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Мультимодальное лечение трехгеминиальной нейронгии, связанной с множественным склерозом: опыт одного центра.

ВВЕДЕНИЕ: Множество связанных со склерозом трехгеминиальных нейрологов (МСРТГН) является сложным заболеванием, которое часто является трудноразрешимым и связано с частыми рецидивами. Цель этого исследования заключается в изучении различных методов нейрохирургического управления этим заболеванием. МЕТОДЫ: В одном центре, где проходят ретроспективный анализ три различных метода: радиочастотная абляция (RF), радиохирургия гамма-ножа (GKRS) и микроваскулярная декомпрессия (MVD)-42 пациента, проходящих лечение для MSrTGN. Были проанализированы и сопоставлены результаты лечения, выживаемость без рец

Совпадение в аннотации оригинала
INTRODUCTION: Multiple sclerosis-related trigeminal neuralgia (MSrTGN) is a challenging disease, often intractable and associated with frequent relapses. This study aims to investigate different modalities for the neurosurgical management of this condition. METHODS: In a single centre offering three different modalities-radiofrequency ablation (RF), gamma k…

Переход от педиатрической помощи к альтернативной склерозовой терапии для взрослых: проблемы, стратегии и терапия.

Множественный склероз (MS) — хроническое аутоиммунное состояние, вызывающее повреждение защитного покрытия нервов в центральной нервной системе. Педиатрический множественный склероз является редкой формой болезни, которая затрагивает 3-5% лиц с множественным склерозом. Множественный склероз (POMS) у педиатрии Onset (Podiatric Onset Multical Sclerosis) имеет весьма иной клинический профиль по сравнению с более распространенным множественным склерозом у взрослых. Помимо классических симптомов множественного склероза, дети, как правило, испытывают различные нетипичные симптомы, которые могут влия

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune condition causing damage to the protective covering of nerves in the central nervous system. Pediatric multiple sclerosis is a rare form of the disease that affects 3-5% of individuals with multiple sclerosis. Pediatric Onset Multiple Sclerosis (POMS) has a rather different clinical profile from the more preval…

Ocrelizumab в качестве первой линии терапии в высокоактивном реанимированном многообразном склерозе.

В последние годы раннее использование высокоэффективных заболеваний, изменяющих иммунотерапию в релапсирующих множественных склерозах (РРМС), продемонстрировало высокую эффективность в предотвращении развития инвалидности. В рамках этого исследования мы изучили оррелизумаб в качестве первой линии терапии RRMS в моноцентрическом ретроспективном исследовании. В нашей амбулаторной клинике оррелизумаб проходил первую терапию в 33 пациентах с ожидаемым весьма активным курсом лечения. Пациенты подвергаются повторной клинической оценке каждые 6 месяцев и по крайней мере ежегодно с помощью черепно-маг

Совпадение в аннотации оригинала
In recent years, early use of highly effective disease modifying immunotherapies in relapsing-remitting multiple sclerosis (RRMS) demonstrated superior efficacy in preventing disability progression. For this study, we investigated ocrelizumab as first line therapy of RRMS in a monocentric, retrospective study. In our outpatient clinic, ocrelizumab was admini…

Consanguineous marriage among familial multiple sclerosis subjects: A national registry-based study.

BACKGROUND: The rising prevalence of familial multiple sclerosis (MS) in Iran has spurred interest in the potential impact of parental consanguinity on the risk of developing the disease. This study aims to aggregate current knowledge on parental consanguinity and its possible effect on MS risk, particularly among familial MS patients from various regions and ethnicities in Iran. The objective is to enhance the understanding of MS genetics and encourage further research in this field. MATERIALS AND METHODS: A cross-sectional study was conducted on clinically definite familial MS (FMS) patient…

Investigating cortical hypoxia in multiple sclerosis via time-domain near-infrared spectroscopy.

OBJECTIVES: Hypoperfusion and tissue hypoxia have been implicated as contributory mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to study cortical oxygenation in vivo in patients with MS and age-matched controls. METHODS: A custom, multiwavelength time-domain near-infrared spectroscopy system was developed for assessing tissue hypoxia from the prefrontal cortex. A cross-sectional case-control study was undertaken assessing patients with secondary progressive MS (SPMS) and age-matched controls. Co-registered magnetic resonance imaging was used to verify the…

Global burden of multiple sclerosis and its attributable risk factors, 1990-2019.

