Результаты поиска

A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer.

PURPOSE: To evaluate the efficacy and safety of docetaxel in patients with paclitaxel-resistant metastatic breast cancer (MBC). PATIENTS AN … vere) adverse events included neutropenic fever (24% of patients), asthenia (22%), infection (13%), stomatitis (9%), neurosensory changes (7%), myalgia (7%), and diarrhea (7%). CONCLUSION: Docetaxel is active in patients with paclitaxel-resistant breast cancer, particularly in those who failed to respond to brief infusions of paclitaxel. Response rates were …

On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.

The role of the spleen and of other organized secondary lymphoid organs for the induction of protective antiviral immune responses was evaluated in orphan homeobox gene 11 knockout mice (Hox11(-/-)) lacking the spleen, and in homozygous alymphoplastic mutant mice (aly/aly) possessing a structurally altered spleen but lacking lymph nodes and Peyer's patches. Absence of the spleen had no major effects on the immune response, other than delaying the antibody response by 1-2 d. In aly/aly mice, the thymus-independent IgM response against vesicular stomatitis virus (VSV) was delayed and reduced, wh…

Phase II study of ketoconazole combined with weekly doxorubicin in patients with androgen-independent prostate cancer.

PURPOSE: A phase II clinical trial was performed to assess the antitumor activity and toxicity of ketoconazole in combination with doxorubic … sclerotic heart disease had a sudden cardiac death. Serious toxic reactions included grade III to V stomatitis and grade III to IV acral erythema in 11 patients (29%), and grade III to IV anal and urethral mucositis in five patients (13%). Grade III to IV neutropenia occurred in 11 patients (29%). Seventeen patients (45%) required hospitalization for complic …

Induction of protective cytotoxic T cells with viral proteins.

Induction of CD8+, class I-restricted T cells by non-infectious, exogenous antigens has been documented for model protein antigens such as o … n and nucleoprotein of lymphocytic choriomeningitis virus (LCMV) and the nucleoprotein of vesicular stomatitis virus (VSV). These viral proteins induced cytotoxic T cells in a T helper cell-independent fashion which lysed infected target cells in vitro and protected mice from viral replication, immunopathological disease and growth of a tumor expressing the …

Susceptibility of the Sf9 insect cell line to infection with adventitious viruses.

Sf9, the insect cell line commonly used for gene expression by recombinant baculovirus (BV), can be infected by St. Louis encephalitis (SLE) virus, a flavivirus, resulting in a persistent, productive, and cytopathic infection, while retaining the ability to be infected with a recombinant baculovirus (rBV). We now demonstrate using double immunofluorescence that single cells are dually infected with SLE virus and rBV. Fourteen additional viruses including additional flaviviruses, other arbovirus classes, vesicular stomatitis virus (VSV), and herpes simplex virus, type 1 (HSV-1) failed to produc…

The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation--data on four cases and review of the literature.

Two women and two men were infected with the human immunodeficiency virus type 1 (HIV-1) transmitted by renal transplantation from i.v. drug-addicted donors in 1984. The four recipients were treated with cyclosporine and methylprednisolone (one patient only for three months because of early graft failure). Two patients died 66 and 74 months after transplantation, one of endocarditis and one of cerebral hemorrhage. Despite several infections including urinary tract infection (n = 8), peritonitis (n = 1), shunt infection (n = 1), bronchitis (n = 1), salmonellosis (n = 1), herpes stomatitis (n = …

Isolation of feline calicivirus and feline herpesvirus from domestic cats 1980 to 1989.

Isolation rates of feline herpesvirus (FHV) and feline calicivirus (FCV) from oropharyngeal swabs, taken from 6866 cats in 1980 to 1989 were … y two (1.7 per cent). FHV was not isolated from any of 412 cases presenting with chronic gingivitis/stomatitis alone; 181 (43.9 per cent) were shedding FCV and when cats with other signs in addition to chronic gingivitis were included, this proportion increased to 70.4 per cent.(ABSTRACT TRUNCATED AT 250 WORDS)

Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas.

Ninety-eight patients with previously-treated advanced soft tissue sarcoma, bone sarcoma, or mesothelioma were randomly assigned to one of t … g toxicities, and severe toxicities resulting from this treatment included nausea and emesis (10%), stomatitis (2%), gastrointestinal toxicity (2%), and anemia (2%). Moderate toxicities included vomiting (24%), hematologic toxicity (24%), neurologic toxicity (7%), diarrhea (7%), mucositis (5%), fever (5%), palpitations (2%), hepatotoxicity (2%), bleeding (2% …

Принуждение циклоспорина А к иммунитету от вирусов в vivo и in vitro с помощью мюрин T-cell.

