Результаты поиска

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2-78%

The Experience and Effectiveness of Nurse Practitioners in Orthopaedic Settings: A Comprehensive Systematic Review.

REVIEW QUESTION/OBJECTIVE: This review asks "What is the experience and effectiveness of nurse practitioners in orthopaedic settings"?The objective of the quantitative component of this review is to synthesise the best available evidence on effectiveness of orthopaedic nurse practitioner specific care on patient outcomes and process indicators.The objective of the qualitative component of this review is to synthesise the best available evidence on the experience of becoming or being an orthopaedic nurse practitioner in relation to role development, role implementation and (ongoing) role evalua

Impact of the National Health Insurance Coverage Policy on the Utilisation and Accessibility of Innovative Anti-cancer Medicines in China: An Interrupted Time-Series Study.

Objective: The study aimed to evaluate the impact of the National Health Insurance Coverage (NHIC) policy on the utilisation and accessibility of innovative anti-cancer medicines in Nanjing, China. Methods: We used the adjusted World Health Organisation and Health Action International methodology to calculate the price and availability of 15 innovative anti-cancer medicines included in the National Health Insurance drug list in 20 tertiary hospitals and six secondary hospitals in Nanjing before and after NHIC policy implementation. Interrupted time-series regression was used to analyse the cha

Совпадение в полном тексте источника
… Patients with low income or a guaranteed minimum income as defined by the local government are included in the PAP. The eligible patients receive a defined free dose of innovative anti-cancer medicines after making an OOP of a defined dose. …

Иммуномодулирующие механизмы мезенхимальных ячеек: цитокинские сети и терапевтический потенциал через иммунные, воспаленные и регенеративные расстройства.

Мезенхимические стромальные клетки (МСЦ) представляют собой многопоточные клетки, характеризующиеся их регенеративной способностью и сильными иммунодуляторными свойствами. В последние годы терапия на базе МСЦ привлекла к себе значительное внимание в качестве потенциального средства лечения широкого круга иммунных и дегенеративных заболеваний. Терапевтические эффекты MSC главным образом получают через паракринную сигнализацию и секрецию цитокинов, которые регулируют иммунную реакцию и содействуют ремонту тканей. В настоящем обзоре основное внимание уделяется пяти ключевым цитокинам, участвующим

EQUITY-MS: оценка качества исследования и лечения множественной скlerозы на основе данных пяти специализированных нейрологических центров в Великобритании — протокол исследования.

ВВЕДЕНИЕ: Социальные определяющие факторы здоровья — это условия, в которых живут люди, и системы вокруг них, которые формируют эти условия. Социальные определяющие факторы здоровья могут влиять на диагностику и лечение людей с множественной склерозом (МС), даже в странах с универсальной системой здравоохранения. Это исследование будет изучать, влияет ли возраст, пол и/или пол, проживание в более социально-экономически уязвимой зоне и принадлежность к миноритарной этнической группе на доступ к диагностике МС и лекарствам, модифицирующим течение болезни (ДМТ) для людей, проживающих в районах об

A review of big data and medical research.

Universally, the volume of data has increased, with the collection rate doubling every 40 months, since the 1980s. "Big data" is a term that was introduced in the 1990s to include data sets too large to be used with common software. Medicine is a major field predicted to increase the use of big data in 2025. Big data in medicine may be used by commercial, academic, government, and public sectors. It includes biologic, biometric, and electronic health data. Examples of biologic data include biobanks; biometric data may have individual wellness data from devices; electronic health data include t

A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand.

BackgroundHematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients. The treatment, however, is very costly, particularly in the context of low and middle income countries, and no studies have been carried out to explore its economic justifiability. This study aimed to estimate the cost-utility of HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for severe thalassemia in Thailand, and to investigate the affordability of HSCT using a budget impact analysis.MethodsA Markov model was used to estimate t

The Danish health care system and epidemiological research: from health care contacts to database records.

