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Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

The Implementation of Chimeric Antigen Receptor (CAR) T-cell Therapy in Pediatric Patients: Where Did We Come From, Where Are We Now, and Where are We Going?

CD19-directed Chimeric Antigen Receptor (CAR) T-cell therapy has revolutionized the treatment of patients with B-cell acute lymphoblastic leukemia (B-ALL). Somewhat uniquely among oncologic clinical trials, early clinical development occurred simultaneously in both children and adults. In subsequent years however, the larger number of adult patients with relapsed/refractory (r/r) malignancies has led to accelerated development of multiple CAR T-cell products that target a variety of malignancies, resulting in six currently FDA-approved for adult patients. By comparison, only a single CAR-T cel

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… Masonic Cancer Center, University of Minnesota . Chimeric Antigen Receptor (CAR)-T Cell Therapy for Patients With Hematologic Malignancies. clinicaltrials.gov; [2022-12-31]. https://clinicaltrials.gov/study/NCT03642626 submitted: August 21, 2018. …

Cell therapies in the clinic.

Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics. Particularly, living cells can simultaneously and dynamically perform complex biological functions in ways that conventional drugs cannot; cell therapies have expanded the spectrum of available therapeutic options to include key cellular functions and processes. As such, cell therapies are currently one of the most investigated

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… Jude Children's Research Hospital) | IV | NCT00085202 (Phase 3) | None No | HSC | N/A | Autologous | Germ cell tumors | N/A (Masonic Cancer Center, University of Minnesota) | IV | NCT00432094 (Phase 2) | None No | HSC | N/A | Allogeneic | Solid tumors | N/A (M.D. …

Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency.

Iron deficiency and iron-deficiency anemia are associated with increased morbidity and mortality in a wide range of conditions. In many patient populations, this can be treated effectively with oral iron supplementation; but in patients who are unable to take or who do not respond to oral iron therapy, intravenous iron administration is recommended. Furthermore, in certain conditions, such as end-stage kidney disease, chronic heart failure, and inflammatory bowel disease, intravenous iron administration has become first-line treatment. One of the first available intravenous iron preparations i

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… failure, CRF chronic renal failure, CRP C-reactive protein, EPO erythropoietin, FeS ferrous sulfate, Hb hemoglobin, IS iron sucrose, ISC iron sucrose complex, IV intravenous, LVDd left ventricular diastolic diameter, LVEF left ventricular ejection fraction, LVSd left ventricular systolic diameter, MLHFQ Minnesota …

Resilience in Cancer Patients.

Background: Being diagnosed with cancer and undergoing its treatment are associated with substantial distress that can cause long-lasting negative psychological outcomes. Resilience is an individual's ability to maintain or restore relatively stable psychological and physical functioning when confronted with stressful life events and adversities. Posttraumatic growth (PTG) can be defined as positive life changes that result from major life crises or stressful events. Objectives: The aims of this study were to 1) investigate which factors can strengthen or weaken resilience and PTG in cancer pa

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… Scale HHI | Herth Hope Index IES-R | The Revised Impact of Event Scale ISEL | Interpersonal Support Evaluation List LAP-R | The Life Attitude Profile–Revised LOT | Life Orientation Test MDASI | MD Anderson Symptom Inventory MFI | Multidimensional Fatigue Inventory MHI | Mental Health Inventory MMPI | Minnesota …

Infectious Diseases

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… Europe) transmitted by Ixodes ticks (which also transmit Lyme disease and Ehrlichia ) → fever, chills, sweats, malaise, myalgias, arthralgias, headache 5–33 days after, particularly in immunosuppressed individuals clinical features —endemic in southern New England, southern New York, Wisconsin, and Minnesota …

Redefining the battle against colorectal cancer: a comprehensive review of emerging immunotherapies and their clinical efficacy.

