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Clinical findings in families with chordoma with and without T gene duplications and in patients with sporadic chordoma reported to the Surveillance, Epidemiology, and End Results program.

OBJECTIVE: To gain insight into the role of germline genetics in the development of chordoma, the authors evaluated data from 2 sets of patients with familial chordoma, those with and without a germline duplication of the T gene (T-dup+ vs T-dup-), which was previously identified as a susceptibility mechanism in some families. The authors then compared the patients with familial tumors to patients with sporadic chordoma in the US general population reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program through 2015. METHODS: Evaluation of family

Rural-Urban Disparities in Survival Among Patients With Malignant Primary Osseous Neoplasms of the Spine and Sacropelvis: A Population-Based Cohort Study.

Background Malignant primary osseous neoplasms of the spine and sacropelvis are rare tumors whose outcomes rely heavily on specialized, guid … ndrosarcoma, osteosarcoma, or Ewing sarcoma of the vertebral column or the pelvic bones, sacrum, or coccyx with known survival time were included. Rurality was defined using SEER county attributes, with nonmetropolitan counties classified as rural. Multivariable Cox proportional hazards models for overall survival and cause-specific survival were adjuste …

Five Herbs Plus Thiamine Reduce Pain and Improve Functional Mobility in Patients With Pain: A Pilot Study.

UNLABELLED: Context • Five herbs-Urtica dioica (stinging nettle), Boswellia serrata, Equisetum arvense, Allium sativum, and Apium graveolens … laneous locations (40.7%) making up the rest of the sites, including the neck, jaw, foot, heel, and coccyx. The mean disease duration was 5.61 y, with a range of 4 mo to 20 y. The average VAS pain subscale score was 58.04 at baseline and 23.33 at follow-up. The mean difference between the 2 scores was 34.71 (confidence interval [CI], 26.16-47.01). A sign …

[CT and MRI manifestations of the axial area primary peripheral primitive neuroectodermal tumors].

OBJECTIVE: To explore CT and MRI manifestations of the axial area peripheral primitive neuroectodermal tumors (pPNETs) in order to improve t … cases in lumbar vertebrae, 1 case in cervical vertebrae, 1 case in cervical spinal canal, 1 case in coccyx, 1 case in the right iliac bone, 1 case in presacral space. Cross sectional the smallest tumor maximum level was 1.1 cmx 1.2 cm in size, the biggest tumor was 8.0 cm x 9.2 cm, the median size was 4.4 cm x 5.7 cm, of them, the tumor of maximal diamet …

Urologic and anorectal complications of sacrococcygeal teratomas: prenatal and postnatal predictors.

PURPOSE: Anorectal and urologic sequelae are observed in long-term survivors of sacrococcygeal teratoma (SCT). In this study we evaluate the incidence and predictors of anorectal and urologic complications in SCT. METHODS: A retrospective review was performed for all SCT patients who underwent resection at a single institution between 2000 and 2012. Enrollment criteria included a minimum of 12months follow-up. Categorical variables were analyzed by Fisher's exact test and continuous variables by Mann Whitney test (p<0.05). RESULTS: Forty-five patients were studied. Anorectal complications oc

Comparison of Non-radiographic Axial Spondyloarthritis and Ankylosing Spondyltis from a Single Rheumatology Hospital in Morocco.

BACKGROUND: According to the new classification criteria developed by The Assessment of SpondyloArthritis International Society, patients with axial spondyloarthritis (axSpA) can be classified in 2 subgroups: Patients with radiographic axial spondyloarthritis: ankylosing spondylitis patients (AS) and those with non-radiographic axial spondyloarthritis (nr-axSpA). OBJECTIVE: The aim of the present study is to describe and discuss the differences and similarities between the two subgroups. PATIENTS AND METHODS: A cross-sectional study was conducted in a single rheumatology hospital in Morocco.

Currarino syndrome: proposal of a diagnostic and therapeutic protocol.

BACKGROUND/PURPOSE: The Currarino syndrome (CS) is a peculiar form of caudal regression syndrome (CRS) characterized by the association of hemisacrum, anorectal malformation (ARM), and presacral mass. The authors analyzed retrospectively their series, and they propose a multidisciplinary diagnostic and therapuetic protocol that until now has not been introduced. METHODS: A series of 6 patients with CS is presented. Five of them were treated initially in other centers. None of them had an early diagnosis. All presented associated anomalies; in 50%, Hirschsprung's disease (HD) and other dysgang

[Experiment study on ultrashort wave for treating vascular crisis after rat tail replantation].