Denmark has a large network of population-based medical databases, which routinely collect high-quality data as a by-product of health care provision. The Danish medical databases include administrative, health, and clinical quality databases. Understanding the full research potential of these data sources requires insight into the underlying health care system. This review describes key elements of the Danish health care system from planning and delivery to record generation. First, it presents the history of the health care system, its overall organization and financing. Second, it details d

Совпадение в полном тексте источника
… Services provided by general practitioners (GPs) and specialists in private practice were funded by mandatory sickness funds, while hospital care was funded by local and federal taxes. 2 The local government reform of 1970 established the current organization of the Danish health care system. 2 Counties … Danish Ministry of Health, the Danish Ministry of Finance, Danish Regions, and Local Government Denmark. Danish strategy for digital health 2018–2022. Available from: www.healthcaredenmark.dk/news/new-danish-strategy-for-digital-health-2018-2022.aspx . Accessed February1, 2019. 16. …

Оказание высококачественной комплексной помощи в области склероза в Германии: проблемы и региональные модели.

Множественная склерозовая (МС) помощь в Германии вступила в стадию, когда терапевтический прогресс все больше сдерживается возможностями родовспоможения. Более ранняя диагностика, более широкий доступ к высокоэффективным методам лечения заболеваний (ДМТ) и более совершенные стратегии мониторинга расширили возможности для достижения благоприятных долгосрочных результатов. В то же время эти достижения усилили потребность в специализированных экспертных знаниях, инфильтрации и инфраструктуре мониторинга, оперативном доступе к изображениям, структурированных процедурах обеспечения безопасности и м

Data resource profile: Transforming Outcomes through Research in Cancer Healthcare in Victoria (TORCH-VIC).

INTRODUCTION: The Transforming Outcomes through Research in Cancer Healthcare in Victoria (TORCH-VIC) is a comprehensive population-based cohort that links cancer diagnoses recorded in the Victorian Cancer Registry with administrative health data to capture the complete cancer journey from pre-diagnosis through long-term outcomes. Established in 2022, TORCH-VIC provides real-world evidence on healthcare utilisation, patterns of care, costs, and outcomes across the cancer continuum in Victoria, Australia. METHODS: TORCH-VIC comprises adults aged 18 years and over diagnosed with colorectal, lun

The role of CD8+ T cells in the immunoregulation of osteoporosis.

INTRODUCTION: Osteoporosis weakens the skeleton by lowering bone mass and damaging bone microarchitecture. A growing body of evidence points to disruptions in osteoimmune homeostasis as a key driver of this disease. In particular, apoptosis of bone cells and immune cells appears to be a critical contributing mechanism. Within the bone marrow, CD8+ T cells display a surprising functional duality: whether they protect bone or promote its loss depends heavily on local signals. Under healthy conditions or after mechanical loading, activated CD8+ T cells help maintain bone mass. They do so mainly b

Mathematical modeling in cancer nanomedicine: a review.

Cancer continues to be among the leading healthcare problems worldwide, and efforts continue not just to find better drugs, but also better drug delivery methods. The need for delivering cytotoxic agents selectively to cancerous cells, for improved safety and efficacy, has triggered the application of nanotechnology in medicine. This effort has provided drug delivery systems that can potentially revolutionize cancer treatment. Nanocarriers, due to their capacity for targeted drug delivery, can shift the balance of cytotoxicity from healthy to cancerous cells. The field of cancer nanomedicine h

:: 8th Европейский конгресс фармацевтики: выдержки из выступлений

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Second-Class Care: How Immigration Law Transforms Clinical Practice in the Safety Net.

This article examines how U.S. immigration law extends into the health care safety net, enacting medical legal violence that diminishes noncitizens' health chances and transforms clinical practices. Drawing on interviews with health care workers in three U.S. states from 2015 to 2020, I ask how federal citizenship-based exclusions within an already stratified health care system shape the clinical trajectories of noncitizens in safety-net institutions. Focusing specifically on cancer care, I find that increasingly anti-immigrant federal policies often reshape clinical practices toward noncitize

Positive fertility outcomes in a female with classic congenital adrenal hyperplasia following bilateral adrenalectomy.

