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Targeting the NLRP3 inflammasome in kidney disease: molecular mechanisms, pathogenic roles, and emerging small-molecule therapeutics.

Inflammatory responses represent a core pathological process driving the progression of both acute and chronic kidney diseases. As a key effector of the innate immune system, the NLRP3 inflammasome is widely activated in renal resident cellsand infiltrating immune cells, positioning it as a critical nexus linking metabolic dysregulation, cellular stress, and tissue injury. Accumulating preclinical and clinical evidence in recent years demonstrates that aberrant activation of the NLRP3 inflammasome directly promotes glomerular damage, tubulointerstitial inflammation, fibrosis, and vascular dysf

Связь между аутоиммунным заболеванием и раком цвета кожи: ретроспективное тематическое исследование 120 876 Пациенты.

ЦЕЛЬ: рак цветности (КЗ) one из наиболее часто диагностируемых раковых заболеваний и одной из главных причин смертности от раковых заболеваний во всем мире. Хотя воспламенительное кишечное заболевание (ИББ) является широко распространенным фактором риска для КПР, потенциальная связь между другими аутоиммунными заболеваниями и КПР неясна. В свете растущей распространенности аутоиммунных заболеваний и их признанной связи с различными вредными явлениями в настоящем исследовании ставится задача изучить вопрос о том, связаны ли с КПР различные аутоиммунные заболевания. МЕТОДЫ: Всего 20 146 пациенто

Совпадение в аннотации оригинала
OBJECTIVE: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths worldwide. W … TS: Only IBD was significantly associated with CRC (OR 1.53; 95% CI 1.33 to 1.75). Type 1 diabetes, rheumatic diseases, autoimmune thyroiditis, and multiple sclerosis did not show a significant association with CRC. Psoriasis showed a non-significant trend towards an association with CRC (OR 1.11; 95% CI 0.97 to 1.27). Coeliac disease was not associated …

Small molecule metabolites: discovery of biomarkers and therapeutic targets.

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject's phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has b

" Interleukin-27 " и " Аутоиммунные расстройства: компрессивный обзор иммунных функций " .

Аутоиммунные расстройства (АД) создают значительное бремя для здоровья и экономики во всем мире, характеризующееся ошибочной атакой иммунной системы организма на его собственные ткани. Хотя конкретные механизмы, лежащие в основе их развития, по-прежнему остаются неясными, речь идет о сочетании генетической предрасположенности (генетических предрасположений) и экологических факторов. Interleukin-27 (IL-27), среди многочисленных участвующих цитокинов, стал ключевым регулятором, выполняющим двойную роль в иммунной модуляции. Этот обзор погружается в молекулярную структуру и механизмы сигнализации

Совпадение в аннотации оригинала
Autoimmune disorders (ADs) pose significant health and economic burdens globally, characterized by the body's immune system mistakenly attac … y, it explores the involvement of IL-27 in autoimmune diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA), offering insights into its potential therapeutic implications. Moreover, its involvement in autoimmune diseases like type 1 diabetes (T1D), inflammatory bowel disease (IBD), myasthenia gravis (MG), Sjögren's syndrome (SS), and G …

A practical approach to joint pain in primary care.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Ann Rheum Dis. 2015;74:1483–7. doi: 10.1136/annrheumdis-2014-207151. 7. Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castaneda J, et al. 2018 updated European League against Rheumatism evidence-based recommendations for the diagnosis of gout. … Ann Rheum Dis. 2020;79:31–8. doi: 10.1136/annrheumdis-2019-215315. 8. West S, Kolfenbach J. Rheumatology Secrets. 4th ed. Philadelphia (United States): Elsevier; 2020. 9. Didier K, Bolko L, Giusti D, Toquet S, Robbins A, Antonicelli F, et al. …

Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias.

Various autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitation and enzyme-linked immunosorbent assays in 193 consecutive IIP patients. Cancer-related factors were analyzed using logistic regression analysis. In total, 22 of 193 patients (11.4%) with IIP had malignant disease. In univariate analysis, positivity for any autoantibody (odds ratio (OR), 3.1; 95%

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… Arthritis Rheum. 2012 41 890 899 10.1016/j.semarthrit.2011.09.008 22078416 30. Trallero-Araguás E. Rodrigo-Pendás J.Á. Selva-O’Callaghan A. Martínez-Gómez X. Bosch X. Labrador-Horrillo M. Grau-Junyent J.M. Vilardell-Tarrés M. … Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: A systematic review and meta-analysis Arthritis Rheum. 2012 64 523 532 10.1002/art.33379 21953614 31. Kaji K. Fujimoto M. Hasegawa M. Kondo M. Saito Y. Komura K. Matsushita T. Orito H. Hamaguchi Y. Yanaba K. …

Associations of Bone Mineral Density with RANKL and Osteoprotegerin in Arab Postmenopausal Women: A Cross-Sectional Study.

