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Psychometric properties of the hematopoietic cell transplantation frailty scale: A prospective observational study.

INTRODUCTION: Frailty is common in patients undergoing hematopoietic stem cell transplantation, thereby increasing toxicity risk and reducin … us, allogeneic), and age groups (18-59, ≥ 60 years) were rejected (p-value >0.05). CONCLUSION: The Chilean version of the Hematopoietic Cell Transplantation Frailty Scale demonstrates adequate reliability and validity, supported by a strong factorial structure to assess transplant candidates. Frailty was associated with a lower performance status, but …

Semen Quality in Patients with Hematological Malignancies: A Retrospective Monocentric Study in the Perspective of Personalized Oncofertility Medicine.

Background/Objectives: The hypothalamic-pituitary-testis axis is known to be dysregulated in patients with hematological malignancies. However, data on the association between the type of hematological malignancies and semen quality are discordant. In the era of personalized medicine, identifying disease-specific patterns of reproductive impairment is crucial to optimize fertility preservation strategies. While patients with leukemia often show a clear deterioration in semen quality, studies on Hodgkin and non-Hodgkin lymphomas have shown that spermatogenesis is not always compromised. Indeed,

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… Recent Global Burden of Disease estimates indicate a rising incidence of Hodgkin lymphoma, particularly in Asian populations, alongside declining global mortality, although increased mortality has been reported in specific countries, including Chile and Ireland [ 7 ]. …

Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities.

New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens. This difference has led to an intensified search for additional potent vaccine adjuvants that meet safety and efficacy criteria and confer long-term protection. This review provides an overview of protein-based adjuvants (PBAs) obtained from different organisms, including bacteria, mollusks, plants, and humans. Notably, despite structural differences, all PBAs show significant immunostimulatory properties, eliciting B-cell- a

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… Funding Statement This study was supported by CONICYT-CHILE FONDECYT Regular Grant 1201600 to MIB. Fellowships were awarded to DDD (ANID N° 21200880) and to MLS (ANID N° 21210946. … F.S. holds a postdoctoral fellowship from the National Commission for Scientific and Technological Research (CONICYT), Chile. Footnotes Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. References 1. Iwasaki A., Omer S.B. …

Demographic, epidemiological, and health transitions: are they relevant to population health patterns in Africa?

BackgroundStudies of trends in population changes and epidemiological profiles in the developing world have overwhelmingly relied upon the concepts of demographic, epidemiological, and health transitions, even though their usefulness in describing and understanding population and health trends in developing countries has been repeatedly called into question. The issue is particularly relevant for the study of population health patterns in Africa and sub-Saharan Africa, as the history and experience there differs substantially from that of Western Europe and North America, for which these conce

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… This was also apparent for the United States between 1880 and 1970, and for England, Wales and Chile ( 2 , 10 ). … Taiwan, Hong Kong, Singapore, South Korea, Sri Lanka, Mauritius, China, Chile, Cuba, Barbados, Costa Rica, and the French overseas departments such as Reunion). …

[Local treatment of Von Willebrand's disease--use of GRF adhesive].

Among the systemic hemorrhagic we find Von Willebrand's, the most prevalent coagulation related illness. It may be defined as a qualitative platelet abnormality which in most cases is transmitted as a dominant mendelian trait. Clinically there is prolonged bleeding time, epistaxis, gingival hemorrhage and increased bleeding after surgery or dental extractions. The purpose of this project was to test the effectivity of a local element such as GRF glue as the only treatment for these patients. With the purpose to avoid the use of a substitute therapy, mainly taking into consideration all the pro

The impact of the COVID-19 pandemic on the oncology services demand in a middle-income setting with universal health insurance.

