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Hypoxia-inducible factor-prolyl hydroxylase inhibitors in treatment of anemia with chronic disease.

AbstractAnemia of chronic disease (ACD) is the most frequent clinical issue in patients with chronic disease. ACD is usually secondary to chronic kidney disease (CKD), cancer, and chronic infection, which is associated with poor health outcomes, increased morbidity and mortality, and substantial economic costs. Current treatment options for ACD are very limited. The discovery of the hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) pathway made it possible to develop novel therapeutic agents (such as hypoxia-inducible factor-prolyl hydroxylase inhibitor, HIF-PHI) to treat ACD by stabilizin

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… These effects make roxadustat a novel treatment option for anemia. [ 14 , 15 ] Up to now, roxadustat has been approved for the treatment of anemia in many countries and regions, such as China, Japan, Chile, South Korea, the European Union, the United Kingdom, etc. …

Applications of Neural Network-Based Plan-Cancer Method for Primary Diagnosis of Mesothelioma Cancer.

"Malignant mesothelioma (MM)" is an uncommon although fatal form of cancer. The proper MM diagnosis is crucial for efficient therapy and has significant medicolegal implications. Asbestos is a carcinogenic material that poses a health risk to humans. One of the most severe types of cancer induced by asbestos is "malignant mesothelioma." Prolonged shortness of breath and continuous pain are the most typical symptoms of the condition. The importance of early treatment and diagnosis cannot be overstated. The combination "epithelial/mesenchymal appearance of MM," however, makes a definite diagnosi

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… A comparative study on machine learning algorithms and a hybrid model of genetic algorithm and neural network for mesothelioma diagnosis. 2020 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB); 2020, October; Via del Mar, Chile. pp. 1–8. 16. Win K. …

Real-World Data and Machine Learning to Predict Cardiac Amyloidosis.

(1) Background: Cardiac amyloidosis or "stiff heart syndrome" is a rare condition that occurs when amyloid deposits occupy the heart muscle. Many patients suffer from it and fail to receive a timely diagnosis mainly because the disease is a rare form of restrictive cardiomyopathy that is difficult to diagnose, often associated with a poor prognosis. This research analyses the characteristics of this pathology and proposes a statistical learning algorithm that helps to detect the disease. (2) Methods: The hospitalization clinical (medical and nursing ones) records used for this study are the ba

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… Chile. 2005;133:655–661. doi: 10.4067/S0034-98872005000600006. 8. Mircsof D. Diagnosis of Amyloidosis: A survey of current awareness and clinical challenges among cardiologists in Switzerland. Cardiol. Ther. 2020;9:127–138. doi: 10.1007/s40119-019-00160-8. 9. Gillmore J.D., Damy T., Ana M. …

A Case of Syphilis with High Bone Arsenic Concentration from Early Modern Cemetery (Wroclaw, Poland).

Venereal syphilis is a sexually transmitted disease caused by Treponema pallidum - Gram-negative, slowly growing bacteria. The spread of the disease in the Old World was due to increased birth rate, urban population growth, migration and lack of knowledge concerning the epidemiology. In the past, the treatment was mainly symptomatic and included application of mercury compounds. The goal of the study was to present the case of advanced venereal syphilis found in early modern (16th-18thc) graveyard localized in Wroclaw, Poland. The object of the study is a cranium of a male whose age at death h

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… Thoracic aortic aneurysm in a pre-Columbian (210 BC) inhabitant of Northern Chile: Implications for the origins of syphilis. Int J Paleopathol. 2016;13:20–26. doi: 10.1016/j.ijpp.2016.01.002. et al. [7] Mays S, Crane-Kramer G, Bayliss A. …

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review.