Background and objective: There is limited information as to the association of several key bone markers with bone mineral density (BMD) in understudied ethnic groups. This study investigated the relationship between circulating levels of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-Β ligand (RANKL) with BMD in Arab postmenopausal women. Materials and methods: In this cross-sectional study, a total of 617 Saudi postmenopausal women from the Osteoporosis Registry of the Chair for Biomarkers of Chronic Diseases were included. Anthropometric data, BMD, and biochemical data

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… Serum osteoprotegerin and its ligand in Paget’s disease of bone: Relationship to disease activity and effect of treatment with bisphosphonates Arthritis Rheum. 2003 48 824 828 10.1002/art.10834 12632438 25. Ziolkowska M. Kurowska M. Radzikowska A. Luszczykiewicz G. Wiland P. Dziewczopolski W. … High levels of osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in serum of rheumatoid arthritis patients and their normalization after anti–tumor necrosis factor α treatment Arthritis Rheum. 2002 46 1744 1753 10.1002/art.10388 12124857 26. Zamani M. Zamani V. Heidari B. …

The Use of Imaging in Management of Patients with Low Back Pain.

Lower back pain (LBP) is one of the most common chief complaints encountered in primary care. Advanced imaging studies, including computerized tomography (CT) and magnetic resonance imaging (MRI), are frequently ordered in the setting of LBP. Structural abnormalities are commonly identified by CT and MRI in patients complaining of low back pain, however, these findings are also found in asymptomatic patients. In the past decade, multiple guidelines have been published to help providers identify patients in whom the use of advanced imaging is appropriate. In this article, we review common condi

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… Imaging of seronegative spondyloarthritis Best Pract Res Clin Rheumatol 2008 22 1045 59 19041076 10.1016/j.berh.2008.09.006 58 Bennett AN Rehman A Hensor EM Marzo-Ortega H Emery P McGonagle D Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis Arthritis Rheum … 2009 60 1331 41 19404934 10.1002/art.24493 59 Battafarano DF West SG Rak KM Fortenbery EJ Chantelois AE Comparison of bone scan, computed tomography, and magnetic resonance imaging in the diagnosis of active sacroiliitis Semin Arthritis Rheum 1993 23 161 76 8122119 10.1016/s0049-0172(05)80037-x …

Bilateral Amyloid Arthropathy of the Hip Joint Presented with Pathologic Fracture in a Hemodialysis Patient: A Case Report.

Pathological hip fractures are associated with substantial morbidity and functional decline. We report a rare case of localized dialysis-related amyloidosis involving both hip joints. A 48-year-old man undergoing long-term hemodialysis presented with atraumatic right hip pain. Radiographs and magnetic resonance imaging revealed a pathological subcapital fracture of the right femoral neck and extensive bilateral femoral neck osteolysis, with amyloid deposition showing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Given the severe bone erosion and im

Совпадение в полном тексте источника
… Semin Arthritis Rheum. 2013;43:405-12. https://doi.org/10.1016/j.semarthrit.2013.07.004 10.1016/j.semarthrit.2013.07.004 10. He C, Ge XP, Zhang XH, Chen P, Li BZ. Multiple myeloma presenting with amyloid arthropathy as the first manifestation: two case reports. …

Diagnostic challenges of systemic juvenile idiopathic arthritis with aberrant M-protein expression: a case report.