BackgroundMultiple sclerosis (MS) is a progressively debilitating disorder that has seen a notable rise in prevalence in recent years. This study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries and territories.MethodsData on the prevalence, death and disability-adjusted life years (DALYs) attributable to MS were obtained from the publically available Global Burden of Disease 2019 project. The estimates are reported as numbers, percentages, and age-standardized rates per 100,000, accompanied by 95% unc…

Epidemiologic Associations Between Inflammatory Bowel Disease and Hodgkin Lymphoma or Multiple Sclerosis.

Background and aimsEpidemiologic evidence suggests that Hodgkin lymphoma (HL) and multiple sclerosis (MS) share a common set of risk factors with Crohn's disease (CD) and ulcerative colitis (UC). It was hypothesized that such shared risk factors would lead to similar geographic distributions of these 4 diagnoses and their concurrence in identical patients.MethodsAll subjects with HL, MS, CD, or UC were identified in the complete Inpatient Standard Analytic File of the Centers for Medicare and Medicaid Services from 2018. In a cross-sectional study, we evaluated whether the frequencies of HL, M…

Twenty Years of Subcutaneous Interferon-Beta-1a for Multiple Sclerosis: Contemporary Perspectives.

Multiple sclerosis (MS) is a chronic, progressive, inflammatory disorder of the central nervous system. Relapsing-remitting MS (RRMS), the most common form of the disease, is characterized by transient neurological dysfunction with concurrent accumulation of disability. Over the past three decades, disease-modifying therapies (DMTs) capable of reducing the frequency of relapses and slowing disability worsening have been studied and approved for use in patients with RRMS. The first DMTs were interferon-betas (IFN-βs), which were approved in the 1990s. Among them was IFN-β-1a for subcutaneous (s…

Frequency of Dimethyl Fumarate-Induced Lymphopenia among Omani Patients with Multiple Sclerosis.

OBJECTIVES: Dimethyl fumarate (DMF) is known to cause lymphopenia when used to treat patients with multiple sclerosis (MS). However, research on DMF therapy in the Arab world, especially in Oman, is scarce. This study aimed to analyse the prevalence of lymphopenia among Omani patients with MS and their reasons for discontinuing DMF therapy. METHODS: In this retrospective study, the medical records of Omani patients with MS who were treated using DMF at two tertiary hospitals in Muscat, Oman, from February 2017 to February 2023 were reviewed. Their demographic, clinical and laboratory data wer…

Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study.

BACKGROUND: Observational studies have suggested an association between multiple sclerosis (MS) and cortical structure, but the results have been inconsistent. OBJECTIVE: We used two-sample Mendelian randomization (MR) to assess the causal relationship between MS and cortical structure. METHODS: MS data as the exposure trait, including 14,498 cases and 24,091 controls, were obtained from the International Multiple Sclerosis Genetics Consortium. Genome-wide association study (GWAS) data for cortical surface area (SAw/nw) and thickness (THw/nw) in 51,665 individuals of European ancestry were o…

Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis.

BACKGROUND: Epstein-Barr virus (EBV) is a likely prerequisite for multiple sclerosis (MS) but the underlying mechanisms are unknown. We investigated antibody and T cell responses to EBV in persons with MS (pwMS), healthy EBV-seropositive controls (HC) and post-infectious mononucleosis (POST-IM) individuals up to 6 months after disease resolution. The ability of EBV-specific T cell responses to target antigens from the central nervous system (CNS) was also investigated. METHODS: Untreated persons with relapsing-remitting MS, POST-IM individuals and HC were, as far as possible, matched for gend…

HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis.

OBJECTIVE: Specific human leucocyte antigen (HLA) alleles are not only associated with higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with the severity of various viral and bacterial infections. Here, we analyzed the most specific biomarker for MS, that is, the polyspecific intrathecal IgG antibody production against measles, rubella, and varicella zoster virus (MRZ reaction), for possible HLA associations in MS. METHODS: We assessed MRZ reaction from 184 Swiss patients with MS and clinically isolated syndrome (CIS) and 89 Swiss non-MS/non-CIS control p…

Ocrelizumab-induced organizing pneumonia in multiple sclerosis: case report and literature review.

Patients with relapsing-remitting multiple sclerosis should be offered disease-modifying therapies as part of their management. Recommended options include integrin antagonist therapy including natalizumab as well as anti-CD20 monoclonal antibodies like, ocrelizumab, rituximab, ofatumumab, and ublituximab. These therapies reduce relapse rates and slow brain lesion accumulation. Disease-modifying therapies selection may depend on patient preferences, potential fetal harm, and specific drug risks, requiring continuous monitoring via tracking clinical relapses and new MRI brain lesions. Natalizum…

Интегрированные транскриптомные Reveals Молекулярные подтипы и сети ceRNA в множестве склерозов.

