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Potential role of immunotherapy and targeted therapy in the treatment of cancer: A contemporary nursing practice.

Immunotherapy and targeted therapy have emerged as promising therapeutic options for cancer patients. Immunotherapies induce a host immune response that mediates long-lived tumor destruction, while targeted therapies suppress molecular mechanisms that are important for tumor maintenance and growth. In addition, cytotoxic agents and targeted therapies regulate immune responses, which increases the chances that these therapeutic approaches may be efficiently combined with immunotherapy to ameliorate clinical outcomes. Various studies have suggested that combinations of therapies that target diff

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… , stomatitis, vomiting, fatigue | [ 32 , 33 ] Regorafenib | Metastatic colorectal cancer (mCRC) | Nausea, weight loss, fever, HTN, rash, mucositis, decreased appetite/food intake, hyperbilirubinemia, dysphonia, asthenia/fatigue, infection, diarrhea, hand foot skin reaction (HFSR), pain | [ 3 , 31 ] Sunitinib … carcinoma refractory to radioactive iodine treatment; unresectable hepatocellular carcinoma; aRCC | Hemorrhage, HTN, gastrointestinal and abdominal pain, nausea, weight loss, decreased appetite, rash, HFSR, infection, fatigue, diarrhea, alopecia | [ 35 , 36 ] Ziv-aflibercept | mCRC | Abdominal pain, dysphonia …

Недостаток голоса, усталость голоса и качество голосовой жизни у пациентов с множественным склерозом.

ЦЕЛЬ: Описывать социально-демографические характеристики лиц с множественным склерозом и коррелировать и сравнивать усталость голоса, расстройства голоса и качество голосовой жизни людей с болезнью и без нее. МЕТОДЫ: Сквозное, количественное исследование 52 Добровольцы с множественным склерозом 52 - контроль за добровольцами в разбивке по полу, возрасту и уровню образования. Социально-демографические и клинические данные собирались с помощью вопросника и анализа медицинских записей. Участники отреагировали на сокращенный индекс инвалидности голоса ( " Voice Disability Index " )VHI-10

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… The V-RQOL assesses the impact of dysphonia on the individual's voice-related quality of life, through 10 items distributed in three domains: socioemotional, physical, and global, measured by simply summing all items. … Therefore, it is essential to conduct more targeted studies in this area to investigate in further detail the markers of dysphonia and their effects on the quality of life of patients with MS. CONCLUSION This study found a prevalence of the disease in young, educated females diagnosed with RRMS. …

Systematic review of pediatric postcricoid cushion and postcricoid lesions.

OBJECTIVES: It is thought that many infants have a prominent venous plexus of the postcricoid area. In the past this entity had occasionally … 14/33) followed by no other medical history (9/33). The most common clinical symptoms were stridor, dysphonia, or weak cry in 30/42, dysphagia in 20/42, sleep disordered breathing in 9/42, and regurgitation or aspiration in 9/42.8/38 of patients diagnosed with postcricoid cushion did not have visualization of the lesion until a Valsalva maneuver was perform …

Clinical practice guideline: improving voice outcomes after thyroid surgery.

OBJECTIVE: Thyroidectomy may be performed for clinical indications that include malignancy, benign nodules or cysts, suspicious findings on … radioactive scanning/treatment, temporary and permanent hypoparathyroidism, temporary or permanent dysphonia postoperatively, and dysphagia. This clinical practice guideline provides evidence-based recommendations for management of the patient's voice when undergoing thyroid surgery during the preoperative, intraoperative, and postoperative period. PURPOS …

Anaplastic thyroid cancer: prevalence, diagnosis and treatment.

UNLABELLED: Anaplastic thyroid cancer (ATC) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well … he follicular subtype. Most ATC patients complain of local compressive symptoms, such as dysphagia, dysphonia, stridor and dyspnea in addition to neck pain and tenderness; in over 70% of the patients the tumor infiltrates surrounding tissues, such as fat, trachea, muscle, esophagus, and larynx. The clinical course of a rapidly enlarging mass that is firm an …

Canine laryngotracheal plasma cell tumors: Ten cases and literature review.

