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Temporal trends of case-fatality in patients undergoing dual-injection coronary chronic total occlusion recanalization.

AIMS: Recently, interventional techniques and material to treat chronic total occlusion (CTO) with percutaneous coronary intervention (PCI) have evolved significantly. Nevertheless, it is still unknown whether this progress improved treatment success and patients' outcome. In a nationwide sample, we sought to analyze trends of patients' characteristics, complications and in-hospital case-fatality of patients undergoing CTO revascularization in Germany. METHODS AND RESULTS: We analyzed data on characteristics, treatments, and in-hospital outcomes for all coronary artery disease (CAD) patients …

[Thunder and lightning-a report on firework-associated acoustic trauma at New Year 2021/2022 (German version)].

BACKGROUND: This cross-sectional study aimed to assess the frequency and type of firework-associated acoustic trauma occurring in Germany on New Year's Eve 2021, despite the ban on firework sales due to the COVID-19 pandemic. MATERIALS AND METHODS: The survey period lasted 7 days, from 28 December 2021 to 03 January 2022. A questionnaire inquired date, type and treatment of trauma, sex, and age of the patient, and whether the trauma occurred when lighting or watching fireworks. Hearing impairment was classified according to the World Health Organization (WHO grades 0 to 4), and concomitant ti…

Real-world treatment patterns and outcomes among metastatic cutaneous melanoma patients treated with ipilimumab.

BACKGROUND: There is a scarcity of real-world data on treatment patterns and outcomes among advanced melanoma patients treated with immunotherapies including ipilimumab, an anti-CTLA-4 antibody approved since 2011. OBJECTIVE: To evaluate ipilimumab and postipilimumab treatment patterns and outcomes among patients with advanced melanoma in Australia, Germany, Italy and Spain, following regulatory approval. METHODS: Retrospective multicentre, multinational, observational chart review study. Data were extracted from the start of ipilimumab therapy until the end of at least 40 weeks of follow-up…

Do payers value rarity? An analysis of the relationship between disease rarity and orphan drug prices in Europe.

Background and Objective: Orphan drugs have been a highlight of discussions due to their higher prices than non-orphan drugs. There is currently no European consensus on the method of value assessment for orphan drugs. This study assessed the relationship between the prevalence of rare diseases and the annual treatment cost of orphan drugs in France, Germany, Italy, Norway, Spain, Sweden, and UK. Methods: Approved orphan drugs and prevalence data were extracted from the European Medicines Agency website. Annual treatment costs were calculated using ex-factory price. Simple regression was used …

Geographic patterns in patient demographics and insulin use in 18 countries, a global perspective from the multinational observational study assessing insulin use: understanding the challenges associated with progression of therapy (MOSAIc).

BACKGROUND: Among patients with type 2 diabetes, insulin intensification to achieve glycemic targets occurs less often than clinically indicated. Barriers to intensification are not well understood. We present patients' baseline characteristics from MOSAIc, a study investigating patient-, physician-, and healthcare environment-based factors affecting insulin intensification and subsequent health outcomes. METHODS: MOSAIc is a longitudinal, observational study following patients' diabetes care in 18 countries: United Arab Emirates (UAE), Argentina, Brazil, Canada, China, Germany, India, Israel…

Cost-effectiveness analysis of PMMA, silicone, or acrylic intra-ocular lenses in cataract surgery in four European countries.

PURPOSE: To compare the cost-effectiveness of different intra-ocular lens (IOL) materials (Hydrophobic acrylic, Polymethylmethacrylate (PMMA), Hydrophilic acrylic and Silicone) implanted after cataract surgery with reference to Nd:YAG laser capsulotomy and Nd:YAG-related complications in four European countries (France, Italy, Germany and Spain). SETTING: A retrospective review of 1,525 patients (eyes), aged 50 to 80 years, operated with phacoemulsification for cataract in 1996 or 1997 in 16 surgical centres (4 per country). METHODS: The study was conducted using a cost-effectiveness approac…

[Meningococcal disease].

