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Bipolar disorder and comorbid anxiety disorders in children and adolescents.

Recent attention has focused on the association between bipolar disorder and comorbid anxiety disorders in children and adolescents. There is a high rate of comorbidity between bipolar disorder and anxiety disorders in children and youths. Often, a child or adolescent with bipolar disorder has multiple comorbid anxiety disorders. In general, anxiety disorders precede the development of bipolar disorder in children. Comorbid disorders may worsen the course of each individual disorder. Pharmacologic management of the comorbid anxiety disorder is complicated by potential mood destabilization in a…

Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents.

OBJECTIVE: The study was designed to determine the validity of the Mood Disorder Questionnaire-Adolescent Version (MDQ-A) as a screening instrument for bipolar disorders (I, II, not otherwise specified, and cyclothymia) in an adolescent outpatient psychiatric population. METHOD: 104 adolescents and their parents completed the MDQ-A. Three versions of the MDQ-A were compared: (1) self report of symptoms by adolescent, (2) attributional report-how the adolescent believed teachers or friends would report his/her symptoms, and (3) parent report of adolescent's symptoms. DSM-IV diagnosis was made …

Psychopathologic structure of bipolar disorders: exploring dimensional phenotypes, their relationships, and their associations with bipolar I and II disorders.

BACKGROUND: Given its diverse disease courses and symptom presentations, multiple phenotype dimensions with different biological underpinnings are expected with bipolar disorders (BPs). In this study, we aimed to identify lifetime BP psychopathology dimensions. We also explored the differing associations with bipolar I (BP-I) and bipolar II (BP-II) disorders. METHODS: We included a total of 307 subjects with BPs in the analysis. For the factor analysis, we chose six variables related to clinical courses, 29 indicators covering lifetime symptoms of mood episodes, and 6 specific comorbid condit…

Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project.

OBJECTIVES: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. DESIGN/METHODS: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these t…

Психотипные рецепты у пациентов с биполярным расстройством до установленного диагностирования биполярного расстройства.

Объективное биполярное расстройство I (БП-I) часто неправильно диагностируется как серьезное депрессивное расстройство (ДДД), что затягивает соответствующее лечение. Цель этого исследования заключалась в изучении методов лечения пациентов BP-I, неправильно диагностированных с помощью MDD, и в оценке воздействия этих режимов на период до диагностики BP-I. 21,771 Пациенты BP-I первоначально неправильно диагностировали MDD и 50,667 Правильно диагностировали пациентов с BP-I. Модели лечения и их влияние на время диагностирования BP-I оценивались с использованием мультиномиальной логистической регр

Совпадение в полном тексте источника
… Bipolar disorder, current episode mixed, severe, without psychotic features F31.64 Bipolar disorder, current episode mixed, severe, with psychotic features F31.7 Bipolar disorder, currently in remission F31.71 Bipolar disorder, in partial remission, most recent episode hypomanic F31.72 Bipolar disorder … , without psychotic features F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features F31.6 | Bipolar disorder, current episode mixed F31.60 | Bipolar disorder, current episode mixed, unspecified F31.61 | Bipolar disorder, current episode mixed, mild F31.62 | Bipolar disorder …

Bipolar At-Risk Criteria and Risk of Bipolar Disorder Over 10 or More Years.

IMPORTANCE: Predicting the onset of bipolar disorder (BD) could facilitate preventive treatments. Among risk measures, bipolar at-risk (BAR) criteria have shown promise in predicting onset of bipolar disorder in the first year in clinical cohorts; however, it is not known whether BAR criteria are associated with the onset of BD in the longer term. OBJECTIVE: To assess the association of BAR criteria with onset of BD over 10 to 13 years follow-up. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study, completed between May 1, 2020, and November 7, 2022, included consenting people s…

Cognitive correlates of impulsive aggression in youth with pediatric bipolar disorder and bipolar offspring.

BACKGROUND: Youth with bipolar disorder (BD) and offspring of individuals with BD (BD-OFF) are characterized by higher levels of impulsive and overt aggression. The cognitive basis underlying these aggressive behaviors are not clarified in this population. The aim of this study was to investigate the relationship between cognitive alterations and aggressive behavior in youth with BD and BD-OFF. METHODS: Forty-two youth with BD, 17 BD-OFF and 57 healthy controls (HCs) were administered the Modified Overt Aggression Scale (MOAS), the Cambridge Neuropsychological Test Automated Battery (CANTAB),…

A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder.

BACKGROUND: Bipolar disorder is a chronic, recurrent disorder with a significant negative impact on quality of life. Effective treatments are available for acute mania. In contrast, there is a lack of consensus on the treatment of acute bipolar depression and long treatment options for bipolar disorder require more study. Aripiprazole is FDA approved for the treatment of acute mania. This paper reviews current data on the efficacy of aripiprazole in the treatment of acute bipolar depression and in maintenance therapy of bipolar disorder. METHODS: PubMed and abstracts of recent conferences wer…

Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression.

OBJECTIVE: Studies using augmentation of pharmacotherapies with omega-3 in bipolar disorder have been conducted; however, to date a specific meta-analysis in this area has not been published. Thus, we present the significant findings from meta-analyses of omega-3 in the treatment of bipolar depression and bipolar mania. DATA SOURCES: PubMed, CINAHL, Web of Science, and Cochrane Library databases were searched for clinical trials up to September 1, 2010, using the search terms bipolar disorder OR bipolar depression OR bipolar mania OR mania OR hypomania OR cyclothymia with the search terms ome…

Overview of patient care issues and treatment in bipolar spectrum and bipolar II disorder.

