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Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.

BACKGROUND: Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as mono … ired to assess the clinical effectiveness and cost-effectiveness of other new treatments, including lacosamide and perampanel. CONCLUSIONS: Focal epilepsy - The SANAD II findings do not support the use of levetiracetam or zonisamide as first-line treatments in focal epilepsy. Generalised and unclassifiable epilepsy - The SANAD II findings do not support the …

Антиконвульсантная терапия в тригеминальной невралгии: системный обзор класса.

Фон/цели Trigemenal Neuralgia (TN) — хроническое нервное заболевание, характеризующееся внезапной, сильной болью в лице. Антиконвульсанты являются краеугольным камнем фармакологического управления, однако сравнительных данных, основанных на фармакологическом классе, по-прежнему недостаточно. Этот систематический обзор был направлен на оценку эффективности и безопасности антиконвульсантов в TN, стратифицированных их механизмом действий. 2020 Руководящие принципы. Исследования с использованием фармакологического подхода, включая пациентов с ТН, опубликованные на английском языке с тех пор 2000,

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… Adjunctive and second-line therapies are under active investigation, including intravenous phenytoin and lacosamide for acute exacerbations [ 10 ], botulinum toxin type A (BoNT-A) injections with high response rates [ 11 , 12 ], and novel agents such as eslicarbazepine, lamotrigine and the selective … Intravenous lacosamide and phenytoin for the treatment of acute exacerbations of trigeminal neuralgia: A retrospective analysis of 144 cases. Cephalalgia. 2022;42:1031–1038. doi: 10.1177/03331024221092435. 11. Wu C.J., Lian Y.J., Zheng Y.K., Zhang H.F., Chen Y., Xie N.C., Wang L.J. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma.

Chimeric antigen receptor T-cell (CAR-T) therapy represents the most important advances in cancer immunotherapy, especially in hematological malignancies such as B-cell lymphomas. CAR-T cell therapy has significant activity in poor risk B-cell lymphomas. CAR-T cell therapy is associated with potentially life-threatening toxicities such as cytokine release syndrome (CRS) and neurotoxicity (NT). While CRS pathophysiology and management are well established, the understanding and treatment of NT continues to develop. All current CAR-T products approved for DLBCL have been associated with NT with

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… -Seizure control with benzodiazepines (for short-term control) and levetiracetam ± lacosamide. -If evidence of increased ICP (stage 1–2 by fundoscopy or opening pressure >20 mmHg), urgent neurology consultation to guide management. -Repeat neuroimaging if persistent grade ≥3 ICANS. … -Seizure control with benzodiazepines (for short-term control) and levetiracetam ± lacosamide. -If evidence of increased ICP (stage 1–2 by fundoscopy or opening pressure >20 mmHg), urgent neurology consultation to guide management. -Repeat neuroimaging if persistent grade ≥3 ICANS. …

Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect?

AbstractCancer is the second leading cause of death worldwide and is a major global health burden. Significant improvements in survival have been achieved, due in part to advances in adjuvant antineoplastic chemotherapy. The most commonly used antineoplastics belong to the taxane, platinum, and vinca alkaloid families. While beneficial, these agents are frequently accompanied by severe side effects, including chemotherapy-induced peripheral neuropathy (CPIN). While CPIN affects both motor and sensory systems, the majority of symptoms are sensory, with pain, tingling, and numbness being the pre

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… In this context, several case studies, small trials, and retrospective studies have provided evidence suggesting potential therapeutic strategies for CIPN. 170 – 173 One case study found that the Na V blocker lacosamide 174 completely relieved neuropathic pain in patients following chemotherapy associated …

Drug treatment for myotonia.

BACKGROUND: Abnormal delayed relaxation of skeletal muscles, known as myotonia, can cause disability in myotonic disorders. The main myotoni … Other agents that have not been tested in RCTs, such as acetazolamide, flecainide, ranolazine, and lacosamide, will need to be considered when planning future clinical trials. Moreover, the RCTs, in particular the small numbers of most trials, highlight the challenges in recruitment and design of robust trials in rare diseases, and research into trial desig …

Прогрессивная многофокальная лейкоэнцефалопатия в химическом антигенном рецепторе T-Cell терапии: тематическое исследование.