Real-world evidence (RWE) is emerging as a fundamental component of the post-marketing evaluation of medicinal products. Even though the focus on RWE studies has increased in Colombia, the availability of secondary data sources to perform this type of research is not well documented. Thus, we aimed at identifying and characterizing secondary data sources available in Colombia. We performed a systematic literature review on PubMed, EMBASE, and VHL using a combination of controlled vocabulary and keywords for the concepts of electronic health records, epidemiologic studies and Colombia. A total

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… A recent analysis of RWE in Latin America published by Justo et al, shows that the landscape of Colombia is similar to Chile, with well‐established national systems and registries, and ahead of Argentina, where there's still fragmented data source management and sporadic use of RWE data for decision‐making … Malformaciones congénitas en Chile y Latino América: Una visión epidemiológica del ECLAMC del período 1995–2008. Rev Med Chil. 2011;139:72‐78. 81. Kahaleh M, Xu M‐M, Zamarripa F, et al. POEM in Latin America: the rise of a new standard. J Clin Gastroenterol. 2019;53:e352‐e355. 82. …

Pituitary metastasis: a rare condition.

Tumor metastasis to the pituitary gland is a rare, not well-documented and life-threatening condition associated with a shortened life span. A better understanding of its clinical manifestations could lead to earlier diagnosis, appropriate therapy and potentially improving quality of life. Therefore, we retrospectively studied the charts of patients with pituitary metastases who were treated at the City of Hope National Medical Center (Duarte, CA) from 1984 to 2018. We reviewed and analyzed tumor origin, primary pituitary clinical manifestation, duration between primary tumor diagnosis and pit

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… Revista Médica de Chile 2000. 128 1015–1018. 106. Rajput R, Bhansali A, Dutta P, Gupta SK, Radotra BD, Bhadada S. Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. Pituitary 2006. 9 155–157. ( 10.1007/s11102-006-8326-0) 107. …

Dynamics of Patient-Based Benefit-Risk Assessment of Medicines in Chronic Diseases: A Systematic Review.

BackgroundA critical gap exits in understanding the dynamics of patient-based benefit-risk assessment (BRA) of medicines in chronic diseases during the disease journey.PurposeTo systematically review and synthesize current evidence on the changes of patients' preferences about the benefits and risks of medicines during their disease journey including the influence of disease duration and severity, and previous treatment experience.MethodsA systematic review of studies identified in PubMed and Embase, from inception to November 2020, was conducted in accordance with the PRISMA (Preferred Report

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… specialized patient newsletter 290 Multiple sclerosis Patients who had never taken a disease-modifying therapy reported less willingness to take one Casciano et al 2011 75 Algeria, Egypt, Iran, Lebanon, Morocco, Tunisia, Saudi Arabia, the United Arab Emirates, China, Malaysia, Thailand, Turkey, Argentina, Chile … patient newsletter | 290 | Multiple sclerosis | Patients who had never taken a disease-modifying therapy reported less willingness to take one Casciano et al 2011 75 | Algeria, Egypt, Iran, Lebanon, Morocco, Tunisia, Saudi Arabia, the United Arab Emirates, China, Malaysia, Thailand, Turkey, Argentina, Chile …

Роль врожденных иммунных клеток в множественном склерозе.

Множественный склероз (MS) — хроническое аутоиммунное, воспалительное и нейродегенеративное заболевание, затрагивающее центральную нервную систему (КНС). MS ассоциируется со сложным взаимодействием между нейродегенеративными и воспалительными процессами, в основном связанными с патогенными Т и В клетками. Однако все большее количество доклинических и клинических данных свидетельствует о том, что врожденный иммунитет играет ключевую роль в поощрении и развитии НР. В этой связи в настоящее время изучаются доклинические и клинические исследования, ориентированные на различные врожденные иммунные

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… This work was funded by the following grants: FONDECYT Regular N° 1231431 (AH), FONDECYT Regular N° 1240944 (NE) and FONIS SA23I0038 (NE), and Programa de Apoyo a Centros con Financiamiento Basal AFB-170004) (CP), all from Agencia Nacional de Investigación y Desarrollo de Chile (ANID). …

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates.

BackgroundTuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.MethodsWe performed random-effects meta-analyses and meta-regressions of studies reporting the association between tuberculosis and cancer risks by searching PubMed, Web of Science, Embase, Cochrane library, and CINAHL from inception to 1 June 2019. Population attributable fractions (PAFs) of cancer incidence attributable to tuberculosis were calculated using relative risks from our meta-analyses and tuberculosis prevalence data from Global Health Data Exch

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… In men, the PAFs were more than 7.2% in Morocco, Sudan, and Vietnam; but less than 1.0% in Australia, Chile, and the United States. In women, the PAFs were more than 4.5% in North Korea, Sudan, and Vietnam; but less than 0.6% in Jordan, Malta, and Spain. …

Immune monitoring, immune phenotyping, and precision intervention in severe pneumonia: current evidence and translational challenges

Severe pneumonia remains a major cause of mortality in critically ill patients, with severe community-acquired pneumonia representing a clinically important and representative scenario. This review focuses primarily on severe community-acquired pneumonia as the clinical context, in which outcomes are determined by the interplay between pathogen burden and heterogeneity of host responses. Beyond pathogen-directed therapies, severe pneumonia is frequently characterized by dynamic and partially overlapping states of hyperinflammation, immune dysfunction, and subsequent immunosuppression. Differen

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… Alipoor , Linköping University, Sweden Daniel Ramos , University of Chile, Chile Özge Kurtkulağı , Çanakkale Onsekiz Mart University, Türkiye Efrain Sanchez-Angarita , Omni Hospital, Ecuador sCAP, severe community-acquired pneumonia; MODS, multiple organ dysfunction syndrome; COVID-19, coronavirus …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

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… Australia), Elaine Harrow (Guideline International Network), Farid Foroutan (Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada), Fei Yutong (GRADE center, Beijing University of Chinese Medicine, China), Gabriel Rada (Epistemonikos Foundation, Santiago, Chile …

Double jeopardy: how BRCA2, TP53, and DNMT3A redefine the link between infertility and cancer risk.

BackgroundGermline mutations in genes governing DNA repair, cell cycle regulation, and epigenetic modification are now recognized as common etiological factors for both cancer predisposition and reproductive dysfunction. This reveals a profound intersection between reproductive biology and oncogenesis.MethodA systematic narrative review was conducted. The literature search spanned PubMed/MEDLINE, Scopus, and Web of Science using keywords and MeSH terms related to infertility phenotypes, cancer predisposition syndromes, and shared molecular mechanisms (e.g., DNA repair, epigenetics).OutcomesThe

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… Edited by: Debanjan Chakroborty , University of South Alabama, United States Reviewed by: Marcia Manterola , University of Chile, Chile Abdelkader Heddar , Laboratoire National de Santé, Luxembourg Abbreviations: BRCA1/2, BReast CAncer gene 1/2; TP53, Tumor Protein 53; DNMT3A, DNA Methyltransferase …

Психометрические свойства сообщаемых пациентами итоговых показателей качества жизни, связанных со здоровьем, в множестве миелом: систематический обзор на основе руководящих принципов КОСМИН.

ЦЕЛЬ: На систематической основе выявлять сообщаемые пациентами итоговые показатели (ПРОМ), используемые для оценки связанных со здоровьем качества жизни (HRQOL), симптомов и бремени заболеваний у пациентов с множественной миеломой (MM), и оценивать их измерительные свойства с использованием методологии КОСМИН. МЕТОДЫ: Был проведен систематический обзор в соответствии с руководящими принципами КОСМИН в отношении пересмотра ПМР. В соответствующих исследованиях сообщалось о разработке PROM, проверке содержания, адаптации к различным культурам или one или более измерительных свойств ПМР, используе

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… A. [ 37 ] Chile/Spanish Validation in Chilean Spanish Chilean patients with MM Internal consistency, construct validity EORTC QLQ-MY20 2025 Chao Liu [ 38 ] China/Chinese Translation and psychometric validation Chinese patients with MM Content validity, structural validity, internal consistency, reliability … A. [ 37 ] | Chile/Spanish | Validation in Chilean Spanish | Chilean patients with MM | Internal consistency, construct validity EORTC QLQ-MY20 | 2025 | Chao Liu [ 38 ] | China/Chinese | Translation and psychometric validation | Chinese patients with MM | Content validity, structural validity, internal …

Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals.