BACKGROUND: Systemic juvenile idiopathic arthritis (sJIA), a severe autoinflammatory subtype of JIA, presents diagnostic challenges due to non-specific clinical features and the absence of definitive biomarkers. Current ILAR classification criteria emphasize exclusion of mimicking conditions, yet misdiagnosis rates persist (20%-35%), particularly in early disease stages. CASE PRESENTATION: A 15-year-old female presented with persistent high-grade fever, anemia (Hb: 84→64→73→91 g/L), thrombocytosis (PLT 592→1,044 × 10⁹/L), and iron overload. Initial evaluations excluded infections (CMV-positive

Совпадение в полном тексте источника
… Ann Rheum Dis. 2016;75(9):1654–60. 5. Lee JJY, Schneider R. Systemic Juvenile Idiopathic Arthritis. Pediatr Clin North Am. 2018;65(4):691–709. 6. Gurion R, Lehman TJ, Moorthy LN. Systemic arthritis in children: a review of clinical presentation and treatment. Int J Inflamm. 2012;2012:271569. 7. …

Navigating the Diagnostic Maze: A Case Report of Immunoglobulin G4-Related Disease.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition characterized by significant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells within affected tissues, with or without elevated serum IgG4 levels. The prevalence of IgG4-RD remains largely undetermined due to diagnostic challenges, as the condition is frequently unrecognized or misdiagnosed. This report describes a case of a 63-year-old man who was ultimately diagnosed with this rare condition after an extensive two-year period of elusive symptoms. Initially presenting with intermittent body pai

Совпадение в полном тексте источника
… 10.1007/s10165-011-0571-z 14 International consensus guidance statement on the management and treatment of IgG4-related disease Arthritis Rheumatol Khosroshahi A Wallace ZS Crowe JL 1688 1699 67 2015 25809420 10.1002/art.39132 15 Rituximab for IgG4-related disease: a prospective, open-label trial Ann Rheum …

Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?

BACKGROUND: Macroglossia due to amyloid depositions can cause cosmetic problems and functional disability, and can lead to life-threatening airway obstruction. Management of macroglossia in systemic amyloidosis is controversial, and the role of surgery is unclear. CASE DESCRIPTION: We present a case of a 66-year-old woman affected by macroglossia due to light chain amyloidosis who presented with eating and breathing difficulties. Because of prior successful results of radiotherapy for localized amyloid disease, our patient was treated with external beam radiation therapy (20 Gy in 10 fraction

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… Otolaryngol Head Neck Surg 1995 121 778 782 7598857 10.1001/archotol.1995.01890070064014 11 Prokaeva T Spencer B Kaut M Ozonoff A Doros G Connors LH Skinner M Seldin DC Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival Arthritis Rheum …

Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)-study protocol for a multicenter randomized double-blind placebo-controlled trial.

BACKGROUND: Since decades, fever and infections have been the most important complications of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the treatment of hematologic malignancies. Neutropenia has long been considered to be the most important risk factor for these complications. However, recent studies have shown that not neutropenia, but the development of mucositis is the most important cause of these complications. Currently, limited options for the prevention and treatment of mucositis are available, of which most are only supportive. The pro-inflammatory c

Совпадение в полном тексте источника
… Arthritis Rheum. 2002;46(11):2838–2846. doi: 10.1002/art.10578. 36. Fleischmann RM, Schechtman J, Bennett R, Handel ML, Burmester GR, Tesser J, et al. … Arthritis Rheum. 1996;39(7):1092–1101. doi: 10.1002/art.1780390704. 38. Antin JH, Weinstein HJ, Guinan EC, McCarthy P, Bierer BE, Gilliland DG, et al. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. …

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Int J Rheum Dis. 2013;16:625–636. doi: 10.1111/1756-185X.12212. 87. Chan T.M., Li F.K., Tang C.S. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. … Ann Rheum Dis. 2013;72:1280–1286. doi: 10.1136/annrheumdis-2012-202844. 93. Gordon C., Jayne D., Pusey C. European consensus statement on the terminology used in the management of lupus glomerulonephritis. Lupus. 2009;18:257–263. doi: 10.1177/0961203308100481. 94. …

Ассоциация неизгладимых неблаговидных мероприятий, связанных с эффективностью иммунных контрольно-пропускных пунктов и общим выживанием в раковых заболеваниях: системный обзор и метаанализ.

