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Incidence and Influencing Factors of Demoralization Syndrome in Elderly Maintenance Hemodialysis Patients: A Multi-Center Cross-Sectional Study.

OBJECTIVE: This observational study aimed to investigate the prevalence and influencing factors of demoralization syndrome (DS) in elderly maintenance hemodialysis (MHD) patients, with a focus on improving their psychological distress levels. METHODS: Convenient sampling was used to select 350 MHD patients aged 60 or older from three tertiary hospitals in China. Data was collected using questionnaires, including the Chinese version of the DS Scale. Statistical analysis was conducted using SPSS 26.0 software. RESULTS: Single factor analysis revealed that sex, average monthly household income,…

The relationship between flourishing, social support, and regulatory emotional self-efficacy in maintenance hemodialysis patients: a network analysis.

BACKGROUND: Patients receiving maintenance hemodialysis (MHD) face significant physical and psychological challenges due to the chronic nature of their condition as well as the demands of treatment regimens. Mental health plays a crucial role in their overall well-being, yet the interplay between psychological factors such as social support, regulatory emotional self-efficacy, and flourishing remains underexplored. OBJECTIVE: This study aims to investigate the complex relationships between social support, regulatory emotional self-efficacy, and flourishing among patients receiving MHD using ad…

Predictors of job maintenance in young and middle-aged patients after percutaneous coronary intervention: A retrospective cohort study.

This study evaluates job maintenance status and predictors of young and middle-aged patients after percutaneous coronary intervention (PCI). A total of 221 young and middle-aged patients after PCI from November 1, 2023 to January 31, 2025 were selected. The job readiness of patients who have not returned to work and the job maintenance of patients who have returned to work were investigated. The survey tools included general information questionnaire, readiness for return-to-work scale (RRTW), social support rating scale, cardiac rehabilitation inventory and self-rating anxiety scale (SAS). At…

Does Control Nutritional Status (CONUT) Score Predict Early and Long-Term Mortality at the Initiation of Maintenance Hemodialysis?

PurposeControlled Nutritional Status (CONUT) score is strongly associated with mortality in various patient groups. This study aimed to assess the CONUT score's ability to predict mortality in Hemodialysis (HD) patients.Patients and methodsData from 243 patients who started HD between 2012 and 2020 were analyzed retrospectively. Laboratory test results within the first month after dialysis initiation were recorded and CONUT scores were calculated.ResultsOver a mean follow-up duration of 32.2 months, the association between early (within six months) and late mortality was assessed. During this

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… A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis . 2001;38(6):1251–1263. doi: 10.1053/ajkd.2001.29222 7. Beto JA, Bansal VK, Hart J, McCarthy M, Roberts D. … Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int . 2003;63(3):793–808. doi: 10.1046/j.1523-1755.2003.00803.x 10. Takagi K, Buettner S, Ijzermans JNM, Wijnhoven BPL. …

Prevalence and determinants of poor glycemic control among diabetic chronic kidney disease patients on maintenance hemodialysis in Tanzania.

BACKGROUND: Poor glycemic control in diabetic chronic kidney disease (CKD) patients on maintenance hemodialysis is of great challenge, resulting in increased risk of morbidity and mortality. This study aimed to determine the prevalence and determinants of poor glycemic control among diabetic CKD patients on maintenance hemodialysis. METHODOLOGY: A cross-sectional study was conducted in 12 dialysis centers located in four regions of Tanzania from March to June 2023. The study population was diabetic CKD patients above 18 years on maintenance hemodialysis for three months or more. A consecutive…

Frailty risk prediction models in maintenance hemodialysis patients: a systematic review and meta-analysis of studies from China.

OBJECTIVES: To systematically evaluate and meta-analyze the performance, validity, and influencing factors of frailty risk prediction models specifically developed for patients undergoing maintenance hemodialysis in China. METHODS: China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, SinoMed, PubMed, Web of Science, Cochrane Library, CINAHL and Embase were searched from inception to October 10, 2024. Two independent reviewers conducted literature screening, data extraction, and risk of bias assessment using the Prediction Model Risk of Bias…

Association of baseline and longitudinal plasma retinol-binding protein 4 with all-cause mortality in maintenance hemodialysis patients.