AimWe analyze the impact of the COVID-19 pandemic on oncology service demand in a middle-income country with universal health coverage.MethodsWe collected data from January 1st-2017 to December 31th-2021 at a reference center in Bogotá-Colombia regarding first-time consultations of cross-cutting services (clinical oncology, hematology, palliative care, radiation oncology); specialized multidisciplinary units (breast, prostate, lung, stomach); inpatient and outpatient systemic therapy; radiotherapy; oncology surgery; and bone marrow transplant. A descriptive time series analysis was performed,

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… Jara JJ de la.Nervi B Estimating the impact of the COVID-19 pandemic on diagnosis and survival of five cancers in Chile from 2020 to 2030: a simulation-based analysis. Lancet Oncol. 2021:1427–1437. doi: 10.1016/S1470-2045(21)00426-5. 12. Garcia-Ramirez J, Nikoloski Z, Mossialos E. …

ISEV2018 абстрактная книга

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Epidemiology of Bacteremia in Patients with Hematological Malignancies and Hematopoietic Stem Cell Transplantation and the Impact of Antibiotic Resistance on Mortality: Data from a Multicenter Study in Argentina.

The epidemiology of bacteremia and the antibiotic resistance profile (ARP) of Gram-negative bacilli (GNB) in hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT) patients may differ according to geographic region. In addition, multidrug-resistant organisms (MDROs) may impact mortality. This is a prospective, observational, and multicenter study. The first episodes of bacteremia in adult patients with HM or HSCT were included. The risk factors for 30-day mortality were identified. One thousand two hundred and seventy-seven episodes were included (HM: 920; HSCT: 357). GN

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… An Emergent Change in Epidemiologic and Microbiological Characteristics of Bloodstream Infections in Adults with Febrile Neutropenia Resulting from Chemotherapy for Acute Leukemia and Lymphoma at Reference Centers in Chile, Ecuador, and Peru Open Forum Infect. …

Short Course of Antibiotic Therapy for Gram-Negative Bacilli Bacteremia in Patients with Cancer and Hematopoietic Stem Cell Transplantation: Less Is Possible.

Data about short courses of antibiotic therapy for Gram-negative bacilli (GNB) bacteremia in immunosuppressed patients are limited. This is a prospective observational study performed on adult patients with cancer and hematopoietic stem cell transplant (HSCT) who developed GNB bacteremia and received appropriate empirical antibiotic therapy (EAT), had a clinical response within 7 days and survived 48 h after the end of therapy. They received antibiotic therapy in the range of 7-15 days and were divided into short course, with a median of 7 days (SC), or long course, with a median of 14 days (L

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… Epidemiology and Clinical Impact of Bacteremia in Neutropenic and Nonneutropenic Patients with Cancer and Stem-Cell Transplant in the Era of Multiresistance Proceedings of the 19 Symposia on the Infections in the Immunocompromised Host Santiago, Chile 13–15 November 2016 …

Oral Presentations

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Естественные и синтетические АМП из Латинской Америки по всему спектру технологий и приложений в области разнообразия.

Биоразнообразие в Латинской Америке примерно 60% в целом по миру, подпитывая научные исследования в области природных продуктов, весьма значимой области открытия наркотиков по сей день. Это сопровождается увеличением числа антимикробных пептидов (АМП), полученных из натуральных продуктов в регионе, которые за последнее десятилетие были переработаны путем модификации, усовершенствования и уточнения их физико-химических свойств и антимикробной эффективности с использованием подходов, которые варьируются от изучения рациональной конструкции и соотношения структуры-активности (САР) до методов иску

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… For exemple, a collaborative study conducted by researchers from Brazil and Chile, three linear peptides, litvan ALF-E33–52 (YVNR­SPYL­KKFE­VHYR­ADVK), litvan ALF-F31–50 (TYFV­TPKV­KSFE­LYFK­GRMT), and litvan ALF-G35–54 (SYST­RPYF­LRWR­LKFK­SKVW), were designed based on the amino acid sequence of the … Building on these findings, more detailed peptidomic analyses of marine fish from the Pacific coast of Chile, combined with bioinformatics tools and antimicrobial assays, have further expanded the repertoire of vertebrate-derived AMPs. …

Oral Presentations

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… minimally invasive treatment for vertebral metastases: a retrospective multicenter study and comparison with literature Alvaro Silva 1,2 , Andres Lisoni 1,2 , Ratko Yurac 1 , Nicolás Rotman Hinzpeter 1 , Ernesto Pino 3 1 Clinica Alemana de Santiago - Universidad del Desarrollo, Spine Surgery, Santiago, Chile … , 2 Hospital Clínico de la Fuerza aérea de Chile, Spine Surgery, Santiago, Chile, 3 Clinica Alemana de Santiago - Universidad del Desarrollo, Traumatology and Orthopaedics, Santiago, Chile Introduction: The aim of this study is to evaluate the clinical outcomes of a series of patients with vertebral …

Navigating Trichosporon Asahii Infections in Pediatric Leukemia: First Reported Case in Central and Eastern Europe Case Report and Literature Review.