ЦЕЛИ: Ингибиторы на контрольно-пропускных пунктах иммунного типа (ИПК) приносят значительные выгоды пациентам, страдающим раком, несмотря на то, что они часто сопровождаются неблагоприятными иммунными явлениями (ОРАЭ). Мы поставили перед собой цель изучить связь IRAE с эффективностью и общим выживанием у больных раком, которые проходят лечение в рамках ICI, и еще больше количественно оценить эту связь за счет стратификации подгрупп. МЕТОДЫ: Пубмед, ЭМБАСЕ и Кокрейнская библиотека с момента создания базы данных 29 Август 2019 систематически подвергались обыску. Были включены статьи, содержащие

Совпадение в полном тексте источника
… Ann Rheum Dis (2018) 77:393–8. 10.1136/annrheumdis-2017-212257 40. Lesueur P, Escande A, Thariat J, Vauleon E, Monnet I, Cortot A, et al. Safety of combined PD-1 pathway inhibition and radiation therapy for non-small-cell lung cancer: A multicentric retrospective study from the GFPC. … Int J Rheum Dis (2019) 22:297–302. 10.1111/1756-185X.13444 60. Okada N, Kawazoe H, Takechi K, Matsudate Y, Utsunomiya R, Zamami Y, et al. Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study. …

Molecular mechanisms and clinical management of cancer bone metastasis.

As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoclasts, together maintain the homeostasis of the bone microenvironment. In contrast, tumor-derived factors act on bone components, leading to subsequent bone resorption or excessive bone formation. The various pathways involved also provide multiple targets for therapeutic strategies against bone metastases. In this review, we summarize the curr

Treatment-related pain in refractory cancer pain: prevalence, mechanisms, and clinical implications in a tertiary referral cohort.

BackgroundThe long-term effects of cancer treatment are increasingly driving persistent pain in cancer survivors; however, the contribution and clinical profile of cancer treatment-related pain (CTRP) in refractory pain populations remain poorly defined.MethodsWe conducted a retrospective cohort study of consecutive patients (N = 622) referred to a tertiary multidisciplinary cancer pain clinic for initial evaluation of refractory pain (January 2021-June 2025). Pain etiology was classified using ICD-11 criteria as treatment-related pain (TRP; MG30.11), tumor-related pain (MG30.10), or non-cance

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… Kostine M Finckh A Bingham CO Visser K Leipe J Schulze-Koops H EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors Ann Rheum Dis 2021 80 1 36 48 10.1136/annrheumdis-2020-217139 32327425 PMC7788064 … Ann Rheum Dis 80(1):36–48 32327425 10.1136/annrheumdis-2020-217139 PMC7788064 15. …

Cancer incidence in immunocompromised patients: a single-center cohort study.

BackgroundDiminished immune defense plays an important role in cancer development. Cancer risk in immunocompromised patients may differ. Identifying individuals with elevated cancer risk can inform strategies for routine cancer screening. This study aimed to understand and compare cancer incidence and risk in three patient groups: recipients of solid organ transplant (SOT) or hematopoietic stem cell transplant (HSCT); diagnosis of primary or secondary immunodeficiency disorder (PID/SID); and recipients of tumor necrosis factor inhibitor (TNF-i) therapy.MethodsThis retrospective cohort study us

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… Ann Rheum Dis. 2013;72(1):79–82. doi: 10.1136/annrheumdis-2012-201969. 20. Kim SC, Pawar A, Desai RJ, Solomon DH, Gale S, Bao M, et al. Risk of malignancy associated with use of tocilizumab versus other biologics in patients with rheumatoid arthritis: A multi-database cohort study. … Semin Arthritis Rheum. 2019;49(2):222–228. doi: 10.1016/j.semarthrit.2019.03.002. 21. Muller M, D'Amico F, Bonovas S, Danese S, Peyrin-Biroulet L. TNF inhibitors and risk of malignancy in patients with inflammatory bowel diseases: A systematic review. …

Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance.

Bone repair and regeneration is a complex spatiotemporal process recruiting a variety of cell types, which need to precisely mediated for ef … aluable. Herein, we discuss the effects of DCs on bone homeostasis and bone-related diseases (i.e., rheumatoid arthritis (RA), periodontitis, bone regeneration, and other bone abnormalities diseases), and introduce the innovative DCs-targeting biomaterials, aimed at promoting bone repair and regeneration. Furthermore, we summarize the underlying crossta …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… Against 3CL Pro [ 99 ] Terrestrimine ( Tribulus terrestris ) Image 21 SARS CoV Against PL Pro [ 100 ] Xanthones Blanco-xanthone ( Calophyllum blancoi ) Image 22 HCoV 229E Against Protease [ 101 ] Pyrano-jacareubin ( Calophyllum blancoi ) Image 23 HCoV 229E Against Protease [ 101 ] Anthraquinones Emodin ( Rheum … Emodin extracted from Rheum officinale and Polygonum multiflorum was also able to block the S-protein binding with ACE-2 receptor in SARS coronavirus [ 102 ]. …