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Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system.

ObjectiveThis project aims to identify the top 30 drugs most commonly associated with constipation and their signal values within the FDA Adverse Event Reporting System database.MethodsWe extracted adverse drug events (ADEs) related to constipation from the FAERS database spanning from January 1, 2004, to September 30, 2023. We compiled the 30 most frequently reported drugs based on the frequency of constipation events. We employed signal detection methodologies to ascertain whether these drugs elicited significant signals, including reporting odds ratio, proportional reporting ratio, multi-it

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… Identification of signal of clindamycin associated renal failure acute: a disproportionality analysis. Curr. Drug Saf. 19, 123–128. 10.2174/1574886318666230228142856 Jeong B., Sung T. S., Jeon D., Park K. J., Jun J. Y., So I., et al. (2022). …

Disorders of the Spinal Cord

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… Trimethoprim-sulfadiazine 15 mg/kg SC, PO BID or ormetoprim-sulfadimethoxine 15 mg/kg PO BID, and clindamycin 15 mg/kg IV, PO for 28 days may improve clinical signs. C. …

Infectious Complications of Cancer Therapy

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… Clindamycin-resistant, toxin A-negative, toxin B-positive Clostridium difficile strains cause antibiotic-associated diarrhea among children hospitalized in a hematology unit. Clin Microbiol Infect. 2003;9:903–904. doi: 10.1046/j.1469-0691.2003.00700.x. 70. Blot E., Escande M.C., Besson D., et al. …

Экспертный консенсус в отношении многодисциплинарного подхода к лечению множественных заболеваний костей, связанных с миеломой.

Этот консенсус по множественным болезням костей, связанным с миеломой, подчеркивает важность многодисциплинарного подхода, который охватывает гематологию, радиологию, ортопедию и дополнительные специальности для решения сложных проблем. МБД, широко распространенное и изнуряющее осложнение множественной миэломы, приводит к боли в костях, переломам и событиям, связанным со скелетом, что оказывает глубокое воздействие на качество жизни пациентов. Эти руководящие принципы обеспечивают тщательную основу для диагностики, лечения и постоянной оценки с уделением особого внимания раннему обнаружению и

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… For early-stage ONJ, conservative approaches are advised, such as maintaining good oral hygiene, using antiseptic mouth rinses (e.g., chlorhexidine), and administering long-term antibiotics to manage infection, commonly amoxicillin-clavulanic acid or clindamycin, due to the frequent presence of Actinomyces …

Re-estimation of the burden of serious fungal diseases in Uganda.

BACKGROUND: It is of utmost importance to monitor any change in the epidemiology of fungal diseases that may arise from a change in the number of the at-risk population or the availability of local data. OBJECTIVE: We sought to update the 2015 publication on the incidence and prevalence of serious fungal diseases in Uganda. METHODS: Using the Leading International Fungal Education methodology, we reviewed published data on fungal diseases and drivers of fungal diseases in Uganda. Regional or global data were used where there were no Ugandan data. RESULTS: With a population of ~45 million, w

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… DHPS) enzymes, the main target of sulfamethoxazole, which inhibits the synthetic pathway of folate, has emerged due to widespread use of the drug in both HIV and non-HIV populations. 87 , 88 The anti-malarial agent, primaquine is an alternative medication for the treatment of PCP, when combined with clindamycin …

Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study.

Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flex

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… (D) Upper view and (E) Sagittal section illustrations of “hAM implantation with partial coverage” nomenclature. 2.6 Postsurgical Care Patients had a 2-week antibiotic course prescribed (Amoxicillin + clavulanic acid, 1 g *3/day, and in case of allergies: Clindamycin 600 mg *3/day). …

Essential Medicinal Chemistry of Essential Medicines.

Since 1977, the World Health Organization publishes a list of essential medicines, i.e., those that satisfy the priority health care needs of the population and are selected with regard to disease prevalence and public health relevance, evidence of clinical efficacy, and safety, as well as comparative costs and cost-effectiveness. The Essential Medicines List (EML) is an invaluable tool for all countries to select those medicines that have an excellent risk/benefit ratio and that are reputed to be of pivotal importance to health. In the present perspective, we describe the chemical composition

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… It should be noticed that among nature-inspired drugs, 5 compounds are prodrugs that are metabolized to an active species that obeys Lipinski’s rule (e.g., chloramphenicol palmitate, clindamycin palmitate, retinol palmitate, tenofovir disoproxil, dabigatran etexilate) and for this reason are not displayed …

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review.

