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Расовые и этнические различия в использовании психотерапии для борьбы с заболеваниями среди взрослых с множественным склерозом: анализ реального мира в рамках программы исследований " Все мы " .

ВВЕДЕНИЕ: Расовые и этнические различия в использовании множественных методов лечения склероза (МС) с модифицирующими заболеваниями (ДМТ) задокументированы, но не до конца описаны на всех этапах лечения. МЕТОДЫ: Мы провели ретроспективное когортное исследование с использованием программы исследований " Все мы " ( " Все мы " ).2024 (выпуск данных) среди взрослых ≥18 годы с подтвержденным MS (N = 3,508). Итогом этого были инициирование DMT, время до первого DMT, отбор наркоклассов, замена, эскалация и прекращение. Высокоэффективные ДМТ были определены как агенты, ≥50% - относ

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Association between the prognostic nutritional index and early mortality of AML patients after allogeneic HSCT: a retrospective cohort analysis.

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is an effective treatment for Acute Myeloid Leukemia (AML). The pre-transplantation Prognostic Nutritional Index (PNI) plays a critical role in determining patient prognosis, however, its correlation with mortality within 180 days after SCT is currently unclear. OBJECTIVE: This study aimed to investigate the association between PNI and mortality within 180 days among AML patients who underwent HSCT. METHODS: We conducted a cohort study by retrospectively collecting data from AML patients who underwent HSCT. The PNI wa

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… The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because This study was approved by the ethics committee of Xinqiao Hospital. …

Fertility management and outcomes after CAR T-cell therapy: an international survey from the Cellular Therapy and Immunobiology working party of the European Society for Blood and Marrow Transplantation.

BACKGROUND: CAR T-cell therapy has become a highly effective treatment for hematological malignancies, and emerging evidence indicates promising benefits for non-oncohematological conditions. As its clinical use broadens, understanding long-term outcomes and late complications is crucial. One critical yet understudied area is fertility, for which current evidence remains limited and no formal guidelines provide direction for patients undergoing CAR T-cell therapy. METHODS: To address this gap, we conducted a cross-sectional survey on behalf of the Cellular Therapy and Immunobiology Working Pa

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… Patients or legal guardians provided written informed consent for data collection and analysis in accordance with the Declaration of Helsinki and with the centers’ ethical research guidelines. Sex was recorded from medical records and reported as a biological variable. …

Типы и результаты лечения у пациентов с множественной миеломой во втором рецидиве в Колумбии (свобода) - многоцентральное исследование наблюдений.

ВВЕДЕНИЕ: Выбор методов лечения для пациентов с рецидивированной множественной миеломой (ММ) является весьма индивидуализированным и характеризуется различными методами лечения. Хотя имеются существенные данные о рецидиве MM в странах с высоким уровнем дохода, данные о методах лечения и клинических результатах при втором рецидиве у населения Латинской Америки по-прежнему ограничены. В этом исследовании описываются клинические характеристики, модели лечения, эффективность и безопасность лечения третьей линии у пациентов, у которых MM испытывает второй рецидив в обычной клинической практике по в

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with national legislation and institutional requirements. Author contributions GQ: Writing – review & editing, Writing – original draft. …

Romiplostim N01 accelerates platelet engraftment in autologousstem cell transplantation using non-cryopreserved peripheral blood stem cells for plasma cell neoplasms.

BACKGROUND: Delayed platelet engraftment remains a major limitation of autologous stem cell transplantation (ASCT) for plasma-cell neoplasms. Romiplostim N01, a thrombopoietin receptor agonist, may enhance early megakaryocytic recovery, while the use of non-cryopreserved peripheral blood stem cells (PBSCs) eliminates dimethyl-sulfoxide-related toxicity and reduces procedural cost. METHODS: This retrospective study evaluated 15 patients receiving non-cryopreserved PBSCs and early Romiplostim N01 after ASCT and compared them with 21 historical controls who received cryopreserved PBSCs and recom

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… The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because This is a retrospective study using de-identified patient data, and obtaining informed consent is impracticable …

Сексуальная последовательность показывает низкочастотные и редкие варианты воздействия на подверженность множественным склерозам в турецких семьях.

Множественный склероз (MS) характеризуется как болезнь центральной нервной системы с иммунной помощью, которая характеризуется хроническим воспалением, обезвоживанием и прогрессивным нейродегенерацией. В этом исследовании мы проанализировали вклад низкочастотных и редких генетических вариантов в подверженность MS в рамках одной из крупнейших на сегодняшний день семейных групп MS, в состав которых входят 215 человек из 59 турецких семей с множественными MS. На всех образцах, включая затронутых и не затронутых членов, была проведена целая последовательность экзотических операций, за которой посл

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… Informed consent was obtained from all participants or their legal guardians prior to their inclusion in the study. DNA isolation and whole exome sequencing Genomic DNA was isolated from peripheral blood using a standard salting-out procedure 40 . …

Strengths and opportunities to clinical trial enrollment among BIPOC, rural dwelling patients in the northwest United States: a retrospective study.

