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Rats resistant to the dextran anaphylactoid reaction.

In one colony of Wistar albino rats 23% were resistant to dextran and to egg-white, these animals (non-reactors) failing to show an anaphylactoid reaction after the intraperitoneal or intravenous injection of either of the two substances. Non-reactors were also found in a few other colonies of Wistar rats but not in colonies of other strains. Procedures which potentiated the anaphylactoid reaction in sensitive rats (reactors) did not alter the response of non-reactors. Dextran failed to release histamine from the perfused hind-quarters of non-reactors although other chemical liberators of hist…