OBJECTIVE: To explore the effect and mechanism of ultrashort wave (USW) for prevention and treatment of vascular crisis after rat tail replantation. METHODS: Eighty 3-month old female Sprague Dawley rats (weighing 232.8-289.6 g) were randomly divided into 5 groups. In each group, based on the caudal vein and the coccyx was retained, the tail was cut off. The tail artery was ligated in group A; the tail artery was anastomosed in groups B, C, D, and E to establish the tail replantation model. After surgery, the rats of group B were given normal management; the rats of group C were immediately g…

Utility of Multimodal Intraoperative Neuromonitoring for Excision of Filum Terminale Ependymoma in Close Proximity to Conus.

Myxopapillary ependymomas (MPEs) are well-circumscribed tumors arising mainly from the caudal neuraxis, i.e., conus medullaris (CM) and filu … tradural and extradural component. The intradural FT extends from the inferior tip of the CM to the coccyx.4 The intradural FT-CM junction is not demarcated, but rather a zone of transition, with neural tissue being incrementally replaced by fibrous tissue of filum, gradually converging to a pure non-neural FT.5 In intramedullary FT MPE in close proximit …

[Acupuncture improves leptomeningeal collateral compensatory efficiency in the affected hemisphere and reduces neuronal damage in cortical M5 region in rats with middle cerebral artery occlusion].

OBJECTIVES: To observe the dynamic compensatory characteristics of the leptomeningeal collateral (LMC) circulation in the affected hemispher … -acupoints (3 mm below the starting point of bilateral axillary midline and 3 mm beside the apex of coccyx) for 30 min. In the butylphthalide group, butylphthalide injection (2.25 mg/kg) was injected into the tail vein once 3 h after successful modeling. Laser speckle blood flow imaging was used to monitor the changes of blood flow perfusion and LMC vasc …

Colorectal cancer with first known case of simultaneous bilateral tibial metastases.

The most common osseous metastatic regions for colorectal cancer are the lumbar and sacral vertebrae and the pelvis. There are few reported cases of isolated solitary tibial metastasis, and simultaneous bilateral solitary tibial metastases in colorectal cancer are even rarer. A 62-year-old female patient was admitted to our inpatient clinic 3 years after receiving initial chemotherapy for a rectosigmoid adenocarcinoma with liver metastasis. The patient complained of left leg pain. Radiographs and magnetic resonance imaging revealed a 3- × 3-cm mass in the right proximal tibia and a 2- × 7-cm m

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… Whole-body technetium 99m bone scans were performed 3 weeks after the operation and showed uptake signals around the coccyx and bilateral tibia mixed with postoperative changes ( Figure 4 ). Figure 3. Postoperative radiographs. … Postoperative technetium 99 m scans showing uptake signals around the coccyx and bilateral tibia (black arrows). (a) anterior view; (b) posterior view. The postoperative course was relatively uneventful, with right leg splinting and ambulation with partial weight-bearing. …

Атипичные презентации Acolovir-Resistant Herpes Simplex Virus в иммунокомпромиссированных пациентах: Серия дел.

Инфекции, связанные с вирусом герпеса (HSV), у иммунокомпромиссированных пациентов могут иметь атипичные представления - от грануломатных до линейных эрозийных повреждений - и превращаться в рефракторную и стандартную терапию. Мы сообщаем three :: случаи некротизации категорической инфекции HSV у иммунокомпромиссированных пациентов с гематологическими малигнациями или предшествующими химиотерапиями, все из которых имеют нетипичные и рефракторные проявления заболевания. One дело касалось 53-year-old :: пациентка с реанимацией/рефрактом острой миэлоидной лейкемией (АМЛ), разработавшая некротизир

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… On examination, there was a cluster of locally scattered, ulcerative, bleeding lesions over the coccyx and upper buttock region (Figure 8 ). … Figure 8 The severe ulcerations exhibited multiple irregular, coalescing ulcers over the coccyx and upper buttock, characterized by red, moist bases and yellowish slough. Surrounding skin appears erythematous and inflamed, with signs of maceration. …

The Value of Transrectal Ultrasound in the Preoperative Diagnosis of Complex Anal Fistula (CAF): Based on a Retrospective Cohort Study.

OBJECTIVE: A case-control study was employed to retrospectively analyze the value of transrectal ultrasound in the preoperative diagnosis of … are the MRI image features: abnormal long bar signal shadow from the dorsal side of the end of the coccyx to the S5 plane, low signal on T1WI, high signal on T2WI, blurred boundary, uneven signal, bifurcation in the lower end of the tail for "Y" shape, one branch opening at the body surface at about 6 o'clock, the other walking horizontally, passing thr …

Unusual presentation of sacrococcygeal teratomas and associated malformations in children: clinical experience and review of the literature.