Introduction: Clinical trials investigating the safety and efficacy of experimental drugs and devices are the cornerstone of medicinal advancement. Enrolling sufficient participants in these trials is vital to ensure adequate statistical power and generalizability. Clinical trial participation is particularly low among certain populations, including medically underserved communities (i.e., rural areas) and Black, Indigenous, and People of Color (BIPOC). Methods: A retrospective study design was used to understand patient outcomes and access/barriers to clinical trial participation in the rural

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients.

Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depleted peripheral blood stem cells from haploidentical family donors after a reduced-intensity conditioning with fludarabine, thiotepa, and melphalan. Thirty pediatric and 30 adult patients with acute leukemia (n = 43), myelodysplastic or myeloproliferative syndrome (n = 6), multiple myeloma (n = 1), solid tumors (n = 6), and non-malignant disorders (n

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… Written informed consent was obtained from either patients or their legal guardians and donors in accordance with the Declaration of Helsinki. Graft processing The hematopoietic stem cell graft was prepared decentralized at six different manufacturing sites across two countries. …

High Serum Carbohydrate Antigen (CA) 125 Level Is Associated With Poor Prognosis in Patients With Light-Chain Cardiac Amyloidosis.

Background and Aims: Patients with light-chain cardiac amyloidosis (AL-CA) are characterized by high levels of serum carbohydrate antigen 125 (CA 125). However, studies have not explored the correlation between CA 125 and AL-CA. The aim of this study was to explore the clinical implications of an increase in CA 125 in patients with AL-CA. Methods and Results: A total of 95 patients diagnosed with AL-CA at the Second Xiangya Hospital were enrolled in this study. Out of the 95 patients with AL-CA, 57 (60%) patients had elevated serum CA 125 levels. The mean age was 59.7 ± 10.0 years with 44 (77.

Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET).

BackgroundCancer is associated with excess morbidity and mortality from coronavirus disease 2019 (COVID-19) following infection by the novel pandemic coronavirus SARS-CoV-2. Vaccinations against SARS-CoV-2 have been rapidly developed and proved highly effective in reducing the incidence of severe COVID-19 in clinical trials of healthy populations. However, patients with cancer were excluded from pivotal clinical trials. Early data suggest that vaccine response is less robust in patients with immunosuppressive conditions or treatments, while toxicity and acceptability of COVID-19 vaccines in th

Post-traumatic growth and cancer survivorship: experiences of living with treatment-related impairment.

PurposeIncreased distress has been associated with impairment related to cancer treatment and with post-traumatic growth (PTG), but the influence of treatment-related impairment on PTG has not been explored. This study aimed to understand the lived experience of PTG for cancer survivors living with treatment-related impairment.MethodsHermeneutic phenomenology was used to develop a deep understanding of the lived experience of adult cancer survivors living with ongoing treatment-related impairment who had experienced self-perceived PTG following their cancer experience. Semi-structured individu

Psychosocial Factors Affecting Wellbeing and Sources of Support of Young Adult Cancer Survivors: A Scoping Review.

Background/objectivesTo identify and analyze what is known about the psychosocial factors affecting the wellbeing and sources of support of young adult (YA) cancer survivors.MethodsThe search strategy included Neoplasms, young adults, psycho* or emotional well* or mental health. The OVID Medline and CINAHL databases were searched. Included were cancer survivors (YA) ages 18-39 at the time of the study. The studies included qualitative and quantitative designs, written in English, and published between January 2016 and October 2024. The results were recorded according to PRISMA-ScR guidelines.R

Доклад по делу: Цитовосстановительная хирургия как терапевтическая попытка лечения внематочной плазматомы.

ВВЕДЕНИЕ: Множественная миелома представляет собой гематологическую порчу, основанную на патологическом моноклональном распространении плазменных клеток, которое обычно происходит в костном мозге. Известные аспекты его симптоматологии включают анемию, почечную недостаточность, гиперкалкемию, остеолитические повреждения костей и потенциальные последствия амилоидоза. Диагностика носит мультимодальный характер и опирается на лабораторные и визуальные методы традиционной радиологии и ядерной медицины. Тогда лечение является достоянием гематолога-онколога. One форма этого заболевания представляет с

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… Ethics statement Written informed consent for publication of anonymized clinical details and images was obtained from the patient(s) or their legal guardians. Written informed consent was obtained from the participant/patient(s) for the publication of this case report. …

Is hypercalcaemia immediately life-threatening? A prospective study.