Canine extramedullary plasma cell tumors (EMPs) most commonly arise in the skin, oral cavity, rectum, and colon. This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs and outcomes of laryngeal and tracheal EMPs in dogs. Five tracheal and 5 laryngeal EMPs were diagnosed at the Penn Vet Diagnostic Laboratory. Clinical information was obtained via submission forms and follow-up questionnaires. All dogs were male (9 castrated), 7 to 15 years old, and of different breeds. Neoplasms were composed of well-differentiated (n = 6)

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… Clinical signs included dyspnea, stridor, cough, collapse/syncope, labored breathing, dysphonia, choking, and hemoptysis. The masses were pedunculated, pink, and had a smooth surface. …

Ludwig's angina and acute myocardial infarction: A case report.

Ludwig's angina was first described in 1839 by German physician, Wilhelm Frederick Von Ludwig as a rapidly and fatal progressive gangrenous cellulitis and edema of the soft tissues of the neck and floor of the mouth with rapid spread to other places like anterior mediastinum. However, Type 2 acute myocardial infarction (MI) due to Ludwig's angina has not been documented. A 62-year-old male presented to the emergency department with visible anterior neck swelling for 1 week, which was preceded by a tooth arch 1 week prior, the patient presented with a high grade fevers, dysphonia, dysphagia, an…

Biportal Endoscopic Posterior Cervical Foraminotomy.

BACKGROUND: Cervical spine pathologies causing nerve-root compression are treated with use of decompression through a variety of techniques. … , preserves segmental motion, and avoids the anterior approach, which is associated with dysphagia, dysphonia, and potential for vascular injury. EXPECTED OUTCOMES: Ruetten et al. conducted a randomized controlled trial comparing endoscopic cervical posterior foraminotomy to traditional microsurgical foraminotomy3. In that study, 87.4% of patients experien …

Prevalence of symptomatic toxicities for novel therapies in adult oncology trials: a scoping review.

BackgroundPatients' self-report of their symptoms can provide important data for the evaluation of treatment benefit and tolerability of oncology drugs. Contemporary treatment approaches, including immunotherapy and molecular targeted therapies, have unique toxicities based on their novel mechanisms of action. This scoping review aimed to summarize evidence from existing reviews and clinical practice guidelines to examine the type and prevalence of toxicities including symptomatic adverse events (sympAEs) for adult cancer patients to inform clinical care and therapeutic trials.MethodsA systema

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… pneumonia Heme: myelosuppression, bleeding (6%), neutropenia (9%), thrombocytopenia (35%) Immune: infections Santoni (2018) | Review of trials data 1 phase 1 b trial 1 phase 2 trial 1 phase 3 trial | Solid tumor (RCC) | VEGFR TK inhibitor (tivozanib) Combination therapy (tivozanib + temsirolimus) | Oral: dysphonia … The most prevalent GI symptoms reported were dysgeusia (38%-68%), decreased appetite (19%-63%), diarrhea (8%-54%), and nausea (22%-47%) with dysphonia, dysphagia, and mucositis also commonly experienced by patients. …

Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma.

Chimeric antigen receptor T-cell (CAR-T) therapy represents the most important advances in cancer immunotherapy, especially in hematological malignancies such as B-cell lymphomas. CAR-T cell therapy has significant activity in poor risk B-cell lymphomas. CAR-T cell therapy is associated with potentially life-threatening toxicities such as cytokine release syndrome (CRS) and neurotoxicity (NT). While CRS pathophysiology and management are well established, the understanding and treatment of NT continues to develop. All current CAR-T products approved for DLBCL have been associated with NT with

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… and migraine Headache: Includes headache and migraine Dizziness: Includes dizziness, presyncope, syncope Dizziness: Includes dizziness and syncope Sleep disorder: Includes sleep disorder, nightmares, and insomnia Aphasia: Includes aphasia, dysphasia Aphasia: Includes aphasia, dysarthria, dysphemia, dysphonia … migraine | Headache: Includes headache and migraine Dizziness: Includes dizziness, presyncope, syncope | Dizziness: Includes dizziness and syncope | Sleep disorder: Includes sleep disorder, nightmares, and insomnia Aphasia: Includes aphasia, dysphasia | Aphasia: Includes aphasia, dysarthria, dysphemia, dysphonia …

The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery.

