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Latino family caregivers: "it's what we do-we take care of our own".

OBJECTIVES: To better understand the interplay of culture and family caregiving among Latinos, we explored the perceptions of caregivers of persons living with dementia on how their culture informs the care they provide. METHODS: This study used a descriptive qualitative design to explore the perceptions of Latino family caregivers of persons living with dementia. A Community-Based Participatory Research (CBPR) approach underpinned the study design and execution, with a Latino Caregiver Advisory Council (LCAC) engaged in study design, recruitment, and interpretation. Individual semi-structure

AdaEndoGS: An Adaptive Enlightening Model for Endoscopy Based on 3D Gaussian Splatting.

Endoscopic reconstruction and rendering technology are crucial for minimally invasive diagnosis and treatment. Due to physical constraints such as limited light source placement and narrow operational space, endoscopic scenes often contain some dark regions that compromise clinical observation and diagnostic accuracy. To address this issue, we propose AdaEndoGS for endoscopic 3D reconstruction with physically consistent dark region illumination enhancement. Specifically, built upon 3D Gaussian Splatting, AdaEndoGS enriches each Gaussian with surface attributes including normal, roughness, and

Choice Blindness in a Military Setting.

ObjectiveWe examined the impact of choice blindness in applied military contexts.BackgroundChoice Blindness occurs in intention-directed decision making when an individual fails to detect when a previously chosen option is covertly changed and confabulates, providing a false justification for why they selected the non-chosen option. Approximately 67-75% of people show Choice Blindness when tested.MethodWe investigated Choice Blindness in simulated military tasks using two experiments. Novices (Experiment 1) and experts (Experiment 2) went through an all-source intelligence, surveillance, and r

Epidemiology of Non-Melanoma Skin Cancer in Europe over the Last Decade: A Systematic Review.

BACKGROUND: Non-melanoma skin cancer (NMSC), principally basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), is incompletely captured by cancer surveillance. OBJECTIVE: To synthesize European epidemiological evidence, with Poland considered in this context. METHODS: PubMed/MEDLINE, Scopus, and Web of Science were searched for publications dated 1 January 2015-31 March 2026, supplemented by registry resources and reference-list searching. Additional eligibility checks during manuscript revision continued until 30 August 2026. The publication-date criterion was distinct fr

Complete decongestive therapy for breast cancer-related lymphedema: An evidence summary.

OBJECTIVE: To identify, appraise, and synthesize the best available evidence on complete decongestive therapy (CDT) for people with breast cancer-related lymphedema (BCRL). METHODS: Using an evidence-based health care pyramid approach, we searched bibliographic databases, guideline and professional organization websites, and clinical decision support sources from inception to October 1, 2025. Eligibility was defined using the PIPOST framework. Methodological quality was independently appraised by three reviewers for guidelines and by two reviewers for other evidence types using evidence-type-

Time-series of shoreline marine debris highlights impact of urbanization on coastal pollution pathways, Nha Trang, Vietnam.

Marine debris mostly originates from land, but the wide variety of sources, types, and transport pathways make understanding of their flow and fate difficult. Vietnam is a developing country with high production and emission of plastic to the sea, and better understanding of shoreline areas as sources, sinks or ephemeral storage areas is needed to inform management. Using the city of Nha Trang, Vietnam as a case study location, four shorelines were surveyed every 4 to 7 days to track the amount of marine debris present. Over a four-month time series, nearly 74,000 marine debris items were docu

Real-World Data Included in Post-authorisation Measures: A Case Study of Approved Advanced Therapy Medicinal Products in the European Union between 2013 and 2024.

BackgroundAdvanced therapy medicinal products (ATMPs) often require long-term monitoring to assess both safety and efficacy post-authorisation due to uncertainties identified during the approval process. This study aims to characterise the use of real-world data (RWD) in post-authorisation measures (PAMs) for ATMPs approved in the European Union.MethodsA systematic extraction of all PAMs from publicly available European Medicines Agency (EMA) regulatory documents for ATMPs approved between January 2013 and December 2024 was performed, followed by the identification of the presence and sources

Совпадение в полном тексте источника
… Information on registry holders, year of registry establishment, funding, country coverage, total number of patients enrolled, PRO collection and the availability of contacts, as well as data protection and privacy policies, were retrieved from the registry-related information sources (HMA-EMA Catalogues … However, the approach of combining multiple information sources may have mitigated this information bias. The inability to analyse final results or reports from PAMs prevented the identification of protocol deviations, particularly for RWD-PAMs. …

Correct Knowledge about Tuberculosis and Determinants among People Living with HIV Attending a District Antiretroviral Treatment Center in the State of Karnataka, India.

