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What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Liposomes are considered one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic. In the past 40⁻50 years, Canadian scientists have made ground-breaking discoveries, many of which were successfully translated to the clinic, leading to the formation of biotech companies, the creation of research tools, such as the Lipex Extruder and the NanoAssemblr™, as well as contributing significantly to the development of pharmaceutical products, such as Abelcet®, MyoCet®, Marqibo®, Vyxeos®, and Onpattro™, which are making positive impacts on patient

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… Visudyne ® Aside from Abelcet ® , another liposomal formulation that was not designed for oncology use is Visudyne ® or liposomal verteporfin, which is a benzoporphyrin derivative that serves as a photosensitzer for photodynamic therapy in the treatment of age-related macular degeneration. … Verteporfin Drugs 2003 63 2521 2554 10.2165/00003495-200363220-00016 14609361 176. Frennesson C.I. Nilsson S.E. Encouraging results of photodynamic therapy with Visudyne in a clinical patient material of age-related macular degeneration Acta Ophthalmol. …

The interplay of mitochondrial dysfunction and altered metabolic pathways in glioblastoma.

Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor, characterized by rapid progression, treatment resistance, and poor prognosis, with a survival rate of less than five years despite advances in medical interventions. A hallmark of GBM is metabolic reprogramming, which supports tumor growth and progression. Mitochondrial dysfunction plays a critical role in this metabolic shift by altering energy production and disrupting key cellular pathways. However, the precise molecular mecha-nisms underlying these alterations remain inadequately understood. This review highlights th

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… Verteporfin, which targets both Complex I and III, has been found effective in inducing cytotoxic effects specifically on glioma stem cells without affecting normal cells. … Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells . FEBS J 2020 ; 287 : 2023 - 2036 . 31868973 10.1111/febs.15187 129 Reisbeck L , Linder B , Tascher G , Bozkurt S , Weber KJ , Herold-Mende C , et al . …

Blockage of Autophagy for Cancer Therapy: A Comprehensive Review.

The incidence and mortality of cancer are increasing, making it a leading cause of death worldwide. Conventional treatments such as surgery, radiotherapy, and chemotherapy face significant limitations due to therapeutic resistance. Autophagy, a cellular self-degradation mechanism, plays a crucial role in cancer development, drug resistance, and treatment. This review investigates the potential of autophagy inhibition as a therapeutic strategy for cancer. A systematic search was conducted on Embase, PubMed, and Google Scholar databases from 1967 to 2024 to identify studies on autophagy inhibito

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… Verteporfin-Based Photodynamic Therapy Overcomes Gemcitabine Insensitivity in a Panel of Pancreatic Cancer Cell Lines Lasers Surg. Med. 2011 43 565 574 10.1002/lsm.21093 22057484 PMC3211106 141. Scott L.J. Goa K.L. … Verteporfin Drugs Aging 2000 16 139 146 10.2165/00002512-200016020-00005 10755329 142. Petroni G. Bagni G. Iorio J. Duranti C. Lottini T. Stefanini M. Kragol G. Becchetti A. Arcangeli A. …

The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment.

Glioblastoma is the most common and aggressive brain tumour in adults, and despite ongoing efforts, effective treatment remains limited. Standard therapies often face challenges because of the tumour's specific biology, its aggressive nature, and the presence of certain physiological barriers in the brain that impede chemotherapeutics from reaching their target. Emerging research in circadian biology highlights the role of the internal circadian clock in tumour progression and treatment response. Evidence suggests that aligning therapy to patients' chronotypes could potentially improve treatme

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… In another study, polymetronidazole-coated verteporfin (VP) and dioleoyl-3-trimethylammonium propane (DOTAP) liposomes encapsulating a YAP small interfering inhibitor (siYAP) and functionalized with angiopep-2 successfully crossed the BBB and released siYAP and VP under hypoxia conditions, reducing tumour … T cell | T lymphocyte TfR | Transferrin receptor TIAM1 | Metastasis-inducing protein-1 TME | Tumour microenvironment TMZ | Temozolomide TTFL | Translational-transcriptional feedback/feed-forward loops VEGF | Vascular endothelial growth factor VEGFR | Vascular endothelial growth factor receptor VP | Verteporfin …

Role of autophagy in cholangiocarcinoma: An autophagy-based treatment strategy.