Due to a high complication and case fatality rate, meningococcal diseases are important health problems both in tropical countries experiencing severe epidemics as well as in countries of moderate climate zones. Worldwide N. meningitidis of sero-groups A, B, and C are predominant and to a lesser extent serogroups W (135) and Y play a role, whereas in Europe more than 90 % of meningococcal diseases are caused by serogroups B and C of N. meningitidis. In Germany and other developed countries the majority of cases occur in very young children and adolescents. Since many years, meningococcal polys…

[Surveillance of nosocomial infections: prospective study in a pediatric intensive care unit. Background, patients and methods].

UNLABELLED: BACKGROUND, PATIENTS AND METHODS: From November 1997 through May 1998, the incidence of nosocomial infections was studied prospectively in a 10-bed multidisciplinary pediatric intensive care unit in Germany. A standardized surveillance [SEKI] system based on the National Nosocomial Infection Surveillance [NNIS] System of the Centers for Disease Control and Prevention [CDC] was used. The CDC definitions for nosocomial infections were adapted to the current practice of pediatric intensive care in Germany. Infection rates were calculated as infections per 100 patients, per 1000 patien…

Results from the VIOLIN study: verbal violence against voluntary migrants and refugees in German public institutions, discrimination and their association with mental health-an online-cross-sectional study : Institutional verbal violence and discrimination against migrants and their impact on mental health.

THEORETICAL BACKGROUND: Verbal violence and discrimination are psychological stressors for migrants and increase the likelihood of mental illness. This cross-sectional online survey examined the frequency of occurrences of institutional verbal violence (IVV) and discrimination reported by voluntary migrants and refugees in Germany, as well as their association with mental health. METHODS: Adult voluntary migrants and refugees in Germany were recruited for the online survey using snowball and community-based sampling. Measurement instruments included the Everyday Discrimination Scale (EDS), th…

In-herd prevalence of Fasciola hepatica and Calicophoron / Paramphistomum spp. infections in German dairy cows with comparison of two coproscopical methods and establishment of real-time pyrosequencing for rumen fluke species differentiation.

Infections with liver and rumen flukes are among the most frequent parasitic diseases in cattle worldwide. In Europe, the predominant liver … ows. On farms with patent F. hepatica infections, the mean in-herd prevalence was 15.8% in northern Germany, 41.6% in southern Germany and 14.0% in the central German farm. Rumen fluke infections resulted in high in-herd prevalences in all regions with a mean prevalence of 46.0% in northern, 48.4% in southern and 40.0% in central Germany. Individual FECs …

Nit-Occlud atrial septal defect occluder device: Histological characterisation of the healing process.

We describe the healing process following transcatheter implantation of the Nit-Occlud ASD-R occluder (PFM medical, Cologne, Germany) for atrial septal defect closure in a sheep model with histological confirmation of neotissue formation covering the device.

Microscope-based augmented reality assistance in keyhole retrosigmoid approach for microvascular decompression: a technical note.

BACKGROUND: The keyhole retrosigmoid approach for microvascular decompression (MVD) demands a high level of microsurgical precision. To improve procedural safety and accuracy, we evaluated the integration of microscope-based augmented reality (MAR) guidance into this approach. METHODS: Three patients with classical trigeminal neuralgia and a clearly identifiable neurovascular conflict were included. Anatomical segmentations were performed using Brainlab Elements software (Brainlab AG, Munich, Germany), employing both automatic and semi-automatic tools. Intraoperatively, the Zeiss Kinevo 900 m…

Echinococcus multilocularis infection acquired in central Europe in a migrant from an E. granulosus-endemic country - A case report.

BACKGROUND: Echinococcosis is a zoonotic infection caused by tapeworms of the genus Echinococcus. Geographic provenance is often used to guide species attribution, but may be misleading in patients who have migrated into endemic areas. CASE PRESENTATION: A cystic hepatic lesion was discovered in a migrant from Eritrea, residing in Germany for 8 years. Imaging studies (Ultrasound, CT, MRI, PET-CT) demonstrated a polycystic structure in the right lobe. Serology was positive for Echinococcus (without species differentiation). Based on the patient's origin and imaging morphology, cystic echinococ…

[Adult Spinal Muscular Atrophy].

