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Sickle cell diseases: What can nuclear medicine offer?

Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of t … tion, chronic hemolytic anemia, splenic sequestration with rapid enlargement of the spleen, delayed sexual maturation and cholelithiasis, with important inter-indivuidual variability. Sickle hepatopathy reflects liver sickling process within hepatic sinusoids and includes gallstone disease, hepatic sequestration, hepatic sideroris, acute sickle cell hepatic crises …

Effects of bromantan on offspring maturation and development of reflexes.

Bromantan (N-[2-adamantil]-N-[para-bromphenyl]amine) is an "actoprotective" drug widely used in Russia as a muscle performance-enhancing agent for sportsmen and as an immunostimulator in medicine. Experiments were conducted to determine whether this compound has adverse effects on the reproduction and development of offspring. Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution. Afterwards, tr

Lactate dehydrogenase-elevating virus: an ideal persistent virus?

LDV contradicts all commonly held views about mechanisms of virus persistence, namely that persistence is primarily associated with noncytopathic viruses, or the selection of immune escape variants or other mutants, or a decrease in expression of certain viral proteins by infected cells, or replication in “immune-privileged sites”, or a general suppression of the host immune system, etc. [1, 2, 5, 54, 77, 78]. LDV is a highly cytocidal virus that invariably establishes a life-long, viremic, persistence in mice, in spite of normal anti-viral immune responses. One secret of LDV's success in pers

THE INFLUENCE OF THE SUPRARENAL GLAND ON THE THYMUS : I. REGENERATION OF THE THYMUS FOLLOWING DOUBLE SUPRARENALECTOMY IN THE RAT.

Experimental evidence has been presented showing that the thymus gland of the rat enlarges rapidly in those animals surviving double suprarenalectomy. The enlargement has been observed to follow bilateral ablation with such constancy that it may be said to occur in all rats which survive double suprarenalectomy in good condition for from 3 to 5 weeks. The thymus enlarges even though the animal loses some weight after operation. Our data, though inconclusive, would seem to indicate a sex difference, the secondary hyperplasia of the thymus being more marked in the female than in the male. This d

[Study on psychiatric disorders and defensive process assessed by the "defense style questionnaire" in sterile males SAMPLE consulting in andrology].

BACKGROUND: The literature about artificial insemination and the associated psychological, psychiatric and sexual disorders is relatively rich. But the majority of these studies is made in gynaecology, with a feminine approach of the disorder. There are very few works led in andrology. This justified the investigation of new trails in order to understand better the clinical context of the sterile man. We undertake a study about the psychiatric disorders among sterile men and about the defense styles. These are a clinical entity recently introduced in the quantitative psychopathology research.

Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls.

BACKGROUND: Children are commonly exposed at background levels to several ubiquitous environmental pollutants, such as lead and persistent organic pollutants, that have been linked to neurologic and endocrine effects. These effects have prompted concern about alterations in human reproductive development. Few studies have examined the effects of these toxicants on human sexual maturation at levels commonly found in the general population, and none has been able to examine multiple toxicant exposures. The aim of the current investigation was to examine the relationship between attainment of men…

Ограничение способности любить и гиперсексуальное поведение в их отношениях с психотиком и паранойей.

Предпосылки к способности к любви (КТЛ) и проблематичной сексуальности можно было бы рассматривать в качестве показателей психопатологических страданий. 521 Темы390 женщин и женщин 131 мужского пола; возрастный период: 18-50) Завербованные субъекты заполнили психометрический протокол, включающий в себя следующие инструменты измерения:1) реестр возможностей любить;2) Гиперсексуальная инвентаризация поведения,3) Краткий список симптомов. Выражения указывают на значительную обратную корреляцию между CTL и как параноидальной идеей, так и психотиком, при этом гиперсексуальность положительно соотнос

In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction.

BACKGROUND: Polycystic ovarian syndrome (PCOS) occurs in 8% to 13% of all women of reproductive age and 50% of women presenting with infertility (i.e. inability to reach a pregnancy after 12 months or more of regular unprotected sexual intercourse). A proportion of these women ultimately need assisted reproductive technology. In vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) are assisted reproduction techniques used to raise the chances of a pregnancy. In women with PCOS, the supra-physiological doses of gonadotrophins used for controlled ovarian hyperstimulation (COH) often

Childhood adversity and adolescent motherhood: A cross-sectional study of trauma, partner age gaps, and parenting in the Dominican Republic.

BACKGROUND: Adolescent pregnancy is increasingly understood as closely associated with pre-existing disadvantage, yet critical gaps remain regarding which adverse childhood experiences (ACEs) are associated with early childbearing, partner characteristics, and parenting trajectories. OBJECTIVE: To examine associations among ACEs, partner characteristics, and parenting practices in adolescent versus adult-onset mothers. PARTICIPANTS AND SETTING: We recruited 1019 mothers of children aged 24-48 months from poverty-focused programs in Santo Domingo, Dominican Republic (November 2024-January 202

MALE OSTEOPOROSIS.