Cholangiocarcinomas (CCAs) are diverse biliary epithelial tumours involving the intrahepatic, perihilar and distal parts of the biliary tree. The three entirely variable entities have distinct epidemiology, molecular characteristics, prognosis and strategy for clinical management. However, many cholangiocarcinoma tumor-cells appear to be resistant to current chemotherapeutic agents. The role of autophagy and the therapeutic value of autophagy-based therapy are largely unknown in CCA. The multistep nature of autophagy offers a plethora of regulation points, which are prone to be deregulated and

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… Some other agents, are DCMI including desmethylclomipramine, verteporfin and clomipramine, impeding the fusion of autophagosome with lysosomes or acidification lysosomes[ 115 ], whereas the addition of DCMI to doxorubicin, in vitro , demonstrated higher effectiveness of the latter[ 116 ]. … A1 | Inhibitor of v-ATPase, inhibition of lysosomal acidification Concanamycin A | Inhibitor of v-ATPase, inhibition of lysosomal acidification Chloroquine (CQ) | Autophagosome-lysosome fusion Hydroxy-chloroquine (HCQ) | Autophagosome-lysosome fusion Clomipramine | Alter acidification of lysosomes Verteporfin …

Преобразование фотоэнергетики в наноматериалах для точной терапостики.

Быстро развивающаяся область тераностистики направлена на интеграцию терапевтических и диагностических функций в единую платформу для точной медицины, позволяющую одновременно лечить и контролировать болезни. Наноматериалы, основанные на преобразовании фотоэнергии, стали разносторонней платформой, использующей уникальные свойства света для активации тераностистики с высокой пространственной и временной точностью. В настоящем обзоре содержится всеобъемлющий обзор последних изменений в области преобразования фотоэнергетики с использованием наноматериалов с уделением особого внимания их применени

A Recent Review on Cancer Nanomedicine.

Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor specificity, dose-related toxicity, low bioavailability, and lack of stability of chemotherapeutics are major hindrances to cancer treatment. Nanomedicine has drawn the attention of many researchers due to its potential for tumor-specific delivery while minimizing unwanted side effects

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… Similarly, micelles of PEG-poly(beta-amino ester) (PBAE)-PEG triblock copolymer were synthesized for pH-dependent delivery of water-insoluble anticancer drug verteporfin [ 154 ]. …

Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications.

Malignant pleural mesothelioma (MPM) tumors are remarkably aggressive and most patients only survive for 5-12 months; irrespective of stage; after primary symptoms appear. Compounding matters is that MPM remains unresponsive to conventional standards of care; including radiation and chemotherapy. Currently; instead of relying on molecular signatures and histological typing; MPM treatment options are guided by clinical stage and patient characteristics because the mechanism of carcinogenesis has not been fully elucidated; although about 80% of cases can be linked to asbestos exposure. Several m

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… for solid tumors and multiple myeloma Hippo/YAP | PI3K-AKT-mTOR | LATS2 altered in 11% | PF-04691502 | - Nedd8 activating enzyme (NAE) | Interferes with YAP (70%) activation | Pevonedistat (MLN4924) | Phase I for hematological malagnancies and melanoma YAP-TEAD | NF2 (40%) and YAP (70%) overactive | Verteporfin … Therapeutic strategies, aimed at disrupting YAP activity, include (1) targeting the Hh pathway as it down-regulates the YAP protein, (2) a small molecule called verteporfin, which inhibits YAP-TEAD transcription factor assembly, and (3) obstructions of lysophosphatidic acid (LPA) and thrombin receptor …

Keyword Index for Volume 110

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… vascular disrupting agent 2170 vascular endothelial growth factor receptor tyrosine kinase inhibitor 2647 vascular targeting agents 1727 vascularisation 2855 vasculogenesis 1179 vegetable 792 VEGF 469, 1433 VEGF inhibitor 1917 VEGF receptor inhibitor 2821 VEGF-A 2700 venous invasion 19 verteporfin …

Biological Evaluation of Naproxen-Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors.

The use of peptide-drug conjugates is emerging as a powerful strategy for targeted drug delivery. Previously, we have found that peptides conjugated to a non-steroidal anti-inflammatory drug (NSAID), more specifically naproxen-dehydrodipeptide conjugates, readily form nanostructured fibrilar supramolecular hydrogels. These hydrogels were revealed as efficacious nano-carriers for drug delivery applications. Moreover, the incorporation of superparamagnetic iron oxide nanoparticles (SPIONs) rendered the hydrogels responsive to external magnetic fields, undergoing gel-to-solution phase transition

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… Verteporfin inhibits lipopolysaccharide-induced inflammation by multiple functions in RAW 264.7 cells Toxicol. Appl. Pharmacol. 2020 387 114852 10.1016/j.taap.2019.114852 31812773 33. Nishanth R.P. Jyotsna R.G. Schlager J.J. Hussain S.M. Reddanna P. …

Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective.

