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Совокупный дефицит слабого индекса и статус отношений предсказывают выживание в множестве миеломы.

Было предложено несколько инструментов для оценки хрупкости в миеломе (ММ), однако большинство из них основаны на наборах данных клинических испытаний. Кроме того, имеются ограниченные данные о взаимосвязи между слабыми и сообщаемыми пациентами результатами и о прогнозируемой ценности социальных детерминант здоровья. В этом исследовании оценивается прогнозируемое воздействие слабой способности на основе совокупного индекса дефицита, а также отношений и социально-экономического статуса (SES) у пациентов с недавно поставленным диагнозом MM. Это ретроспективное исследование включало 515 в клинике

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… A large population-based study previously showed that marriage was associated with improved cancer-specific survival and OS in patients with MM independent of age, SES, and educational status, and the impact was more pronounced in males. 26 Our study also showed that having a partner (married or committed …

Cancer burden across the South Asian Association for Regional Cooperation in 2022.

ObjectiveThe objective of this study is to present a cross-sectional analysis of cancer burden in the South Asian Association for Regional Cooperation (SAARC) region and explain unique characteristics of its cancer burden as compared with the rest of the world.Methods and analysisUsing publicly available data from the Global Cancer Observatory (GCO) and the World Bank, we collected cancer statistics and population statistics for Afghanistan, Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka from 2017 to 2022.ResultsThe number of newly diagnosed cases in the region was 1 8

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… has an extremely high cervical cancer burden, accounting for 132 000 new cases annually and more than one-fourth of overall cervical cancer deaths worldwide. 15 16 Contributors may include lack of funding for HPV vaccinations, stigma surrounding sexuality, differences in genital hygiene, low age at marriage …

The effect of growth hormone on ovarian function recovery in a mouse model of ovarian insufficiency.

ObjectivesTo evaluate the effects and mechanisms of action of growth hormone (GH) in the recovery of ovarian function in ovarian insufficiency induced by cyclophosphamide (CP) in a mouse model.Materials and methodsAfter inducing ovarian insufficiency by administering 400 mg/kg of CP intraperitoneally to 6-week-old ICR mice, the mice were divided into four groups (control, CP, 1 mg/kg GH, and 2 mg/kg GH) with 10 mice in each group. GH was administered a week later for 7 days. Five mice from each group were sacrificed the next day, and their ovaries were collected for histological examination. T

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… Moreover, the demand for fertility preservation among cancer survivors is expected to increase, given the increasing postponement of marriage and childbearing among women worldwide. …

Спектр и эпидемиология неврологических расстройств и нервно-мышечных аномалий у педиатрического населения Сиалкота, Пакистан.

СВЕДЕНИЕ И ЦЕЛЬ: Неврологические заболевания и нейромускульные аномалии являются сложными условиями, влияющими как на центральную, так и на периферию нервной системы. Цель этого исследования заключалась в изучении частотности, характерных особенностей, фенотипных особенностей и семейных характеристик педиатрических неврологических расстройств и нейромускульных аномалий в пакистанском районе Сиалкот. МЕТОДОЛОГИЯ: С февраля было проведено перекрестное исследование, в ходе которого пациенты были набраны из больниц третичной медицинской помощи по всему району Сиалкот, 2024 до декабря, 2024. Для ан

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… been reported from Rawalpindi and Hazara region of Pakistan, where neurological conditions outnumbered neuromuscular anomalies. 20 , 21 This persistent burden in developing settings is attributed to factors such as premature birth, malnutrition, birth asphyxia, perinatal infections, and consanguineous marriages …

Доклад по делу: Существенное сокращение повреждений и структурные нейронные изменения после лечения ибогина при множественном склерозе.