The Japan Association of Endocrine Surgery published the first edition of the "Clinical guidelines on the management of thyroid tumors" in 2010 and the revised edition in 2018. The guideline presented herein is the English translation of the revised third edition, issued in 2024. The aim is to enhance health outcomes for patients suffering from thyroid tumors by facilitating evidence-based shared decision-making between healthcare providers and patients, as well as standardizing the management of thyroid tumors. The focus is on adult patients with thyroid tumors, addressing clinically signific

Relapsing polychondritis: tracheobronchial involvement and differential diagnoses.

This review is describing the diagnostic and therapeutic approach to tracheobronchial involvement in relapsing polychondritis (RP), with a focus on differential diagnoses of inflammatory origin. RP is a systemic auto-immune disease that mainly affects cartilage structures, progressing through inflammatory flare-ups between phases of remission and ultimately leading to deformation of the involved cartilages. Besides the damage of auricular or nasal cartilage, tracheobronchial and cardiac involvement are the most severe, and can seriously alter the prognosis. Tracheobronchial lesions are assesse

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… Laryngeal chondritis Laryngeal chondritis is observed in 40% of cases ( 15 - 18 , 21 ), with various manifestations such as dry cough, hoarseness, dysphonia/aphonia, or thyroid cartilage pain. … Respiratory symptoms (dyspnea, cough, dysphonia, hemoptysis) are rare but should alert clinicians to the appearance of such involvement. Flexible bronchoscopy findings are variable, with inflammatory mucosa, erosions, and ulcerations, sometimes associated with subsequent stenosis. …

Pharmacokinetic, pharmacodynamic, efficacy, and safety data from two randomized, double-blind studies in patients with asthma and an in vitro study comparing two dry-powder inhalers delivering a combination of salmeterol 50 microg and fluticasone propionate 250 microg: implications for establishing bioequivalence of inhaled products.

BACKGROUND: The use of dry-powder inhalers (DPIs) to administer respiratory medicines is increasing, and new DPIs are likely to be developed … dverse events occurred in both groups (2 [dysphagia and tremor] in the RPID group and 3 [2 cases of dysphonia, 1 case of mucous-membrane irritation] in the Diskus group). There were 270 patients (136 females, 134 males) in the clinical efficacy and safety study, most (94%) of whom were white; mean (SD) age was 37.2 (17.0) years (range, 11-77 years) in the R …

Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report.

BackgroundAdenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease.Case presentationWe report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation th

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… Case presentation We report a case of an 82-year-old white man, who never smoked tobacco or consumed alcohol, who presented with a 3-month history of tracheitis and dysphonia. …

Workplace and social support, treatment satisfaction, and their impact on quality of life in Swedish women with multiple sclerosis: a cross-sectional survey study.

OBJECTIVE: To evaluate health-related quality of life (HRQoL), in relation to support from work, social, as well as treatment satisfaction, in women with multiple sclerosis (MS). Further, to predict the satisfaction on these support dimensions based on sociodemographic and clinical variables. DESIGN: Cross-sectional survey: a web-based questionnaire conducted in 2021 of people with MS (PwMS) linked to Nationwide Swedish registers. SETTING: Sweden. PARTICIPANTS: Working women with MS, living in Sweden, aged 20-50 responding to the survey during the spring of 2021 (n=2967). OUTCOME MEASURES:

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… Visible symptoms (movement/ambulation problems, vision problems, bladder, bowel and sexual dysfunction and dysphonia, dysarthria and dysphagia). …

Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran.

Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers, TTR mRNA silencers, TTR fibril disruptors, inhibitor of TTR fibril seeding and gene therapy. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, able to penetrate into hepatocytes, where it selectively targets TTR mRNA, reducing TTR production. We

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… The patient had depressed mood, dysphonia, diffuse muscular hypotrophy, moderate/severe proximal and distal hyposthenia at 4 limbs, areflexia, and distal hypoesthesia at upper and lower limbs. NIS was 61, PND score 3b and FAP stage II. … The logopedic examination showed moderate dysphonia and ipophonia with reduced phonatory times. The psychological evaluation concluded for post-stress depression. Fibrolaryngoscopy showed a vocal cords paresis and signs of gastroesophageal reflux. …

Многоцелевые лекарственные препараты: новые 2025 и послерыночного контроля за безопасностью наркотиков, 2022-2024.

Полифармакология предназначена для развития соединений, действующих по крайней мере на two целевые показатели (многоцелевые лиганды, МТДЛ). В 2025, Европейское агентство по медицине (ЕМА), 38 наркотиков, и 11 из них были MTDL. Большинство из них - антитела-наркотики, биконкретные антитела или ингибиторы киназы, все из которых указаны для лечения опухолей, включая датопотамаб дерукстекан (гормон-позитивный рецептор, HER2-negative Рак молочной железы), тизотумаб ведотин (сокращенная шейная карцинома), линвосельтамб (четвёртая линия лечения множественной миеломы) и эрдафитиниб (сокращенная уротел

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… and myelosuppression; females - hypertension, diarrhea, nausea, and pain; elderly - more susceptible to asthenia) fatigue, hypertension, diarrhea, asthenia, dysphonia, stomatitis; neurological, renal, and cardiovascular toxicities; new : dehydration; myelosuppression, peripheral neuropathy, posterior … and myelosuppression; females - hypertension, diarrhea, nausea, and pain; elderly - more susceptible to asthenia) | fatigue, hypertension, diarrhea, asthenia, dysphonia, stomatitis; neurological, renal, and cardiovascular toxicities; new : dehydration; myelosuppression, peripheral neuropathy, posterior …

The Schnitzler syndrome.

The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of

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… Edematous swelling of the face (angioedema) is very rare [ 3 , 10 , 11 ] and significant mucosal swelling with dyspnea and/or dysphonia is exceptional. Many patients report exacerbating factors including heat exposure, cold-exposure, alcohol consumption, some aliments, physical work, stress,... …

A Rare Case of Systemic Amyloidosis Involving the Thyroid in a Young Patient.

Thyroid amyloidosis is a rare condition associated with thyroid pathologies such as medullary carcinoma, papillary carcinoma, amyloid goitre, and benign lesions, with a clinically palpable goitre being exceptionally uncommon. As a result, many cases of benign thyroid enlargement caused by amyloid deposits remain undiagnosed. A 28-year-old male patient noticed progressive neck circumference enlargement, voice alteration, decreased appetite, weight loss, dysphagia, fever, and night sweats. Fine-needle aspiration biopsy of the thyroid gland did not reveal the cause of the goitre. A total thyroide

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… Patients with amyloidosis involving the head and neck region may present with a spectrum of clinical manifestations, including dysphonia, alterations in vocal timbre, and airway obstruction [ 17 ]. …

Supraglottic airway devices versus tracheal intubation for airway management during general anaesthesia in obese patients.

BACKGROUND: The number of obese patients requiring general anaesthesia is likely to increase in coming years, and obese patients pose consid … R 0.10, 95% CI 0.03 to 0.31), and there was no significant difference in the risk of sore throat or dysphonia (RR 0.25, 95% CI 0.03 to 2.13). On average, PLMA placement took 5.9 seconds longer than TT placement (95% CI 3 seconds to 8.8 seconds). There was no significant difference in the proportion of successful first placements of a device, with 33/35 (94. …