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Development and Feasibility Assessment of a Multimodal Digital Health Technology for Remote Monitoring of Symptoms in Myasthenia Gravis.

INTRODUCTION: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Patients with MG are typically evaluated by neuromuscular experts through in-person neurologic examinations. These assessments are time-consuming, require significant disease expertise, and capture only a snapshot of disease. METHODS: Given this need, we developed a multimodal digital health technology (DHT) called BioDigit MG, for monitoring MG symptoms and objectively measuring disease severity. BioDigit MG includes tablet-guided speech and video-based assessments, electronic patient-reported outcomes releva

Assessment of nicotine and cannabis co-use among adolescents and the association with nicotine and cannabis dependence symptoms.

SIGNIFICANCE: Adolescent nicotine and cannabis co-use is common, but prior studies use imprecise measurement of co-use which may not capture the most problematic behaviors such as same-day use. METHODS: This cross-sectional study examined patterns of nicotine and cannabis co-use among Southern California high school students in Fall 2022 (N = 3823). Participants were classified into five mutually exclusive past-month nicotine and cannabis use groups: 1) same-day co-use: use of both substances on the same day at least once; 2) past-month co-use: use of both without same-day use; 3) exclusive n

Design and Assessment of an Electronic Bladder Diary for Collecting Patient Reported Symptoms Regarding Overactive Bladder.

The aim of this study was to design an electronic bladder diary (BD) and investigate whether it could be an alternative to a paper BD in collecting patient reported data regarding overactive bladder symptoms. We designed a web-based electronic BD to collect information about void frequency, urgency, incontinence, and fluid intake. A reliability study with crossover design was conducted to compare the electronic and paper BD. The reported voiding frequency was compared between the diary formats and the diary quality was evaluated based on the extent of complete and correct filled out diary days

Leveraging a randomized trial to assess relationships between transeptal puncture, brain emboli, and migraine symptoms.

BACKGROUND: Catheter ablation procedures with transseptal punctures (usually for atrial fibrillation) are often associated with migraine-related visual auras, but the mechanism remains unknown. Whether this phenomenon is mediated by the creation of an atrial septal defect from transseptal puncture or by silent acute brain emboli detected on magnetic resonance imaging related to the procedure remains to be investigated. OBJECTIVE: This study aimed to evaluate whether randomization to a transseptal puncture during catheter ablation for ventricular arrhythmias is associated with postprocedural v

Development of a New Voice Assessment Tool: Persian Adductor Laryngeal Dystonia-Vocal Symptoms Scale.

INTRODUCTION: In the current research, the development of a new Persian scale designed to assess the voice symptoms and their impacts on communicative participation of patients with adductor laryngeal dystonia (AdLD). METHODS: The research was conducted in two phases: 1. items were generated, and the scale was developed. 2. The patients with AdLD and primary muscle tension dysphonia (P-MTD) completed the Persian adductor laryngeal dystonia-vocal symptoms scale (PAdLD-VSS) to establish validity (content, convergent, construct) and reliability (test-retest and internal consistency). After the p

Assessing the Level of Panic Symptoms, Anxiety, and Quality of Life Among People Experiencing Panic Attacks.

PURPOSE: To assess the severity of panic symptoms, anxiety levels, and quality of life (QOL) among individuals experiencing panic attacks (PAs), as well as their associations with participants' characteristics. METHOD: This cross-sectional study used data gathered through an internet-based survey covering demographic characteristics, panic symptoms, anxiety levels, and QOL completed by 126 individuals aged 18 to 60 years sampled from the general population in Egypt. RESULTS: Data analysis showed that 26.2% and 73.8% of participants experienced severe and extreme panic symptoms, respectively.

Assessing the impact of elexacaftor/tezacaftor/ivacaftor on anxiety & depression symptom scores in adults with Cystic Fibrosis.

The mental health effects of elexacaftor/tezacaftor/ivacaftor (ETI) on adults with CF are still uncertain with mixed findings from published studies. To systematically investigate the impact of ETI on symptoms of anxiety and depression in adults with CF, Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire (PHQ-9) scores were evaluated at baseline, 6 months, and 12 months post-ETI. Overall, GAD-7 and PHQ-9 scores improved at 6 months post-ETI, with a greater proportion of individuals experiencing a clinically significant improvement (vs. worsening) of their symptoms, which w

Assessing obsessive-compulsive symptoms in a subclinical and clinical sample: the development of the Hungarian version of the OCI-R.