Cancer stem cells (CSCs) are characterized by intrinsic self-renewal and tumorigenic properties, and play important roles in tumor initiation, progression, and resistance to diverse forms of anticancer therapy. Accordingly, targeting signaling pathways that are critical for CSC maintenance and biofunctions, including the Wnt, Notch, Hippo, and Hedgehog signaling cascades, remains a promising therapeutic strategy in multiple cancer types. Furthermore, advances in various cancer omics approaches have largely increased our knowledge of the molecular basis of CSCs, and provided numerous novel targ

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… For example, several small-molecule inhibitors of the YAP1 transcriptional complex, including Verteporfin, CA3 and vestigial-like protein 4 (VGLL4) mimicking peptide, were shown to have potent antitumor activity in various cancer types, especially inhibiting tumorigenesis, CSCs enrichment and resistance … Verteporfin inhibits growth of human glioma in vitro without light activation Sci. Rep. 2017 7 7602 10.1038/s41598-017-07632-8 28790340 PMC5548915 118. Morales F. Giordano A. Overview of CDK9 as a target in cancer research Cell Cycle Georget. …

A noticeable difference? Productivity costs related to paid and unpaid work in economic evaluations on expensive drugs.

Productivity costs can strongly impact cost-effectiveness outcomes. This study investigated the impact in the context of expensive hospital drugs. This study aimed to: (1) investigate the effect of productivity costs on cost-effectiveness outcomes, (2) determine whether economic evaluations of expensive drugs commonly include productivity costs related to paid and unpaid work, and (3) explore potential reasons for excluding productivity costs from the economic evaluation. We conducted a systematic literature review to identify economic evaluations of 33 expensive drugs. We analysed whether eva

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… Oxaliplatin | Colorectal cancer Paclitaxel | Bladder cancer, ovarian cancer, melanoma Rituximab | Leukemia, lymphomas Infliximab | Ankylosing spondylitis, Crohn’s disease, rheumatoid arthritis Intravenous immunoglobulin | Autoimmune diseases Trastuzumab | Breast cancer Botulin toxin | Several types of spasm Verteporfin …

Development of novel gene signatures for the risk stratification of prognosis and diagnostic prediction of osteosarcoma patients using bioinformatics analysis.

BackgroundOsteosarcoma (OS) is a common malignant bone cancer in children and teenagers that originates from osteoblast cells. Although many biomarkers have been reported in OS, they have not improved the prognosis of this disease. This study sought to identify effective biomarkers for the early diagnosis and prognosis of OS using a comprehensive bioinformatics analysis.MethodsOS-associated microRNAs (miRNAs) were screened in the Human microRNA Disease Database (HMDD). The differentially expressed genes (DEGs) related to OS were screened using 3 data sets (GSE16088, GSE36001, and GSE56001) fro

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… Cancer Treat Res 2009 ; 152 : 15 - 32 . 10.1007/978-1-4419-0284-9_2 20213384 5 Morice S Mullard M Brion R The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth. …

Acceptance of health technology assessment submissions with incremental cost-effectiveness ratios above the cost-effectiveness threshold.

ObjectivesIn health technology assessment (HTA) agencies where cost-effectiveness plays a role in decision-making, an incremental cost-effectiveness ratio (ICER) threshold is often used to inform reimbursement decisions. The acceptance of submissions with ICERs higher than the threshold was assessed across different agencies and across indications, in order to inform future reimbursement submissions.MethodsAll HTA appraisals from May 2000 to May 2014 from National Institute for Health and Care Excellence (NICE), Scottish Medicines Consortium (SMC), Pharmaceutical Benefits Advisory Committee (P

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… cell carcinoma | Malignant disease and immunosuppression | 45,000–75,000 | Accepted | X | X | | | Tamsulosin hydrochloride | Lower urinary tract symptoms associated with benign prostatic hyperplasia | Obstetrics, gynecology, and urinary tract disorders | 45,000–75,000 | Restricted | X | | | | Verteporfin …

Promising Highly Targeted Therapies for Cholangiocarcinoma: A Review and Future Perspectives.

To overcome the poor prognosis of cholangiocarcinoma (CCA), highly targeted therapies, such as antibody-drug conjugates (ADCs), photodynamic therapy (PDT) with/without systemic chemotherapy, and experimental photoimmunotherapy (PIT), have been developed. Three preclinical trials have investigated the use of ADCs targeting specific antigens, namely HER2, MUC1, and glypican-1 (GPC1), for CCA. Trastuzumab emtansine demonstrated higher antiproliferative activity in CCA cells expressing higher levels of HER2. Similarly, "staphylococcal enterotoxin A-MUC1 antibody" and "anti-GPC1 antibody-monomethyl

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… cancer | 762 nm | | | | | | Redaporfin | Head and neck cancer | 749 nm | | | | | | Silicon phthalocyanine | Cutaneous T-cell lymphoma | 675 nm | | | | | | SnET2 | Cutaneous metastatic breast cancer, basal-cell carcinoma, Kaposi’s sarcoma, prostate cancer | 664 nm | | | | | | Verteporfin …

Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research.

