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Внутренний ядерный слой в педиатрическом множестве склерозов.

ЦЕЛИ: Множественный склероз педиатрии (POMS) приводит к повреждениям зрительного нерва и сетчатки вследствие оптического неврита (ON) и потенциальной субклинической активности. Нейроаксональные повреждения сетчатки проявляются в разбавлении перипиллярного слоя сетчатки (PRNFL), а также в мешковой ганглионной клетке и внутреннем плексиформном слое (GCIP). Была высказана мысль о том, что толщина внутреннего ядерного слоя (ИНЛ) будет увеличиваться в результате провокационной деятельности или после острого ВН и уменьшится от хронического нейродегенерации. Макулярные микроциклы в INL были описаны у

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… For underage participants, parents or legal guardians gave additional consent. Visual Acuity and Clinical Disability For each patient, disease duration, Expanded Disability Status Scale (EDSS) score, MS Severity Scale (MSSS), and disease-modifying therapy were recorded. …

End-of-life management of multiple myeloma patients in the era of CD38 and immunotherapy.

BACKGROUND: In spite of spectacular advances in the treatment of multiple myeloma, a majority of patients will die from this disease or related complications. While a great amount of focus has been dedicated to the development of novel therapies, little attention has been paid to latter stages of patient follow-up. PATIENTS AND METHODS: In order to describe patient management during this critical period as well as the immediate causes and circumstances of death, we have analyzed a single center series of 100 patients diagnosed with myeloma who died between 2016 and 2021. RESULTS: Patients re

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Cost analysis of childhood hematopoietic stem cell transplantation in Sichuan, China.

ObjectiveTo analyze the inpatient cost of hematopoietic stem cell transplantation (HSCT) in children, so as to support clinical decision-making.MethodsStudy population were children who received HSCT in a tertiary children's hospital (Sichuan, China) between 1st January 2020 and 31st December 2021. The median and interquartile range (IQR) of total cost at 100 days post transplantation were calculated. Subgroup analyses were conducted based on age, gender, transplantation types, and post-transplant complications. The cost differences between subgroups were analyzed to determine whether it had a

Association between advanced lung cancer inflammation index levels and ischemic stroke in patients with atrial fibrillation: a propensity score-matching analysis.

IntroductionInflammation is closely associated with atrial fibrillation (AF) complicated by stroke. The Advanced Lung Cancer Index (ALI) is a comprehensive indicator of inflammation; however, its relationship with AF-related stroke is unclear. Therefore, this retrospective study was conducted to explore the correlation between ALI and ischemic stroke in patients with AF.MethodsPatients were divided into two groups according to the optimal cutoff value of ALI: low ALI and high ALI groups. The primary outcome was ischemic stroke in patients with AF. To ensure robustness of the findings, propensi

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Prognostic significance of FDG-PET/CT based radiomics analysis in newly-diagnosed multiple myeloma: a comparative study with clinical assessment.

ObjectiveThis study aimed to construct and validate a fusion diagnostic model based on Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography(FDG-PET/CT) radiomics for predicting overall survival of multiple myeloma (MM) patients.MethodsA total of 199 patients newly diagnosed with MM were included from two centers. All patients underwent whole-body PET/CT scans within one month before the initiation of treatment and were followed up for over five years. Radiomic features of MM were extracted from CT images and dimensionality reduction was performed by LASSO regression analysis. Co

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. Author contributions FL: Data curation, Software, Writing – original draft. …

Аутоиммунные реакции на белки, связанные с миелином, в качестве диагностических и прогнозирующих биомаркеров релапсирующего многократного склероза: ассоциации с герпесвирусом-6 и вирусом Эпштейн-Барр.

патогенез релапсирующего многократного склероза (RRMS) связан с аутоиммунными атаками миелиновых белков и возобновлением вируса Эпштейн-Барр (EBV) и человеческого герпесвируса 6 (HV-6). Однако связь между вирусными реактивными и аутоиммунными биомаркерами остается неясной. ЦЕЛИ: Изучение ответов иммуноглобулина (Ig)G/IgA/IgM на белки, связанные с миелином, совместно с EBV и HHV-6 репликационные маркеры в RRMS.Мы наняли 55 пациентов с RRMS и 63 здоровыми средствами контроля и провели оценку ответов IgG/IgA/IgM по семи компонентам, связанным с миелином, а также по EBV с применением ядерного анти

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… Informed consent was obtained and documented from all RRMS patients, or their legal guardians or parents when applicable, as well as from control subjects prior to enrolment in the study. …

Efficacy and safety of reduced-dose daratumumab plus bortezomib and dexamethasone (DVd-lite) in newly diagnosed MGRS patients.

