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Heat-producing thermoeffector plasticity in response to prolonged iterative exposure to a high-heat loss environment: no indication of thermoregulatory fatigue.

Previous studies have suggested that, during prolonged cold exposure, shivering thermogenesis may gradually be attenuated, supposedly reflecting a state of central fatigue (aka 'thermoregulatory fatigue') provoked by extended shivering activity, that precipitates hypothermia. The purpose of this study was to revisit the validity of this notion. Twelve noncold-acclimatized men participated in three ∼10-h sessions, during which they performed repeatedly three 120-min cold-water immersions. To induce discrete amounts of heat-producing thermoeffector output, presumptively leading to distinct level…

Perceived quality of life, fatigue and the metabolic cost of walking in generalized hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome.

INTRODUCTION: Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience chronic pain, leg fatigue and/or pain, which may contribute to a higher metabolic cost of walking. How these subjective measures may manifest in an elevated metabolic cost of transport and perceived pain at varying walking speeds remains to be evaluated. METHODS: We recruited 11 HSD/hEDS participants (33 ± 14 yrs, 170 ± 6. cm, weight 71 ± 11 kg) and 11 age- and sex-matched controls. Self-reported subjective outcome measures of health-related quality of life, fat…

Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction.

BACKGROUND/AIM: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multi-organ inflammation and damage acro … SLE with cardiac complications, evaluating the therapeutic impact of molecular hydrogen therapy on fatigue, immune modulation, and cardiac function. CASE REPORT: A 51-year-old female with SLE and acute decompensated heart failure initially received steroids and immunomodulators for disease management. Subsequently, molecular hydrogen therapy was introdu …

Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction.

BACKGROUND/AIM: Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are chronic autoimmune diseases that often coexist. They shar … E, SS, and interstitial lung disease (ILD), evaluating the effects of molecular hydrogen therapy on fatigue, immune modulation, and cardiac function. CASE REPORT: We present the case of a 69-year-old female diagnosed with Sjögren's syndrome, SLE, and ILD. The patient exhibited chronic symptoms, including xerostomia, xerophthalmia, and respiratory distres …

Combined training improves functional capacity, fatigue, and quality of life in individuals with multiple sclerosis: a systematic review and meta-analysis.

INTRODUCTION: Multiple Sclerosis (MS) severely affects strength, coordination, gait, and balance, leading to significant challenges for individuals. While exercise is known to benefit MS management, most studies focus on single modalities, leaving a gap in understanding the effects of combined training (CT) interventions. This systematic review aims to address this gap by examining the impact of diverse CT interventions on muscle strength, balance, gait speed, endurance, fatigue, and quality of life in people with MS (PwMS). The findings will provide valuable insights for enhancing rehabilitat…

Надежность и действительность персидской версии " Усталой шкалы для моторных и когнитивных функций " (P-FSMC) у иранского народа с множественным склерозом.

ПУРПОСЕ: В этом исследовании была дана оценка психометрической характеристике персидской версии шкалы утомления моторных и когнитивных функций (P-FSMC) у иранского народа с множественным склерозом (PwMS). МАТЕРИАЛЫ И МЕТОДЫ: В этом поперечном исследовании приняли участие 303 PwMS и 102 системы контроля за состоянием здоровья. Была изучена структурная действительность с использованием анализа исследовательских факторов (ИФА) и анализа подтверждающих факторов (КФА). Конструктивная действительность была определена на основе корреляции P-FSMC с шкалой утомления (FSS) и шкалой влияния утомления (FI

Совпадение в аннотации оригинала
PURPOSE: This study evaluated the psychometric feature of the Persian version of the Fatigue Scale for Motor and Cognitive Functions (P-FSMC) in Iranian People with Multiple Sclerosis (PwMS). MATERIALS AND METHODS: In this cross-sectional study, 303 PwMS and 102 healthy controls participated. Structural validity was explored using exploratory factor analysi…

Новая программа сознательности и психообразования для лечения усталости головного мозга, оценённая после повреждения мозга и множественных склерозов.

Фон: Усталость является общей долгосрочной проблемой после заболеваний, затрагивающих мозг, оказывающих существенное воздействие на трудоспособность, социальную деятельность и качество жизни. Лечение запрашивалось в системе здравоохранения и пациентами. Цель этого случайного экспериментального исследования состоит в том, чтобы оценить новую программу " Усталость мозга " и " Уменность " (BF-M) для участников, страдающих длительной усталостью после приобретенного повреждения мозга или множественным склерозом. БФ-М состоит из шести совещаний групп раз в две недели. Ведется мед

Совпадение в аннотации оригинала
Background: Fatigue is a common long-term problem after illnesses affecting the brain, having substantial impact on work ability, social activities, and quality of life. Treatment has been requested in the healthcare and by patients. The aim of this randomized pilot study is to evaluate a new Brain Fatigue and Mindfulness program (BF-M) for participants suff…

Отопление и усталость головы: воздействие на периферийные и центральные функции и точность двигателей у здоровых мужчин и мужчин с множественным склерозом.