Population aging is a reality that is being faced worldwide, and Brazil is no different. Osteoporosis was considered to be a postmenopausal women's disease for many years. Men have many development and hormonal factors that differentiate their skeletal maturation, which affects the incidence of osteoporosis and fractures. An up-to-date review of the specific literature within the Medline system is presented.

Clinical Practice Guidelines for management of Sexual Disorders in Elderly.

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Infectious Diseases

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Infectious Diseases

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Клиническое описание и социально-демографическая характеристика лиц, страдающих киберсексуальной зависимостью, в рамках долгосрочных программ терапевтической поддержки.

ЦЕЛЬ: Киберсексуальная зависимость и гиперсексуальное поведение представляют собой растущие проблемы в области психического здоровья во всем мире. В ходе этого исследования были проанализированы социально-демографические и клинические характеристики когорты мужчин, проходящих курс лечения, а также была изучена взаимосвязь между продолжительностью терапевтической помощи и симптоматической строгостью. МЕТОД: В рамках программ терапевтической поддержки было проведено исследование по наблюдению, описательному и сквозному изучению с участием преимущественно мужской клинической группы (n = 27; 26 му

Development of a Health-Related Quality of Life Tool for Adolescents and Young Adults With Cancer.

ImportanceA diagnosis of cancer during adolescence and young adulthood disrupts key developmental stages, affecting multiple domains of health-related quality of life (HRQOL). To provide a comprehensive assessment of the HRQOL issues of adolescents and young adults (AYAs) with cancer, a questionnaire dedicated to this age group is needed.ObjectiveTo develop an HRQOL questionnaire, as a supplement to the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, that measures issues of relevance and importance to AYAs with cancer.Design, setting, and participantsThis survey stu

The Interplay between Immune System and Microbiota in Osteoporosis.

Osteoporosis is a disease characterized by low bone mass and alterations of bone microarchitecture, with an increased risk of fractures. It is a multifactorial disorder that is more frequent in postmenopausal women but can be associated to other diseases (inflammatory and metabolic diseases). At present, several options are available to treat osteoporosis trying to block bone reabsorption and reduce the risk of fracture. Anyway, these drugs have safety and tolerance problems in long-term treatment. Recently, gut microbiota has been highlighted to have strong influence on bone metabolism, becom

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

Роль окситоцина и Васопрессина в нейропсихиатрических расстройствах: терапевтический потенциал агонистов и антагонистов.

Окситоцин (OT) и вазопрессин (AVP) являются гипоталамическими нейропептидами, которые традиционно ассоциируются с их регулирующей ролью в размножении, гомеостазисе воды и социальном поведении. Интересно, что в последние годы эта роль расширилась и эти нейропептиды стали лечебными мишенями для различных нейропсихиатрических заболеваний, таких, как аутизм, зависимость, шизофрения, депрессия и тревожное расстройство. В связи с химическими и физическими характеристиками этих нейропептидов, включая короткий период полураспада, плохое проникновение через мозговые барьеры, беспорядочность для AVP и O

Совпадение в полном тексте источника
… Furthermore, after 1 week of medium dosage of intranasal AVP (IN-AVP; 0.5 IU/kg), the partner preference is disrupted in male prairie voles, while an increase of novel object recognition was observed in animals of both sexes, and females increased play behavior before sexual maturation [ 159 ]. … In agreement with other studies, after sexual maturation the high dosage of IN-AVP (5.0 IU/kg) produced an augmentation of aggression in males [ 159 ]. Regarding research in humans, IN-AVP effects on social processing of male and female faces have been reported. …

Advances in real-world research on fertility preservation in men with malignant tumours.

Malignant tumours have become one of the diseases that seriously threaten human health, and their incidence is increasing year by year. Worldwide, malignant tumours have become one of the most common causes of death in men. With the continuous progress of comprehensive oncological treatment, the cure rate and the survival rate of malignant tumours have been increasing, and the survival cycle has been prolonged, so the issue of fertility preservation in male malignant tumour patients has received widespread attention. In this review, researchers will discuss the real-world research progress rel

Сексуальное здоровье после неврологических расстройств: всеобъемлющий обзор данных о лечении.

Предыстория/задачи: Сексуальная дисфункция (СД) и более широкие проблемы сексуального здоровья являются распространенными после неврологических расстройств, однако улики вмешательства разрознены по различным условиям и результатам. В ходе этого зонтичного обзора были собраны и оценены на систематической основе данные о мерах, направленных на УР и сексуальное здоровье неврологических групп населения, а также квалифицированные выводы с использованием достоверной информации. Методы: с момента создания были проведены обыски PubMed, Web of Science, Cochrane Bibrary, Embase, PsycINFO, EBCOCOhost и S