INTRODUCTION: Elevated levels of retinol-binding protein 4 (RBP4) have been linked to conditions including cardiovascular disease, type 2 diabetes, obesity, and insulin resistance. However, the associations between baseline and longitudinal RBP4 levels with all-cause mortality in maintenance hemodialysis patients remain uncertain. The aim of this study was to investigate this issue. METHODS: A total of 342 consecutive patients undergoing maintenance hemodialysis at a single hemodialysis center between 2010 and 2022 were assessed. Enzyme-linked immunosorbent assay was used to quantify plasma R…

Heat stress and stocking density disrupt telomere maintenance through shelterin complex dysregulation and oxidative damage in broiler chickens.

BACKGROUND: Heat stress and high stocking density are major stressors in broiler chickens, compromising welfare and productivity. These stre … RAP1, TRF1, or TRF2 expression. CONCLUSION: Heat stress and high stocking density disrupt telomere maintenance, likely through oxidative damage and dysregulation of shelterin components (POT1, TPP1). These findings highlight the need for improved management practices to mitigate stress-induced cellular damage in broiler production.

Current Status and Determinants of Fatigue in Chinese Older Adults Receiving Maintenance Hemodialysis: A Multicentre Cross-Sectional Study.

BACKGROUND: Fatigue is highly prevalent in older adults receiving maintenance hemodialysis and seriously affects quality of life. However, evidence on the current status of fatigue and its determinants in this population remains scarce, especially in the unique socio-cultural context of China. AIM: A multicenter cross-sectional study to investigate the current status of fatigue and analyze associated factors in Chinese older adults receiving maintenance hemodialysis to provide information for targeted interventions. METHODS: This multicenter cross-sectional study was conducted between July 2…

Response to First-Line Chemotherapy Predicts Response to Maintenance Avelumab Therapy in Japanese Patients With Advanced Urothelial Carcinoma.

OBJECTIVES: The association between the response to first-line chemotherapy and maintenance of avelumab remains unclear. We identified factors associated with the response to avelumab in patients with advanced urothelial carcinoma using real-world data. METHODS: We retrospectively enrolled 100 patients with advanced urothelial carcinoma treated with maintenance avelumab therapy between March 2021 and April 2024 at Nagoya University and nine affiliated hospitals. The complete/partial-response group was defined as patients with complete response or partial response as the best response to first…

Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Real-World Results From an Early Access Program in Malaysia.

AIM: Avelumab first-line (1L) maintenance was approved for treatment of advanced urothelial carcinoma (UC) based on results from the JAVELIN Bladder 100 Phase 3 trial. We report real-world data from an early access program (EAP) for avelumab 1L maintenance treatment in Malaysia. METHODS: Data from patients with locally advanced or metastatic UC who received ≥ 1 dose of avelumab 1L maintenance treatment between September 2021 and January 2023 were obtained retrospectively. Patient and treatment characteristics, best response to treatment, and safety were assessed. RESULTS: Data were provided …

Comparative Study of Intravenous vs Inhalational Maintenance Anaesthesia on Postoperative Emergence Agitation and Recovery Parameters After General Anaesthesia.

BACKGROUND: Emergence agitation (EA) is a common phenomenon observed in patients recovering from general anaesthesia, potentially leading to self-injury and compromised recovery quality. OBJECTIVES: This research aims to evaluate the outcome of intravenous and inhalational maintenance anaesthesia on postoperative EA and other recovery parameters. MATERIALS AND METHODS: This research was conducted with 100 patients undergoing elective surgeries under general anaesthesia. Patients were divided into two groups: Group I received intravenous maintenance with propofol, while Group II received inha…

Calf circumference predicts sarcopenia and all-cause mortality in older patients undergoing maintenance hemodialysis: A prospective cohort study.

BACKGROUND: The role of calf circumference (CC) in predicting sarcopenia and mortality of patients undergoing maintenance hemodialysis (MHD) remains debated. This study assessed CC's predictive value, optimal threshold, and mortality association in older patients undergoing MHD. METHODS: An observational cohort study was conducted on older adult patients undergoing MHD. Sarcopenia was defined by European Working Group on Sarcopenia in Older People. Logistic regression and receiver operating characteristic (ROC) analysis were used to explore the relationship between CC and sarcopenia. Kaplan-M…

Correlation between parathyroid volume and calcium and phosphorus metabolism in maintenance hemodialysis patients based on Doppler ultrasound technology.

