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Epidemiology, clinical features, and outcomes of peripheral T-cell lymphoma in Latin America: an international, retrospective, cohort study.

BACKGROUND: Peripheral T-cell lymphomas represent a rare and heterogeneous group of mature T-cell neoplasms characterised by aggressive beha … newly diagnosed peripheral T-cell lymphoma across 11 countries in Latin America (Argentina, Brazil, Chile, Colombia, Cuba, Guatemala, Mexico, Paraguay, Peru, Uruguay, and Venezuela). We used the hospital-based registries of the Grupo de Estudio Latinoamericano de Linfoproliferativos (retrospective registry; Jan 1, 2000, to June 30, 2023), the Brazilian …

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.

BACKGROUND: Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establ … hina, India, Mexico, Nigeria, Pakistan, Peru, Sri Lanka, and Viet Nam) and one high-income country (Chile). Hospitals were eligible if they had no or inconsistent relevant, disease-specific protocols, and were willing to implement the care bundle to consecutive patients (aged ≥18 years) with imaging-confirmed spontaneous intracerebral haemorrhage presen …

Islatravir in combination with doravirine for treatment-naive adults with HIV-1 infection receiving initial treatment with islatravir, doravirine, and lamivudine: a phase 2b, randomised, double-blind, dose-ranging trial.

BACKGROUND: Islatravir is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1 infection. We aimed to assess the efficacy and safety of islatravir-based regimens for the treatment of HIV-1. METHODS: We did a phase 2b, randomised, double-blind, comparator-controlled, dose-ranging trial at 24 clinics or hospitals in four countries (Chile, France, the UK, and the USA). Treatment-naive adults (≥18 years) with plasma HIV-1 RNA concentrations of at least 1000 copies per mL, CD4 T-cell counts of at least 200 cells per mL, and a calculate…

Health problems in agricultural workers occupationally exposed to pesticides.

Agricultural workers are susceptible to several health problems as a result of occupational exposure to toxic substances, especially pesticides. The aim of this review was to describe the health issues associated with occupational exposure to pesticides in agricultural workers. A descriptive study, in the form of an integrative literature review, was conducted based on articles retrieved from the LILACS, SciELO and PubMed databases, published between January 2015 and October 2018. The searches were conducted using the keywords "pesticides," "workers' health," "occupational exposure" and "agric

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… Muñoz-Quezada et al. 29 | Exposure to organophosphate (OP) pesticides and health conditions in agricultural and non-agricultural workers from Maule, Chile | To investigate pesticide exposure and health status in agricultural workers in the region of Maule, Chile. | A questionnaire was used to assess … A study performed in Chile 30 found that the pesticides most commonly used in vineyards were associated with health problems in farmers. Several disorders were identified in the sample, with acute poisoning being the most significant and prevalent. …

Rapid Fire Presentations

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… Extraforaminal full-endoscopic approach to the L5 pars for L5 - S1 foraminal pathology: technical note and early clinical results Cristian Ricardo Correa Valencia 1 , Matias Nahuelpan 2 , Facundo Van Isseldyk 3 , Diego Prado 4 , Marcus Vinícius Serra 5 , Jin-Sung Kim 6 1 Universidad de La Frontera, Temuco, Chile … Hernan Henriquez Aravena, Temuco, Chile, 3 Hospital Privado de Rosario, Rosario, Argentina, 4 Instituto Neurocirugía Dr. Alfonso Asenjo, Santiago, Chile, 5 Santista Institute of Neurosurgery and Spine, Santos, Brazil, 6 Seoul St. …

Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations.

BACKGROUND AND OBJECTIVES: Lupus nephritis (LN) remains a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although recent years have witnessed the approval of several targeted therapies, achieving long-term, drug-free remission remains challenging. This commentary evaluates the global landscape of interventional LN clinical trials from 2001 to 2026 to identify emerging trends and strategic gaps in drug development. METHODS: We analyzed 200 interventional pharmacological trials retrieved from three major global registries: ClinicalTrials.gov, Chinadrugtrials.org

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… Argentina, Belgium, Brazil, Canada, China, Colombia, Czechia, France, Germany, Hungary, Mexico, Netherlands, Philippines, Russia, South Korea, Spain,Thailand,United Kingdom | NCT01714817 (Terminated) | Phase III | 2013 | Abatacept (BMS-188667) | United States, Argentina, Australia, Brazil, Canada, Chile … , Belgium, France, Thailand, United States, United Kingdom, Philippines, Spain, Argentina, South Korea | III+/- V, IV +/- V [excluding III(C), IV-S(C), and IV-G(C)], V CTR20140843 | Phase III | 2015 | BMS-188667 | China, Argentina, Australia, Brazil, Canada, Chile, Colombia, India, Israel, Italy, Japan …

NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease.

Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as partners in each one of them. Copy number arrays showed aberrations in 69% of the tumors, including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases. Deletion of 7

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. We undertook the present work to perform the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage. METHODS: We analyzed 3,710 individuals from the US and 4 countries of Latin America who were diagnosed as having SLE, and healthy controls. Samples were genotyped with HumanOmni1 BeadChip. Data on out-of-study controls genotyped with HumanOmni2.5 were also included. Statistical analyses were performed using SNPtest and SNPGWA

Ультразвуковые характеристики развития в Гвинейских свиньях: сходства с беременностью человека.

ИСТОРИЯ ВОПРОСА: Биометрические исследования и анализ кровотока имеют основополагающее значение для оценки развития фетоплацета во время беременности. Гвинейские свиньи были предложены в качестве хорошей модели для изучения развития плода и связанных с этим осложнений, связанных с гестацией; однако продольный рост и изменения кровотока в утробе не были должным образом описаны. Цель этого исследования состояла в том, чтобы описать рост плода и плаценты и кровотечение основных внутриматочных сосудистых кроватей в ходе обычной беременности среди свиней-мореносцев, а также обсудить актуальность эт

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… Animals euthanized at G35 and G60 were submitted to a maternal anesthetic overdose (sodium thiopentone 200 mg·kg −1 i.p., Opet, Laboratorio, Chile). … Institutional Review Board Statement The animal study protocol was approved by the Institutional Animal Care and Use Committee (CICUA) of the Universidad de Chile (20354-MED-UCH, date of approval 08/04/2020). Informed Consent Statement Not applicable. …

Диверсификация глобальных тенденций заболеваемости раком ранней стадии: сопоставление с тенденциями заболеваемости раком более поздней стадии и тенденциями смертности от рака ранней стадии.

Глобальное увеличение заболеваемости раком в раннем возрасте (определяемым как рак, диагностируемый на 20-49 ) является серьезной проблемой в области здравоохранения. Мы расследовали 1) отличается ли тенденция заболеваемости раком раннего зарождения от тенденции заболевания раком на более позднем этапе и 2) увеличиваются ли одновременно как частотность, так и смертность от рака раннего возраста. 2000 и 2017 от раковых заболеваний Five Базы данных о смертности на континентах и Всемирной организации здравоохранения (ВОЗ). Общенациональная распространенность ожирения среди взрослых 20-49 Годы был

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… We retrieved ASRs of early-onset and later-onset cancer incidence in the following 44 countries with available incidence data during the study period: Argentina, Australia, Austria, Bahrain, Belarus, Canada, Chile, China, Colombia, Costa Rica, Croatia, Cyprus, Czech Republic, Denmark, Ecuador, Estonia … For early-onset colorectal cancer mortality, statistically significant positive AAPC ranged from 0.6% (95% CI 0.2–0.9) in the USA to 3.6% (95% CI 1.5–5.8) in Chile (Additional file 1 : Table S6 ). …

A head-to-head comparison of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.

BackgroundThe EQ-5D-5L and 15D are generic preference-accompanied health status measures with similar dimensions. In this study, we aim to compare the measurement properties of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.MethodsIn August 2021, an online cross-sectional survey was conducted in a representative adult general population sample (n = 1887). The EQ-5D-5L and 15D descriptive systems and index values were compared in terms of ceiling and floor, informativity (Shannon's Evenness index), agreement, convergent and known-groups validity for 41

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… Two countries (Norway and Chile) mention the 15D as an acceptable instrument in their health technology assessment guidelines [ 15 , 16 ]. … Ministerio de Salud de Chile. Guía Metodológica para la Evaluación Económica de Intervenciones en Salud en Chile [Methodological Guide for the Economic Evaluation of Health Interventions in Chile]. https://www.orasconhu.org/case/sites/default/files/files/EE_FINAL_web.pdf . Published 2013. …

A multi-country study to co-design and evaluate digital educational resources to support conversations about ending fertility treatment.

STUDY QUESTION: How can educational resources be feasibly co-designed and used to support conversations between staff and patients about end … elgium, Finland, Germany, Italy, Portugal, Spain, and UK) and South America (Argentina, Brazil, and Chile). Staff were invited to participate through fertility professional and scientific associations, and patients and advocates via charities and social media. Eligibility criteria were being aged 18 or older and working in fertility care (for staff) or …

Reliable information for cancer control in Cali, Colombia.

BackgroundThe Cali Population Cancer Registry (RPCC) has been in continuous operation since 1962 with the objective of producing valid statistics on the incidence of cancer, its patterns, trends and survival rates.MethodsDuring the period 2008-2012, 23,046 new cases were registered and during 2011-2015 there were 12,761 cancer deaths. The trend of the rates was described with the APC average annual change rate and with the Joinpoint analysis. We analyzed the individual data of 38,671 adults (15-99 years) diagnosed with cancer between 1995-2009, and we calculated the standardized net survival b

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… From 1995 to 2009, the 5-year net survival of patients with gastric cancer in Cali was less than 20%, with a healing fraction of 15% and an average survival time of 6 months for uncured cases 22 ; similar results were observed in Chile and Costa Rica. … The 5-year net survival was like that found in Argentina, Chile, Ecuador and Costa Rica and very low compared to that observed in developed countries 24 . …

Consensus Statement: Importance of Timely Access to Multiple Myeloma Diagnosis and Treatment in Central America and the Caribbean.