Множественный склероз (MS) — изнуряющее нейродегенеративное заболевание, характеризующееся демиэлированием и нейронной потерей. Традиционная терапия часто не может остановить прогрессирование заболеваний или обратный неврологический дефицит. Ибогаин, психоактивный алкалоид, был предложен в качестве потенциального нейрогенеративного агента в силу его многогранного фармакологического профиля. Мы представляем два тематических исследования пациентов MS, которые прошли новое лечение ибогином, высветив значительные нейроимации и клинические улучшения. Пациент А продемонстрировал существенное сокраще

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… Patient B Also in February 2023, Ambio received a 44-year-old female (“PB”) who was diagnosed with secondary progressive MS (SPMS) in 2018, as well as complex PTSD (CPTSD) from childhood trauma and a recent divorce following 17 years of marriage. …

Романтические отношения, сексуальность и близость между молодыми людьми и подростками с тяжелыми психическими заболеваниями: обзор литературы.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Лица с тяжелыми психическими заболеваниями (СМИ), включая шизофрение и психотические расстройства, часто сталкиваются с серьезными проблемами в развитии и поддержании романтических и интимных отношений. Несмотря на сильное стремление к общению и сексуальному выражению, эти люди часто сталкиваются с такими препятствиями, как общественное осуждение, когнитивные проблемы и психические симптомы, влияющие на социальное функционирование. В рамках существующих исследований основное внимание уделяется прежде всего общей социальной вовлеченности, а не специфическим сложностям ром

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… Additionally, marital status may affect illness progression differently by sex, with symptoms exacerbated in women and alleviated in men, possibly due to differing patterns of marriage retention based on symptom severity [ 9 , 10 ]. … Their perception of desirability is deeply affected, leading to lower self-esteem and a sense of being unfit for marriage or stable relationships. …

Association between radiotherapy and overall survival or cancer-specific survival in patients with solitary plasmacytoma of bone at pre-B cell grade: a real-world study using the SEER database.

Limited real-world studies have compared radiation therapy (RT) to non-RT for patients with solitary plasmacytoma of bone (SPB). This study investigated the impact of RT on long-term survival outcomes in patients with SPB at the pre-B cell grade within a real-world context. We conducted a retrospective cohort analysis using data from the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with SPB at the pre-B cell grade between 2010 and 2017. Patients were categorized into two groups based on receipt of RT. We used Cox proportional hazards models to estimate haz

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… Schone B S, Weinick M (1998) Health-related behaviors and the benefits of marriage for elderly persons. Gerontologist 38(5):618–627. 10.1093/geront/38.5.618 27. …

Эффективность различных стратегий лечения беременных женщин с множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Борьба с множественным склерозом (МС) в период беременности сопряжена с серьезными проблемами. Цель этого исследования заключалась в оценке экономической эффективности трех стратегий лечения в период беременности с точки зрения системы здравоохранения Соединенного Королевства. МЕТОДЫ: Была разработана модель Маркова для оценки результатов и расходов в области здравоохранения, связанных с тремя стратегиями лечения: непрерывным лечением в течение всего периода беременности, лечением до первого триместра, за которым следует прекращение и прекращение после зачатия после возо

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… Hoch JS, Briggs AH, Willan AR (2002) Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. Health Econ 11(5):415–430 26. …

Mental Health Assessment of Cancer Patients: Prevalence and Predictive Factors of Depression and Anxiety.

BackgroundPatients with oncological diseases often have mental disorders in the form of comorbidity. The aim of this study was to research the association of cancer with the presence of symptoms of depression and anxiety in primary health care patients.MethodsThis prospective observational study done in 2020 included adult users of health care at the Health Center Trstenik, Central Serbia, aged 19 and over, both sexes, with a diagnosis of oncological disease. A research instrument to assess depressive symptoms is used PHQ-9 (The Patient Health Questionnaire) questionnaire, derived from PRIME M

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… Table 1: Sociodemographic characteristics of cancer patients Variables | | N° (%) Gender | Male | 76 (30.4) | Female | 174 (69.6) Environment | Rural | 131 (52.4) | Urban | 119 (47.6) Marital status | Unmarried | 5 ( 2 ) | Marriage | 171 (68.4) | Widow(er) | 50 (19.9) | Divorced | 24 (9.7) Education …

When to Use Methadone for pain: A Case-Based Approach.

