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A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… Zataria multiflora (ZEO) and Cinnamomum zeylanicum (CEO) vapor-phase essential oils exert antifungal activity against P. citrinum via physical volatile diffusion and chemical synergistic effects ( Imaz et al., 2023 ) ( Table 1 , Figure 11 ). … . † ZEO, zataria multiflora essential oils; CEO, cinnamomum zeylanicum essential oils; CEA, citrus extract a; SPE, saffron petal extract; LCEO, litsea cubeba essential oil; EOs, essential oils. ‡ MIC, minimum inhibitory concentration; MFC, minimum fungicidal concentration; BVPE, bamboo vinegar powder …

β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid wit

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… According to Essential Oil Database (EssOilDB) ( http://nipgr.res.in/Essoildb/ ), BCP as a plant volatile compound is commonly found in basil ( Ocimum spp.), cinnamon ( Cinnamomum spp.), black pepper ( Piper nigrum L.), cloves ( Syzygium aromaticum ), cannabis ( Cannabis sativa L.), lavender ( Lavandula … Moreover, Shahwar et al. 29 noted that BCPO derived from Cinnamomum tamala leaf extracts exhibited moderate cytotoxic activity against human ovarian cancer cell line, A‐2780. The antiproliferative effect of BCP on several cancer cell lines was reported by Dahham et al. 30 . …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Ohwi | LPS-induced male BALB/C mice | 50 mg/kg | ↓: ICAM-1, VCAM-1, E-selectin, TNF-α, IL-1β | Lung | NA | Wang et al. (2019b) Ethanol extract of Cinnamomum cassia | Cinnamomum cassia (L.) … Modern studies have confirmed the therapeutic effect of Cinnamomum cassia (L.) J.Presl in sepsis by inhibiting the activation of inflammatory vesicles. …

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, anothe

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… Cinnamomum cassia Cinnamomum cassia , which contains coumarins, cinnamic acid, as well as cinnamaldehyde, was described as a neuroinflammation-inhibiting compound, capable of exerting its action through attenuation of iNOS, COX-2 expression and NF-κB [ 125 ]. … The study by Kim et al. [ 126 ] presented that the administration of Cinnamomum Cortex (the bark of C. cassia ) water extract could induce a significant suppression of the activation of astrocytes and microglia. After cold allodynia causing oxaliplatin injection, C. …

Dietary supplements for dysmenorrhoea.

BACKGROUND: Dysmenorrhoea refers to painful menstrual cramps and is a common gynaecological complaint. Conventional treatments include non-s … bal medicines (German chamomile (Matricaria chamomilla, M recutita, Chamomilla recutita), cinnamon (Cinnamomum zeylanicum, C. verum), Damask rose (Rosa damascena), dill (Anethum graveolens), fennel (Foeniculum vulgare), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), guava (Psidium guajava), rhubarb (Rheum emodi), uzara (Xysmalobium undu …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… activity of essential oil from Ocimum viride towards COLO 205 cells Food and Chemical Toxicology 2010 48 1 336 344 2-s2.0-72149107574 19852999 10.1016/j.fct.2009.10.021 138 Unlu M Ergene E Unlu GV Zeytinoglu HS Vural N Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum … of Citrus reticulate (Petitgrain Mandarin) and Pelargonium graveolens (Geranium) essential oils Research Journal of Agriculture and Biological Sciences 2009 5 5 740 747 152 Tung YT Chua MT Wang SY Chang ST Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon ( Cinnamomum …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Alternative approaches for oral candidiasis include essential oils (e.g., Allium tubeorosum , Cinnamomum cassia , Cinnamomum zeylanicum , Coriandrum sativum , Pelargonium graveolens , and Zataria multiflora ) and phytochemicals (citral, thymol, curcumin) [ 176 , 177 , 178 , 179 ]. … Several phytotherapeutic alternatives, such as Acacia nubica , Nigella sativa , Boswellia papyrifera , Melaleuca alternifolia , Moringa oleifera , Zingiber officinalis , Piper nigrum , Eugenia caryophillus , and Cinnamomum verum , have been suggested, with positive effects on the treatment of this disease …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… Ginger ( Zingiber officinale ) | Variable effect: from no significant effect on PLT aggregation (by ADP and epi) ( 138 ) to reduced PLT aggregation with epinephrine only ( 139 ) to reduced PLT aggregation and inhibition of TXB 2 production* ( 140 ) Green tea ¶ | Reduced platelet aggregation ( 13 , 141 ) Cinnamomum …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… Nimolicinol Image 90 Azadirachta indica protease inhibition [ 35 ] Lactucopicrin Image 91 Lactuca virosa 3CL Pro inhibition and ACE2 [ 55 ] Cordioside Image 92 Tinospora cordifolia binds with main protease [ 175 ] Vindolinine Image 93 Catharanthus roseus binds with NSP15 [ 35 ] Camphorating D Image 94 Cinnamomum … indica | protease inhibition | [ 35 ] Lactucopicrin | Image 91 | Lactuca virosa | 3CL Pro inhibition and ACE2 | [ 55 ] Cordioside | Image 92 | Tinospora cordifolia | binds with main protease | [ 175 ] Vindolinine | Image 93 | Catharanthus roseus | binds with NSP15 | [ 35 ] Camphorating D | Image 94 | Cinnamomum …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