BACKGROUND: Many women suffer from daily distressing symptoms related to lymphedema following breast cancer treatment. Lymphedema, an abnormal accumulation of lymph fluid in the ipsilateral body area or upper limb, remains an ongoing major health problem affecting more than 40% of 3.1 million breast cancer survivors in the United States. Patient-centered care related to lymphedema symptom management is often inadequately addressed in clinical research and practice. mHealth plays a significant role in improving self-care, patient-clinician communication, and access to health information. The-Op

Ремонт тканей в центральной нервной системе: эпигенетическое программирование регуляторных Т клеток.

Регулирующие Т клетки хорошо известны своей иммуномодуляционной ролью, но также их регенеративная функция все чаще признается в различных типах тканей, включая скелетные мышцы, легкие и центральную нервную систему (ЦНС). В CNS Tregs, как было показано, поощряют дифференциацию олигодендроцитов в прекурсорных клетках, и их взаимодействие с микроглией поддерживает стимулирующую регенеративную микроокружную среду в мозгу. Подавляющая функция Tregs в значительной степени зависит от эпигенетической сигнатуры, в частности метилации ДНК, определенной сети связанных с Treg генов, включая FOXP3, CTLA4,

The concept of exceptionality: a legal farce?

How do we decide which treatments should be offered by the National Health Service (NHS) when we cannot afford to fund them all? In the absence of a positive appraisal by the National Institute for Health and Clinical Excellence (NICE), which mandates the provision of a treatment by the NHS, Primary Care Trusts (PCTs) are free to decide whether to provide a particular drug to some, or all, of their population. However, as public bodies, it is a well-established principle of Administrative Law that PCTs are not at liberty to fetter the exercise of their own discretion. They must recognise the p

Establishment of the First Comprehensive Adult and Pediatric Hematopoietic Stem Cell Transplant Unit in the United Arab Emirates: Rising to the Challenge.

Hematopoietic stem cell transplantation (HSCT) is increasingly indicated for various malignant and non-malignant diseases. In the United Arab Emirates (UAE), patients that could benefit from the procedure commonly need to seek medical care abroad in view of the lack of a comprehensive HSCT facility that could offer the full spectrum of interventions and monitoring protocols. This comes with considerable challenges related to coverage and logistics of travel. It also limits the continuity of clinical care, and presents inconvenience to patients who come from a different cultural background. In

Challenges of airway management in a patient with temporomandibular joint ankylosis complicating forceps delivery--a case report.

INTRODUCTION: These guidelines provide a comprehensive and practical framework for preventing osteoporosis. They are designed for use by healthcare professionals, including orthopaedic surgeons, primary care physicians, specialists, nurses, and allied health providers, as they work with patients at risk of or already diagnosed with osteoporosis. METHODOLOGY: This iterative process involved multiple questionnaires sent to a panel of 62 osteoporosis and bone health experts. Experts, including clinicians, researchers, and academicians, were selected based on their recognised expertise and contri

Successful Management of Neutropenic Sepsis Is Key to Better Survival of Patients With Blood Cancer in Sri Lanka: Real-World Data From the Resource-Limited Setting.

PurposeSepsis is the main cause of nonrelapse mortality, and there are no published data on applicability of supportive care protocols from high-income countries such as Sri Lanka. The aim of the study was to investigate management and mortality of neutropenic episodes among Hemato-Oncology patients.Materials and methodsRetrospective analysis of clinical characteristics, management, morbidity, and mortality of neutropenic Hemato-Oncology patients presented to the Lanka Hospital Blood Cancer Centre from January 1, 2019 to December 31, 2019 was performed.ResultsA total of 169 neutropenic episode