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Surveillance for Violent Deaths - National Violent Death Reporting System, 39 States, the District of Columbia, and Puerto Rico, 2018.

PROBLEM/CONDITION: In 2018, approximately 68,000 persons died of violence-related injuries in the United States. This report summarizes data … , New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin), three states with data from counties representing a subset of their population (21 California counties, 28 Illinois counties, and 39 Pennsylvania counties), the District of Columbia, and Puerto R …

Studies to Assess the Utility of Serum Neurofilament Light Chain as a Biomarker in Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and disabling dose-limiting toxicities of chemotherapy. We report here the results of two separate non-interventional studies (49 patients), which evaluated blood neurofilament light chain (NfL) as a biomarker of CIPN in breast cancer patients treated with paclitaxel. All patients underwent a standard treatment protocol that was established independently of the present studies. NfL was measured in serum using an ultrasensitive single-molecule array and compared with the self-administered European Organization for Resea

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… sites who provided patient data that were used in this analysis: School of Nursing, University of Michigan; Division of Medical Oncology, Ohio State University—James Comprehensive Cancer Center; Department of Anesthesiology, Washington University; Department of Neurological Sciences, The University of Vermont …

Inhibition of Heat Shock-Induced H3K9ac Reduction Sensitizes Cancer Cells to Hyperthermia.

Heat stress, clinically known as hyperthermia, is a promising adjunctive modality in cancer treatment. However, the efficacy of hyperthermia as a monotherapy is limited and the underlying mechanism remains poorly understood. Targeting histone modifications is an emerging strategy for cancer therapy, but little is known regarding the role of heat stress in altering these modifications. Here, we report that heat shock inhibits H3K9 acetylation (H3K9ac) via histone deacetylase 6 (HDAC6) regulation. Heat shock inhibits the interaction between HDAC6 and heat shock protein 90 (HSP90), enhances nucle

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… Then, the absorbance at 450 nm was measured by Gen5 Microplate Reader (BioTek Instruments, Vermont, USA) using the area scanning method (8×12 points for a 96 well plate). The results were calculated by GraphPad Prism 8.0 software. …

The Persistence of Stigma and Other Challenges Experienced by Medical Cannabis Users: A Thematic Synthesis of Qualitative Studies.

BackgroundThe legislation, practices, and guidance shaping patient and professional access to medical cannabis (MC) for managing chronic pain and other conditions vary widely across jurisdictions. Despite promising evidence of effectiveness, challenges persist for those trying to access or prescribe MC. Little is known about how patients navigate these complex environments. We aimed to understand the evidence related to personal lived experiences associated with using MC for chronic pain and other conditions in negotiating these challenges.SummaryWe used a framework by Thomas and Harden for co

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… ] All legal | Zhou et al. [ 57 ] Florida | 2016 | – | MC legal | Luque et al. [ 46 ] Michigan | 2008 | 2018 | MC legal | Peters [ 66 ] Maine | 1999 | 2016 | MC legal | Piper et al. [ 68 ] All legal Pennsylvania | 2016 | – | MC legal | Reed et al. [ 60 ] DC | 2010 | ​ | MC legal | Zhou et al. [ 57 ] Vermont … We considered two groups of study results related to the topics of perception of stigma and social consequences: the studies in which data were collected after legalization of MC (see Table 3 for studies published in Denmark, before 2018 in Canada, some US states – e.g., Rhode Island, Florida, MI, Vermont …

Assisted Reproductive Technology Surveillance - 
United States, 2013.

PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART a … ng twins; the corresponding percentages among all infants were 10.1% for singletons (range: 6.8% in Vermont to 14.8% in Mississippi) and 56.6% for twins (range: 44.7% in New Hampshire to 68.9% in Louisiana). INTERPRETATION: The percentage of infants conceived with ART varied considerably by reporting area. In most reporting areas, multiple births from AR …

Assisted reproductive technology surveillance -- United States, 2010.

PROBLEM/CONDITION: Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advan … % in Wyoming), compared with 12.0% among all infants born in the general population (range: 8.4% in Vermont to 17.9% in Guam); 6.6% of ART infants were born very preterm (range: 0 in Maine to 14.5% in Puerto Rico), compared with 2.0% among all infants born in the general population (range: 1.3% in Alaska to 3.0% in the District of Columbia). INTERPRETATI …

Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events.

BackgroundWe conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM).Patients and methodsThe data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients.ResultsSREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (

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… Pietropaoli MP, Damron TA, Vermont AI. Bone metastases from squamous cell carcinoma of the head and neck. J Surg Oncol. 2000; 75: 136–141. 8. Kapoor A, Kalwar A, Narayan S, Kumar N, Singhal MK, Kumar HS. …

Receipt of Selected Preventive Health Services for Women and Men of Reproductive Age - United States, 2011-2013.

PROBLEM/CONDITION: Receipt of key preventive health services among women and men of reproductive age (i.e., 15-44 years) can help them achie … rom 11 states (Hawaii, Maine, Maryland, Michigan, Minnesota, Nebraska, New Jersey, Tennessee, Utah, Vermont, and West Virginia). The National Health Interview Survey (NHIS) is a nationally representative survey of noninstitutionalized civilians in the United States. NHIS collects data on a broad range of health topics, including the prevalence, distributi …

Psychopathological Aspects in Childhood Hematopoietic Stem Cell Transplantation (HSCT): The Perception of Parents and Adolescents.