ЦЕЛЬ: Цель этого исследования заключалась в оценке того, вызовет ли локальное нагревание головы и шеи в сочетании с длительными субмаксимальными испытаниями при термонейтральной температуре периферийные и центральные изменения у здоровых мужчин и мужчин с множественным склерозом (МС). МЕТОДЫ: Мы изучили воздействие нагрева головы (при 44°C ± 0,5°C рядом с кожей) на мужчин с повторно излучающими эмиссию MS (n = 16; возраст: 31,8 ± 7,6 года) и здоровых мужчин (n = 18; возраст: 27,6 ± 4,3 года). Обе группы завершили местные испытания на отопление и контроль (1 неделя отдельно), включая 100 эпизод

Совпадение в аннотации оригинала
OBJECTIVE: This study aimed to evaluate whether localized heating of the head and neck, combined with prolonged submaximal exercise at a the … covery. RESULTS: Local heating inhibits central activation and reduces exercise-induced peripheral fatigue compared with non-heating conditions (p < 0.05) in men with MS. Head-neck heating led to a greater increase in Tmu during exercise in both groups. During high-intensity exercise (75 % MVC), local heating increased perceived effort in men with MS, im …

Changes in fatigue of Parkinson's disease during the recurrent COVID-19 pandemic: Findings from the longitudinal analysis of the PHASE study.

BACKGROUND: According to Japanese law, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the COVID-19 pandemic f … January and February in the following years: 2021, 2022, 2023, and 2024. RESULTS: The Parkinson's fatigue scale score in 2021 (mean: 35.3) increased significantly in 2022 (49.84), 2023 (49.33), and 2024 (54.71) (p < 0.001). After adjusting for baseline score using a mixed linear model with random intercept, the Parkinson's fatigue scale was significantl …

The effects of mental fatigue on fine motor performance in humans and its neural network connectivity mechanism: a dart throwing study.

While it is well known that mental fatigue impairs fine motor performance, the investigation into its neural basis remains scant. Here, we investigate the impact of mental fatigue on fine motor performance and explore its underlying neural network connectivity mechanisms. A total of 24 healthy male university students were recruited and randomly divided into two groups: a mental fatigue group (MF) and a control group (Control). Both groups completed 50 dart throws, while electroencephalography (EEG) data were collected. Following the Stroop intervention, participants in the MF group exhibited …

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea.

Cognitive impairment, depression and (mental) fatigue represent the most frequent neuropsychiatric symptoms of the post-COVID syndrome. Neuroinflammation, oxidative stress and mitochondrial dysfunction have been identified as common pathophysiological mechanisms underlying these symptoms. Attempts to treat post-COVID-associated cognitive impairment and fatigue with different drugs available for other diseases have not yet been successful. One probable explanation could be that these drugs work by one specific mechanism of action only and not in a broad multi-target way. Therefore, they will no…

Effects of Mat Pilates on quality of life, fatigue and body image in head and neck cancer survivors: a randomized clinical trial.

PURPOSE: To analyze the effect of a protocol based on the Mat Pilates method in an intervention group compared to a usual care control group, on quality of life, fatigue and body image of head and neck cancer survivors. METHODS: This was a randomized clinical trial with 30 survivors, allocated into an intervention group and a control group. The intervention group underwent a 12-week Mat Pilates, twice a week, one hour long, and the control group attended two lectures and received weekly follow-up throughout the study period. Data collection took place through individual face-to-face interview…

Benefits of a group-based running session on feelings of energy and fatigue: No augmenting effect of green exercise during the defoliation season.

This randomized controlled trial investigated the impact of a brief session of group-based running on feelings of energy and fatigue, comparing exercise in a local nature reserve versus an outdoor built environment, and a sedentary control condition. Sixty-six physically active university students participated, with 56 providing full data for each time point. Consistent with previous research, participants in both exercise groups reported significantly increased energy and decreased fatigue compared to those in the sedentary control group. However, the type of outdoor environment did not signi…

Feasibility of a novel blended-care intervention for fatigue after acquired brain injury: a pilot study of the Tied by Tiredness intervention.