The case studies are written in this article to illustrate how methadone might be used for pain in the Indian context. These cases might be used for discussion in a multidisciplinary team, or for individual study. It is important to understand that pain requires a multidisciplinary approach as opioids will assist only with physical, i.e. neuropathic and nociceptive pain, but not emotional, spiritual, or relational pain or the pain of immobility. The social determinants of pain were included to demonstrate how emotional, relational, and psychological dimensions of pain amplify the physical aspe

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… Her marriage was an emotional trauma to the family. …

Множественный склероз в Германии: анализ данных об административной распространенности и оказании услуг в области здравоохранения в официальной системе здравоохранения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Данные об использовании медицинских услуг в связи с множественным склерозом (МС) в Германии являются недостаточными. Цель этого исследования заключалась в анализе административной распространенности НР, использования лекарств и типов специалистов, занимающихся лечением НР в амбулаторных условиях в Баварии. МЕТОДЫ: Были использованы данные о Псевудонимных претензиях, представленные баварскими врачами, аккредитованными в системе обязательного медицинского страхования (ШСИ). Согласно определению, административная распространенность НР имеет ≥1 Диагноз MS (Международная клас

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… Patients were identified based on their insurance number, which remains fixed during a period of insurance with a particular provider, but can change, for example in the case of marriage, retirement or health-insurance mergers. …

ИАНКОН 2023 Выдержки из плаката

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Advancing Hematopoietic Stem Cell Transplantation (HSCT) in Africa: A Pathway to Curing Hematological Disorders.

BackgroundHematopoietic stem cell transplantation (HSCT) offers a curative option for numerous hematological disorders, notably sickle cell disease and thalassemia, which are highly prevalent in Africa. Despite its potential, access to HSCT remains limited due to infrastructural, economic, and socio-cultural challenges across the continent.MethodsThis review synthesizes current literature and reports on the status of HSCT in Africa, analyzing data from existing transplant centers, national registries, and peer-reviewed studies to assess progress, challenges, and prospects for expanding HSCT se

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… HSCT in Egypt In Egypt, thalassemias and SCD are the most common inherited recessive disorders associated with consanguineous marriage. The first HSCT was performed in 1989, and the program started on a narrow scale. …

Research in haematological cancers: What do patients in the Netherlands prioritise?

IntroductionThe experiential knowledge of patients can provide research communities with complementary perspectives on disease. The aim of this study was to identify and prioritise everyday problems and research needs of haematological cancer patients and people who have undergone a stem cell transplantation.MethodsA mixed-method participatory research approach (the Dialogue Model) was applied, including interviews (n = 19), four focus group discussions (n = 27), a questionnaire (n = 146) and a stakeholder dialogue meeting (n = 30) with patients in the Netherlands.ResultsPatients' physical dis

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… Marriage is often put to the test, as partners are also affected: You don’t get cancer by yourself, you have to fight it together [as spouses]. If you both deal with the anxiety in a different way, there are two parallel circuits. That can be harder than expected. …

Efficacy and Safety of Pegfilgrastim in Patients With Severe Congenital Neutropenia.

BACKGROUND: Severe congenital neutropenia (SCN) is commonly treated with granulocyte colony-stimulating factor (G-CSF) to reduce neutropenia and the associated risk of infections. Pegfilgrastim, a long-acting form of G-CSF, provides the benefit of less frequent dosing; however, its application in SCN has not been extensively studied. This study aims to assess the long-term safety and effectiveness of transitioning SCN patients from standard G-CSF therapy to pegfilgrastim. METHODS: We followed eight patients with severe congenital neutropenia (five males, average age 17.8 years) who had been o

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… However in Iran, HAX1 is the most prevalent mutation due to the high rate of consanguinity and relative marriage [ 4 ]. …

What Defines Quality of Life for Older Patients Diagnosed with Cancer? A Qualitative Study.