Tuberculosis (TB) is a major global public health concern. People living with HIV (PLHIV) are at an increased risk of developing active TB, with a 20-fold higher risk compared with those without HIV infection. Gaps in TB knowledge among PLHIV patients have been linked to delays in the diagnosis of TB and poor adherence to TB medications, resulting in substantial morbidity and mortality. In the current study, the correct knowledge of TB and its determinants among PLHIV patients attending a district antiretroviral therapy (ART) center in Karnataka, India, was assessed. A cross-sectional study wa

Family Support Services and Reported Parent Coping Among Caregivers of Children with Emotional, Behavioral, or Developmental Disorders.

OBJECTIVE: Caregivers of children with special health care needs (CSHCN) experience substantial strain caring for their child's special needs because of high needs for health and other support services. Caregivers of CSHCN with emotional, behavioral, or developmental problems (EBDPs) report stress and poor mental health at higher rates than caregivers of other CSHCN. Although family support services are associated with caregiver mental health and well-being among families of CSHCN, the association of these factors with caregiver coping has been underexamined. METHOD: Using the Double ABCX Mod

Simulation of biochemical dynamics of C a 2 + and P L C in fibroblast cell.

Calcium dynamics is not only responsible for maintaining the framework and functions of the cell but also plays a role in the dynamics of other biochemical systems in the cell. Phospholipase C- γ l ( P L C ) has a crucial role in the function of fibroblast cells. Experiments have shown that P L C and C a 2 + have interdependent dynamics in fibroblast cells. However, no reaction-diffusion model exists for the two-way feedback system dynamics of C a 2 + and P L C in fibroblasts till date. The computational model is designed to investigate the impact of variations in several

Эпидемиология на основе сточных вод для наблюдения за инфекционными заболеваниями в медицинских учреждениях.

ЦЕЛЬ ОБЗОРА: Мониторинг на основе сточных вод (ОВС) (эпидемиология) с использованием близкого к источнику пробоотбора (НСС) в крупных зданиях, больницах и домах по уходу проводится по трем основным направлениям: современная СВП, преимущества/возможности НСС для больничных систем контроля за инфекциями и новые результаты наблюдения за сточными водами в больницах и последствия для политики. ПОСЛЕДНИЕ ВЫВОДЫ: Сточные воды обеспечивают совокупные, анонимные источники данных, в которых пространственное разрешение может быть увязано с обслуживаемыми группами населения. В больницах налажена четкая св

A Cross-Sectional Study To Assess Knowledge of Monkeypox Among Medical Students and Graduates in India.

Background and aim Monkeypox outbreaks in several nations have brought focus to the emerging virus. The clinical presentation of monkeypox is less severe than smallpox but is fairly comparable, presenting with fever, headache, lymphadenopathy, back discomfort, myalgia, and skin rashes. The misinformation spread on social platforms had a major impact on the effectiveness of outbreak control measures. The clinical management of breakouts depends on the adequate knowledge of the healthcare personnel about the disease. This study aims to assess the knowledge of medical students and graduates regar

Implementation of routine genomic surveillance provided insights into a locally acquired outbreak caused by a rare clade of Salmonella enterica serovar Enteritidis in Queensland, Australia.

Salmonellosis is a significant public health problem globally. In Australia, Salmonella enterica serovar Enteritidis is one of the main causes of salmonellosis. This study reports how the implementation of routine genetic surveillance of isolates from human S. Enteritidis cases enabled identification of the likely source of an outbreak that occurred in a remote town in Far North Queensland, Australia. This study included patient, food and water samples collected during an outbreak investigation. S. Enteritidis of the novel sequence type 5438 was isolated from all seven patient samples and one

Neural Mechanisms of Facial Emotion Recognition in Autism: Distinct Roles for Anterior Cingulate and dlPFC.