BackgroundIn Central America and the Caribbean, multiple myeloma (MM) patients face significant barriers to diagnosis and treatment. The aim of this study is to describe the current situation of MM in the region, discuss the current barriers to timely diagnosis and proper treatment, and develop consensus recommendations to address these issues.MethodsNine experts from five countries took part in a virtual consensus meeting on MM in Central America and the Caribbean. During the meeting, experts analyzed the disease burden, the current conditions for disease management, and access to treatment i

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… A 2019 study of patients in Brazil, Panama, Mexico, Guatemala, Chile, and Colombia reported high rates of comorbidity in MM patients, including a variety of chronic diseases and other medical conditions. … The 2019 study undertaken in Brazil, Panama, Mexico, Guatemala, Chile, and Colombia found that hematologists were the first point of contact for 24.9% of MM patients, followed by internists and general practitioners at 15.4%. …

Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial.

INTRODUCTION: Recombinant human erythropoietin (r-HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r-HuEPO, Epoetin theta (Eporatio®), was investigated and compared to placebo in a randomised, double-blind clinical trial in adult cancer patients receiving nonplatinum-based chemotherapy. The primary efficacy endpoint was the responder rate (complete haemoglobin (Hb) response, i.e., Hb increase ≥2 g/dl) without the benefit of a transfusion within the previous 4 weeks. RESEARCH DESIGN AND METHODS: 186 patients were randomised to s.c. treatment for 12 weeks with either Epoeti

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… The study protocol, amendments, informed consent documents and other relevant study-related documents were reviewed and approved by independent ethics committees of all participating countries (Argentina, Belarus, Brazil, Bulgaria, Chile, India, Moldova, Romania, Russia, Ukraine). … Taskova Varna; Chile: O. Giannini Tassara Viña del Mar; India: G. Narayanan Kerala, B. Vadhiraja Karnataka, C. Goswami West Bengal, V. Gupta Gujarat, M. Walia Delhi, K. Prabhash Maharastra, A. Ranade Pune, V. Choudhary Chattisghar, H. Malhotra Rajasthan; Moldova: I. Corcimaru Chisinau; Romania: C. …

E-Posters

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The impact of government reimbursement negotiation on targeted anticancer medicines use and cost in China: A cohort study based on national health insurance data.

BackgroundHigh prices of targeted anticancer medicines (TAMs) result in financial toxicity for patients and the health insurance system. How national price negotiation and reimbursement policy affect the accessibility of TAMs for cancer patients remains unknown.MethodsIn this population-based cohort study, we used national health insurance claims data in 2017 and identified adult patients with cancer diagnoses for which price-negotiated TAMs were indicated. We estimated the half-month prevalence of price-negotiated TAMs use before and after the policy implementation in September 2017. We calcu

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… By contrast, a 19.2% annualised growth rate of oncology drug expenditures was observed in Chile from 2012-2013 to 2016-2017, with a gradual increase in OOP costs after expanded coverage [ 36 ]. … Vargas V, Leopold C, Castillo-Riquelme M, Darrow JJ.Expanding Coverage of Oncology Drugs in an Aging, Upper-Middle-Income Country: Analyses of Public and Private Expenditures in Chile. J Glob Oncol. 2019;5:1-17. 10.1200/JGO.19.00223 37. …

Predicting PANSS symptoms in schizophrenia spectrum disorders using speech only: an international, multi-centre, computational secondary analysis across multiple languages.

BACKGROUND: Speech carries cues to variation in mental state in schizophrenia, typically indexed with clinician-rated scales such as Positiv … recruited between 2005 and 2026 from ten global sites in the Czech Republic, United States, Spain, Chile, France, Switzerland, the Netherlands, Türkiye, Germany, and China, and clipped their speech recordings into 6,664 segments. Across three featuresets, acoustic-prosodic profile, pretrained multilingual embeddings, and their concatenation, we compare …

Lymphadenectomy or sentinel node biopsy for the management of endometrial cancer.

RATIONALE: Endometrial cancer, which affects the lining of the uterus, is the most common form of uterine cancer (96%), and the sixth most c … ains ongoing) with 2074 women. Studies were conducted in the UK, South Africa, Poland, New Zealand, Chile, Italy, Egypt and Brazil, and published between 2008 and 2023. Another 10 studies are ongoing. Three studies (1955 participants) compared no lymphadenectomy with pelvic lymphadenectomy, one study (50 participants) compared no lymphadenectomy with pe …