Invasive fungal infections pose significant challenges in the management of immunocompromised patients, particularly those undergoing treatment for hematologic malignancies. Trichosporon asahii is a rare but severe cause of invasive trichosporonosis, associated with mortality rates. Effective management is complicated by its resistance to echinocandins and reduced susceptibility to polyenes, necessitating azole-based therapy. This paper aims to illustrate the diagnostic challenges associated with Trichosporon infections, analyze the complexities of treatment, review and synthesize known risk f

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… | Patient’s Gender | Neutropenia Presence | Isolation Place | Symptoms | Organs Involved | Antifungal Prophylaxis | Empirical Treatment | Targeted Treatment | Treatment Outcome | Country Giacomozzi et al 2023 42 | 2 | M | Present | Blood | Fever | Spleen, kidneys | NA | CAS | VOR then CAS | Alive | Chile …

Autologous stem cell transplantation in patients older than 65 years with multiple myeloma: a real-world study.

IntroductionThe treatment of elderly multiple myeloma (MM) patients with autologous stem cell transplantation (ASCT) is a controversial procedure. Most clinical trials evaluating the safety and efficacy of ASCT have primarily included patients younger than 65 years.Design and methodsThis was a retrospective analysis of patients with MM who underwent ASCT between 2008 and 2018. Patients at or over 65 years were compared with patients under 65 years. We analyzed treatment-related mortality (TRM), response rate, progression-free survival (PFS) and overall survival (OS).ResultsTwo hundred and twen

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… patients, 11 , 24 the percentage of patients who access the ASCT worldwide based on real-life data is less than expected. 25 In a retrospective multicenter study of Latin America, 32.7% of patients with MM underwent ASCT, however the percentages varied between countries from 69% in Argentina to 3% in Chile …

Long-term home mechanical ventilation using a noninvasive ventilator via tracheotomy in patients with myasthenia gravis: a case report and literature review.

Neuromuscular diseases (NMD) are indications for long-term home mechanical ventilation (HMV). Noninvasive ventilation is preferred to HMV. However, invasive mechanical ventilation (IMV) is more appropriate if the patient has uncontrollable airway secretions, the possibility of aspiration, failure to wean, or severe weakness of the respiratory muscles. But if the patient undergoes multiple intubation or tracheotomy, it will be more painful and unbearable. For some end-stage NMD patients who need long-term tracheostomy, HMV using noninvasive ventilator via tracheotomy may be a conservative care

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… Results of the home mechanical ventilation national program among adults in Chile between 2008 and 2017. BMC Pulm Med 2021; 21: 394. 3. Kim HI, Cho JH, Park SY, et al. Home mechanical ventilation use in South Korea based on National Health Insurance Service Data. Respir Care 2019; 64: 528–535. 4. …

Indirect Treatment Comparison of Daratumumab, Pomalidomide, and Dexamethasone Versus Standard of Care in Patients with Difficult-to-Treat Relapsed/Refractory Multiple Myeloma.

IntroductionThe phase 3 APOLLO study demonstrated significantly better progression-free survival (PFS) and clinical responses with daratumumab, pomalidomide, and dexamethasone (D-Pd) versus pomalidomide and dexamethasone (Pd) in patients with relapsed/refractory multiple myeloma (RRMM). On the basis of these results and those from the phase 1b EQUULEUS trial, D-Pd was approved in this patient population. In the absence of head-to-head data comparing D-Pd with further standard of care (SOC) therapies, indirect treatment comparisons (ITCs) can provide important information to help optimize treat

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… Matching for balance, pairing for heterogeneity in an observational study of the effectiveness of for-profit and not-for-profit high schools in Chile. Ann Appl Stat. 2014;8:204–231. doi: 10.1214/13-AOAS713. 22. Phillipo D, Ades A, Dias S, Palmer S, Abrams K, NJ W. …