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Сегментация с искусственным интеллектом и автоматизированный расчет индекса каллосу с корпусом при множественном склерозе.

ЦЕЛИ: Определить различия в индексе каллосум с корпусом (ККИ) между пациентами, страдающими хроническим множественным склерозом (MS), и здоровыми людьми, а также оценить сегментацию каллосумов с корпусом у пациентов с КБ с использованием технологий искусственного интеллекта. CCI может быть надежно измерен на магнитно-резонансной съемке (MRI) и предложен в качестве возможного маркера атрофии мозга в MS. В ходе этого исследования были сканированы 150 пациентов, страдающих МЗ (продолжительность болезни - 12,6 5,9 года), и 150 здоровых пациентов. Индекс corpus callosum был измерен вручную на основ

Percutaneous vertebroplasty and interventional tumor removal for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement: a prospective pilot study.

ObjectiveThe aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement.Patients and methodsA total of 124 patients were selected for PVP and ITR (n = 71, group A) and PVP alone (n = 53, group B). A 14 G needle and guide wire were inserted into the vertebral body, followed by sequential dilatation of the tract until the last cannula reached the anterior portion of the pedicle. Tumors were then ablated with a radiof

Co-Encapsulation of Multiple Antineoplastic Agents in Liposomes by Exploring Microfluidics.

The inherent complexity of cancer proliferation and malignancy cannot be addressed by the conventional approach of relying on high doses of a single powerful anticancer agent, which is associated with poor efficacy, higher toxicity, and the development of drug resistance. Multiple drug therapy (MDT) rationally designed to target tumor heterogeneity, block alternative survival pathways, modulate the tumor microenvironment, and reduce toxicities would be a viable solution against cancer. Liposomes are the most suitable carrier for anticancer MDT due to their ability to encapsulate both hydrophil

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial.

CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65-79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) nega

A systematic literature review of the assessment of treatment burden experienced by patients and their caregivers.

BackgroundMany older adults with multiple chronic conditions, particularly those who are functionally impaired, spend considerable time juggling the competing demands of managing their conditions often assisted by caregivers. We examined methods of assessing the treatment burden experienced by this population as a first step to identifying strategies to reduce it.MethodsSystematic searches were performed of the peer-reviewed and grey-literature (PubMed, Cochrane library, CINAHL, EMBASE, Web of Science, SCOPUS, New York Academy of Medicine Grey Literature Review, NLM catalog and ProQuest Digita

Use of a Chemotherapy Toxicity Prediction Tool to Decrease Risks for Hospitalization in Older Patients.

Objectives Performance status (PS) scales such as the Eastern Cooperative Oncology Group (ECOG) PS and the Karnofsky Performance Index have limited utility in selecting therapies and predicting related adverse events in older patients with cancer. In July 2016, medical oncologists at our institution adopted the Cancer and Aging Research Group toxicity prediction score (CARG), a toxicity prediction tool, to identify patients who are "fit" for chemotherapy versus those who are "frail" and may experience severe complications. Methods Our retrospective review included referrals of beneficiaries 75

Surrogate endpoints in mature B-cell neoplasms - meaningful or misleading?

Indolent mature B-cell neoplasms are a group of diseases in which recent therapeutic advances have led to an improved overall survival (OS) extending beyond several years. While cause of celebration for patients and caregivers, the increasingly long observation periods necessary to capture treatment effects are complicating trial design and possibly hindering swift access to more effective therapies. Surrogate endpoints are a tool with the potential of earlier study readouts, however, their validity needs to be proven in each individual disease and therapeutic setting. The validation of surrog

Management of multiple myeloma during COVID-19 pandemic.

At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic. The virus that causes COVID-19 is designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In February 2020, the World Health Organization designated the disease COVID-19, which stands for coronavirus disease 2019.

Прогнозирующее значение SGK1: Ретроспективное исследование в одном центре.

Цель Это исследование направлено на оценку прогнозируемого значения сыворотки/глюкокортикоидной киназы 1 (SGK1) выражение в периферийных моноядерных клетках крови (PBMC) нескольких миеломных (MM) лиц, проходящих автологическую трансплантацию гематопоиетических стволовых клеток (AHSCT) по сравнению с традиционными минимальными остаточными заболеваниями (MRD) и оценками бесперебойной цепи света (SFLC). 85 Лица, которые прошли курс AHSCT. Выражение генов SGK1 измерялось в PBMC с использованием количественных ПЦР в режиме реального времени (qRT-PCR) в исходных условиях и в определенных интервалах

Клиникопатологические характеристики и результаты недиабетических реалистических заболеваний у пациентов с типом 2 Диабет: Ретроспективное кохартное исследование.

В рамках этого исследования была проведена оценка клиникопатологических профилей и прогностических траекторий подтипов недиабутических почечных заболеваний (NDRD), соотносящихся с типом 2 - сахарный диабет (T2D). 123 пациенты с доминирующими подтипами NDRD: IgA нефропатия (IgA nephropaticy)T2D-IgAN, n = 52), мембранная нефропатия (T2D-MN, n = 48), и подоцитопатии ()T2D-Podo, n = 23). Мультивариатная коксовая регрессия использовалась для выявления прогнозируемых факторов для результатов почечной деятельности в течение медианного периода последующей деятельности: 80 месяцев (межквартальный диапа

гинекологическое здоровье: недостающее звено во всеобъемлющем мониторинге лечения множественных склерозов.