OBJECTIVE: The present study sought to measure and internally validate neural markers of facial emotion recognition (FER) in adolescents and young adults with ASD to inform targeted intervention. METHOD: We utilized fMRI to measure patterns of brain activity among individuals with ASD (N = 21) and matched controls (CON; N = 20) 2 s prior to judgments about the identity of six distinct facial emotions (happy, sad, angry, surprised, fearful, disgust). RESULTS: Predictive modeling of fMRI data (support vector classification; SVC) identified mechanistic roles for brain regions that forecasted co

Analyzing the role of in situ coal fire in greenhouse gases emission in a coalfield using remote sensing data and their dispersion and source apportionment study.

In situ coal fires significantly pollute the environment in many countries of the world. Monitoring these pollutants is challenging due to extensive area coverage and spatial variations. Thus, the present study demonstrates the method of deriving the spatial and temporal profiles of columnar density of three major greenhouse gases (carbon monoxide (CO), sulfur dioxide (SO2), and nitrogen dioxide (NO2)) in an in situ coal fire region (Jharia coalfield (JCF), India) using high-resolution satellite data (TROPOMI) of the European Space Agency (ESA). The study also demonstrates a new methodology fo

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features.

IMPORTANCE: Rabies is a neglected tropical viral disease most often transmitted through the bite of an infected animal. OBJECTIVE: This study assessed the level of knowledge, attitudes, and practices of the Shone Town community toward rabies. METHODS: A survey-based cross-sectional study was conducted in Shone town, Ethiopia, from November 2022 to April 2023. Woreda was selected purposefully, while Kebeles and the study populations were selected by simple random sampling. Four hundred and sixteen respondents were interviewed using a semi-structured questionnaire. RESULTS: All respondents ha

Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia.

Aberrant anion secretion across the bronchial epithelium is associated with airway disease, most notably in cystic fibrosis. Although the cystic fibrosis transmembrane conductance regulator (CFTR) is recognized as the primary source of airway anion secretion, alternative anion transport mechanisms play a contributing role. An alternative anion transporter of growing interest is SLC26A9, a constitutively active chloride channel that has been shown to interact with CFTR and may also contribute to bicarbonate secretion. Interest in SLC26A9 has been fueled by genome-wide association studies that s

Current State of Salmonella, Campylobacter and Listeria in the Food Chain across the Arab Countries: A Descriptive Review.

Foodborne infections caused by bacterial pathogens are a common cause of human illness in the Middle East, with a substantial burden of economic loss and public health consequences. This review aims at elucidating recent literature on the prevalence of Non-Typhoidal Salmonella (NTS), Campylobacter and Listeria monocytogens in the food chain in the Arab countries, and to consolidate available evidence on the public health burden and the status of antimicrobial resistance (AMR) among the concerned three pathogens. The reviewed evidence points to a scarcity of understanding of the magnitude of NT

Salmonella fecal shedding in pigs from birth to market and its association with the presence of Salmonella in palatine tonsils and submandibular lymph nodes at slaughter.

Salmonella is an important cause of foodborne illnesses in humans. Food-producing animals, including swine, are a major source of Salmonella in food products. This study investigated on farm Salmonella fecal shedding in pigs at different production stages - from weaning to marketing - and its association with the presence of Salmonella in tissues at slaughter. Fourteen groups from 8 commercial farrowing sources (N = 809 pigs) were monitored 5 times from birth to slaughter. Fecal and tissue samples were collected from pigs and cultured for Salmonella. A survey was conducted to collect farm mana

Auditory compensation for head rotation is incomplete.

Hearing is confronted by a similar problem to vision when the observer moves. The image motion that is created remains ambiguous until the observer knows the velocity of eye and/or head. One way the visual system solves this problem is to use motor commands, proprioception, and vestibular information. These "extraretinal signals" compensate for self-movement, converting image motion into head-centered coordinates, although not always perfectly. We investigated whether the auditory system also transforms coordinates by examining the degree of compensation for head rotation when judging a moving