Recent studies have reported lifetime prevalence estimates of 1.0% for bipolar I disorder, 1.1% for bipolar II disorder, and 2.4% to 4.7% for subthreshold bipolar disorder, illustrating the need for consensus definitions of bipolar spectrum disorders. These definitions will aid researchers in studying viable treatments options, as well as help clinicians in the differential diagnosis of patients. Broader definitions of bipolar spectrum disorders would also allow clinicians to more accurately diagnose patients, rather than placing them in the catchall category of bipolar disorder not otherwise …

Validation of the Barcelona Bipolar Eating Disorder Scale for bipolar patients with eating disturbances.

BACKGROUND: Eating disturbances are frequent in bipolar disorder and are associated with poor outcome. Our objective is to assess the psychometric properties of a specific scale for the evaluation of eating disturbances in bipolar patients. SAMPLING AND METHODS: Validation study of 2 groups with a 6-month follow-up (90 patients diagnosed with bipolar and eating disturbances and 40 healthy controls). RESULTS: The scale showed: (1) adequate feasibility (non- response <2.5%); (2) adequate reliability (Cronbach's alpha coefficients = 0.79 and 0.57 in groups A and B; intraclass correlation coeffi…

Resilience and Attachment in Patients with Major Depressive Disorder and Bipolar Disorder.

BACKGROUND: Resilience represents one of the fundamental elements of attachment and has often been investigated in mood disorders. This study aims to investigate possible correlations between attachment and resilience in patients with major depressive disorder (MDD) and bipolar disorder (BD). METHODS: 106 patients (51 MDD, 55 BD) and 60 healthy controls (HCs) were administered the 21-item Hamilton Depression Rating Scale (HAM-D-21), the Hamilton Anxiety Rating Scale (HAM-A), the Young Mania Rating Scale (YMRS), the Snaith-Hamilton Pleasure Scale (SHAPS), the Barratt Impulsiveness Scale-11 (BI…

Clinical differences between bipolar disorder and borderline personality disorder: a case report.

The clinical difference between bipolar disorder and borderline personality disorder has always been a diagnostic challenge, especially with type II bipolar disorder and subthreshold symptoms, opening a diagnostic bias with the consequent repercussions of inappropriate treatment. Both pathologies are often misdiagnosed initially. The objective of this article is to emphasise the main clinical differences between the two pathologies. We present the case of a patient with a long history of psychiatric symptoms that started in childhood, with considerable functional impairment, who met the criter…

Pharmacological Treatment for Comorbid Bipolar Disorder and Obsessive-Compulsive Disorder in Adults.

Comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is fairly common, and the treatment of these conditions when comorbid is challenging. Serotonin reuptake inhibitors, the first option for treatment of OCD, can worsen BD symptoms, and mood stabilizers are generally not efficacious for OCD. Our goal in this article is to assess the clinical effectiveness of pharmacotherapies for comorbid BD-OCD in adults. We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases on April 30, 2017, and we also searched the reference lists of iden…

Disentangling pediatric bipolar disorder and attention deficit-hyperactivity disorder: A neuropsychological approach.

The clinical and diagnostic debate circulating pediatric bipolar disorder (PBD) has been highlighted as one of the most controversial themes in child psychiatry. With atypical symptomatic expression, constituting its predominant diagnostic discrepancy, PBD is manifested through prolonged manic episodes and affective storms, lacking the symptomatic cycling and episodic nature presented in adult BD. Apart from its unique clinical presentation, the substantial symptomatic overlap with attention deficit hyperactivity disorder (ADHD) indicate an important diagnostic challenge in PBD. Specifically, …

Comorbidity of bipolar I disorder and conduct disorder: a familial risk analysis.

OBJECTIVE: To investigate the association between pediatric bipolar I (BP-I) disorder and conduct disorder (CD) using familial risk analysis. METHOD: We compared diagnoses in relatives of youth in four proband groups defined by the presence or absence of BP-I and CD: (1) probands with neither CD nor BP-I (probands: N = 550; relatives: N = 1656), (2) probands with CD and without BP-I (probands: N = 40; relatives: N = 127), (3) probands with BP-I and without CD (probands: N = 197; relatives: N = 579), and (4) probands with both CD and BP-I (probands: N = 176; relatives: N = 488). All subjects w

A Comparison of Self-Reported Impulsivity in Gambling Disorder and Bipolar Disorder.

The present study investigated self-reported impulsivity in gambling disorder (GD) and bipolar disorder (BD). Participants with GD (n = 31), BD (n = 19), and community controls (n = 68) completed diagnostic interviews and symptom severity and functioning assessments. Participants also completed the UPPS-P Impulsive Behavior Scale composed of five dimensions including urgency (i.e., acting rashly under conditions of negative or positive emotion), lack of perseverance (i.e., inability to maintain focus), lack of premeditation (i.e., inability to consider negative consequences), and sensation see…

Metabolomics of Major Depressive Disorder and Bipolar Disorder: Overview and Future Perspective.

Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their shared clinical features result in high rates of misdiagnosis due to a lack of biomarkers that allow their differentiation. BD is more frequently misdiagnosed as MDD because of overlapping symptomology, often later onset of mania, and frequent occurrence of depressive episodes in patients with BD. Misdiagnosis is also increased when patients with BD present symptoms indicative of a clinically significant depressive ep…

Early Maladaptive Schemas: A Comparison Between Bipolar Disorder and Major Depressive Disorder.

BACKGROUND: It is still unclear how bipolar disorder (BD) differentiates from major depressive disorder (MDD) outside major mood episodes. To further elucidate this area, the present study compared the two mood disorders in terms of early maladaptive schemas (EMSs) during remission. METHOD: The sample consisted of 49 participants with BD and 30 participants with MDD who were currently in remission. The participants completed the Young Schema Questionnaire. RESULTS: The BD group scored significantly higher than the MDD group on seven EMSs: abandonment, failure to achieve, insufficient self-co…