Цимерическая антигенная рецепторная (CAR) T-клетотерапия — это новая иммунотерапия, которая продемонстрировала замечательные показатели реакции на рефрактные гематологические заболевания, включая множественные миеломы (ММ). Синдром цитокина (CRS) и нейротоксичность являются хорошо описываемыми побочными эффектами этой терапии. В результате иммунной дисфункции, многообразной терапии, лимфоразрушающей химиотерапии до инъекции клеток, а также продолжительной аплазии клеток B, бенефициары CAR-клеточной терапии также подвергаются повышенному риску инфицирования. Прогрессивная многофукальная лейкоэн

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… In addition, because of the neurologic deterioration, oral acyclovir was switched to IV ganciclovir to extend viral coverage to include CMV due to the patient's prior history, and lacosamide was added to levetiracetam for seizure prophylaxis. …

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases.

Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significant health challenges due to their debilitating effects on the musculoskeletal system. 14-3-3 proteins, a family of conserved regulatory molecules, play a critical role in the pathology of these diseases. This review discusses the intricate structure and multifunctionality of 14-3-3 proteins, their regulation of signaling pathways, and their interactions with other proteins. We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts, osteoclasts, chon

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… Mammalian cells 245 Constrained peptide 18 / An inhibitor of 14-3-3ζ / 109 Molecular Tweezers IC 50 = 480/520 μmol/L The tweezers inhibit binding between the 14-3-3 protein and two partner proteins—a phosphorylated (C-Raf) protein and an unphosphorylated one (ExoS)—in a concentration-dependent manner / 246 Lacosamide … peptide 18 | | / | An inhibitor of 14-3-3ζ | / | 109 | Molecular Tweezers | | IC 50 = 480/520 μmol/L | The tweezers inhibit binding between the 14-3-3 protein and two partner proteins—a phosphorylated (C-Raf) protein and an unphosphorylated one (ExoS)—in a concentration-dependent manner | / | 246 | Lacosamide …

Обзор необщей внеэпиптической центральной нервной системы (СКС) симптомов заражения вирусом гепатита С (ГКВ): доклад по делу.

Цель настоящего доклада состоит в том, чтобы пролить свет на все более описываемый сценарий внеэптических проявлений центральной нервной системы (СНС) инфекции гепатита С (ГКВ). Мы представляем возможный редкий случай острого распространенного энцефаломиэлита, который проявляется как повреждения кольца на магнитно-резонансной съемке (MRI) в исследовании головы, проведенном на джентльмене в возрасте 50 лет, который представил в больницу неврологические характеристики, с явной демонстрацией рипонуклеиновой кислоты (RNA) в пробах цереброспайнальной жидкости пациента. Был также рассмотрен вопрос о

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… Further treatment with oral lacosamide, levetiracetam, and sodium valproate prevented further acute seizure attacks in the patient. …

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy.

Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies against fibroblast growth factor receptor 3 define a subset of patients with consistent reports of neuropathic pain harboring a distinct clinical phenotype characterized by small-fiber and non-length-dependent neuropathy, suggesting dorsal root ganglia (DRG) dysfunction. FGFR3-autoantibody-positive sera (FGFR3-AbS) bind to sensory neurons within dorsal root ganglia (DRG). The target of autoantibodie

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… Yang , et al., “ (S)‐lacosamide Inhibition of CRMP2 Phosphorylation Reduces Postoperative and Neuropathic Pain Behaviors through Distinct Classes of Sensory Neurons Identified by Constellation Pharmacology ,” Pain 157 , no. 7 ( 2016 ): 1448 – 1463 , 10.1097/j.pain.0000000000000555 . 26967696 PMC4936788 … Li , et al., “ CRISPR/Cas9 Editing of Nf1 Gene Identifies CRMP2 as a Therapeutic Target in Neurofibromatosis Type 1‐related Pain That Is Reversed by (S)‐Lacosamide ,” Pain 158 , no. 12 ( 2017 ): 2301 – 2319 , 10.1097/j.pain.0000000000001002 . 28809766 PMC6362827 45 F. Giraud , E. Pereira , F. …

Therapeutic potential of alpha-tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol-induced seizures.