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… Some of the most frequently used essential oils as cancer treatments include: Origanum vulgare, Thymus vulgaris, Cymbopogon citratus, Lavandula angustifolia, Melaleuca alternifolia, and Cinnamomum verum, along with several of the essential oil active components: carvacrol, thymol, citral, linalool, linalyl … morphology; FTIR confirmed functional groups | IC50 against HepG2: 13.8 μg/mL (AgNPs), 22.9 μg/mL (essential oil); Dose-dependent cell death (36.31% mortality at 10 μg/mL AgNPs vs. 12.49% for oil); Morphological changes (circular shape, membrane shrinkage, vacuolization) | ( 123 ) Cinnamon cassia ( Cinnamomum …

Role of TRP Channels in Cancer-Induced Bone Pain.

The burden of cancer is growing in almost every country. Bone metastases significantly affect the prognosis and lead to an increase in mortality and morbidity. The management of cancer-induced bone pain (CIBP) still shows various unmet needs. Opioid use is burdened by a number of possible side effects. Moreover, recent progresses in cancer treatment significantly increased the life expectancy of cancer patients, even those with metastatic disease. In this narrative review, we reported the main findings regarding TRP channel function in cancer pain models. TRP cation channels play a key role in

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… For instance, camphor, a terpenoid from the wood of the camphor laurel tree ( Cinnamomum camphora ), is a TRPV1 [ 23 ], TRPV3 [ 24 ], and TRPA1 agonist at low concentrations, as well as a TRPA1 antagonist at high concentrations, thus possibly mediating its analgesic effect [ 25 ]. …

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.

Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a commo

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… (up to 47.5% in fresh berries), Cinnamomum iners Reinw. ex Blume (up to 35.9% in leaves), Salvia officinalis L. (up to 31.8% in aerial parts), Helichrysum melaleucum (up to 35.4% in aerial parts), Uvariodendron calophyllum RE Fries (up to 32.5% in the stem bark), and Zingiber nimmonii (J. …

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

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… ), Maidong (Ophiopogon japonicus), Gancao (Glycyrrhiza uralensis), Zhi Heshouwu (Polygonum multiflorum), Ejiao (Donkey-hide gelatin), Wuweizi (Schisandra chinensis), Dangshen (Codonopsis pilosula), Cuguojia (Testudinis Carapax Et Plastrum prepared with vinegar), Dazao (Ziziphus jujuba), and Guizhi (Cinnamomum …

A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer.

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common

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… PKM2, a valuable therapeutic target for cancer, mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation [ 81 , 82 ]. 2′-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia , exerts anticancer effects through multiple mechanisms and …

Traditional herbal medicine for the prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis with association rule analysis.

IntroductionThis systematic review and meta-analysis evaluated the preventive efficacy and safety of orally-administered traditional herbal medicine (THM) for the management of chemotherapy-induced peripheral neuropathy (CIPN) in patients with cancer.MethodsRandomized controlled trials (RCTs) evaluating the efficacy of orally-administered THM in the prevention of CIPN published up to 30 April 2024 were retrieved from nine databases. The primary outcome was the incidence of CIPN, and the secondary outcomes included changes in neuropathic pain intensity, nerve conduction study parameters, Karnof

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… The essential oil from the twigs of Cinnamomum cassia presl alleviates pain and inflammation in mice . J. Ethnopharmacol. 194 , 904 – 912 . 10.1016/j.jep.2016.10.064 27780753 Sureda A. Tejada S. Khan U. M. Selamoglu Z. ( 2023 ). …

Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry.

Many of the drugs used in treatment today have been designed based on the "specificity paradigm". Resistance has developed against drugs designed using this approach, leading to a decrease in their effectiveness. In addition, it is well-documented in the literature that diseases with complex etiologies, such as Alzheimer's, Parkinson's, and cancer are influenced by multiple genetic and/or environmental factors. As a result, specificity paradigm is often insufficient for treating these diseases. Therefore, there is a need to develop drugs that interact with multiple targets simultaneously throu

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… Using a library of 40 compounds derived from Curcuma longa and Cinnamomum seylanicum , they identified quercetin and curcumin as the most promising hepatoprotective agents. …

Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation.

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthet

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… Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Front. Pharmacol. 2021;12:600139. doi: 10.3389/fphar.2021.600139. 6. Bellik Y., Boukraâ L., Alzahrani H.A., Bakhotmah B.A., Abdellah F., Hammoudi S.M., Iguer-Ouada M. …

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… camphor [ kam′for ] a ketone derived from the cinnamon tree, Cinnamomum camphora , or produced synthetically; used externally as an antiphlogistic and antiseptic; applied in liniments as a counterirritant; administered as a steam inhalant as an expectorant. …

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C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of