Результаты поиска

Neonatal stress hyperglycemia mimicking diabetes mellitus secondary to massive intraparenchymal brain abscess due to escherichia coli sepsis: A case report.

Stress hyperglycemia is a common metabolic response in critically ill neonates but may rarely present with extreme hyperglycemia mimicking neonatal diabetes mellitus. We report a term female neonate presenting on day 18 of life with lethargy, poor feeding, dehydration, and severe hyperglycemia (>1000 mg/dL), hypernatremia, and acute kidney injury. Insulin therapy was initiated due to suspicion of neonatal diabetes mellitus. Blood cultures grew Escherichia coli, confirming neonatal sepsis. Neuroimaging revealed a massive right fronto-parieto-temporal intraparenchymal abscess with significant ma…

Acid-Base and Electrolyte Disorders: Calcium Disorders.

Calcium is an essential element for normal physiologic function. Normal serum calcium is maintained within a close range of 8.4 to 10.4 mg/d … , which can be observed or treated surgically. Patients with severe hypercalcemia may have profound dehydration and require inpatient treatment with intravenous fluids, bisphosphonates, and calcitonin.

De novo formation of human sebaceous glands using self-assembled skin substitutes.

Sebaceous glands (SGs) contribute to skin physiology by producing sebum, which forms a lipid barrier preventing dehydration. Various skin conditions, including acne vulgaris and seborrheic dermatitis, are linked to their dysfunction. Several questions remain concerning the formation and regulation of these glands because there are few human tridimensional models available to address them. In this study, we investigated the conditions that allow SG formation in human tissue-engineered skin substitutes. We tested whether the source of epithelial cells, fibroblasts, and the extracellular environm…

A Case of Post-Transplantation Lymphoproliferative Disorder Following Kidney Transplantation.

This was a case of a 65-year-old gentleman known to have diabetes mellitus and hypertension since 2012 and post renal transplantation in 201 … on and off for 6 months, worse in the month prior to presentation. His examination was positive for dehydration, abdominal distension, and generalized abdominal tenderness. He had a normal hematological profile and renal function. A CT scan of the abdomen showed features of small bowel obstruction from the distal ileal to distal jejunal bowel loops. The patie …

Antipsychotic-Associated Hypothermia With Bradycardia and QT Prolongation in an Older Adult.

Second-generation antipsychotics may cause rare but potentially life-threatening disturbances in thermoregulation and cardiac conduction. We … ted adverse reaction to second-generation antipsychotics was suspected, with advanced age, frailty, dehydration, and recent infection considered predisposing factors. Quetiapine and risperidone were discontinued, after which body temperature and the QT interval normalized within five days, heart rate returned to baseline, and mental status, renal function, le …

Temperature-metabolism relationships above and below the body fluid freezing point in the freeze-tolerant white worm, Enchytraeus albidus.

Enchytraeus albidus is a freeze-tolerant oligochaete with potential for long-term cryopreservation storage as live feed in aquaculture. In t … ression is strongly correlated with intracellular osmolality, which increases due to freeze-induced dehydration. Theoretical calculations based on MR data suggest that glycogen stores could support frozen aerobic metabolism for up to 3-4 months at -14 °C, aligning with overwinter survival observed in Arctic populations. These findings indicate that E. albidus …

Management of earthquake-related acute renal injury.

This frontier will highlight the principles of diagnosis and management of earthquake crush syndrome and related acute kidney injury (AKI) b … . AKI is caused by three mechanisms. Prerenal factors include: (1) Hypovolemia due to bleeding; (2) Dehydration due to lack of water; (3) Ischaemia-reperfusion injury; and (4) Cardiac depression caused by released toxins. Renal factors include the nephrotoxic effects of the uric acid and bilirubin, tubular casts obstructing the tubules, or the direct depositi …

Tuning casein coagulation and structure: Exploring the effects of ionic strength and glycerol.

Casein-based materials offer a sustainable platform for advanced biomaterials, yet the impact of ionic strength on their macroscopic structu … city compared to those formed in 300 mM buffer. Treatment with glycerol, which also induces partial dehydration, proved valuable in preventing structural collapse during drying, enabling structural insights through scanning electron microscopy. Additionally, glycerol played a crucial role in enhancing the samples' rehydration capability. The study also reveal …

Physiological and Metabolic Responses to Water Restriction in Ewes Under Semi-Arid Conditions.

The aim of this study was to evaluate the effect of different water restrictions on the thermoregulation and blood hematological and metabol … water supply reduction up to 40%. Following an 80% reduction in water supply, animals exhibit mild dehydration, characterized by increased serum urea levels and decreased alanine aminotransferase activity.

Exercise and Kidney Health: Core Curriculum 2026.

Exercise triggers complex effects on kidney physiology that vary with intensity, duration, and environmental conditions. While moderate physical activity improves cardiovascular and renal outcomes, intense or prolonged exertion, particularly in endurance sports, can lead to acute kidney injury. Adaptations in kidney physiology during exercise include reduced plasma flow, altered glomerular filtration, and hormone-mediated fluid retention. These changes are protective but may become maladaptive with dehydration, heat stress, or excessive fluid intake. High-intensity exercise increases oxidative…

Successful Therapeutic Management of Trypanosomosis in a Dog-A Case Report.

BACKGROUND: Trypanosomosis is one of the most important and deadliest diseases of canines. Usually within 3 to 4 weeks an infected dog dies in the acute form of the disease. The use of inappropriate doses of anti-trypanosomatid drugs in animals leads to the development of huge resistance in the organisms. METHODS: The present study communicates the successive therapeutic management of clinical trypanosomiasis with five doses of diminazine aceturate injection. One mongrel dog came with the clinical signs of persistent fever, tachycardia, severe dehydration, pale mucous membrane, corneal opacit…

Synergistic risks: Lamotrigine induced rash potentiating lithium toxicity.

