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Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion.

PURPOSE: To determine the efficacy of epithelial debridement and diamond burr polishing (ED + DBP) in managing recurrent corneal erosion (RCE) and visually significant epithelial irregularity associated with epithelial basement membrane dystrophy (VS-EBMD). METHODS: Retrospective, interventional, consecutive case series of all ED + DBP procedures performed between December 1, 2002, and December 1, 2014. RESULTS: ED + DBP was performed in 91 eyes (66 patients) for the management of RCE and VS-EBMD. Sixty percent (55/91) of the procedures were performed for RCE, of which 65% (36/55) were assoc…

Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients.

Diamond Blackfan Anemia (DBA) is a congenital anemia usually caused by diverse mutations in ribosomal proteins. Although the genetics of DBA are well characterized, the mechanisms that lead to macrocytic anemia remain unclear. We systematically analyzed the proteomes of red blood cell membranes from multiple DBA patients to determine whether abnormalities in protein translation or erythropoiesis contribute to the observed macrocytosis or alterations in the mature red blood cell membrane. In depth proteome analysis of red cell membranes enabled highly reproducible identification and quantitativ…

Gape size, its morphological basis, and the validity of gape indices in western diamond-backed rattlesnakes (Crotalus atrox).

Maximum gape is important to the ecology and evolution of many vertebrates, particularly gape-limited predators, because it can restrict the sizes and shapes of prey that can be eaten. Although many cranial elements probably contribute to gape, it is typically estimated from jaw length or jaw width, or occasionally from a combination of these two measures. We measured maximum gape directly for 18 individuals of the western diamond-backed rattlesnake, Crotalus atrox. We measured each individual's body length, several external cranial dimensions, several cranial osteological dimensions from clea…

Углеродные бриллиантовые покрытия для хирургических инструментов сокращают количество белков и прионово-амилоидных биообращений и улучшают последующую очистку.

Углеродные углеродные покрытия (DLC) могут быть противообрастающими поверхностями против микробных и белковых соединений. В частности, хирургические инструменты из нержавеющей стали подвергаются воздействию тканевого белка и стойкого прионного белка, что делает неэффективными методы обеззараживания, используемые в стерильных отделениях обслуживания, что потенциально повышает риск ятрогенического креуцфельда-Якоба во время хирургических операций. В ходе этого исследования были проанализированы адсорбция белков и амилоидов, связанных с прионом, на поверхностях ДКН и эффективность коммерческих чи

Совпадение в аннотации оригинала
Doped diamond-like carbon (DLC) coatings offer potential antifouling surfaces against microbial and protein attachment. In particular, stainless steel surgical instruments are subject to tissue protein and resilient prion protein attachment, making decontamination methods used in sterile service departments ineffective, potentially increasing the risk of iat…

Cleft palate, bilateral external auditory canal atresia, and other midline defects associated with Diamond-Blackfan anemia: case report.

Diamond-Blackfan anemia (DBA) is associated with congenital anomalies especially of the midline. When present, facial anomalies are reminiscent of Treacher-Collins syndrome, and both DBA and Treacher-Collins syndrome are disorders of ribosomal biogenesis. Herein, we describe a female infant with multiple midline defects associated with DBA and reaffirm the absence of RPS-19 mutations in DBA patients with facial anomalies.

Minimizing Risk in Scleral Buckle Surgery: A Novel Approach to Belt Loop Creation Using a Guarded Diamond Blade.

PURPOSE: To describe a novel technique for scleral belt loop formation during scleral buckle (SB) surgery using a guarded diamond limbal relaxing incision (LRI) blade to minimize the risk of scleral perforation and improve groove consistency. METHODS: A conventional scleral buckle procedure was performed for rhegmatogenous retinal detachment (RRD) with the placement of a #240 encircling band. Four partial-thickness scleral grooves were created in each quadrant using a guarded diamond LRI blade with a preset depth of 150 µm. The band was passed through the resulting belt loops and secured with…

Clinical Outcomes Following Diamond Burr Debridement of Spontaneous Chronic Corneal Epithelial Defects: A Retrospective Study of 521 Dogs.

