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Капиллероскопия с капиллароскопией в диабетической ретинопатии: микровирусные озарения, клиническая ценность и проблемы с переводом - обзор повествования.

Диабетическая ретинопатия (DR) является одним из основных микроваскуловых осложнений сахарного диабета и одной из основных причин предотвратимой потери зрения. В настоящее время DR рассматривается как проявление системной диабетической микроангиопатии, а не изолированного окулярного расстройства. Оценка на основе сетчатки может не в полной мере отражать системное микроваскулярное бремя, особенно в тех случаях, когда доступ к специализированной сетчатке сетчатки ограничен. Капиллероскопия с капиллярным влагом (НКЦ) позволяет напрямую и неинвазивно визуализировать периферическую капиллярную морф

Совпадение в аннотации оригинала
Diabetic retinopathy (DR) is a leading microvascular complication of diabetes mellitus and a major cause of preventable vision loss. DR is n … sistency in discriminating current severity. Auxiliary features include neoangiogenic patterns, megacapillaries, and crossing capillaries, while the proposed core pattern comprises reduced capillary density and avascular areas. Among these parameters, avascular areas showed the most consistent pooled association with current DR severity. Selected single-cohor …

VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARING NORMAL AND OPTIC DISK PIT EYES.

PURPOSE: Optic disk pits (ODPs) are typically detected incidentally as small, gray, unilateral, oval-shaped excavation in the temporal optic … rization of three layers in the optic nerve over a 4.5-mm × 4.5-mm region. The radial peripapillary capillaries, the nerve head capillaries, and the choriocapillaris were automatically segmented based on the OCT system software, and the capillary perfusion density (CPD) was quantified for each layer. Kruskal-Wallis one-way analysis of variance was used to com …

Vascular Birthmarks as a Clue for Complex and Syndromic Vascular Anomalies.

Vascular birthmarks are common in neonates (prevalence: 20-30%) and mostly incidental findings sometimes with spontaneous regression (salmon patch and nevus simplex). Capillary malformations are found in about 1% and infantile hemangiomas are found in 4% of mature newborns. Vascular malformations are classified according to their most prominent vessel type. The term "capillary malformation" (port wine stain) includes a wide range of vascular lesions with different characteristics; they may be isolated or part of specific syndromic conditions. Part of the infantile hemangiomas and of the vascul

Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross-Sectional Study.

OBJECTIVE: To compare microvascular damages on nailfold capillaroscopy (NFC) with macrovascular manifestations evaluated by hand power Doppl … diographs and NFC. RESULTS: UAO and pathologic FPBF were associated with severe capillary loss (<4 capillaries/mm) on NFC (odds ratio [OR] 4.04 [95% confidence interval (95% CI) 1.23-13.29]; P < 0.05, and OR 3.38 [95% CI 1.03-11.05]; P < 0.05, respectively). Digital ulcer history was associated with UAO (OR 10.71 [95% CI 3.36-34.13]; P < 0.0001), pathologic …

Potential of dried blood self-sampling for cyclosporine c(2) monitoring in transplant outpatients.

Background. Close therapeutic drug monitoring of Cyclosporine (CsA) in transplant outpatients is a favourable procedure to maintain the long-term blood drug levels within their respective narrow therapeutic ranges. Compared to basal levels (C(0)), CsA peak levels (C(2)) are more predictive for transplant rejection. However, the application of C(2) levels is hampered by the precise time of blood sampling and the need of qualified personnel. Therefore, we evaluated a new C(2) self-obtained blood sampling in transplant outpatients using dried capillary and venous blood samples and compared the Cs

Nailfold Capillaroscopy and Clinical Applications in Systemic Sclerosis.

Capillary microscopy is a safe and non-invasive tool to evaluate the morphology of the microcirculation typically affected in SSc. Next to being paramount for the "(very) early" diagnosis of SSc eyes are also geared toward capillaroscopy with the aim to be able to use it as a biomarker, especially in the prediction of future occurrence of DU. The following review will explain what capillary microscopy is and will focus additionally on studies evaluating the association between capillaroscopy and DU.