The effects of alpha-tocopherol on seizure parameters, locomotor-cognitive functions, inflammatory response, oxidative stress response, histopathological changes, immunohistochemical parameters, and miRNA fold changes were investigated in rats with traumatic brain injury (TBI) and pentylenetetrazol (PTZ)-induced seizures. Sprague-Dawley male rats were randomly divided into three groups: Control (n = 8), TBI + PTZ (n = 10), and TBI + PTZ + tocopherol (n = 10). After inducing TBI in animals using the weight-drop method, increased post-injury seizure susceptibility was achieved by administering s

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… posttraumatic epilepsy Cell Mol Neurobiol 43 8 4059 4069 10.1007/s10571-023-01429-2 37889439 10.1007/s10571-023-01429-2 PMC11407727 Demirtas C Akca M Aykin U Surmeneli YE Yildirim H Yildirim M Effective protection against status epilepticus caused by lithium-pilocarpine: combination of midazolam and lacosamide … Brain Behav 2025 15 5 e70546 10.1002/brb3.70546 40350720 PMC12066809 Demirtas C, Akca M, Aykin U, Surmeneli YE, Yildirim H, Yildirim M (2025b) Effective protection against status epilepticus caused by lithium-pilocarpine: combination of midazolam and lacosamide. …

Продуктирует ли анальгезия в тригеминальной невралгии? Обновленный системный обзор и метаанализ.

Предыстория/цели: Тригеминальная нейронгия (ТН) представляет собой излучающееся состояние, которое в основном регулируется в рамках первичной медико-санитарной помощи, где карбамазепин остается единственной рекомендуемой терапией первой линии. Предварительные метаанализы сообщают о сокращении боли в конце лечения с помощью иглоукалывания, но не приводят к стратифицированным результатам в силу риска предвзятости, проверяют качество отчетности о результатах боли или изучают вопрос о том, сохраняются ли последствия анальгезии после периода лечения. В рамках этого обновленного систематического обз

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… When first-line therapy fails, second-line oral options including gabapentin, pregabalin, baclofen, and lacosamide are frequently used [ 11 ]. Surgical alternatives carry risks of sensory loss and recurrence [ 12 ]. …

How I treat unique and difficult-to-manage cases of CAR T-cell therapy-associated neurotoxicity.

With growing indications for chimeric antigen receptor (CAR) T-cell therapy, toxicity profiles are evolving. There is an urgent and unmet need of approaches to optimally manage emerging adverse events that extend beyond the standard paradigm of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (ICANS). Although management guidelines exist for ICANS, there is little guidance on how to approach patients with neurologic comorbidities, and how to manage rare neurotoxicity presentations, such as CAR T-cell therapy-related cerebral edema, severe motor complications

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… We chose antiseizure medications, such as levetiracetam or lacosamide that could be easily converted to be administered IV. …

The pathogenesis, diagnosis, prevention, and treatment of CAR-T cell therapy-related adverse reactions.

Chimeric antigen receptor (CAR)-T cell therapy is effective in the treatment of refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell lymphoma, and multiple myeloma). In addition, it is being explored as a treatment option for solid tumors. As of 31 March 2022, seven CAR-T therapies for hematological malignancies have been approved worldwide. Although CAR-T therapy is an effective treatment for many malignancies, it also causes adverse effects. The incidence of cytokine release syndrome (CRS), the most common adverse reaction after infusion of CAR-T ce

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… q6h, IV) or methylprednisolone equivalent (1 mg/kg q12h, IV) • Corticosteroids as outlined for grade 2 ICANS if symptoms worsen despite anti-IL-6 therapy, or for ICANS without concurrent CRS | • Control seizures with benzodiazepines (for short-term control) and levetiracetam ± phenobarbital and/or lacosamide … Status epilepticus to be treated as per institutional guidelines • High-dose corticosteroids methylprednisolone (1 g/day, IV) for 3 days continued until improvement to grade 1 ICANS and then taper | • Control seizures with benzodiazepines (for short-term control) and levetiracetam ± phenobarbital and/or lacosamide …

Abstracts - IANCON 2025

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Роль фитохимикатов в борьбе с нейропотической болью: сколько успехов мы добились?

