Результаты поиска

The role of integrins in melanoma: a review.

Integrins are the major family of cell adhesion receptors in humans and essential for a wide range of normal physiology, including formation … a tissue is feasible, and molecular tests may fully replace interventional surgical methods such as sentinel lymph node biopsies in the future. Because of their central role in mediating invasion and metastasis, integrins are likely to be useful biomarkers. Integrins are also attractive candidate targets for interventional therapy. This article focuses on the role of …

[Our performance of supraclavicular, intercostobrachial and lateral femoral cutaneous block in a patient with high risk undergoing malign melanoma surgery on the forearm].

The practice of anesthesia can include the need to accommodate surgical interventions on multiple extremities in a single procedure. General … melanoma of the left lateral forearm. Surgical resection of the lesion, dissection of the axillary sentinel lymph node, and grafting from the lateral left thigh were planned. As the surgical procedure involved more than one extremity, a combination of anesthetic blocks was applied using ultrasound guidance. The use of supraclavicular, intercostobrachial, and lateral …

Primary malignant melanomas of the female lower genital tract: clinicopathological characteristics and management.

The female lower genital tract melanomas mainly include vulvar, vaginal and cervical melanoma. There is little clinical data on the melanomas thus making them highly lethal with their prognosis being worse than for cutaneous melanoma and other gynecological malignancies. Surgery is still the primary treatment for gynecological melanomas with wide local resection (WLE) of tumors with adequate margins being preferred for early-stage vulvar melanoma while complete resection of the primary tumor is the standard treatment for early-stage cervical and vaginal melanoma. Sentinel lymph node biopsy see…

Merkel cell carcinoma of the eyelid: A review.

Merkel cell carcinoma (MCC) is a rare, aggressive tumor of both epithelial and neuroendocrine origin, which carries a mortality rate of up to 40%. MCC tumors typically present as painless, expanding nodules on the sun-exposed skin areas of older, white patients. Eyelid and periocular tumors comprise approximately 2.5% of all cases of MCC and may be mistaken for chalazia or basal cell carcinomas. Immunosuppression is a significant risk factor, particularly in solid-organ-transplant recipients, patients with chronic lymphocytic leukemia, and patients with HIV. Sentinel lymph node biopsy is often…

Clinical characteristics and management of primary granulocytic sarcoma of the breast: A case report.

RATIONALE: Primary granulocytic sarcoma of the breast is a rare and poor-prognosis malignancy. Clinicians do not have sufficient knowledge of this disease and often misdirect it as other soft tissue sarcomas or inflammation. PATIENT CONCERNS: A 42-year-old female presented with a self-discovered asymptomatic growing and palpable right breast mass that had been present for 4 months. DIAGNOSES: The patient was diagnosed as primary myeloid sarcoma. INTERVENTIONS: The patient received modified radical mastectomy in the right breast and sentinel lymph node biopsy. Pathological diagnosis is prima…

Extramammary Paget's disease: a review of the literature.

Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. The disease typically affects older individuals aged 60-80 years and is … earch for an associated malignancy should be initiated. If invasive disease is present on biopsy, a sentinel lymph node biopsy may guide further treatment. Mohs micrographic surgery appears to be superior to wide local excision when considering tissue sparing ability and disease recurrence. Nonsurgical interventions have also been investigated with varied results. Re …

[A Case of Breast Neuroendocrine Carcinoma].

A 73-year-old woman visited our hospital with the chief complaint of a mass in the left breast. Breast ultrasonography revealed a hypoechoic … mography( CT)and bone scintigraphy revealed no metastasis. Simple mastectomy of the left breast and sentinel lymph node biopsy were performed. Final pathological examination of the tumor also led to the diagnosis of breast neuroendocrine carcinoma(T2N0M0, StageⅡA, Luminal A-like). After surgery, endocrine therapy is planned, considering the breast cancer subtype. Bre …

Polo-like kinase-1 immunoreactivity is associated with metastases in cutaneous melanoma.

BACKGROUND: Polo-like kinase-1 (PLK-1) is one of the key regulators of cell cycle progression. Increased expression of PLK-1 was observed in … increased PLK-1 was more frequent in tumors with concurrent regional nodal metastases and positive sentinel lymph node biopsy status. All primary tumors associated with co-existing distant metastases exhibited high PLK-1 expression in melanoma cells. Conversely, PLK-1 expression in stromal cells was more frequent in tumors without nodal metastases. PLK-1 expression …

Two-step axillary operation increases risk of arm morbidity in breast cancer patients.

An investigation of the impact of axillary surgery on arm morbidity in patients who underwent sentinel lymph node biopsy (SLNB), axillary clearance in a one-step procedure, and axillary clearance in a two-step procedure, respectively, was performed. Over a period of 2 years 438 patients with invasive breast carcinoma or carcinoma in situ underwent SLNB at our clinic. Of these 393 were interviewed on symptoms of swelling, numbness, pain, reduced strength, reduced mobility and fatigue more than 1 year postoperatively. Using a standardised symptom score system postoperative morbidity was register…

Vulvar invasive squamous cell carcinoma occurring in a young woman with systemic lupus erythematosus.

BACKGROUND: Although several studies have demonstrated a possible relationship between systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma, Hodgkin's lymphoma, leukemia and several solid tumors, it is still debatable whether SLE patients have an increased incidence of cancer overall. CASE: We describe a 25-year-old patient with SLE who developed invasive squamous cell carcinoma of the vulva. The patient underwent radical vulvectomy and bilateral groin sentinel lymph node dissection and until to date, one year after surgery, she is alive without evidence of recurrent disease. CONCLU…

Surgery for early and minimally invasive breast cancer.