Pyogenic granuloma in a finger of a rheumatoid arthritis patient.

Pyogenic granuloma is benign soft tissue tumor which mainly occurs in gingiva, lips, tongue and finger. We report the patient of pyogenic granuloma in the distal phalanx of the index finger of the rheumatoid patient. The tumor enlarged rapidly and surgical excision was performed. Pathological examination showed lobular hyperplasia of capillary vessels and the expression of vascular endothelial growth factor at capillary vessels in inside of tumor.

[Reversible microangiopathies following massive weight loss].

A 17-year-old patient presented with loss of weight, acrocyanosis and trophic lesions of the tips of the toes. There were no clinical or immunological signs of connective tissue disease. Capillary microscopy revealed a severe organic microangiopathy and arteriolar spasm. A change in the patient's occupational conflict situation was followed by complete recovery and capillary findings normalized. The possible connection between anorexia-like affection and capillariopathy remains unclear.

Mesenteric angiography of non-tropical sprue.

Detailed angiographic findings in 2 cases of proved sprue are described. There are dilatation of the superior mesenteric artery and its small bowel branches selectively, and increased capillary blush. Early draining into dilated veins is also noted. These findings are similar to those of the superior mesenteric arteriogram performed with pharmacological vasodilators. This similarity suggests that the dilated vessels in non-tropical sprue may be due to capillary dilatation.

Fever of unknown origin characterized by acute kidney injury and nephrotic syndrome diagnosed as intravascular large B-cell lymphoma of kidney: case report and literature review.

A 60-year-old Chinese female patient was admitted to the hospital with complaint of intermittent fever for more than seven months. The main clinical manifestations were acute kidney injury and nephrotic syndrome which developed into a hemophagocytic syndrome. The symptoms did not improve with antibiotics. Moreover, prednisone could only reduce the fever. Finally, a kidney biopsy showed many CD20-positive cells in the glomerulus and some in the peritubular capillaries. This led to a diagnosis of renal intravascular large B-cell lymphoma.

Myopathy associated with anti-signal recognition peptide antibodies: clinical heterogeneity contrasts with stereotyped histopathology.

We report three patients with anti-signal recognition particle antibodies who had different presenting clinical pictures, mimicking acute polymyositis, limb-girdle muscular dystrophy, and acute rhabdomyolysis. Muscle biopsies typically showed necrotizing myopathy with little or no inflammation and deposits of membrane attack complex (C5b-9) in endomysial capillaries. The clinical course was severe in two patients and mild in one. The combination of corticosteroid with either an immunosuppressive agent or intravenous immunoglobulins was required to improve the condition of these patients.

Wegener's granulomatosis. Immunomicroscopic and ultrastructural study of four cases.

Four cases of Wegener's granulomatosis involving lung are reported in which immunomicroscopy demonstrated that the parenchymal and vascular infiltrates were composed primarily of T cells and monocytes. No IgG, IgA, IgM, or C3 was identified in pulmonary vessels or alveolar septa. Ultrastructural studies failed to demonstrate dense deposits in alveolar septal capillaries or interstitium. These findings indicate that a cellular immune mechanism is active in these forms of pulmonary vasculitis and that immune complex deposition does not play a role.

Causes of venous ulceration: a new hypothesis.

Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped white cells occlude the capillaries and result in ischaemia of the skin of the leg.

Looking Beyond the Surface: Multimodal Assessment of Subclinical Microvascular Changes in Juvenile SLE Using OCTA and Nailfold Capillaroscopy.

