in parallel have a wide range of potential applications in epidemiologic research. Here, a multiplex enzyme-linked immunosorbent assay-based protein array (ELISA-array) was developed to simultaneously detect five Flaviviridae infections. The platform was based on an indirect ELISA and 15 antigens were constructed for specific antibody detection against five Flaviviridae viruses (Japanese B, tick-borne encephalitis, West Nile, dengue, and yellow fever viruses) and four serotypes of dengue virus. The specificity was evaluated by calculating t…

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.

BACKGROUND: The genus Flavivirus encompasses more than 50 distinct species of arthropod-borne viruses, including several major human pathogens, such as West Nile virus, yellow fever virus, Japanese encephalitis virus and the four serotypes of dengue viruses (DENV type 1-4). Each year, flaviviruses cause more than 100 million infections worldwide, some of which lead to life-threatening conditions such as encephalitis or haemorrhagic fever. Among the viral proteins, NS3 and NS5 proteins constitute the major enzymatic components of the viral replication complex and are essential to the flavivirus…

Silent circulation of arboviruses in Cameroon.

OBJECTIVES: To investigate the silent circulation and transmission of arthropod-borne viruses (arboviruses) in the Fako Division of Cameroon … us Flavivirus: 24 (30.4%) were cross-reactive, but 11.4% reacted monotypically with Zika, 5.1% with yellow fever virus (YFV), 5.1% with dengue virus-2 (DENV-2), 2.5% with DENV-1 and 1.3% with Wesselsbron virus, respectively. The plaque reduction neutralisation test used to specify the agent that elicited the response could not resolve 33.3% of the cross reacti …

Адаптивность и адаптивная фенотипическая пластичность взрослого тела у комаров Aedes aegypti с последствиями для способности переносчиков денге.

Адаптивная фенотипическая пластичность имеет особенно важное значение для организмов с циклами развития, которые переходят в офгенетические ниши, в результате чего отдельные стадии жизни в разной степени подвержены неоднородным и зачастую напряженным экологическим условиям. Желтая лихорадка и вектор лихорадки денге, Aedes aegypti, как правило, образуются в небольших резервуарах с водой, в которых развивающиеся водные личинки подвергаются конкуренции за ресурсы с конкретикой и высокой вероятностью сушки среды обитания. Здесь мы изучили наследственность (h(2)) и фенотипную пластичность среди лаб

Совпадение в аннотации оригинала
Adaptive phenotypic plasticity is particularly important to organisms with developmental cycles that undergo ontogenetic niche shifts that differentially subject individual life stages to heterogeneous and often stressful environmental conditions. The yellow fever and dengue fever vector mosquito, Aedes aegypti, typically breeds in small water-filled contain…