OBJECTIVE: To evaluate clinical outcomes following diamond burr debridement (DBD) of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs, and to identify predisposing factors and treatment choices that may affect outcomes. ANIMALS STUDIED: Medical records of dogs treated for SCCED by DBD between January 2018 and May 2023 at an ophthalmology referral centre were retrospectively reviewed. PROCEDURE: Data collected included breed, age, eye affected, prior treatment, co-morbidities, treatment after the DBD procedure, time to healing, further procedures, and complications. Outcomes we…

Portable single-step ethanolamine-functionalized boron-doped diamond immunosensor for dual detection of CEA and CYFRA 21-1.

A single-step ethanolamine-functionalized boron-doped diamond (BDD) immunosensor for the dual detection of carcinoembryonic antigen (CEA) and cytokeratin fragment 21-1 (CYFRA 21-1). Unlike conventional multi-step carbodiimide-based coupling strategies, the ethanolamine (ETA) modification provides a simplified amine-terminated surface for efficient antibody immobilization. Comprehensive characterization confirmed successful layer-by-layer assembly: scanning electron microscopy (SEM) revealed surface morphological evolution, while X-ray photoelectron spectroscopy (XPS), Contact angle measurement…

Dual FLT3/PIM inhibitor dapolsertib in acute myeloid leukemia: results from the phase 1/2 DIAMOND-01 trial.

Acute myeloid leukemia (AML) is an aggressive hematopoietic cancer with poor survival outcomes. Despite improvements with recent FMS-like tyrosine kinase 3 (FLT3) inhibitors, resistance is common, and responses are short. Dapolsertib (MEN1703) is a novel, first-in-class dual inhibitor of PIM (proviral integration site for Moloney murine leukemia virus) and FLT3 kinases, with activity in both FLT3-mutated and wild-type cells. A phase 1/2 open-label, multicenter, dose-escalation study (DIAMOND-01) investigated the maximum tolerated dose (MTD) of single-agent dapolsertib and assessed its safety, …

Efficacy and safety of novel topical pigment-correcting regimen with biweekly diamond tip microdermabrasion procedures on facial hyperpigmentation.

BACKGROUND: Facial hyperpigmentation can negatively affect an individual's emotional and psychosocial well-being. AIMS: Assess safety and tolerability of a combination of microdermabrasion (DG) procedures using a novel brightening pro-infusion serum (EC-DG) with a targeted at-home treatment regimen in subjects with mild to severe facial hyperpigmentation, including melasma, post-inflammatory hyperpigmentation, and dark spots. PATIENTS/METHODS: This 12-week, open-label study enrolled 18 subjects (Fitzpatrick skin types I-IV) who underwent 6 in-office DG procedures with EC-DG (one procedure ad

Compensatory gastric stretching following subtotal gastric resection due to gastric adenocarcinoma in a diamond python (Morelia spilota spilota).

CASE REPORT: A 7-year-old male diamond python (Morelia spilota spilota) presented with a 2-month history of anorexia and a discrete intracoelomic mass, approximately 15 cm in length, located 90 cm from the head and approximately two-thirds of the snout to vent length. Physical examination determined the mass was likely to be stomach, testes or the right kidney. Radiographs showed a soft tissue opacity mass in the region of the stomach; fine needle aspirate demonstrated cellular debris admixed with bacteria and degenerate heterophils. Exploratory coeliotomy revealed a gastric mass involving 90%…

Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia.

BACKGROUND: Diamond-Blackfan anemia (DBA) was the first ribosomopathy associated with mutations in ribosome protein (RP) genes. The clinical phenotypes of DBA include failure of erythropoiesis, congenital anomalies and cancer predisposition. Mutations in RPL5 are reported in approximately 9 ~ 21 % of DBA patients, which represents the most common pathological condition related to a large-subunit ribosomal protein. However, it remains unclear how RPL5 downregulation results in severe phenotypes of this disease. RESULTS: In this study, we generated a zebrafish model of DBA with RPL5 morphants a…

Abnormal circumferential strain measured by echocardiography is present in patients with Shwachman-Diamond syndrome despite normal shortening fraction.

BACKGROUND: Shwachman-Diamond Syndrome (SDS) is an autosomal recessive disorder characterized by bone marrow failure and exocrine pancreatic dysfunction. Heart failure has been described in patients with SDS. Circumferential strain (ε(cc)) is a measure of cardiac performance that may identify dysfunction when standard measures are normal. PROCEDURES: Patients with SDS were identified and the echocardiographic database queried. Cardiac anatomy and function were recorded, and ε(cc) was measured retrospectively. RESULTS: From 1995-2013, 27 patients with biallelic SBDS mutations confirming the d…

Electrochemical incineration of diclofenac in neutral aqueous medium by anodic oxidation using Pt and boron-doped diamond anodes.