BackgroundClone-directed therapy is essential for managing monoclonal gammopathy of renal significance (MGRS), as it reduces the nephrotoxic monoclonal protein burden and preserves renal function. However, due to the rarity and frequent misdiagnosis of MGRS, there is no evidence-based standard first-line treatment for MGRS.MethodsThis open-label, single-arm, prospective clinical trial assessed the efficacy and safety of the combination of reduced-dose daratumumab (Dara), bortezomib, and dexamethasone (DVd-lite) in ten newly diagnosed MGRS patients. The treatment protocol consisted of six cycle

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… Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin. Author contributions HX: Project administration, Writing – review & editing, Visualization, Methodology, Data curation, Writing – original draft, Formal analysis, Investigation. …

Repetitive transcranial magnetic stimulation for chemotherapy-induced peripheral neuropathy in multiple myeloma: A pilot study.

OBJECTIVE: Chemotherapy-induced peripheral neuropathy is one of the major toxicities in multiple myeloma patients, often resulting in dose reductions or treatment interruptions. Repetitive transcranial magnetic stimulation is a safe non-invasive neuromodulation therapy with potential benefits for chemotherapy-induced peripheral neuropathy. The objective of this study was to investigate the efficacy of repetitive transcranial magnetic stimulation treatment on chemotherapy-induced peripheral neuropathy in multiple myeloma patients. MATERIALS AND METHODS: We screened 30 multiple myeloma patients

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… Our study obtained approval from the institutional review committee of First Peoples’ Hospital of Lianyungang (approval number: LW-20230320001) and was conducted in accordance with the Declaration of Helsinki; informed consent was obtained from all subjects and/or their legal guardians. …

Clinical outcomes of radiation therapy for transgender and gender-expansive people with cancer.

INTRODUCTION: Approximately 1.6 million people in the US identify as transgender, many of whom undergo gender-affirming medical or surgical therapies. While transgender individuals are diagnosed with cancer at similar rates as those who are cisgender, the impacts of radiation therapy on outcomes of gender-affirming care in transgender, nonbinary, and gender-expansive people with cancer are understudied. We report on the experiences and outcomes of transgender and gender-expansive patients receiving radiation therapy for cancer treatment. METHODS: This study is a multi-institutional retrospect

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… The institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because there is minimal risk from a retrospective chart review. …

Palestinian Patients with Cancer at King Hussein Cancer Center.

BackgroundThe Palestinian Ministry of Health (MoH) routinely refers Palestinian patients with cancer to King Hussein Cancer Center (KHCC), the largest cancer center in the Middle East.AimsWe aimed to describe the characteristics of Palestinian patients with cancer.MethodsWe performed a retrospective chart review of all Palestinian patients with cancer who were treated at KHCC during 2018 and 2019, of which demographic and clinical characteristics were presented.ResultsWe initially started with 521 cases, out of which 41 (7.9%) cases were excluded due to misdiagnosis as malignant on pathology r

Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.

OBJECTIVE: Little is known about shifting from pediatric to adult-focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow-up in the US pediatric-onset MS (POMS) population. METHODS: Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition-of-care practices. A cohort of POMS/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between < 18 and ≥ 18-years of age. The primary outcome was 1- and 2-year lapse in last follow-up visit, measured from last recorded datab

Cancer Mortality by Ethnicity in Colombia Between 2011 and 2022: A Population-Based Study.

ObjectivesTo examine cancer mortality rates in Colombia by ethnic groups (Indigenous, Rom, Raizal, Afro-Colombian, and Mestizo) and assess trends from 2011 to 2022.MethodsNational vital statistics from death certificates and the Colombian census data were used. Crude and direct age-standardized mortality rates were determined by ethnicity for the study period, by year, sex, and cancer type and Joinpoint analysis was conducted to examine trends.ResultsAge-standardized cancer mortality of Mestizos (60.1 per 100,000 population) was lower than in Rom and Raizales (557.3 and 77.7 per 100,000), and

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… Written informed consent to participate in this study was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and the institutional requirements. …

Частота, характеристики и иммунологические композиции атаксии в антиNMDAR, связанной с антителным энцефалитом.

ВВЕДЕНИЕ: Очень редко взрослый антителный энцефалит NMDAR (NMDAR-E) приводит к стойкой атрофии мозга и атаксии. В педиатрии НМДАР-Е широко распространена трансгенитальная атаксия мозга. Атаксия церебельного типа может быть связана с mielin oligodendrocyte glycoprotein (MOG), аквапорин-4 (AQP-4), членом семьи 11 (KLHL11), похожим на келч, и субъектом рецептора 2 (GluK2) глютаматного кайната, все из которых могут быть совместно окуны в NMDAR-E. Здесь мы стремились изучить частоту, долгосрочные результаты и иммунологические сопутствующие атаксии в НМДАР-Е.МЕТОДЫ: В ходе этого наблюдения пациенты

Sitz bath with different concentrations of diluted povidone-iodine for prevention of perianal infection in patients with hematological malignancies undergoing chemotherapy: a randomized controlled trial in a tertiary hospital in China.