PURPOSE: Juvenile systemic lupus erythematosus (jSLE) is characterized by immune-mediated microvascular injury. Optical coherence tomography … ns persisted between capillary dilatation and ganglion cell layer thickness (r =  -0.705), crossing capillaries and SCP density (r = 0.785), and abnormal capillaries and FAZ parameters (r =  -0.654).No consistent associations were observed between retinal parameters and disease activity. CONCLUSION: jSLE is associated with subclinical retinal structural and …

Is there a need for a CT scan of the pancreatic phase? A perfusion and simulation study of the pancreas, an HCC, and the kidney cortex.

To explore the peak enhancement time of a hepatocellular carcinoma, the pancreas, and the kidney cortex and its determinants.We obtained a time enhancement curve from the perfusion CT scans of 11 advanced HCC patients (40 volumes at 1.25 s time interval, slab slice 90 mm, bolus of 50 ml of iodinated contrast agent, 350 g iodine/ml, flow 5 ml/s). Small regions of interest were drawn on the abdominal aorta, the HCC, the cortex of the right kidney, and on the pancreas. The behavior of the contrast agent in the capillary and in the surrounding tissue was further explored with a finite element mode

Impact of the 2022 pulmonary hypertension definition on haemodynamic classification and mortality in patients with aortic stenosis undergoing valve replacement.

AIMS: With the 2022 pulmonary hypertension (PH) definition, the mean pulmonary artery pressure (mPAP) threshold for any PH was lowered from ≥25 to >20 mmHg, and the pulmonary vascular resistance (PVR) value to differentiate between isolated post-capillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH) was reduced from >3 Wood units (WU) to >2 WU. We assessed the impact of this change in the PH definition in aortic stenosis (AS) patients undergoing aortic valve replacement (AVR). METHODS AND RESULTS: Severe AS patients (n = 503) undergoing pre-AVR cardiac heart catheterization were

Histological analysis of the medial gastrocnemius muscle in young healthy children.

Introduction: Histological data on muscle fiber size and proportion in (very) young typically developing (TD) children is not well documented and data on capillarization and satellite cell content are also lacking. Aims: This study investigated the microscopic properties of the medial gastrocnemius muscle in growing TD children, grouped according to age and gender to provide normal reference values in healthy children. Methods: Microbiopsies of the medial gastrocnemius (MG) muscle were collected in 46 TD boys and girls aged 2-10 years subdivided into 4 age groups (2-4, 4-6, 6-8 and 8-10 years)

Quantitative Assessment Parameters of Peripapillary Regions with Branch Retinal Vein Occlusion by Using Optical Coherence Tomography Angiography.

PURPOSE: To investigate the baseline parameters of peripapillary regions in both eyes of patients with unilateral branch retinal vein occlus … ly affects the blood vessel density in the macular area but also decreases the radial peripapillary capillaries. The capillary density is mainly affected in the affected hemifield but not in the unaffected hemifield.

Updating Understanding of Macular Microvascular Abnormalities and Their Correlations With the Characteristics and Progression of Macular Edema or Exudation in Coats' Disease.

OBJECTIVE: To investigate the associations of macular microvascular abnormalities with the characteristics and progression of macular edema … SCP (P = 0.009) and DCP (P = 0.010) were lower in refractory group than in improved group. Dilated capillaries with incomplete vessel walls and adjacent inflammatory cells were detected in the neuroretina of the macula in histopathological specimen. CONCLUSIONS: Macular capillary abnormalities, including telangiectasia and VD loss, were positively detected …

Structural and microvascular changes of the peripapillary retinal nerve fiber layer in Von Hippel-Lindau disease: an OCT and OCT angiography study.

Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic disease caused by VHL gene mutation. Retinal hemangioblastomas (RH) are vas … ovascular changes of the peripapillary retinal nerve fiber layer, in which glial cells, neurons and capillaries (the radial peripapillary capillary plexus) interact. VHL patients with or without peripheral RH were enrolled and compared to healthy controls. Mean peripapillary retinal nerve fiber layer (pRNFL) thickness was measured by means of optical coherenc …