Результаты поиска

Bone Phenotype in Autosomal Dominant Polycystic Kidney Disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a systemic ciliary disorder, yet the impact on bone health remains insufficiently defined. Given the expression of polycystins in osteocytes, osteoclasts and extracellular matrix, a disease-specific bone phenotype has been hypothesized. This study aimed to comprehensively characterize the bone phenotype in ADPKD across stages of chronic kidney disease (CKD) and Mayo Imaging Classification (MIC). In this cross-sectional study, 81 patients with ADPKD, 15 with CKD of other etiologies, and 21 healthy individuals were included. Bone phenotype …

Common Gynecologic Issues in Patients Post-Kidney Transplantation.

Advances in kidney transplantation have transformed survival and quality of life for women with end-stage renal disease, necessitating a focus on long-term health care for this population. Female kidney transplant recipients (KTR) experience a unique spectrum of gynecologic issues shaped by persistent hormonal dysregulation, lifelong immunosuppression, and complex surgical history. These factors contribute to increased rates of abnormal uterine bleeding, endometrial hyperplasia, and early menopause. Furthermore, common conditions such as fibroids, endometriosis, pelvic pain, and pelvic organ p…

Weight trajectories and kidney function in early childhood.

INTRODUCTION: Postnatal growth profile is believed to have an impact on the risk of later obesity and of cardiovascular and kidney disease. We aimed to study the association between different trajectories of weight gain during infancy and early childhood and the renal function in prepubertal children. METHODS: Longitudinal study of 1,004 children aged 7-9 years, divided into four groups of weight gain trajectories from birth to 6 years (I: eutrophic/reference; II: early-onset persistent accelerated weight gain; III: childhood-onset accelerated weight gain; and IV: early transient weight gain)…

Immune tolerance: Parallels between pregnancy and kidney transplantation.

Pregnancy represents a unique immunological paradox in which the maternal immune system must tolerate the semi-allogeneic fetus expressing paternal antigens. The success of pregnancy depends on a highly coordinated network of immune tolerance mechanisms, encompassing the placental barrier, chemokine-guided leukocyte migration, restricted alloantigen presentation, regulatory T cells, tolerogenic natural killer cells, immune checkpoint molecules, and both hormonal and metabolic adaptations. In contrast, achieving long-term acceptance of transplanted organs-referred to as "operational tolerance"-

Kidney Injury Molecule: a Biomarker and much more.

Kidney injury molecule 1 (KIM-1), encoded by HAVCR1, was initially identified as one of the most highly induced proteins in injured proximal tubule epithelial cells and subsequently established as a sensitive tissue, urinary, and circulating biomarker of kidney injury. Yet KIM-1 is not just a marker of epithelial damage. It is a phosphatidylserine receptor that enables injured proximal tubule cells to recognize and internalize apoptotic cells and luminal cargo. This process engages intracellular trafficking, autophagy-related processing, and immune regulatory pathways, with consequences that a…

Apixaban Use Before Kidney Transplantation: Is Reversal Necessary?

UNLABELLED: The use of apixaban prior to kidney transplantation is on the rise. However, optimal perioperative management remains uncertain, particularly regarding the need for preoperative reversal with four-factor prothrombin complex concentrate (4F-PCC). Prior reports suggest clinically relevant bleeding without reversal, but potential thrombotic consequences of prophylactic 4F-PCC warrant caution. We hypothesized that withholding preoperative 4F-PCC in patients taking apixaban before kidney transplantation would not increase early postoperative surgical-bed bleeding. METHODS: This retrosp…

Kidney Elastography in Adult Nephrology: A Narrative Review.

Chronic kidney disease (CKD) represents a rising global health crisis traditionally monitored through routine biochemical markers that may not fully reflect underlying structural alterations. While renal biopsy remains the invasive reference standard for histopathological assessment, ultrasound elastography, particularly shear wave elastography (SWE), has emerged as a promising non-invasive imaging technique for assessing the mechanical properties of the renal parenchyma. This narrative review examines the role of renal elastography in adult nephrology, linking the pathophysiology of renal fib…

Urine inflammatory protein levels decrease following kidney transplantation.

BACKGROUND: Kidney transplant recipients are subjected to several types of immunosuppressants in order to prevent rejection of the graft. Over-immunosuppression increases the risk of infectious complications and thesepatients require a delicate balance. Inflammatory profiles from the urine can help identify which biomarkersmay guide clinicians in balancing over vs. under-immunosuppression. METHODS: Urine samples were obtained from 10 complete kidney donor-recipient pairs at a pre-operative visit ~1 weekprior to or at time of transplant and then for the recipients, ~3 months following transpla…

Management of Vitamin D in Chronic Kidney Disease.