An increasing number of early and minimally invasive breast cancers are being detected by mammography screening. The role of image-guided co … dical segmental extension. It also influences local recurrence following breast-conserving surgery. Sentinel lymph node dissection may supplant standard axillary dissection as a major prognostic determinant of metastatic disease. These areas of scientific investigation continue to define the role of surgery in early and minimally invasive breast cancer.

When two lives intersect: melanoma in pregnancy: mechanisms, risks, and management strategies.

Pregnancy-associated melanoma is one of the more frequently encountered malignancies during gestation, although its overall incidence remains low. Current evidence suggests that pregnancy itself does not adversely affect melanoma-specific survival when the tumour stage is considered, yet clinical management remains challenging. Physiological skin changes can obscure early detection, and limitations on imaging modalities and systemic therapies restrict standard diagnostic and treatment options. Additional uncertainty surrounds the safety and timing of sentinel lymph node biopsy during pregnancy…

Severe Refractory Hypotension Following Patent Blue V Injection: A Case of Atypical Perioperative Anaphylaxis.

Background and Clinical Significance: Patent Blue V (PBV) is widely used for sentinel lymph node mapping but may rarely cause severe hypersensitivity reactions. These reactions can present atypically, with predominant cardiovascular collapse and minimal cutaneous manifestations, potentially delaying recognition and treatment. Case Presentation: We report the case of a 52-year-old woman who developed sudden and prolonged refractory hypotension shortly after PBV injection during melanoma surgery. The reaction initially occurred in the absence of bronchospasm or early significant cutaneous manife…

Melanoma Colonizing Basal Cell Carcinoma: A Rarely Described Entity.

BACKGROUND: Collision tumors combining basal cell carcinoma (BCC) and melanoma are exceptionally rare, and their distinction from melanoma c … ith ulceration and perineural invasion, but no lymphovascular involvement. Margins were negative. A sentinel lymph node biopsy was recommended but was declined by the patient. CONCLUSION: This case illustrates the diagnostic complexity and clinical effect of BCC-melanoma collision/colonization tumors. Prognosis is dictated by the melanoma component, underscoring the …

[pT1c Breast Cancer Presenting with Skin Rupture without Skin Invasion-A Case Report].

We report a case of breast bleeding caused by breast cancer without skin invasion. A woman in her 70s was aware of a mass in her right breas … entified, a biopsy was performed, and a diagnosis of breast cancer was made. A right lumpectomy and sentinel lymph node biopsy was carried out. Pathological diagnosis was invasive ductal carcinoma. No skin invasion was observed. The final diagnosis was pT1c, pN0 (sn), M0, pStageⅠ. After surgery, the patient was treated with tamoxifen and radiation therapy, and is cur …

Systemic Sarcoidosis Mimicking Metastatic Melanoma: Unveiling the Masquerade.

The coexistence of melanoma and sarcoidosis presents significant diagnostic challenges, particularly when imaging studies reveal suspicious lesions that may represent either metastatic disease or granulomatous inflammation. This complexity is compounded by the overlapping clinical and radiological features of both conditions. We present the case of a woman in her 80s with a history of pulmonary sarcoidosis who developed a thick melanoma (5.1 mm Breslow depth) and subsequently underwent wide local excision with a negative sentinel lymph node biopsy. Surveillance imaging revealed an FDG-avid lyt…

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

Совпадение в полном тексте источника
… Lymph Nodes: Mapping and Metastasis Indocyanine green is widely used to map sentinel lymph nodes in various cancers safely and easily. Indocyanine green has not been widely used due to conflicting research results. … Performance of Indocyanine green for sentinel lymph node mapping and lymph node metastasis in colorectal cancer: A diagnostic test accuracy meta-analysis. Surg. Endosc. 2020;34:1035–1047. doi: 10.1007/s00464-019-07274-z. 64. …

Metastasis of breast cancer to liver through direct lymphatic drainage: a case report.

Breast cancer liver metastasis (BCLM) is considered to occur by hematogenous spread of primary breast cancer cells. We herein present a case of lymphatic BCLM that was confirmed by preoperative imaging for sentinel lymph node biopsy (SLNB). A woman in her early 70s was diagnosed with clinical stage T2N0M0 invasive lobular cancer of the left breast. She underwent mastectomy with SLNB. Preoperative lymphoscintigraphy showed intense accumulation of isotope in the upper abdomen, corresponding to segment IV of the liver on single-photon emission computed tomography/computed tomography (SPECT/CT). H…

Synchronous Occurrence of Primary Breast Carcinoma and Primary Colon Adenocarcinoma.

A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy … lon operation, followed by adjuvant chemotherapy. In the first operation, left total mastectomy and sentinel lymph node biopsy were performed. One week after her initial operation, the patient underwent right hemicolectomy. After operations, the patient did not develop postoperative complications and was sent to medical oncology department for adjuvant chemotherapy.

Melanoma occurrence under long-term etanercept treatment for psoriasis: a case report.

Melanoma occurrence during treatment with anti-tumor necrosis factor is considered an incidental event, although very recent studies suggest … lanoma, 1.2 mm Breslow thickness, one mitosis/hpf, with no vascular or neural invasion (stage T2b). Sentinel lymph node biopsy was negative. There were no apparent melanoma risk factors: normal total nevus count, photo type IV, no childhood sunburns, no family history of melanoma, and no previous immune suppressive drugs and/or phototherapies. Etanercept 50 mg/week h …