The treatment of cancer can have a significant impact on quality of life in older patients and this needs to be taken into account in decision making. However, quality of life can consist of many different components with varying importance between individuals. We set out to assess how older patients with cancer define quality of life and the components that are most significant to them. This was a single-centre, qualitative interview study. Patients aged 70 years or older with cancer were asked to answer open-ended questions: What makes life worthwhile? What does quality of life mean to you?

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… Staying in your own home | Being able to live in your own home and not move to a nursing home Social functioning | Partner | Being together with a partner or having the comforting memories of a good marriage or relationship Family (including partner) | The support or presence of other family Community …

Large variation in radiation therapy fractionation for multiple myeloma in Australia.

AIM: To evaluate the patterns of use of different radiation therapy (RT) fractionation for multiple myeloma (MM) bone disease. METHODS: This is a population-based cohort of patients with MM who had RT between 2012 and 2017 as captured in the statewide Victorian Radiotherapy Minimum Data Set in Australia. Data linkage was performed to identify subsets of RT delivered within 3 months of death. RT fractionation was classified into four groups: single-fraction (SFRT), 2-5, 6-10, and > 10 fractions. Changes in RT fractionation use over time were evaluated with the Cochran-Armitage test for trend.

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… Data from VRMDS were linked with the Victorian Cancer Registry and the Registry of Births, Deaths and Marriages to capture data on death. We further analyzed a subset of RT delivered at the end of life (EOL), defined as at least one fraction palliative RT courses delivered within 90 days of death. …

Identification of Psychological and Social Problems in Caregivers of Individuals Diagnosed with Hematologic Malignancy.

ObjectiveCaring for patients with hematological malignancy could lead to many problems in different aspects regarding the lives of caregivers. However, there is limited data on the emotional and social problems of caregivers, who deal with patients of hematological malignancy. The aim of this study is to determine the emotional and social problems in caregivers of individuals diagnosed with hematological malignancy.MethodsThe study was carried out descriptively to identify the emotional and social problems in the relatives of the patients diagnosed with hematological malignancy as their caregi

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… Questions regarding the caregiver were related to the age, gender, marital status, socioeconomic status, working status, degree of relation to the patient, the state of sharing the same home with the patient, duration of marriage if married, the change in professional life, the year/hour allocated to …

Latent profile analysis of fear of progression in Chinese hematologic malignancy survivors.

Fear of disease progression (FoP) is a multidimensional concept that refers to the fear or worry about disease progress. Little is known about the distinct FoP profiles and their determinants in culturally specific contexts, especially among hematologic malignancies (HM) patients in China. This study aimed to identify heterogeneous profiles of FoP and their associated predictors among Chinese patients with HM. A convenience sample of patients suffering from HM were enrolled from March 2023 to February 2024. To gather multidimensional data from the Fear of Progression Questionnaire-Short Form (

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… Variables | Frequency ( n ) | Percent (%) Gender Male | 247 | 54.29 Female | 208 | 45.71 Age (at the time of the survey, years) < 35 | 135 | 29.67 35 ~ 65 | 273 | 60.00 > 65 | 47 | 10.33 Residence Urban area | 221 | 48.57 Rural area | 126 | 27.69 Suburban area | 108 | 23.74 Marriage status Unmarried …

Measurement Properties of Patient-Reported Outcome Measures for Adolescent and Young Adult Survivors of a Central Nervous System Tumor: A Systematic Review.

Purpose: To identify and evaluate patient-reported outcome measures (PROMs) for assessing survivorship-related concepts for adolescent and young adult (AYA) survivors of central nervous system (CNS) tumors. Methods: We searched five electronic databases. Two researchers independently screened all titles for inclusion and used consensus-based standards for the selection of health measurement instruments (COSMIN) guidance to grade the quality of evidence for each measurement property. Results: Four studies met eligibility criteria: single-item pain thermometer; single-item fatigue thermometer; 3

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… speech, hearing, and balance. 6–8 The large majority of young CNS tumor survivors experience at least one ongoing symptom, 9 and more than half experience life-altering and long-term disability. 10 This negatively impacts their social well-being, ability to attain developmental milestones, rates of marriage …