5q spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease affecting 1: 11000 live births and ranging from intrauterine … t in specialized neuromuscular centers. Since October 2021, SMA is part of the newborn screening in Germany. When SMA is clinically suspected, timely genetic diagnostics is crucial for a rapid start of treatment, since "time is motor neuron". The different therapeutic options must be discussed with patients and families, and patient expectations must be m …

Is it all MIS-C? Unusual findings in a series of nine German patients with multi-system inflammatory syndrome in children after SARS-CoV-2 infection.

OBJECTIVES: Multi-system inflammatory syndrome in children (MIS-C) is a post-viral inflammatory vasculopathy of children and adolescents following Covid-19 infection. Since the incidence of SARS-CoV-infections has been increasing in Germany since October 2020, we observe an increasing number of children presenting with MIS-C. DESIGN: We present detailed clinical characteristics of a cohort of nine children with MIS-C admitted to a tertiary PICU at the University Hospital of Cologne between March 2020 and February 2021. RESULTS: The clinical sings and symptoms are largely in line with recent …

[57-years old patient with bulla and striatic erythema located at the limbs].

HISTORY: A female patient aged 57 presented at the emergency room with painful skin lesions after repeated gardening days. Bullae and striate erythema were ovserved in light exposed areas. The patient was transferred to the Dermatology Department at the University hospital Jena, Germany. FINDINGS AND DIAGNOSIS: Blood test showed raised levels of inflammation parameters. The general body examination showed no abnormalities. Dermatits bullosa pratensis (grass dermatitis), was diagnosed, based on the patient case history, the examination results and the typical skin lesions. THERAPY AND COURSE:…

Management of Hodgkin lymphoma in the era of brentuximab vedotin: real-world data from five European countries.

We examined real-world data on management of relapsed/refractory Hodgkin lymphoma (R/R HL) in five European countries and the consistency of these data with guideline recommendations. Retrospective clinical and epidemiologic data for 509 patients with R/R HL treated between January 2014 and March 2015 were collected at centers in France, Germany, Italy, Spain, and the United Kingdom. Mean age was 46.3 years; 73.3% were receiving second-line therapy for a first relapse during the reporting period. Most patients received ABVD as front-line chemotherapy, except in Germany where escalated BEACOPP …

Analysis of German nutrition brochures for pregnant women with evidence-based patient information criteria.

OBJECTIVE: To evaluate nutrition brochures for pregnant women in Germany based on evidence-based patient information (EBPI) criteria. METHODS: Nutrition brochures for pregnant women in Germany were collected. Brochures addressing the risk of salmonellosis, toxoplasmosis or listeriosis were analyzed by two researchers independently. RESULTS: Fifty brochures reporting any information on the risk of infection were analyzed. Most brochures did not include literature citations and only few brochures gave a risk description, predominantly verbally, which usually leads to an overestimation of the a…

Молекулярная филогография вируса энцефалита, переносимого клещами, в Центральной Европе.

В целях более глубокого понимания процессов движения штаммов вируса энцефалита (ТБЭВ), переносимого клещами, в Центральной Европе были определены генные последовательности Е 102 штаммов ТБЭВ, собранные в период с 1953 по 2011 год на 38 участках в Чешской Республике, Словакии, Австрии и Германии. Байезийский анализ показывает 350-летнюю историю эволюции и распространение в Центральной Европе двух основных линий - А и В. В отличие от востока и запада на уровне Евразийского континента местные центральноевропейские модели расползания указывают на исторический разброс запада и востока, за которым с

Совпадение в аннотации оригинала
In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of t…

Contextual and individual determinants of health among Aussiedler and native Germans.

Aussiedler, also referred to as ethnic German immigrants from countries of the former Soviet Union and other parts of Eastern Europe, constitute one of the largest immigrant groups in Germany. Little is known about their health relative to the health of native Germans. Using the German Microcensus 2005, which includes information about the health of 10,022 Aussiedler and 322,813 native Germans aged 20+ we find that in both groups high regional centrality depresses health, as does living in a region with low GDP. The proportion of foreigners does not have any consistent effect. The two groups d…