OBJECTIVES: The prevalence of clinical obsessive-compulsive disorder (OCD) is around 1-2% in the population. Questionnaires, such as the OCI-R, are a useful tool in the diagnositc process. The purpose of this study was to develop the Hungarian version of the OCI-R, examine its validity and reliability, and its ability to differentiate between clinical and subclinical OCD. METHODS: Confirmatiory factor analysis was carried out on the subclinical sample (N = 4301). Reliability analysis was carried out on both samples, and Mann-Whitney tests were used to compare the two samples. RESULTS: The si

The assessment of preschool children with ESSENCE symptoms: concordance between parents, preschool teachers and child psychologists.

BACKGROUND: It is important to detect children with Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE) in order to implement early intervention and support for the child and family. Standardized instruments for assessment in different contexts of behaviour problems, engagement and psychosocial health obtain an objective picture of the preschool child's mental health. AIM: To explore and compare parents', preschool teachers' and child health care psychologists' assessment of behaviour, everyday function, engagement, social interaction and psychosocial heal

Assessment of depression symptoms among cancer patients: a cross-sectional study from a developing country.

Cancer patients experience psychological symptoms such as depression during the cancer treatment period, which increases the burden of symptoms. Depression severity can be assessed using the beck depression inventory (BDI II). The purpose of the study was to use BDI-II scores to measure depression symptoms in cancer patients at a large tertiary hospital in Palestine. A convenience sample of 271 cancer patients was used for a cross-sectional survey. There are descriptions of demographic, clinical, and lifestyle aspects. In addition, the BDI-II is a tool for determining the severity of depressio

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… The Edmonton symptom assessment system (ESAS) as a screening tool for depression and anxiety in non-advanced patients with solid or haematological malignancies on cure or follow-up. Support Care Cancer. 2014;22:783–793. doi: 10.1007/s00520-013-2034-x. 19. … The Edmonton symptom assessment system as a screening tool for depression and anxiety. J. Palliat. Med. 2006;9:296–303. doi: 10.1089/jpm.2006.9.296. 28. Mystakidou K, Tsilika E, Parpa E, Smyrniotis V, Galanos A, Vlahos L. …

Assessing age of onset and clinical symptoms over time in patients with heterozygous pathogenic DHDDS variants.

Mono-allelic DHDDS variants are associated with seizures, intellectual disability, and movement disorders. The age of onset and progression rates of symptoms vary greatly among patients, spanning from infancy to late adulthood. Yet, the reasons behind this clinical variability and the underlying pathophysiological mechanisms of the disease have remained elusive. We investigated the age of onset and the progression of symptoms over time in 59 patients with heterozygous DHDDS variants, drawing from medical literature and incorporating five previously unreported cases from the FCDGC Natural Histo

Addition of constitutional symptoms to the SLEDAI-2K improves overall disease activity assessment: A pilot study.

OBJECTIVE: Constitutional symptoms (fatigue, lymphadenopathy, and weight loss) are not included in the SLE disease activity index-2000 (SLEDAI-2K). In this pilot study, we assessed the concurrent and construct validity of a revised SLEDAI-2K (SLED-R) that included these symptoms with the original SLEDAI-2K (SLED-O), using the physician global assessment of disease activity (PGA) as the reference. METHODS: Our revised SLED-R substituted the SLED-O's fever descriptor with a constitutional descriptor that included fever, fatigue, lymphadenopathy, and/or weight loss. SLED-O, SLED-R, PGA and patie

The repeatability of tests for dry eye signs and symptoms in the dry eye assessment and management (DREAM) study.

PURPOSE: To assess the repeatability of measures for dry eye disease (DED) symptoms and signs in the DREAM study. METHODS: At screening and baseline visits approximately 2 weeks apart, participants were assessed for symptoms by Ocular Surface Disease Index (OSDI) and Brief Ocular Discomfort Index (BODI), and signs by the same physician in the same order: tear break-up time (TBUT), corneal staining, conjunctival staining, Meibomian gland evaluation, and the Schirmer test. The repeatability of DED symptoms and signs was assessed by interclass correlation coefficient (ICC), 95 % limits of agreem

Testing associations between assessments of cognitive flexibility and eating disorder symptoms in adolescent bulimia nervosa.