Был изучен иммуноподавляющий эффект Cyclosporin A на антивирусную реакцию с помощью клеток Т. При вводе внутриперитонального вируса CS-A была отменена антивациния, антилимфоцитный хориомингит (LCMV) и антивесикулярный стоматит (VSV) T-клектовая реакция в зависимости от дозы. Как правило, 50-60 мг/кг были эффективными в деле полного пресечения реакции первичных Т-клеток. В отличие от этого 10-20 мг/кг часто значительно повышают чувствительность Т-клеток по сравнению с мерами контроля. Было отмечено, что лечение CS-A начинается до инъекции вируса и до 12 часов после инфекции; CS-A получает 24 ча

Совпадение в аннотации оригинала
The immunosuppressive effect of Cyclosporin A on T-cell-mediated antiviral immune responses was examined. When administered intraperitoneally CS-A abrogated anti-vaccinia virus, anti-lymphocytic choriomeningitis virus (LCMV), and anti-vesicular stomatitis virus (VSV) T-cell responses in a dose-dependent fashion. Usually 50-60 mg/kg were efficient in suppress…

N-(phosphonacetyl)-L-aspartate (PALA) in advanced soft tissue sarcoma: a phase II trial of the EORTC soft tissue sarcoma group.

Thirty-six patients with measurable or evaluable advanced soft tissue sarcoma were entered in a phase II trial with PALA. Among the 27 evalu … Toxic effects were generally mild to moderate and included cutaneous toxicity (17), diarrhea (14), stomatitis (13), ocular manifestations, consisting of conjunctivitis, corneal ulceration and/or photophobia (11), nausea and vomiting (6) and, possibly, seizures (2). There was no evidence of drug-related myelosuppression. It is concluded that PALA given at th …

Reduced Morphine Consumption with Photobiomodulation in Head and Neck Cancer: A Matched Cohort of 280 Cases.

INTRODUCTION: Radiation-induced oral mucositis (RIOM) may cause severe pain and impaired quality of life during head and neck radiotherapy (RT). Preventive photobiomodulation (PBM) has shown promising clinical benefits. MATERIALS AND METHODS: Eligible patients had oropharyngeal or oral cavity cancer and were opioid-naïve at the start of curative-intent RT. Patients in the PBM group were treated between 2020 and 2023. PBM was applied to the entire oral mucosa at 2.25 J/cm2 (λ = 660 nm). Extraoral PBM was delivered using an LED cluster device at 6 J/cm2 (λ = 810 nm) to target the pharyngolaryng

Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a detailed safety analysis of the randomized OptiTROP-Breast01 study.

BACKGROUND: Sacituzumab tirumotecan (sac-TMT) is a novel anti-trophoblast cell-surface antigen 2 antibody-drug conjugate and has been approv … emphasis was placed on hematologic toxicities (including anemia, neutropenia, thrombocytopenia) and stomatitis, which were defined as key AEs in this study. RESULTS: 262 patients (130 for sac-TMT, 132 for TPC) were included. Median time to the onset of grade 3 or higher key AEs primarily occurred within the first two cycles. Most patients with key AEs in th …

Oral mucositis secondary to datopotamab deruxtecan for advanced-stage cancer managed with cryotherapy after topical steroid failure: A case series study.

BACKGROUND: Datopotamab deruxtecan (Dato-DXd) is a trophoblast cell surface antigen 2-directed antibody-drug conjugate (ADC) approved for the treatment of unresectable, metastatic, hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancers, and previously treated metastatic epidermal growth factor receptor-positive non-small cell lung cancers. Despite its considerable success in clinical oncology, ADC therapy can lead to severe adverse events, including oral mucositis (OM), which can negatively affect patients' quality of life and threaten patients' ability to

Circulating Plasma miRNA-548L as Novel Predictive Biomarker of Radiotherapy-Induced Severe Oral Mucositis in Patients with Laryngeal Cancer.