Мониторинг безопасности методов лечения болезней (ДМТ), используемых для лечения множественных склерозов (МС), в значительной степени не учитывает область гинекологического здоровья. Цель этого тематического обзора состоит в том, чтобы предоставить врачам по НР обзор трех категорий осложнений, описанных на сегодняшний день, а также стратегий уменьшения рисков. К ним относятся повышенный риск позитивности вируса папилломы человека (ВПВ) и связанных с ним шейных дисплазий/канцеров; подстрекательский и инфекционный вагинит и подверженность бактериальному вагинозу (ВВ); и герпесвирусные инфекции,

Treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty.

BACKGROUND: In oncologic patients with metastatic spinal disease, the ideal treatment should be well tolerated, relieve the pain, and preserve or restore the neurological function.The combination of fluoroscopic guided radiofrequency ablation (RFA) and kyphoplasty may fulfill these criteria. METHODS: We describe three pathological vertebral fractures treated with a combination of fluoroscopic guided RFA and kyphoplasty in one session: a 62-year-old man suffering from a painful L4 pathological fracture due to a plasmocytoma, a 68-year-old man with a T12 pathological fracture from metastatic he

Construction of CXCR4 Receptor-Targeted CuFeSe2 Nano Theranostic Platform and Its Application in MR/CT Dual Model Imaging and Photothermal Therapy.

INTRODUCTION: Targeting, imaging, and treating tumors represent major clinical challenges. Developing effective theranostic agents to address these issues is an urgent need. METHODS: We introduce an "all-in-one" tumor-targeted theranostic platform using CuFeSe2-based composite nanoparticles (CuFeSe2@PA) for magnetic resonance (MR) and computed tomography (CT) dual model imaging-guided hyperthermia tumor ablation. Plerixafor (AMD3100) is bonded to the surface of CuFeSe2 as a targeting unit. Due to the robust interaction between AMD3100 and the overexpressed Chemokine CXC type receptor 4 (CXCR4

Effects of bisphosphonates after denosumab discontinuation and treatment effect heterogeneity using causal machine learning.

Discontinuation of denosumab is associated with a rebound increase in osteoporotic fracture (OF) risk, and bisphosphonates (BPs) are commonly recommended as sequential therapy to mitigate this risk. However, their real-world effectiveness-and whether certain patients benefit more than others-remains unclear. To address this question, we employed a causal machine learning approach capable of estimating heterogeneous treatment effects. We conducted a nationwide retrospective cohort study using Korean health insurance claims data and applied the causal survival forest model to evaluate the effect

Determinants of Overall and Readmission-Free Survival in Patients with Metastatic Epidural Spinal Cord Compression.

BACKGROUND: The aim of this study was to assess the surgical outcomes and survival of patients surgically treated for metastatic epidural spinal cord compression (MESCC), with a specific focus on identifying factors that influence overall survival and readmission-free survival. METHODS: All patients who underwent surgery for spine metastases at our department in the period 2018-2022 were included in the study. RESULTS: A total of 175 patients (n = 71 females, median age 67.15 years) were included. The most common primary tumors were lung carcinoma (n = 31), prostate carcinoma (n = 31), breas

Review of health-related quality of life data in multiple myeloma patients treated with novel agents.

In multiple myeloma (MM), health-related quality of life (HRQoL) data is becoming increasingly important, owing to improved survival outcomes and the impact of treatment-related toxicity on HRQoL. Researchers are more frequently including HRQoL assessments in clinical trials, but analysis and reporting of this data has not been consistent. A systematic literature review assessed the effect of novel agents (thalidomide, bortezomib and lenalidomide) on HRQoL in MM patients, and evaluated the subsequent reporting of these HRQoL results. A relatively small body of literature addresses HRQoL data i

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… Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;24:547–561. doi: 10.1016/s0885-3924(02)00529-8. …

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Trends in descriptions of palliative care in the cancer clinical practice guidelines before and after enactment of the Cancer Control Act (2007): content analysis.

BackgroundPalliative care was a priority issue in the Cancer Control Act enacted in 2007 in Japan, and this has resulted in efforts being made toward educational goals in clinical settings. An investigation of how descriptions of palliative care for the treatment of cancer have changed in clinical practice guidelines (CPGs) could be expected to provide a better understanding of palliative care-related decision-making. This study aimed to identify trends in descriptions of palliative care in cancer CPGs in Japan before and after enactment of the Cancer Control Act.MethodsContent analysis was us

Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.

PurposeTo evaluate the effects of physical exercise on key clinical outcomes (such as quality of life (QoL), aerobic capacity, fatigue, and muscle strength) in patients undergoing haematopoietic stem cell transplantation.MethodsPRISMA systematic review and meta-analysis from inception to April 2025. PubMed, Embase, Cochrane Library, Web of Science and Scopus databases were searched for eligible studies. Methodological quality and risk of bias were evaluated with the Pedro scale and the Risk-Of-Bias Tool for randomized trials (ROB2.0) respectively.ResultsAn initial search retrieved 5217 article

The surgical management and treatment of metastatic lesions in the proximal femur: A mini review.

Review current treatments of metastatic lesions in the proximal femur.We reviewed published literature related to diagnosis and surgical treatments and summarized current treatment options.Surgical management mainly consist of internal fixation, hip replacement, and percutaneous femoroplasty (PFP) which has been newly applied in clinical practice.An appropriate series of treatments is necessary for patients to avoid the occurrence of paraplegia and prolong survival time.