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Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

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… Weinshilboum began his affiliation with the Mayo Medical School and Mayo Clinic in Rochester, Minnesota, in 1972 where he is presently Professor of Molecular Pharmacology & Experimental Therapeutics and Internal Medicine as well as Mary Lou and John H. Dasburg Professor in Cancer Genomics Research. …

AL Amyloidosis: Current Chemotherapy and Immune Therapy Treatment Strategies: JACC: CardioOncology State-of-the-Art Review.

Immunoglobulin light chain (AL) amyloidosis is an incurable plasma cell disorder characterized by deposition of fibrils of misfolded immunoglobulin free light chains (FLC) in target organs, leading to failure. Cardiac involvement is common in AL amyloidosis and represents the single most adverse prognostic feature. A high index of clinical suspicion with rapid tissue diagnosis and commencement of combinatorial, highly effective cytoreductive therapy is crucial to arrest the process of amyloid deposition and preserve organ function. The clinical use of molecularly targeted drugs, such as protea

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… Incidence of AL amyloidosis in Olmsted County, Minnesota, 1990 through 2015 Mayo Clin Proc 94 2019 465 471 30713046 10.1016/j.mayocp.2018.08.041 PMC6401262 9 Kyle R.A. Larson D.R. Therneau T.M. …

EANM guidelines on the use of [18F]FDG PET/CT in diagnosis, staging, prognostication, therapy assessment, and restaging of plasma cell disorders.

We provide updated guidance and standards for the indication, acquisition, and interpretation of [18F]FDG PET/CT for plasma cell disorders. Procedures and characteristics are reported and different scenarios for the clinical use of [18F]FDG PET/CT are discussed. This document provides clinicians and technicians with the best available evidence to support the implementation of [18F]FDG PET/CT imaging in routine practice and future research.

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… According to updated data of the Southeastern Minnesota cohort (with a long-term follow-up) adverse risk factors for progression of MGUS to active MM include an M-protein ≥ 15 g/L and an abnormal SFLC ratio in patients with non-IgM MGUS. …

Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy.

Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various immune cell types and perform multiple purposes and duties involved in the induction of innate and adaptive immunity. Their capability to propagate immunity makes them attractive targets for the expansion of numerous immunotherapeutic approaches targeting cancer. These immunotherapeutic strategies include using TLR ligands/agonists as monotherapy or combined therapeutic strategies. Several TLR agonists have demonstrated significant efficacy in advanced clinical trials. In recent years, multiple reports est

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… Apart from TLR9, monophosphoryl lipid A (MPLA), a TLR4 ligand derived from the lipopolysaccharide (LPS) of Salmonella Minnesota, is used as an adjuvant in a prophylactic vaccine against human papillomavirus types 16 and 18, which are common causes of cervical cancer ( 109 ). …

Е-постеры.

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… offered to all patients that have right criteria. 597 P034: Heterogeneity of surgical approach for adult spinal deformity patients Kenneth Holton 1 , Michael Laroque 2 , Elisa Hofmeister 2 , Paul Soriano 1 , and David Polly 1 1 Department of Orthopaedic Surgery 2 Medical School, University of Minnesota … significant variation exists in the surgical treatment of patients undergoing primary spinal deformity surgery. 656 P035: Placement of multiple points of pelvic fixation in spinal deformity surgery Andrew Ormseth 1 , Kenneth Holton 1 , and David Polly 1 1 Department of Orthopaedic Surgery, University of Minnesota …

Abstracts From the 42nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand held on June 16-18, 2024

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… Pancreas Transplant Unit, Monash Medical Centre, Melbourne, 2 Renal Transplant Unit, Monash Medical Centre, Melbourne, 3 Department of Vascular and Transplantation Surgery, Monash Medical Centre, Melbourne Background: Pancreas transplants were performed successfully in 1966 1 at the University of Minnesota …

Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis - 2021.

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Oral Presentations

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… Sembrano 1 , Nathan Hendrickson 1 , and David Polly 1 1 University of Minnesota, Minneapolis, United States Introduction: Higher magnitude deformity corrections, particularly in the sagittal plane, are known to be higher risk for pelvic fixation failure, but the impact of increased pelvic fixation …

Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Brian Van Ness, University of Minnesota, Minneapolis, MN 353. Ivan Van Riet, Vrine Universiteit Brussel, Brussels, Belgium 354. Isabelle Vande Broek, Vrije Universiteit Brussel, Brussels, Belgium 355. Karin Vanderkerken, Vrije Universiteit Brussel, Brussels, Belgium 356. …

Cancer related cognitive impairment: a downside of cancer treatment.