OBJECTIVES: To investigate the correlation between parathyroid glands (PTGs) volume and calcium and phosphorus metabolism in maintenance hemodialysis (MHD) patients with Doppler ultrasound. METHODS: MHD patients at the Hemodialysis Center of the Third Affiliated Hospital of Zunyi Medical University from January 1, 2024, to January 31, 2024, were selected as study subjects. To investigate the correlation between the number and size of PTGs detected by bedside ultrasound and indicators of calcium and phosphorus metabolism. RESULTS: A total of 135 patients were included, of whom 90 had explored…

First Reported Successful Use of Infliximab Maintenance Therapy for Dual Treatment of Crohn Disease and Idiopathic Retroperitoneal Fibrosis.

This case report describes the novel use of infliximab as maintenance therapy for both Crohn disease and idiopathic retroperitoneal fibrosis in a patient with concurrent disease. A 34-year-old man with Crohn disease developed a pelvic mass and hydroureteronephrosis, leading to an idiopathic retroperitoneal fibrosis diagnosis. Given shared inflammatory pathways, he was treated with prednisone followed by infliximab. Post-treatment imaging showed mass reduction and hydronephrosis improvement. After 1 year, he remains stable. This case highlights infliximab's potential in managing both conditions…

Hostility is Associated with Interferon γ Inducible Protein 10 in Opioid Maintenance Treatment Patients with Chronic Hepatitis C.

OBJECTIVE: Levels of circulating cytokines has been shown to be related to psychological distress. We have earlier shown that the symptoms of hostility may be related to levels of interferon γ inducible protein 10 (IP-10) in a group of general psychiatric in-patients receiving psychotropic medication. Here we investigate this association in a group of patients with chronic hepatitis C virus (HCV) infection with or without opioid maintenance treatment (OMT). METHODS: In a cross-sectional study, out-patients were interviewed for psychological distress using the Symptoms Check-List-90-R (SCL-90-…

Capecitabine combined with immunotherapy as maintenance therapy improves survival in recurrent/metastatic nasopharyngeal carcinoma: a retrospective cohort study.

BACKGROUND: We evaluated the clinical impact of combining capecitabine with immunotherapy (Immu/Cape) compared to immunotherapy monotherapy (Immu) as maintenance in recurrent/metastatic (R/M) nasopharyngeal carcinoma (NPC) patients following initial chemo-immunotherapy. METHODS: We retrospectively analyzed 257 R/M NPC patients who achieved disease control after chemo-immunotherapy and received either Immu/Cape or Immu maintenance. Propensity score matching (PSM) was performed to balance baseline characteristics. Endpoints included progression-free survival (PFS) and overall survival (OS). RE…

Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the predominant histological subtype of primary liver cancer with high cancer-related mortality. Despite t … by which NRF2-mediated transcriptional activation of MTs protects HCC cells against ISN through the maintenance of cellular redox homeostasis and mitochondrial function. ISN combined with pharmacological inhibition of MTs may be a prospective and available therapeutic approach for the clinical treatment of HCC.

Real-life experiences of switching from intravenous to subcutaneous vedolizumab maintenance therapy in patients with inflammatory bowel disease.

BACKGROUND: A few prospective cohort studies support the safety of switching from intravenous to subcutaneous administration of vedolizumab during maintenance therapy in patients with inflammatory bowel disease. Real-life data on switching after intravenous induction therapy are lacking. OBJECTIVE: The aim was to obtain real-world data on subcutaneous vedolizumab treatment in patients with inflammatory bowel disease after switching from intravenous vedolizumab induction or maintenance therapy, and to evaluate treatment persistence, safety, and changes in disease activity and serum vedolizumab…

High serum levels of ustekinumab are associated with better clinical outcomes during maintenance treatment for inflammatory bowel disease.

BACKGROUND: Ustekinumab (UST) is an effective treatment option in Crohn's disease (CD) and ulcerative colitis (UC). However, it still remain … TL). RESULTS: We included 125 patients, 117 with CD. In P1, 62.4% of patients were on subcutaneous maintenance, and the median USTTL1 was 3.1 μg/mL (1.6-5.3). In 44.8% of CD patients (48/117), clinical remission was achieved, with USTTL1 significantly higher than those who did not achieve remission (3.7 μg/mL (2.3-5.4) vs 2.3 μg/mL (1.1-5.2); p = 0.04). In t …