BACKGROUND: Sacrococcygeal teratomas are the most common and best known extragonadal teratomas in neonates and infants, but they sometimes p … tomas. Sacrococcygeal teratomas are commonly considered as lesions at particular risk, in which the coccyx must always be removed together with the mass and overlying skin, taking particular care of the deep pelvic fascia to prevent functional disorders of the bladder and anal canal, as well as any motor alterations of the lower limbs, usually due to iat …

Giant sacral chondrosarcoma in an elderly male : a case report.

UnlabelledPrimary sacral tumours are rare, therefore experience of managing their associated complications are very limited. Effective surgical treatment of pelvic chondrosarcoma remains a major challenge for orthopaedic surgeons, due to the complex anatomic structure of the pelvis, the lack of defined compartment borders, the close vicinity to vital structures, and the risk of jeopardizing pelvic structural stability. We report a rare case of a giant sacral chondrosarcoma (100cm x 80cm) in an elderly male who successfully underwent tumour resection with good functional outcome and recovery. L

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… Intra-operative by the tumour mass was noted to have originated from S1 down to the coccyx and mid buttock and encased the left sciatic nerve on the left side. …

Apical lung mass-A rare presentation of multiple myeloma.

Multiple myeloma is a neoplastic proliferation of immunoglobulin-producing plasma cells with clinical features resulting from infiltration of plasma cells into bones and other organs. Multiple myeloma manifesting as an apical lung mass is less common and very few cases have been reported. We report the case of a 50-year-old female who presented with an apical lung mass which happened to be multiple myeloma arising from the upper ribs into the lung. At the time of diagnosis, patient had axillary lymph node metastasis with extensive bony involvement. This case report and literature review provid

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… CT scan of the chest, abdomen, and pelvis done showed pleural based mass eroding the right second rib, 6 local metastatic lymph nodes (LN) outside right rib cage, lytic skeletal metastasis on right scapula, eighth, ninth ribs, iliac bones, left ischium, sacrum, coccyx, throughout thoracic and lumbar …

AI-Assisted Detection and Localization of Spinal Metastatic Lesions.

ObjectivesThe integration of machine learning and radiomics in medical imaging has significantly advanced diagnostic and prognostic capabilities in healthcare. This study focuses on developing and validating an artificial intelligence (AI) model using U-Net architectures for the accurate detection and segmentation of spinal metastases from computed tomography (CT) images, addressing both osteolytic and osteoblastic lesions.MethodsOur methodology employs multiple variations of the U-Net architecture and utilizes two distinct datasets: one consisting of 115 polytrauma patients for vertebra segme

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… In this stage, each vertebra is individually isolated and segmented, starting from the cervical spine and extending through to the lower spine, inclusive of the sacrum and coccyx. … In the initial stage, the augmentations enhanced the training of the neural network tasked with isolating individual vertebrae from the cervical to the lower spine, including the sacrum and coccyx. …

Radially Emitting Diode Laser Closure of Transsphincteric Fistula-in-Ano.

BACKGROUND: There has been a shift in the treatment of fistula-in-ano toward a focus on the preservation of continence while simultaneously … 1 experienced recurrence and worsening of their disease process with subsequent involvement of the coccyx (previous deep postanal space abscess). LIMITATIONS: Limitations to our study include its nonrandomized prospective nature, single center and surgeon experience, and small patient sample size. CONCLUSIONS: Radially emitting diode laser closure is …

Primary lymphoma of bone: a population-based study of 2558 patients.

BackgroundPrimary lymphoma of bone (PLB) is an extremely rare malignancy arising in the skeletal system. There is no consensus over the best definition of PLB. Most of the published articles are single-institutional retrospective studies with a limited sample size. The rarity of PLB and discrepancies on diagnostic criteria has resulted in a vague understanding of PLB.MethodsWe retrospectively analyzed the clinical characteristics and prognostic factors of 2558 PLB patients who were registered in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2016. Survival rates w

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… A total of 1430 cases (55.9%) had primary axial bone lesions (including vertebral column, rib, sternum, clavicle, pelvic bones, sacrum, coccyx, and associated joints), while 223 cases (8.7%) had craniofacial bone lesions (including mandible, bones of skull and face and associated joints) and 905 cases … Primary anatomic sites (ICD site code) | Number | Percentage Vertebral column (C41.2) | 767 | 29.98% Long bones of lower limb and associated joints (C40.2) | 597 | 23.34% Pelvic bones, sacrum, coccyx and associated joints (C41.4) | 356 | 13.92% Long bones of upper limb, scapula, and associated joints …