Cancer treatment is associated with long lasting cognitive impairment in cancer survivors. This cognitive impairment is often termed cancer related cognitive impairment (CRCI). Cancer survivors treated for tumors outside the central nervous system are increasingly diagnosed with CRCI. The development of strategies to mitigate the negative effects of cancer treatment on the brain are crucial. Although neuroimaging research has proposed several candidate mechanisms, the pathogenic underpinnings of CRCI remain uncertain. As such, preventative and treatment strategies have not been identified. To

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… This study was supported by the University of Minnesota. …

Realizing Innate Potential: CAR-NK Cell Therapies for Acute Myeloid Leukemia.

Next-generation cellular immunotherapies seek to improve the safety and efficacy of approved CD19 chimeric antigen receptor (CAR) T-cell products or apply their principles across a growing list of targets and diseases. Supported by promising early clinical experiences, CAR modified natural killer (CAR-NK) cell therapies represent a complementary and potentially off-the-shelf, allogeneic solution. While acute myeloid leukemia (AML) represents an intuitive disease in which to investigate CAR based immunotherapies, key biological differences to B-cell malignancies have complicated progress to dat

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… NCT01974479 | Suspended | National University Hospital Singapore Haplo NK | NKG2DL | AML/MDS | NCT04623944 | Active | Multiple Sites (USA) PBNK | NKG2DL | Solid Tumors | NCT03415100 | Active [ 130 ] | Guangzhou Medical University iPSC-NK | CD19 | CLL/NHL | NCT04245722 | Active [ 133 ] | University of Minnesota …

The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session

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Cutting edge of immune response and immunosuppressants in allogeneic and xenogeneic islet transplantation.

As an effective treatment for diabetes, islet transplantation has garnered significant attention and research in recent years. However, immune rejection and the toxicity of immunosuppressive drugs remain critical factors influencing the success of islet transplantation. While immunosuppressants are essential in reducing immune rejection reactions and can significantly improve the survival rate of islet transplants, improper use of these drugs can markedly increase mortality rates following transplantation. Additionally, the current availability of islet organ donations fails to meet the demand

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… Evolution of kidney, pancreas, and islet transplantation for patients with diabetes at the University of Minnesota . Am J Surg . ( 1993 ) 166 : 456–91 . doi: 10.1016/S0002-9610(05)81142-0 8238742 12 Shapiro AM Lakey JR Ryan EA Korbutt GS Toth E Warnock GL . …

Extraintestinal Cancers in Inflammatory Bowel Disease: A Literature Review.

BackgroundInflammatory bowel disease (IBD) is a group of chronic multifactorial inflammatory disorders including two major entities: Crohn's disease (CD) and ulcerative colitis (UC). Preliminary evidence suggests that patients with IBD may be at increased risk of developing intestinal and extraintestinal cancers (EICs). Actually, little is known about the association between IBD and EICs, and there is ever-growing concern regarding the safety of immunomodulators and biological therapy, which may represent a risk factor for carcinogenesis.AimsThe aim of this review is to summarize the evidence

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… Effect of Medications on Risk of Cancer in Patients with Inflammatory Bowel Diseases: A Population-Based Cohort Study from Olmsted County, Minnesota. Mayo Clin. Proc. 2015;90:738–746. doi: 10.1016/j.mayocp.2015.03.024. 60. …

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK).

Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition t

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases.

Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae a

Infectious Diseases

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… Europe) transmitted by Ixodes ticks (which also transmit Lyme disease and Ehrlichia ) → fever, chills, sweats, malaise, myalgias, arthralgias, headache 5–33 days after, particularly in immunosuppressed individuals clinical features —endemic in southern New England, southern New York, Wisconsin, and Minnesota …

Oral Presentations

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2,4 Dinitrophenol as Medicine.

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950's to suggest that warfarin, a rat poison, could be repositioned into a breakthrough drug in humans to protect against strokes as a blood thinner. Yet it was approved in 1954 as Coumadin® and has been prescribed to billions of patients as a standard of care. Similarly, no one can forget the horrific effects of thalidomide, prescribed or available without a prescri

Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference.

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