Lithium and lamotrigine are mood stabilizers approved for the treatment of bipolar disorder. Lithium's narrow therapeutic index and comparat … ntrations are exquisitely sensitive to physiological factors affecting renal function, such as age, dehydration, and sodium imbalance. Sodium depletion can cause increased lithium reabsorption in the kidneys, potentially leading to toxicity (Joshi et al., 2019). Lamotrigine is known to carry the risk of causing rash, which in severe cases can be fatal. The ra …

Establishment and application of a droplet digital PCR assay for sensitive detection of porcine deltacoronavirus.

BACKGROUND: Porcine deltacoronavirus (PDCoV) is a newly emerging coronavirus that causes severe diarrhea and dehydration in newborn piglets, and can infect multiple animal species including humans, posing a substantial threat to global swine production and human health. To address these challenges, we developed a droplet digital PCR (ddPCR) method for detecting the N gene of PDCoV in clinical samples. RESULTS: Our ddPCR method exhibited good linearity, reproducibility, and repeatability. In comparison to conventional quantitative real-time PCR (qPCR), the ddPCR assay demonstrated exceptional s…

Nano-Confined Hydrogel Microspheres with Programmable Mechanics and Molecular Lubricity.

The simultaneous integration of high elasticity and lubricity-hallmarks of biological tissues-remains a fundamental challenge in synthetic hydrogels due to the intrinsic trade-off between "dehydration-induced" elasticity and "hydration-dependent" lubrication. Herein, inspired by the dynamic architecture of living systems, the construction of "living" biodegradable hydrogel microspheres is reported that reconcile this contradiction through internal nano-reinforcement and external molecular lubrication. Crystalline disc-like Laponite nanosheets are intercalated within GelMA networks, acting as d…

Nonswellable Curdlan/Linseed Gum Biogel with Water Retention Modulation: A Therapeutic Platform for Post-Traumatic Urethral Stricture Reconstruction.

Despite the potential of hydrogels in urethral tissue engineering, their efficacy in urethral repair is hindered by swelling caused by urine … (LG) was integrated into the gel network to achieve water retention regulation, thereby preventing dehydration during urethral compression. Finally, cuttlefish ink nanoparticles (CINPs) with inherent immunomodulatory properties were added to regulate the inflammatory microenvironment in the area of urethral injury. The resulting biogel (Cur/LG/CINPs) exhibit …

Current treatment of hereditary nephrogenic diabetes insipidus in children.

Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by the inability of the kidneys to respond to arginine vasopressin, leading to polyuria, polydipsia, and chronic dehydration. This condition often results in severe complications, including growth failure, behavioral problems, and irreversible brain damage, particularly in young children with hereditary forms. Early diagnosis and effective management are critical for minimizing these complications and improving patients' quality of life. Current treatments focus primarily on symptom management through dietary interventions, …

Cryptosporidium parvum screening in young calves with diarrhoea in Sulaymaniyah Governorate, Iraq.

The parasitic protozoan Cryptosporidium parvum causes cryptosporidiosis in young calves, leading to diarrhoea and financial losses in the fa … re, heart rate, and respiratory rate. PCR positivity in our study was substantially correlated with dehydration. Overall, this study highlights the need for prompt identification and intervention for the management of C. parvum infections in young calves.

Гут Микробиота в вирусной модели множественного склероза: Modulation and Pitfalls путем перорального антибиотического лечения.

Вирусные инфекции ассоциируются с множественным склерозом (МС), иммунизированным заболеванием в центральной нервной системе (КНС). Так как вирус мюрин-энцефаломиелита (TMEV) может вызвать MS-подобные демиелинации, инфекция TMEV является наиболее широко используемой вирусной моделью для MS. Хотя точная патофизиология неизвестна, изменённые бактериальные популяции были связаны с различными иммунными генами в CNS. Мы стремились определить роль кишечного микробиота в инфекции ТМЕВ путем применения антибиотического коктейля в питьевой воде до (прогилактического управления) или после (терапевтическо

Совпадение в аннотации оригинала
Viral infections have been associated with multiple sclerosis (MS), an immune-mediated disease in the central nervous system (CNS). Since Th … uced water intake in the antibiotic group of mice, resulting in significant body weight loss. Since dehydration and stress could affect immune responses and gut microbiota, caution should be exercised when planning or evaluating the oral antibiotic cocktail treatment in experimental animals.

Development and validation of a stability-indicating method, structural elucidation of new degradation products from misoprostol by LC-MS time-of-flight, and an ex vivo study of vaginal permeation.

Misoprostol (MSP) is commonly prescribed in obstetrics and gynecology clinical practice for labor induction, cervical ripening, first-trimes … 405.2705, and 387.2259, respectively. These results suggest that the degradation mechanism involves dehydration of the β-hydroxy ketone moiety, followed by isomerization to its most resonance-stable form and de-esterification. Finally, the in vitro permeation study revealed that the esterified form of MSP was unable to permeate the mucosa and required prior d …

Lignin-based flame retardant via sequential purification-nanoparticle formation, and NP coupled chemical modification.

A nonhalogenated and ecofriendly flame-retarding material was developed using lignin, one of the main components of lignocellulosic biopolym … charcoal residue increased by 25 %. The flame-retarding mechanism of L-FR involved low-temperature dehydration, thermal decomposition of cellulose by the phosphorus component of PA and generation of expansive gas by the nitrogen component of PEI. These results showed that lignin-based raw material processing, polymer processing, and chemical modification wer …