During the COVID-19 pandemic, elderly patients with underlying condition, such as tumors, had poor prognoses after progressing to severe pneumonia and often had poor response to standard treatment. Mesenchymal stem cells (MSCs) may be a promising treatment for patients with severe pneumonia, but MSCs are rarely used for patients with carcinoma. Here, we reported a 67-year-old female patient with lung adenocarcinoma who underwent osimertinib and radiotherapy and suffered from radiation pneumonitis. Unfortunately, she contracted COVID-19 and that rapidly progressed to severe pneumonia. She respo

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… infarction, Hyperlipidemia | No | Chloroquine, Lopinavir/Ritonavir, Inotropic agent, Immunoglobulin, Cefepime, Teicoplanin, Steroids, Tracheostomy | BM | 90×10 6 /L VD With aspirin | Remission | Discharged on day 138 Payandeh 2022 ( 95 ) | Iran | M | 28 days | Pneumonia | No | Ampicillin, Cefotaxime, Clindamycin …

Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.

Transplant recipients have an increased risk of complications, including graft dysfunction and infections, which can be life-threatening if not recognized early. Pneumonia ranks as one of the most frequent complications in both solid organ and hematopoietic stem cell transplants. Clinical symptoms manifest late during infections in immunocompromised patients. An aggressive approach centered on early confirmatory diagnosis and a low threshold for empiric therapy is often the most effective strategy. The isolation of a pathogen in an upper airway sample does not necessarily mean the same organis

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… For patients with sulfa allergies, alternatives such as clindamycin/primaquine are available. In severe cases, adjunctive steroids are recommended. Prophylactic options include TMP-SMX, atovaquone, dapsone, or pentamidine [ 75 ]. …

Management and Clinical Outcomes of Scleredema Diabeticorum: A Scoping Review.

Background/objectivesThe objective of this scoping review was to systematically map the available evidence for the management of scleredema diabeticorum (SD) to summarize the documented clinical outcomes with the aim to inform clinical practice and identify research gaps.MethodsWe conducted a scoping review identifying studies published in English from January 2005 to July 2025 through a comprehensive search of Scopus, MEDLINE, and the Cochrane Library. Eligible studies included randomized controlled trials, observational studies, case series, and case reports on treatment interventions and cl

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… specified | Worsened with respiratory failure and died suddenly at home [ 49 ] (2007) | Germany | 3 patients (A 55-year-old male, a 57-year-old female, and a 58-year-old female) with type 2 DM and progressive skin thickening | 2 years (55 M), 20 years (57F), 2 months (58F) | 55 M: UVA-1; 57F: UVA-1 + IV clindamycin …

Rapid Fire Presentations

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Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel.

Bispecific antibodies (BsAbs) are emerging as an important novel class of immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be more widely used in clinical practice. However, this new class of therapies is associated with a distinct adverse event (AE) profile that includes cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as AEs leading to increased infection risk such as cytopenias and hypogammaglobulinemia, and infections themselves. As preliminary data with this class of agents shows an increased risk of infection

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… sulfonamide (level IIC) • Inhaled or intravenous pentamidine for patients with neutropenia (level IIB) | • Treat as per standard anti-microbial regimens for PJP: ◦ Trimethoprim-sulfamethoxazole for 21 days (level III) ◦ Atovaquone 750 mg po BID for 21 days (for mild cases, sulfonamide allergy) (level III) ◦ Clindamycin …

Tumor-Treating Fields in Glioblastomas: Past, Present, and Future.

Tumor-treating fields (TTFields), a noninvasive and innovative therapeutic approach, has emerged as the fourth most effective treatment option for the management of glioblastomas (GBMs), the most deadly primary brain cancer. According to on recent milestone randomized trials and subsequent observational data, TTFields therapy leads to substantially prolonged patient survival and acceptable adverse events. Clinical trials are ongoing to further evaluate the safety and efficacy of TTFields in treating GBMs and its biological and radiological correlations. TTFields is administered by delivering l