Нетрофическая боль — это сложное и изнурительное состояние, вызванное повреждением нерва, которое характеризуется такими ощущениями, как горение, покалывание и стрельба. Она часто связана с такими условиями, как множественный склероз (MS), синдром Гильен-Барре (GBS) и диабетическая полиномропата. Лечение обычной боли часто обеспечивает ограниченное облегчение и сопровождается существенными побочными эффектами, подчеркивая необходимость изучения альтернативных вариантов лечения. Фитохимические вещества, являющиеся биоактивными соединениями, полученными от растений, привлекли внимание к их потен

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… Other AEDs, such as lamotrigine and carbamazepine, block sodium channels, while lacosamide enhances sodium channel inactivation. Valproate and clonazepam affect GABAergic neurotransmission, and topiramate combines sodium channel blockade with enhanced GABA function. …

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

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… 3.4 (11—21) NS Carbamazepine (5, 100%), valproic acid (3, 60.0%), clobazam (2, 40.0%), clozapine (3, 60.0%), phenobarbital (2, 40.0%), quetiapine (5, 100%), phenytoin (3, 60.0%), clonazepam (4, 80.0%), risperidone (2, 40.0%), divalproate (1, 20.0%), levetiracetam (1, 20.0%), oxcarbazepine (1, 20.0%), lacosamide … 3.4 (11—21) NS Carbamazepine (5, 100%), valproic acid (3, 60.0%), clobazam (2, 40.0%), clozapine (3, 60.0%), phenobarbital (2, 40.0%), quetiapine (5, 100%), phenytoin (3, 60.0%), clonazepam (4, 80.0%), risperidone (2, 40.0%), divalproate (1, 20.0%), levetiracetam (1, 20.0%), oxcarbazepine (1, 20.0%), lacosamide …

The potential of dibenzazepine carboxamides in cancer therapy.

Cancer is a leading cause of mortality worldwide, with most conventional treatments lacking efficacy and having significant challenges like drug resistance. Finding new molecules is quite challenging in terms of cost, time and setbacks. Hence, drug repurposing is considered sensible for skipping the long process of drug development. Dibenzazepine carboxamides, as traditional anticonvulsants, primarily function by blocking voltage-gated sodium channels, which not only mitigate seizures but also influence mood disorders through modulation of serotonin and dopamine. Recent studies have uncovered

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… Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide . Neuropharmacology 89 , 122 – 135 . 10.1016/j.neuropharm.2014.09.008 25242737 Hernandez-Plata E. Ortiz C. S. Marquina-Castillo B. …

Minimal important differences for fatigue patient reported outcome measures-a systematic review.

BackgroundFatigue is the most frequent symptom reported by patients with chronic illnesses. As a subjective experience, fatigue is commonly assessed with patient-reported outcome measures (PROMs). Currently, there are more than 40 generic and disease-specific PROMs for assessing fatigue in use today. The interpretation of changes in PROM scores may be enhanced by estimates of the so-called minimal important difference (MID). MIDs are not fixed attributes of PROMs but rather vary in relation to estimation method, clinical and demographic characteristics of the study group, etc. The purpose of t

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… Borghs S de la Loge C Cramer JA Defining minimally important change in QOLIE-31 scores: Estimates from three placebo-controlled lacosamide trials in patients with partial-onset seizures Epilepsy Behavior 2012 23 3 230 234 10.1016/j.yebeh.2011.12.023 22341962 28. …

Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.

In the last few years, monoclonal antibodies (mAbs) such as elotuzumab and daratutumab have brought the treatment of multiple myeloma (MM) into the new era of immunotherapy. More recently, chimeric antigen receptor (CAR) modified T cell, a novel cellular immunotherapy, has been developed for treatment of relapsed/refractory (RR) MM, and early phase clinical trials have shown promising efficacy of CAR T cell therapy. Many patients with end stage RRMM regard CAR T cell therapy as their "last chance" and a "hope of cure". However, severe adverse events (AEs) and even toxic death related to CAR T

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… When the patients exhibit clinical seizure or non-convulsive status epilepticus in EEG, benzodiazepines or other anticonvulsive drugs such as valproate, phenytoin, barbiturate, lacosamide, and propofol can be given to terminate seizures ( 68 , 134 , 136 ). …