OBJECTIVE: Cognitive rigidity, or difficulty adapting to changing demands, is commonly observed in anorexia nervosa. Less is known, however, about cognitive flexibility (CF) in bulimia nervosa (BN) and, particularly, adolescence. Clarifying this relation and best assessment practices may guide informed clinical decision-making. The current study compared how two measures of CF (i.e., Wisconsin Card Sort Task [WCST] and Trail Making Task [TMT]) relate to BN symptoms among adolescents. METHODS: Data from a subsample (n = 78) of adolescents with BN were analyzed. Linear and hurdle regressions we

Assessment of transcranial Doppler indices after MgSO4 administration in severe preeclamptic women with neurologic symptoms.

PURPOSE: To investigate the effect of intravenous MgSO4 on maternal cerebral hemodynamics as well as the association between altered Doppler indices of the ophthalmic arteries and ocular lesions in patients with preeclampsia. METHODS: After each of the 15 included patients was diagnosed with preeclampsia, MgSO4 was infused followed by transcranial Doppler tests of the indices of the ophthalmic, anterior, middle, posterior cerebral, vertebral, and basilar arteries, followed by a second MgSO4 infusion. The peak, mean, diastolic velocity, and pulsatile and resistance indices of each artery were

Assessment of Gastroesophageal Reflux Symptoms and Sleep Quality Among Women in the Nurses' Health Study II.

IMPORTANCE: Limited data exist on the association of gastroesophageal reflux (GER) symptoms with sleep quality. OBJECTIVE: To prospectively investigate the association between GER symptoms and sleep quality. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study included data from the Nurses' Health Study II of female nurses in the US. Participants self-reported the frequency and duration of GER symptoms beginning June 2005, with updates every 4 years through June 2015. Follow-up was completed June 2019, and data were analyzed from November 15, 2022, to June 4, 2023. EXPOSURES: Fr

Remote Assessment of ADHD Symptoms Based on Mobile Game Performance in Children with ADHD: A Proof of Concept.

The use of game-based digital medicine is gaining increasing interest in helping children with ADHD to improve their attention outside the clinical setting. In this process, it is important to continue monitoring children's responses to the use of digital medicine. In this work, we introduce novel digital markers and an analytic pipeline to estimate ADHD-related symptomatic levels during the self-administration of attention games. The digital markers, capturing the children's characteristics of attention and inattention spans, were extracted and translated into clinically-accepted measures of

Assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms.

PURPOSE OF REVIEW: To provide a detailed overview of the assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms. RECENT FINDINGS: COVID-19-related olfactory dysfunction can have a detrimental impact to the quality of life of patients. Prior to the COVID-19 pandemic, olfactory and taste disorders were a common but under-rated, under-researched and under-treated sensory loss. The pandemic has exacerbated the current unmet need for accessing good healthcare for patients living with olfactory disorders and other sympto

Assessment of autonomic symptoms may assist with early identification of mild cognitive impairment with Lewy bodies.

OBJECTIVES: Autonomic symptoms are a common feature of the synucleinopathies, and may be a distinguishing feature of prodromal Lewy body disease. We aimed to assess whether the cognitive prodrome of dementia with Lewy bodies, mild cognitive impairment (MCI) with Lewy bodies (MCI-LB), would have more severe reported autonomic symptoms than cognitively healthy older adults, with MCI due to Alzheimer's disease (MCI-AD) also included for comparison. We also aimed to assess the utility of an autonomic symptom scale in differentiating MCI-LB from MCI-AD. METHODS: Ninety-three individuals with MCI a

Prevalence of Bleeding Symptoms in Denmark Using the Patient-administered Bleeding Assessment Tool (self-BAT).

INTRODUCTION: The patient-administered bleeding assessment tool (self-BAT) is a screening tool developed to identify individuals in need of work-up for bleeding disorders. Nonetheless, large studies on self-BAT scores on healthy individuals according to gender and age are lacking. AIM: Determine cut-offs for abnormal total score of self-BAT and investigate the prevalence of bleeding symptoms in blood donors and individuals representative of the general Danish population. METHODS: Blood donors, 15,600 children (<18 years) and 18,200 adults from the general Danish population, were invited to c