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… | √ | √ | ORR, KPS | 4 years NCT04218019 (GERAS) | Suspended | 2 | 68 | ndGBM | Early/late TTFields | | √ | √ | √ | SCTR | 2 years NCT03223103 | Active, not recruiting | 1 | 13 | ndGBM | Poly-ICLC + TTFields + peptides | √ | √ | | | DLT, ORR | 5 years NCT04469075 | Recruiting | 1 | 58 | ndGBM | Clindamycin …

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… Clindamycin and cephalosporins have proved as best agents. If septic arthritis does not improve in 2–3 days, a surgical intervention with joint incision and thorough cleaning of the joint cavity is inevitable. An occasional relief joint puncture and lavage are important. …

Proceedings 27th Symposium ESVN‐ECVN

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Chinese expert consensus on the diagnosis and clinical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect that occurs after treatment for systemic diseases. However, most institutions currently rely on empirical methods to make diagnosis and treatment plans, and there is a lack of consensus or guidelines for the classification, staging and treatment of MRONJ in China. To address this gap and improve prognosis, an expert panel representing 11 renowned domestic medical colleges and affiliated hospitals in China was convened. The panel made a comprehensive literature review of previous treatment experiences and research findings to

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… The recommended therapeutic antibiotics for MRONJ patients include penicillin, amoxicillin, metronidazole, quinolones, clindamycin, doxycycline, erythromycin, ciprofloxacin and sitafloxacin [88] , [89] . …

Mathematical modeling in cancer nanomedicine: a review.

Cancer continues to be among the leading healthcare problems worldwide, and efforts continue not just to find better drugs, but also better drug delivery methods. The need for delivering cytotoxic agents selectively to cancerous cells, for improved safety and efficacy, has triggered the application of nanotechnology in medicine. This effort has provided drug delivery systems that can potentially revolutionize cancer treatment. Nanocarriers, due to their capacity for targeted drug delivery, can shift the balance of cytotoxicity from healthy to cancerous cells. The field of cancer nanomedicine h

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… Gonzalez, 'Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data', Clin. Pharmacokinet. 1–11 (2017) Hosoya H, Dobroff AS, Driessen WHP, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D’Angelo S, Ferrara F, Proneth B. …

Гут Микробиота Нарушение гематологовой терапии рака: Молекулярное понимание и последствия для эффективности лечения.

Гематологическая магнелезность (ГМ), включая лейкемию, лимфому и множественные миеломы, связана с бесконтрольным распространением аномальных кровеносных клеток, что создает серьезные клинические проблемы из-за их неоднородности и различных методов лечения. Несмотря на недавние достижения в области лечения, благодаря которым повысились показатели выживаемости, особенно в случае хронической лимфоцитической лейкемии и острой лимфоболической лейкемии, такие методы лечения, как химиотерапия и трансплантация стволовых клеток, часто нарушают микробиоту, что может негативно сказаться на результатах ле

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… . | [ 115 ] Ruminococcaceae | Decrease Erysipelotrichaceae | Decrease Enterobacteriaceae | Increase Allogeneic stem cell transplant | 96 patients | AML ALL LP MM | Family | Lachnospiraceae | Decrease | Antibiotics: piperacillin–tazobactam, ticarcillin, meropenem, clindamycin, metronidazole, and intravenous …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… The most likely contributors to colonization resistance, the gram-positive non-spore forming, lactic acid-producing bacilli, particularly bifidobacteria, are particularly susceptible to antibiotics known to impair colonization resistance, including the penicillins, rifamycin, clindamycin, erythromycin …

Osteonecrosis of the Jaw and Antiresorptive Agents in Benign and Malignant Diseases: A Critical Review Organized by the ECTS.

CONTEXT: Antiresorptive therapy significantly reduces fracture risk in patients with benign bone disease and skeletal-related events (SREs) in patients with bone metastases (BM). Osteonecrosis of the jaw (ONJ) is a rare but severe condition manifested as necrotic bone lesion or lesions of the jaws. ONJ has been linked to the use of potent antiresorptive agents, termed medication-related ONJ (MRONJ). OBJECTIVE: We aimed to identify the differences various aspects of MRONJ among distinct patient categories and provide recommendations on how to mitigate the risk and optimally manage MRONJ in eac

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… Although there is no consensus, the regimen most widely used in countries with widespread antibiotic resistance includes broad-spectrum antibiotics, such as amoxicillin/clavulanic acid, and clindamycin or metronidazole in combination or even as monotherapy. …