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Proceedings of the RAMI Intern Section Meeting.

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Human microbiomes in cancer development and therapy.

Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy

Gut microbiota shapes cancer immunotherapy responses.

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.

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… PD-L1 mAb, αCTLA-4 mAb, or combination treatment 208 Melanoma; NSCLC; lung cancer; RCC; etc. 5565 β-Lactam; quinolone; vancomycin; daptomycin; etc. αPD-1/PD-L1 mAb, αCTLA-4 mAb, or combination treatment 209 Advanced melanoma 1585 Systemic antibiotic αCTLA-4 mAb 210 NSCLC; RCC; AML 338 Piperacillin; clindamycin … , or combination treatment | 208 Melanoma; NSCLC; lung cancer; RCC; etc. | 5565 | β-Lactam; quinolone; vancomycin; daptomycin; etc. | αPD-1/PD-L1 mAb, αCTLA-4 mAb, or combination treatment | 209 Advanced melanoma | 1585 | Systemic antibiotic | αCTLA-4 mAb | 210 NSCLC; RCC; AML | 338 | Piperacillin; clindamycin …

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

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… Certain antimicrobial agents such as penicillin, rifampin, clindamycin, macrolides, bacitracin, and vancomycin significantly impair colonization resistance, probably because they inhibit gram-positive, non-sporulating, lactic acid-producing bacilli, such as Bifidobacterium spp. …

The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies.

Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and preclinical experimental evidence has shown that the efficacy of immunotherapy in tumor treatment varies markedly among individuals. The commensal microbiome mainly colonizes the intestinal lumen in humans, is affected by a variety of factors and exhibits individual variation. Moreover, the gut is considered the largest immune organ of the body due to its influence on the immune system. In t

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… . | [ 248 ] Acute myeloid leukemia (AML); NSCLC; RCC | ICI; chemotherapy | 338 | Piperacillin; clindamycin; metronidazole. meropenem; vancomycin; furantoin; rifampin. rifaximin; tobramycin | [ 249 ] RCC | αPD-1 mAb | 69 | β-Lactam; quinolone | [ 170 ] Melanoma | αPD-1 mAb; αCTLA-4 mAb; combined | 568 …

PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

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Естественные и синтетические АМП из Латинской Америки по всему спектру технологий и приложений в области разнообразия.

Биоразнообразие в Латинской Америке примерно 60% в целом по миру, подпитывая научные исследования в области природных продуктов, весьма значимой области открытия наркотиков по сей день. Это сопровождается увеличением числа антимикробных пептидов (АМП), полученных из натуральных продуктов в регионе, которые за последнее десятилетие были переработаны путем модификации, усовершенствования и уточнения их физико-химических свойств и антимикробной эффективности с использованием подходов, которые варьируются от изучения рациональной конструкции и соотношения структуры-активности (САР) до методов иску

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… ALF-G35–54 demonstrated the broadest and most potent antibacterial activity (2.5–40 μM), inhibiting the growth of most tested bacterial strains, including clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) 16003 (cefoxitin-resistant) and 17022 (resistant to cefoxitin, ciprofloxacin, clindamycin …

Repurposed Drugs in Gastric Cancer.

Gastric cancer (GC) is one of the major causes of death worldwide, ranking as the fifth most incident cancer in 2020 and the fourth leading cause of cancer mortality. The majority of GC patients are in an advanced stage at the time of diagnosis, presenting a poor prognosis and outcome. Current GC treatment approaches involve endoscopic detection, gastrectomy and chemotherapy or chemoradiotherapy in an adjuvant or neoadjuvant setting. Drug development approaches demand extreme effort to identify molecular mechanisms of action of new drug candidates. Drug repurposing is based on the research of

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porok

Neutrophil diversity and function in health and disease.

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells,

Oral Presentations

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Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

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… other infections such as mucormycosis possibly helpful Therapy intensive debridement (mainly subcutaneous near the eye, sometimes repeatedly performed 66 up to exenteration as ultima ratio 67 ) in combination with broad spectrum antibiotics (mostly broad-spectrum penicillin or cephalosporins plus clindamycin …

Neutrophil extracellular traps in homeostasis and disease.

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the

Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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