Colorectal cancer (CRC) is the third most common cancer globally and presents a significant challenge owing to its high mortality rate and the limitations of traditional treatment options such as surgery, radiotherapy, and chemotherapy. While these treatments are foundational, they are often poorly effective owing to tumor resistance. Immunotherapy is a groundbreaking alternative that has recently emerged and offers new hope for success by exploiting the body's own immune system. This article aims to provide an extensive review of clinical trials evaluating the efficacy of various immunotherap

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… . | II | -Patients received 13-mer mutant ras peptide, spanning aa 5– 17 - 250 µg of DETOX - 25 µg of monophosphoryl lipid A (MPL) | -DETOX (cell wall skeleton of Mycobacterium phleia) - MPL from Salmonella Minnesota R 595 | -The vaccine is feasible, safe, and has a positive effect on immune response …

Should oncologists trust cannabinoids?

Cannabis enjoyed a "golden age" as a medicinal product in the late 19th, early 20th century, but the increased risk of overdose and abuse led to its criminalization. However, the 21st century have witnessed a resurgence of interest and a large body of literature regarding the benefits of cannabinoids have emerged. As legalization and decriminalization have spread around the world, cancer patients are increasingly interested in the potential utility of cannabinoids. Although eager to discuss cannabis use with their oncologist, patients often find them to be reluctant, mainly because clinicians

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… Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. I . . J. Am. Chem. Soc. 62 ( 1 ), 196 – 200 . 10.1021/ja01858a058 Adamska A. Elaskalani O. Emmanouilidi A. Kim M. Abdol Razak N. B. Metharom P. ( 2018 ). …

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events.

Immune effector cell (IEC) therapies offer durable and sustained remissions in significant numbers of patients with hematological cancers. While these unique immunotherapies have improved outcomes for pediatric and adult patients in a number of disease states, as 'living drugs,' their toxicity profiles, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), differ markedly from conventional cancer therapeutics. At the time of article preparation, the US Food and Drug Administration (FDA) has approved tisagenlecleucel, axicabtagene ciloleuc

KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.

The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations. However, m

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… The University of Minnesota Veterans Administration Center for Chronic Disease Outcomes Research in Minneapolis, Minnesota was contracted to conduct systematic evidence review and provided expertise in guideline development methodology. …

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018.

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Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018.

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Oral Presentations

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From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.

This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. It outlines the multifaceted anticancer mechanisms of bioactive compounds-such as polyphenols, carotenoids, omega-3 fatty acids, phytosterols, alkaloids, isothiocyanates, polysaccharides, phenolic acids, flavonols, and amide-bearing compounds-which include antioxidant and anti-inflammatory activities, induction of apoptosis and autophagy, modulation of the tumor microenvironment, interference with cell cycle regulation and signaling pathways, and regulation of

RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS.

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Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity.

Acute radiation dermatitis (ARD) is a common adverse effect experienced by patients undergoing radiation therapy. Effective assessment tools to accurately measure and manage ARD's impact on patients' quality of life and treatment outcomes is needed. The aim of this study was to evaluate the diverse tools and outcome measures used in the assessment of ARD. A systematic review of MEDLINE®, Embase, and Cochrane was conducted for records 1946-March 2024. A total of 423 studies, including 227 randomized controlled trials (RCTs), were included in the analysis. The review identified 58 distinct tools

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… Oncology, Princess Margaret Hospital, HKSAR, China); Satoshi Hirakawa, MD (Department of Supportive Care in Cancer, Seirei Hamamatsu General Hospital, Hamamatsu, Japan); Gustavo Nader Marta, MD, PhD (Radiation Oncology, Hospital Sírio-Libanês, Sao Paulo, Brazil); Robert Miller, MD (Mayo Clinic, Rochester, Minnesota …

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy.

During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. Indeed, type I IFNs are now appreciated as a critical component of dendritic cell (DC) driven T cell responses to cancer. Here we focus on IFN-α and IFN-β, and their antitumor effects, impact on immune responses and their use as therapeutic agents. IFN-α/β share many properties, including activation of the JAK-STAT signaling pathway and induction of a variety of cellular p

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… Also, the 3-O-deacylated monophosphoryl lipid A (MPLA) is a less toxic LPS derived from Salmonella minnesota R595 and used with alum in a prophylactic vaccine against human papillomavirus 16 and 18 (Cervarix ® , GSK Vaccines) [ 233 ]. …

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

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… Louis Park, Minnesota; St. John’s Health System, Springfield, Missouri; University of Michigan Faculty Group Practice, Ann Arbor, Michigan. …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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