Background/Objectives: Oral mucositis (OM) is a common complication in laryngeal cancer (LC), during radiotherapy (RT), significantly affecting patient outcomes. Identifying sensitive biomarkers to predict OM severity is therefore crucial. MicroRNAs, which regulate inflammatory pathways involved in OM, are promising candidates. This retrospective study aimed to evaluate plasma miRNA-548L as a predictive biomarker for the occurrence and severity of OM in LC patients undergoing RT. Methods: The expression levels of the selected miRNAs were analyzed in plasma samples obtained from 76 LC patients

Multifunctional selenium nanoplatforms for synergistic ferroptosis inhibition and immune microenvironment remodeling in oral mucositis.

Oral mucositis (OM) is a common inflammatory disorder characterized by epithelial barrier destruction, uncontrolled inflammation, and impaired mucosal repair. Despite the complex tissue microenvironment in OM, which is driven by interconnected pathological processes, current therapeutic approaches are hindered by their predominant focus on single factors. In this study, we identified ferroptosis as a key driver of OM progression through clinical sample analysis and mechanistic validation, revealing that disrupted selenium metabolism and decreased Glutathione Peroxidase 4 (GPX4) expression prom

Effectiveness of oral cryotherapy in preventing methotrexate-induced oral mucositis in pediatric patients with acute lymphoblastic leukemia: a randomized controlled trial.

PURPOSE: To evaluate whether oral cryotherapy (OC) using ice-cold saline reduces the incidence and severity of high-dose methotrexate (HD-MTX)-induced oral mucositis (OM) in children with acute lymphoblastic leukemia (ALL). METHODS: This single-center, open-label, parallel-group randomized controlled trial (RCT) enrolled children aged 3-18 years with ALL undergoing consolidation therapy with HD-MTX. Participants were randomly assigned (1:1) to either OC (ice-cold saline oral rinses) or standard oral care alone. HD-MTX was administered at doses of 3 g/m2 or 5 g/m2 over 24 h. The primary outcom

[Clinical analysis of 11 cases of oral adverse reactions associated with novel anti-tumor drugs].

Objective: To analyze the clinical characteristics of oral adverse reactions associated with novel anti-tumor drugs, providing references for early diagnosis and treatment to improve cancer patients' qualities of life and therapeutic efficacies. Methods: Clinical data and photographs of 11 tumor patients treated at Beijing Hospital from January 2020 to April 2025, who developed oral adverse reactions after receiving targeted therapy, antibody-drug conjugates (ADC), or immune checkpoint inhibitor (ICI), were collected. A retrospective analysis was conducted to summarize the clinical characteris

Long-Term Clinical Consequences of Severe Oral Mucositis in Survivors of Lip, Oral Cavity, and Pharynx Cancer Versus Leukemia: A Propensity-Score-Matched Comparative Cohort Study Using Real-World Data.

BACKGROUND/OBJECTIVES: Severe oral mucositis is widely viewed as a transient toxicity of antineoplastic therapy. Whether its long-term consequences differ between cancers that directly damage the upper aerodigestive tract (cancers of the lip, oral cavity, pharynx [CLOP]) and systemic hematologic malignancies is unknown. The aim of this study was to compare lifetime risks of mortality, dysphagia, malnutrition, respiratory disease, and cardiovascular disease in propensity-score-matched survivors of CLOP cancer versus leukemia with and without a history of ulcerative oral mucositis. METHODS: Pop

Comparative efficacy of two photobiomodulation protocols transcutaneous versus intraoral in the prevention of oral mucositis in head and neck cancer: a randomized study protocol.

UNLABELLED: This study aims to compare the clinical efficacy of transcutaneous photobiomodulation (PBMT) with an 808 nm infrared laser versus intraoral PBMT with a 660 nm red laser in the prevention of oral mucositis (OM). The study is designed to assess whether the transcutaneous approach is non-inferior to the intraoral standard, thereby contributing to the optimization and standardization of PBMT protocols in head and neck cancer (HNC) supportive care. METHODS: A randomized pilot study is being conducted with 54 patients (n = 27 per group) undergoing radiotherapy (60-70 Gy) for HNC. Partic

A rare case of cytomegalovirus mucositis resembling an immune-related adverse event during treatment with nivolumab and ipilimumab.

Immune checkpoint inhibitor (ICI) therapy may be accompanied by immune-related adverse events (irAEs). Severe irAEs frequently require immunosuppressive treatment with high-dose corticosteroids and, in refractory cases, additional agents such as infliximab. Under these circumstances, patients may become susceptible to opportunistic infections, including cytomegalovirus (CMV), which can present with clinical features closely resembling irAEs. We report the case of a 79-year-old man with malignant melanoma of the sphenoid sinus who was treated using nivolumab and ipilimumab. He developed immune-