BackgroundThe incidence of perianal infection in patients with hematologic malignancies undergoing chemotherapy can reach 40-50%. Despite advances in medical technology and improved management strategies, the rate of perianal infection following chemotherapy remains substantial. Currently medicated sitz baths are not widely adopted in clinical practice due to their side effects and limited applicability. Povidone-iodine (PI) is a commonly used clinical broad-spectrum antiseptic, yet its efficacy in preventing perianal infection has not been adequately studied. Therefore, we aimed to evaluate t

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… Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin. Author contributions YQL: Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing. …

Association of image-defined risk factors with clinical features in thoracic neuroblastoma and the development of a prognostic prediction model.

BackgroundImage-defined risk factors (IDRFs) were critical in managing and predicting outcomes for neuroblastoma. This study systematically evaluated baseline clinical features, IDRFs prevalence, and prognosis in thoracic neuroblastoma, explored the association between IDRFs and these features, and developed a nomogram to predict event-free survival (EFS).MethodsClinical and prognostic data were collected retrospectively from pediatric patients diagnosed with thoracic neuroblastoma at Children's Hospital of Nanjing Medical University. Logistic regression was used to identify factors associated

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… Written informed consent for participation was not required from the participants or the participants' legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Construction and validation of a risk prediction model for perianal infection in HSCT patients: a retrospective cohort study.

BackgroundPerianal infection is a frequent and detrimental complication in patients undergoing hematopoietic stem cell transplantation (HSCT), leading to significant morbidity and extended hospital stays. Despite its clinical significance, a substantial gap remains in our ability to proactively identify high-risk individuals. However a validated predictive model is actually lacking and it is still unclear how to identify these patients before the onset of infection.ObjectiveThis study aimed to develop and to validate a risk prediction model for the accurate assessment of perianal infection ris

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… Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin. Author contributions XW: Data curation, Formal Analysis, Methodology, Writing – original draft, Writing – review & editing. …

Letermovir does not affect long-term polyclonal immune reconstitution after allogeneic hematopoietic stem cell transplantation with ATG-based GvHD prophylaxis.

INTRODUCTION: Letermovir (LET) is an effective prophylaxis for human cytomegalovirus (HCMV) reactivations in HCMV-seropositive patients after allogeneic stem cell transplantation (allo-SCT). HCMV promotes polyfunctional T-cell responses, leading to HCMV-specific immune reconstitution (IR), thus contributing to polyclonal IR. METHODS: We retrospectively analyzed HCMV-seropositive patients undergoing allo-SCT with ATG-based GvHD prophylaxis to assess the impact of LET on timing and quality of polyclonal IR. Two cohorts were identified: a pre-emptive treatment (PET) historical cohort transplante

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… Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. …

Advancing Hematopoietic Stem Cell Transplantation (HSCT) in Africa: A Pathway to Curing Hematological Disorders.

BackgroundHematopoietic stem cell transplantation (HSCT) offers a curative option for numerous hematological disorders, notably sickle cell disease and thalassemia, which are highly prevalent in Africa. Despite its potential, access to HSCT remains limited due to infrastructural, economic, and socio-cultural challenges across the continent.MethodsThis review synthesizes current literature and reports on the status of HSCT in Africa, analyzing data from existing transplant centers, national registries, and peer-reviewed studies to assess progress, challenges, and prospects for expanding HSCT se

Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery.

ObjectivesEven though postoperative chemotherapy can eliminate residual tumor cells in patients with colorectal cancer (CRC), severe adversity, weakened immunity and drug resistance are still problems. Adjuvant cytokine-induced killer (CIK) cell therapy is an alternative to CRC patients after surgery. The present study investigated the efficacy of adjuvant CIK cell therapy combined with chemotherapy in postoperative CRC patients.MethodsThis retrospective analysis included 137 postoperative CRC patients, including 71 who received adjuvant chemotherapy alone (control group) and 66 who received a

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… Written informed consent was provided by all patients or their legal guardians. The medical records of CRC patients who underwent radical tumor resection from February 2008 to July 2014 were reviewed. …

Клиническая-радиологическая-патологическая характеристика диабетической мастопатии: анализ 21 Дела.

Характеристика клинических-радиологических характеристик диабетической мастопатии (DMP) с уделением особого внимания особым ультразвуковым выводам, которые могут помочь дифференциальному диагностике и сократить ненужное вмешательство. 21 патологически подтвержденные повреждения DMP 17 (больные)2014-2024). Маммографические и ультрасонографические характеристики были независимо оценены two Радиологи в соответствии с системой представления данных и представления данных по грудным вскармливаниям (BI-RADS, BI-RADS) 5th издание). Были проанализированы клинические данные, включая историю диабета. 58

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… Written informed consent to participate in this study was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and the institutional requirements. …