AIM: Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему (КНС). Несмотря на обширные исследования, его молекулярные подтипы и механизмы по-прежнему плохо понимаются, что препятствует выявлению эффективных терапевтических целей. Мы использовали КонсенсусClusterPlus для анализа транскриптомных данных из 215 образцов пациентов MS, идентифицируя различные молекулярные подтипы. Для дальнейшей характеристики этих подтипов были проведены анализ различных выражений и оценки изменчивости. Кроме того, на предмет возможного взаимодействия с СЕРНА б

Совпадение в аннотации оригинала
AIM: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS). While extensively studied, its molecular subtypes and mechanisms remain poorly understood, hindering the identification of effective therapeutic targets. METHODS: We used ConsensusClusterPlus to analyze transcriptome data from 215 MS patient samples, ide…

Heat shock protein 70 gene polymorphisms in Iranian patients with Multiple sclerosis.

Genetic factors are effective reagents in susceptibility to multiple sclerosis (MS). Previous studies have shown the relationship between heat shock protein (HSP) gene polymorphisms. So, HSP70 single nucleotide polymorphisms (SNPs) were evaluated as MS risk factors. Here, DNA genotyping was done for HSP70 gene polymorphisms, including HSP70-1 +190 G>C, HSP70-1 -110 A>C, HSP70-1 +438 A>C, and HSP70-hom +2437 A>G in two groups including Iranian MS patients and controls. A standard phenol/chloroform method isolated DNA samples from peripheral blood. Sequence-specific amplification (SSP) polymeras…

Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI.

The application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. Additionally, the study of CNN-derived attention maps, which indicate the most relevant anatomical features for CNN-based decisions, has the potential to uncover key disease mechanisms leading to disability accumulation. From a cohort of patients prospectively followed up after a f…

Resting-state functional connectivity in multiple sclerosis patients receiving nabiximols for spasticity.

BACKGROUND: Nabiximols (Sativex®) is a cannabinoid approved for multiple sclerosis (MS)-related spasticity. Its mechanism of action is partially understood, and efficacy is variable. OBJECTIVE: To conduct an exploratory analysis of brain networks connectivity changes on resting state (RS) functional MRI (fMRI) of MS patients treated with nabiximols. METHODS: We identified a group of MS patients treated with Sativex® at Verona University Hospital, who underwent RS brain fMRI in the 4 weeks before (T0) and 4-8 weeks after (T1) treatment start. Sativex® response was defined as ≥ 20% spasticity …

Newly Diagnosed Tumefactive Demyelinating Lesion and Multiple Sclerosis After COVID-19 Infection.

INTRODUCTION: To describe the parainfectious or postinfectious effects of COVID-19 infection on the first demyelinating presentation of Multiple Sclerosis and tumefactive demyelinating lesion (TDL) developing with Longitudinally Extensive Transverse Myelitis (LETM). METHODS: We present six patients who presented with a first CNS demyelination event or whose demyelinating lesions had aggravated after COVID-19 infection between May and December 2020. Nasopharyngeal swab SARS-CoV-2 PCR positivity was detected in five cases and cerebrospinal fluid (CSF) PCR was positive in one. The symptoms, neur…

Incidence of multiple sclerosis relapses and pseudo-relapses following COVID-19 vaccination.

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic created an urgency for an effective vaccine. The FDA approved vaccines offered by Pfizer-BioNTech (BNT162b2), ModernaTX (mRNA-1273) and Janssen/Johnson & Johnson (Ad26.COV2.S) have shown minimal side effects (SE) in general population studies. Multiple sclerosis (MS) patients were not specifically represented in the above studies. The MS community is interested in how these vaccines behave in people with MS. In this study, we compare the SE experienced by MS to that of the general population after SARS-CoV-2 vaccination and evaluate …

Serum glial fibrillary acidic protein and disability progression in progressive multiple sclerosis.

OBJECTIVE: Progression prediction is a significant unmet need in people with progressive multiple sclerosis (pwPMS). Studies on glial fibrillary acidic protein (GFAP) have either been limited to single center with relapsing MS or were based solely on Expanded Disability Status Scale (EDSS), which limits its generalizability to state-of-the-art clinical settings and trials applying combined outcome parameters. METHODS: Serum GFAP and NfL (neurofilament light chain) were investigated in EmBioProMS participants with primary (PP) or secondary progressive MS. Six months confirmed disability progre…