OBJECTIVE: Hypercalcaemia is often considered as an emergency because of a potential risk of life-threatening arrhythmias or coma. However, there is little evidence, apart from case studies, that hypercalcaemia can be immediately life-threatening. The aim of our study was to prospectively assess whether hypercalcaemia (Ca ≥ 3 mmol/L) was associated with immediately life-threatening complications. DESIGN AND METHODS: We conducted a prospective observational study aiming to include the first one hundred patients aged ≥18 who had a calcium concentration ≥3 mmol/L, admitted to the emergency depar

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… Written informed consent was obtained from all patients or legal guardians or the patient’s next of kin when neurological status prohibited consent. All data were presented as median and first (Q1) and third (Q3) quartiles. …

Уровни внутриутробного интерлейкина-6 связаны с прогрессирующими заболеваниями и клинической жесткостью при множественном склерозе.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: MS характеризуется устойчивым воспалением центральной нервной системы (КНС). Расследование засекреченного воспаления CNS, связанного с прогрессивными MS, может выявить новые биомаркеры и терапевтические цели. Цереброспинская жидкость (CSF) интерлейкин-6 (IL-6) может быть заметно повышена в нейроинфламентных условиях, таких, как расстройство спектра нейромиелита и миэлина олигодендроцита гликпротеина, связанного с антителами. В этом исследовании изучалась связь между уровнями IL-6 CSF, прогрессивными заболеваниями и остротой заболеваний в MS.МЕТОДЫ: Для анализа проб ХФУ у

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… Before enrolment, written informed consent was obtained from all participants or their legal guardians. The study was conducted according to Unity Health Toronto’s ethical standards and the Declaration of Helsinki. …

Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit.

ObjectiveAnalyze the outcomes of critically ill patients who developed new-onset organ dysfunction and received systemic chemotherapy during their ICU stay.DesignRetrospective cohort study.SettingA tertiary medical center in Germany with an Intensive Care Medicine department consists of 11 intensive care units comprising 140 beds, serving all subspecialties of adult intensive care medicine.Patients167 patients receiving systemic oncological treatment from January 1st, 2015 to December 31st, 2021, with a data cut-off on December 31st, 2022.InterventionsNone.Measurements and main resultsA total

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Valve repair after infective endocarditis secondary to perforation caused by Streptococcus gordonii: A case report.

BackgroundWe report a case of infective endocarditis (IE) in a patient with congenital heart valve lesions accompanied by IE, which was diagnosed based on blood culture analysis that revealed the presence of a gram-negative bacterium, Streptococcus gordonii.Case summaryThe patient had a history of precordial valve disease diagnosed by cardiac ultrasound, as well as a 4-mo history of fever. He was subjected to comprehensive anti-infection and anti-heart failure treatment in the internal medicine department. Further examination revealed sudden dislodgement from and perforation through the aortic

Intravenous zoledronate for pediatric langerhans cell histiocytosis with bone involvement.

Bone involvement in pediatric Langerhans cell histiocytosis (LCH) causes pain, functional impairment, and frequent relapse, creating a need for adjunctive therapies with rapid skeletal benefit. At National University Hospital, Singapore, a tertiary pediatric hematology-oncology referral centre, we retrospectively evaluated eight children with osseous LCH treated with intravenous zoledronate between January 2020 and December 2025. Three had multisystem disease (two risk-organ-positive), four had multifocal bone LCH, and one had unifocal bone LCH. Pain response (clinical improvement) and radiolo

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… The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants' legal guardians/next of kin because this was a retrospective chart review involving existing clinical data collected as part of routine care, …

Sacroplasty with or without screw fixation for sacral metastatic tumors.

INTRODUCTION: Cementation (sacroplasty) with or without ablation has been shown to improve pain and function for patients with sacral metastatic disease. Percutaneous screw fixation with sacroplasty (PSFS) may provide superior outcomes in select patients. METHODS: Thirty patients with sacral metastases who underwent sacroplasty with or without ablation and screw fixation at a single institution were retrospectively reviewed. Patients were compared based on treatment (PSFS or sacroplasty alone) and fracture status (pathological or impending) with an ANCOVA. Traumatic fractures were excluded. P

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… The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because the current project does not involve direct contact with subjects, therefore an informed consent process …

Канадский совместный проект по генетической восприимчивости к многочисленным склерозовым группам населения и этиологии болезней.

В предыдущих генетических и эпидемиологических исследованиях анализировались подгруппы канадского Совместного проекта по генетической приемлемости для группы пациентов с множественным склерозом (CCPGSMS), однако всеобъемлющий анализ населения, охваченного исследованиями, еще не проведен. ЦЕЛЬ: В этом ретроспективном исследовании рассматриваются модели множественного склероза (МС) 13,663 Члены групп, включая 4,821 лиц с НР или подозреваемых НР и 8,842 Члены семьи.Мы сгруппировали участников в эпидемиологические подгруппы по возрасту MSshore, клинической стадии диагностики, типу симптомов при на

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… Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin. Author contributions AP: Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing. …