PURPOSE: Evidence-based treatments for fatigue after brain injury are scarce and often not personalized. An approach to foster personalization is Experience Sampling Methodology (ESM), consisting of repeated daily measurements of fatigue and related factors in daily life. We investigated the feasibility and usability of a novel six-week ESM-based intervention for fatigue after brain injury. MATERIALS AND METHODS: Ten individuals with acquired brain injury (six men; four women) aged between 36-70 years (M = 53.3, SD = 12.9) used a mHealth application for three days each week during six-weeks; …

Higher Levels of Multiple Types of Stress Are Associated With Worse State Anxiety and Morning Fatigue Profiles in Patients Receiving Chemotherapy.

BACKGROUND: Anxiety and fatigue are common problems in patients receiving chemotherapy. Unrelieved stress is a potential cause for the co-occurrence of these symptoms. OBJECTIVES: The aims of this study were to identify subgroups of patients with distinct state anxiety and morning fatigue profiles and evaluate for differences among these subgroups in demographic and clinical characteristics, as well as measures of global, cancer-specific, and cumulative life stress and resilience and coping. METHODS: Patients (n = 1335) completed measures of state anxiety and morning fatigue 6 times over 2 c…

COVID-19 Anxiety and Mental Health in Healthcare Workers: Examining the Role of Compassion Fatigue During the Last Wave of the Pandemic.

OBJECTIVE: Pandemics have been shown to affect both physical and mental health, with healthcare workers (HCWs) bearing a particularly heavy burden. During the COVID-19 pandemic, HCWs faced a high volume of cases, extended work hours, and heightened pandemic-related stressors, which placed them at increased risk for mental health issues. This study examines the effects of COVID-19-related anxiety on HCWs' mental health, specifically exploring the roles of compassion fatigue (comprising burnout and secondary traumatic stress) as potential mediators in this relationship. METHOD: A sample of 104 …

The effects of two different fatigue protocols on movement quality during anticipated and unanticipated change of directions in female soccer players.

OBJECTIVE: This study compared neuromuscular control under two fatigue protocols during anticipated and unanticipated change of direction (COD) maneuvers and evaluated their effects on the risk of non-contact ACL injuries. METHOD: Forty-five female soccer players (mean age: 22.22 ± 2.24 years; mean height: 166.24 ± 3.33 cm; mean mass: 59.84 ± 5.03 kg) were divided into three groups: functional fatigue (Soccer specific fatigue ptotocol-SOFT90), non-functional fatigue (Bruce protocol), and control group. Before and after the implementation of neuromuscular control fatigue protocols were evaluat…

Age-related effects of neuromuscular fatigue and acute recovery responses on maximal and rapid torque measures of the leg extensors and flexors.

PURPOSE: To examine the effects of neuromuscular fatigue and recovery on maximal and rapid torque characteristics in young and old men for the leg extensors and flexors. METHODS: Twenty-one young (age = 24.8 years) and 19 old (72.1 years) men performed maximal voluntary contractions (MVCs) before and at 0, 7, 15, and 30 min following an intermittent submaximal fatigue task. Outcome measures included endurance time, maximal (peak torque; PT) and rapid (absolute and normalized rate of torque development; RTD and nRTD) torque characteristics. RESULTS: The old men had greater endurance times tha…

A pilot randomized controlled trial of a yoga program for alleviating cancer-related fatigue and psychological distress in women with gynecological cancer.

PURPOSE: Yoga can alleviate cancer-related fatigue and psychological distress while improving health-related quality of life. However, most studies focused on breast cancer. This study aimed to evaluate the feasibility and acceptability of a yoga program for women with gynecological cancer and estimate its preliminary effects on cancer-related fatigue, psychological distress, and health-related quality of life. METHODS: This pilot study used a single-blinded randomized controlled trial design. Participants in the intervention group received the yoga program and usual care, while the control g…

[Dose-effect relationship of moxibustion for rheumatoid arthritis of liver and kidney deficiency and its effect on fatigue: a randomized controlled trial].

OBJECTIVE: To observe the effects of moxibustion with different frequency on the disease activity and fatigue of rheumatoid arthritis (RA) with liver and kidney deficiency on the basis of western medication treatment. METHODS: A total of 135 RA patients with liver and kidney deficiency were randomly divided into a high-frequency moxibustion group (45 cases, 3 cases dropped out), a low-frequency moxibustion group (45 cases, 2 cases dropped out) and a western medication group (45 cases, 2 cases dropped out, 1 case discontinued). Leflunomide tablet was taken orally in the western medication grou…