Active targeting is a valuable and promising approach with which to enhance the therapeutic efficacy of nanodelivery systems, and the development of tumor-targeted nanoparticles has therefore attracted much research attention. In this field, the research carried out in Italian Pharmaceutical Technology academic groups has been focused on the development of actively targeted nanosystems using a multidisciplinary approach. To highlight these efforts, this review reports a thorough description of the last 10 years of Italian research results on the development of actively targeted nanoparticles t

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… polymer nano-sized carriers via biotin, mixed micelles made of Pluronics P123/F127 (synthetic triblock copolymers containing hydrophilic and hydrophobic regions) have been prepared using the thin-film hydration method to load repurposed drugs, such as the anthelmintic niclosamide and the photosensitizer verteporfin … Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells Mater. Sci. Eng. C 2017 71 1 9 10.1016/j.msec.2016.09.064 27987651 70. Conte C. Moret F. Esposito D. Poggetto G.D. Avitabile C. Ungaro F. Romanelli A. Laurienzo P. Reddi E. Quaglia F. …

Health state utilities in patients with diabetic retinopathy, diabetic macular oedema and age-related macular degeneration: a systematic review.

BackgroundHealth state utility values (HSUVs) are important in the assessment of the cost effectiveness of new interventions. In the case of visual conditions, models generally tend have tended to be built around a set of health states defined by visual acuity (VA). The aim of this review was to assess the impact of VA on HSUVs in patients with diabetic retinopathy, diabetic macular oedema or age-related macular degeneration.MethodsA systematic literature search was undertaken in major bibliographic databases to identify articles reporting on the relationship between HSUVs and vision. Data wer

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… Verteporfin photodynamic therapy cohort study: report 2: Clinical measures of vision and health-related quality of life. Ophthalmology. 2009;116:2463–2470. doi: 10.1016/j.ophtha.2009.10.031. Sahel JA, Bandello F, Augustin A, Maurel F, Negrini C, Berdeaux GH. et al. …

Optimizing Cancer Treatment: A Comprehensive Review of Active and Passive Drug Delivery Strategies.

Nanocarriers as powerful tools for delivering drugs to tumors provide new strategies for cancer treatment. These delivery systems encompass a diverse variety of structures, including polymeric nanoparticles (NPs), liposomes, dendrimers, micelles, and inorganic NPs such as gold and silica. Each type exhibits distinct physicochemical advantages that contribute to stability, drug-loading capacity, and targeting efficacy. Engineered nanocarriers can be utilized for the active targeting of tumor-specific receptors or for passive targeting of tumors via the enhanced permeability (EPR) and retention

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… The PEGylated liposomal carrier was later modified for the delivery of other drugs, such as amphotericin B (Ambisome ® ) for fungal infections and verteporfin (Visudyne ® ) for wet macular degeneration. …

Autophagy in tumor immune escape and immunotherapy.

The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involves the degradation of damaged proteins and organelles via lysosomal pathways, maintaining cellular homeostasis. This process not only supports tumor cell survival but also profoundly impacts the efficacy of cancer immunotherapies. The modulation of autophagy in tumor cells or immune cells exerts dual effects on tumor immune escape and immunotherapy. However,

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… Liang J Wang L Wang C Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis Exerting Antitumor Efficacy Cancer Immunol Res 2020 8 952 965 10.1158/2326-6066.CIR-19-0159 32265228 PMC8204534 Liang J, Wang L, Wang C, et al. … Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis. Exerting Antitumor Efficacy Cancer Immunol Res. 2020;8:952–65. 32265228 10.1158/2326-6066.CIR-19-0159 PMC8204534 61. …

Nanomedicine: Principles, Properties, and Regulatory Issues.

Several scientific areas have benefited significantly from the introduction of nanotechnology and the respective evolution. This is especially noteworthy in the development of new drug substances and products. This review focuses on the introduction of nanomedicines in the pharmaceutical market, and all the controversy associated to basic concepts related to these nanosystems, and the numerous methodologies applied for enhanced knowledge. Due to the properties conferred by the nanoscale, the challenges for nanotechnology implementation, specifically in the pharmaceutical development of new dru

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… Solution for Infusion | Advanced HIV-related Kaposi's Sarcoma | Cytarabine DepoCyte® | Suspension for injection | Lymphomatous meningitis | Mifamurtide Mepact® | Powder for concentrate for dispersion for infusion | Osteosarcoma | Morphine DepoDur® | Suspension for injection | Pain Nanocomplex | Verteporfin …