Vitamin D plays a vital role in numerous physiological processes, including immune function, cardiovascular health, and bone maintenance. The adequacy of its status has been strongly associated with morbidity and mortality across diverse populations, particularly among individuals with chronic kidney disease (CKD). Given the kidneys' critical role in vitamin D metabolism and homeostasis, deficiency is highly prevalent in this population and has been linked to adverse outcomes and poor survival. In this review, we provide a comprehensive overview of vitamin D, its sources, metabolism, physiolog…

Kidney transplant outcomes in patients with complement dysregulation.

BACKGROUND: Complement dysregulation is a key mechanism underlying atypical hemolytic uremic syndrome and complement-mediated thrombotic microangiopathy in kidney transplantation, and is associated with post-transplant recurrence, graft dysfunction, and graft loss. Although Western cohort data are well established, integrated transplant outcome data combining genetic analysis, anti-factor H (AFH) antibody profiling, and individualized therapy from Indian and other South Asian populations remain limited, despite a distinct biologic profile in this region. AIM: To evaluate clinical characterist…

New ideas about mechanism in APOL1 kidney disease.

Apolipoprotein L1 risk variants contribute to high rates of kidney disease among individuals of African ancestry. These gain-of-function variants cause toxicity to kidney cells, but the mechanism of injury is not clear. Many theories have been proposed, yet the field has not arrived at a consensus. Kim et al. make a compelling argument for a peroxisomal pathway of injury specifically activated under hypoxic conditions. Introducing cellular context reframes the debate about apolipoprotein L1 mechanism of disease.

Ten Наводки на биопсию почек у больных раком.

Ренальная биопсия — это важный диагностический инструмент, который следует учитывать у больных раком, население которого часто страдает почечной дисфункцией, многофакторной и клинической активностью. Точное выявление основных повреждений часто имеет решающее значение для руководства онкологической терапией, предотвращения дальнейшего упадка почечной железы и улучшения общих результатов. Однако проведение биопсии в этой уязвимой группе пациентов требует тщательной оценки процедурных рисков и клинического контекста. Это...10 Брошюра < < Советы > > обеспечивает практическую основу для

Совпадение в полном тексте источника
… In this setting, the speed of haematologic response is a key determinant of kidney recovery and long-term kidney survival [ 57 ]. … Bleeding complications of native kidney biopsy: a systematic review and meta-analysis . Am J Kidney Dis . 2012 ; 60 : 62 – 73 . 10.1053/j.ajkd.2012.02.330 22537423 87. Kellum JA , Lameire N , Aspelin P et al. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. …

Green nephrology: environmentally sustainable kidney care in pediatrics.

Climate change represents a major threat to the health and wellbeing of children and families worldwide. Changes to the environment are already having and increasingly will have an impact on kidney health, particularly in pediatrics, where children are more vulnerable to heat injuries, environmental toxins, and issues related to access to care. At the same time, the environmental cost of healthcare is high, contributing substantially to greenhouse gas emissions, waste generation, and resource depletion. Within healthcare, the environmental impact of kidney care-particularly dialysis therapies-…

Recent progress in pig-to-human kidney xenotransplantation.

Even though the patient kept up his dialysis regimen as he had before xenotransplantation, this is a significant development for xenotransplantation. This benchmark for xenotransplantation has the following significant findings. Firstly, from the patient's perspective, the patient was able to regain energy and quality of life and experience normal metabolic filtration (creatinine clearance) during the functional period, thanks to the transplant, which significantly reduced his need for dialysis. Secondly, this is a historic accomplishment for xenotransplantation because it set up a new global

Animal Models of Malaria-Associated Acute Kidney Injury.

Malaria-associated acute kidney injury (MAKI) is a critical complication of severe malaria, particularly in infections caused by Plasmodium falciparum, which is responsible for most malaria-related deaths. MAKI affects 40-60% ofs severe malaria cases, significantly increasing mortality, especially in pediatric patients. Its pathogenesis remains unclear, though mechanisms such as hemodynamic disturbances, oxidative stress, and immune responses are implicated. Animal models, particularly murine and nonhuman primates, provide valuable insights into MAKI's underlying processes. Murine models, thou…