The degradation of diclofenac, a common non-steroidal anti-inflammatory drug, in aqueous medium has been studied by anodic oxidation (AO) using an undivided cell with a Pt or boron-doped diamond (BDD) anode. Operating without pH regulation, AO with Pt acidifies the solution with precipitation of its protonated form, whereas using BDD, the solution becomes alkaline and only attains partial mineralization. Total incineration of low contents of the drug is feasible by AO with BDD in a neutral buffer medium of pH 6.5. Comparative treatment with Pt gives poor decontamination. The diclofenac decay a…

Influence of the Structure of Perfluoroalkylsilanes Self-Assembled Monolayers on Tribological Properties of TiOx-Incorporated Diamond-like Carbon Coatings.

This paper reports the effects of formed perfluoroalkylsilane self-assembled monolayers (SAMs) on the tribological and corrosion properties of TiOx-incorporated diamond-like carbon (TiOx-DLC) coatings deposited on a Ti6Al4V substrate. The SAMs were formed using 1H,1H,2H,2H -perfluorodecyltrichlorosilane (FDTS) and (3,3,3 -trifluoropropyl) trichlorosilane (FPTS) compounds. Their presence was confirmed using techniques such as ellipsometry, time-of-flight secondary ion mass spectrometry, and Fourier-transform infrared spectroscopy. The results of the ball-on-disc test indicate the role of the st…

Characteristics of In Vivo Lesion Formation With a Temperature-Controlled Diamond-Tip Radiofrequency Ablation Catheter in the Ventricle: A Preclinical Model.

BACKGROUND: Power-controlled radiofrequency ablation with irrigated-tip catheters has been the norm for ventricular ablation for almost 2 de … re delivered with a temperature-controlled radiofrequency system utilizing a chemical vapor deposit diamond for efficient thermal diffusivity. In phase I, 17 ablation settings were tested (temperature set points, 50/60/70 °C; ablation duration, 15/30/60/90/120 s; and power limit, 30/50 W). Four and one of these sets of parameters were further tested in ph …

Polycrystalline Diamond as a Potential Material for the Hard-on-Hard Bearing of Total Hip Prosthesis: Von Mises Stress Analysis.

Due to polymeric wear debris causing osteolysis from polymer, metal ions causing metallosis from metal, and brittle characteristic causing fracture failure from ceramic in the application on bearing of total hip prosthesis requires the availability of new material options as a solution to these problems. Polycrystalline diamond (PCD) has the potential to become the selected material for hard-on-hard bearing in view of its advantages in terms of mechanical properties and biocompatibility. The present study contributes to confirming the potential of PCD to replace metals and ceramics for hard-on…

Depletion of the Shwachman-Diamond syndrome gene product, SBDS, leads to growth inhibition and increased expression of OPG and VEGF-A.

Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by bone marrow failure and leukemia predisposition, pancreatic exocrine dysfunction, and skeletal abnormalities, manifesting as skeletal dysplasia and osteoporosis. Mutations in SBDS have been shown to cause SDS, but the function of the SBDS gene product is unclear. Accelerated angiogenesis has recently been described in bone marrow cells from SDS patients. To clarify the unknown function of SBDS, we performed experiments analyzing the cellular effects of depleting SBDS by RNA interference. The growth of HeLa cel…

Preparation time and sealing effect of cavities prepared by an ultrasonic device and a high-speed diamond rotary cutting system.

The purpose of this study was to compare a high-speed handpiece to an ultrasonic device regarding the time taken for cavity preparation in bovine incisor teeth (n = 12), and to evaluate microleakage after the restorations. Two cylindrical cavities each were prepared on the labial surfaces of 12 teeth. One of them was made with a diamond tip in group 1 (G(1) = 12) coupled with a high-speed handpiece, and the other with a chemical vapor deposition (CVD) tip in group 2 (G(2) = 12) coupled with an ultra-sound device (n = 24). The time taken for each preparation was measured with a stopwatch. The c…