Background: Data about psychosocial sequelae of childhood Hematopoietic Stem Cell Transplantation (HSCT) are limited and the association with a specific donor type or other medical factors is largely unknown (Chang et al., 2012). The aim of the present study was to compare the psychological aspects of pediatric HSCT survivors with healthy peers. A secondary aim was to detect whether parents and children differed in the perception of mental health status. The influence of medical factors on psychological status was also examined. Method: Thirty seven HSCT survivors (23 males) with a mean age of

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… Burlington, VT : University of Vermont, Research Center for Children, Youth, & Families . Ahomäki R. Gunn M. E. Madanat-Harjuoja L. M. Matomäki J. Malila N. Lähteenmäki P. M. ( 2015 ). Late psychiatric morbidity in survivors of cancer at a young age: a nationwide registry-based study . Int. J. …

Global Budget Revenue Model and Care for Patients Receiving Chemotherapy.

ImportanceMaryland's Global Budget Revenue (GBR) model provided fixed global payments to hospitals, aiming to control revenue growth while improving care quality. The implications of GBR implementation in 2014 for cancer care have not been robustly evaluated.ObjectiveTo examine the association between GBR implementation and subsequent changes in episode-based Medicare payments, hospital utilization, and quality of care among Medicare beneficiaries undergoing systemic therapy for cancer.Design, setting, and participantsThis cohort study used a difference-in-differences approach to compare chang

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… We included Medicare beneficiaries in Maryland and 11 control states: Connecticut, Delaware, Illinois, Massachusetts, Michigan, New Jersey, New York, Ohio, Rhode Island, Vermont, and West Virginia. …

Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative.

PurposeTo provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.MethodsWe used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.ResultsA total of 6,860 breakthrough cases were

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… California, Davis—UL1TR001860: UC Davis Health Clinical and Translational Science Center • University of California, San Francisco—UL1TR001872: UCSF Clinical and Translational Science Institute • University of California, Los Angeles—UL1TR001881: UCLA Clinical Translational Science Institute • University of Vermont—U54GM115516 …

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

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ICIMH 2022 Abstracts

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Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… Center—U54GM104938: Oklahoma Clinical and Translational Science Institute (OCTSI) • University of Rochester—UL1TR002001: UR Clinical & Translational Science Institute • University of Southern California—UL1TR001855: The Southern California Clinical and Translational Science Institute (SC CTSI) • University of Vermont—U54GM115516 …

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… Zeglin-Sawczuk, University of Vermont Medical School, Burlington, VT, USA Background Acute stent thrombosis is reported in 0.5-0.7% of cases within the first 24 hours after PCI. …

MICAL1 promotes the proliferation in acute myeloid leukemia and is associated with clinical prognosis and immune infiltration.

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has a poor prognosis and a high rate of relapse. Dysregulated metabolism plays an important role in AML progression. This study aimed to conduct a comprehensive analysis of MRGs using TCGA and GEO datasets and further explore the potential function of critical MRGs in AML progression. In this study, we identified 17 survival-related differentially expressed MRGs in AML using TCGA and GEO datasets. The 150 AML samples were divided into three molecular subtypes using 17 MRGs, and we found that three molecular

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… The light absorbance at 450 nm was determined by employing a microplate reader manufactured by BioTek Instruments (Winooski, Vermont, United States). …

Виртуальная реальность в области аутизма и физической терапии: метааналитический обзор клинических результатов и терапевтической эффективности.

Технология Virtual Reality (VR) стала трансформативной терапевтической инновацией в сфере здравоохранения, обеспечивая императивность three- многомерная, многочувствительная среда, способствующая практическому обучению, реабилитации и взаимодействию. Хотя результаты многочисленных исследований свидетельствуют о его преимуществах, эмпирические исследования в области основанных на VR методов лечения расстройства аутистического спектра (ASD) и физической терапии (PT) по-прежнему ограничиваются методологическими несоответствиями, небольшими размерами выборки и изменяющимися схемами вмешательства.

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… Footnotes Edited by: Reuben Escorpizo , University of Vermont, United States Reviewed by: Kyriaki Sarri , University of Macedonia, Greece Elio Salvadori , Bruno Kessler Foundation (FBK), Italy Data availability statement The original contributions presented in the study are included in the article …

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1.

PURPOSE: Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone

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… The purity and the quantity of obtained RNA were measured by a spectrophotometer at 260 and 280 nm wavelength (Epoch, BioTek Instruments, Vermont, USA). …

Recent trends in specialty pharma business model.

The recent rise of specialty pharma is attributed to its flexible, versatile, and open business model while the traditional big pharma is facing a challenging time with patent cliff, generic threat, and low research and development (R&D) productivity. These multinational pharmaceutical companies, facing a difficult time, have been systematically externalizing R&D and some even establish their own corporate venture capital so as to diversify with more shots on goal, with the hope of achieving a higher success rate in their compound pipeline. Biologics and clinical Phase II proof-of-concept (POC

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… Mylan acquired Vermont based Bertek Inc. in 1993, and in 1999 renamed the company Mylan Technologies Inc. (MTI). MTI is the first company to receive approval for generic nitroglycerin, estradiol, clonidine, and fentanyl transdermal patches. MTI also does contract manufacturing work for others. …

Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients.

Herpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can have significant impact on patients' quality of life. HSV commonly causes oral and genital mucocutaneous infections whereas VZV is responsible for varicella/chickenpox and herpes zoster/shingles, but cancer patients are at particularly higher risk of complications including disseminated and visceral infections due to impaired cell-mediated immunit

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… Ther. 2021;19:1415–1425. doi: 10.1080/14787210.2021.1917992. 63. van der Beek M.T., Vermont C.L., Bredius R.G.M., Marijt E.W.A., van der Blij-de Brouwer C.S., Kroes A.C.M., Claas E.C.J., Vossen A.C.T.S. Persistence and antiviral resistance of varicella zoster virus in hematological patients. Clin. …