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact. The emergence of several variants during the pandemic has presented numerous challenges in preventing and managing this disease. The development of vaccines has played a pivotal role in controlling the pandemic, with a significant portion of the global population being vaccinated. This, along with the emergence of less virulent SARS-CoV-2 variants, has led to a reduction in the severity of COVID-19 outcomes for the overall population. Nevertheless, i

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… (7.8) Singh 2023 [ 109 ] February 2021–April 2022 US | Unvaccinated recipients of KT with COVID-19 ( n = 118) | Vaccinated/Unvaccinated | Retrospective | 11 (8.0) | 4 (3.3) | – | – Vaccinated recipients of KT with COVID-19 ( n = 282) | 12 (3.0) | 3 (1.0) Toro 2023 [ 100 ] January 2020–December 2021 Chile … Finally, another study conducted in Chile reported a 14% rate of hospitalization for COVID-19 in patients with end-stage renal disease (ESRD) [ 100 ]. …

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

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… 76·2) | 80·4 (79·3–81·3) | 69·2 (69·1–69·2) | 74·5 (73·3–75·5) | 65·9 (62·9–68·5) | 69·3 (66·2–72·1) | 61·1 (58·8–63·2) | 65·3 (62·5–67·9) Argentina | 75·9 (75·8–76·0) | 79·7 (78·3–81·0) | 68·9 (68·9–69·0) | 73·6 (72·0–75·0) | 65·9 (62·9–68·4) | 68·9 (65·7–71·8) | 61·0 (58·7–63·0) | 64·7 (61·8–67·4) Chile … –17·6) | 19·7 (18·9–20·3) | 14·0 (14·0–14·0) | 16·3 (15·6–16·9) | 13·3 (12·1–14·3) | 14·9 (13·5–16·2) | 10·7 (9·7–11·5) | 12·3 (11·1–13·5) Argentina | 17·6 (17·5–17·6) | 19·3 (18·4–20·2) | 13·9 (13·9–13·9) | 15·7 (14·8–16·5) | 13·4 (12·2–14·4) | 14·7 (13·3–16·1) | 10·6 (9·7–11·4) | 11·9 (10·7–13·2) Chile …

Cancer incidence and mortality in Quito: information to monitor cancer control policies.

IntroductionCancer represents a challenge for global public health, since it requires a comprehensive strategy for its control. In this context, the Population-Based Cancer Registries (PBCR) are key actors for the generation of public policies that guarantee their implementation.ObjectiveThis study analyses the trend in cancer incidence and mortality rates in the city of Quito during the period 1985-2017 and discusses them within the framework of the National Strategy against cancer proposed in 2017 for Ecuador.MethodsAge-standardized incidence and mortality rates are established using data fr

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… this stagnation, probably the increase in the diffuse histological type compared to the intestinal one, whose natural history would have different connotations, particularly in the earlier age of presentation, a situation reported in countries such as the United States, Canada, the United Kingdom, Chile …

Multicity study of air pollution and mortality in Latin America (the ESCALA study).

INTRODUCTION: The ESCALA* project (Estudio de Salud y Contaminación del Aire en Latinoamérica) is an HEI-funded study that aims to examine t … rticulate matter < or = 10 pm in aerodynamic diameter (PM10) and to ozone (O3) in cities of Brazil, Chile, and México. Analyses for PM10 and O3 were also stratified by age group and O3 analyses were stratified by season. Generalized linear models (GLM) in Poisson regression were used to fit the time-series data. Time trends and seasonality were modeled …

A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… Adolescent/M, T-ALL | Nasal cavity | PCR sequencing | – | AMB (IV): 3–5 mg/kg/d | Recovery | Bhavsar et al., 2022 P. oxalicum | 2024, China | 56/F, T2DW | Lung | ITS sequencing | FLC: >256, AMB: 0.25, VRC: 0.38, ITR: 0.5 | AMB (IV): 400 mg/d, 6 mg/kg/d | Recovery | Wang et al., 2024 P. digitatum | 2022, Chile …

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On CAR-Ts, decentralized in-house models, and the hospital exception. Routes for sustainable access to innovative therapies.

Chimeric Antigen Receptor T cells, or CAR-Ts, are a novel class of gene and cell 'one-shot' therapies based upon collecting, reprogramming, and using patients' own immune cells to treat their cancer. The article discusses the status, prospects, and some relevant legal issues of this frontier of personalized medicine. In particular, it explores the legitimacy of 'in-house' CAR-Ts, ie treatments manufactured and delivered to patients within the same clinical center by relying upon automated cell processing systems, a decentralized model which is very different from the one currently adopted for

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… WMA, Statement on Patenting Medical Procedures , Santiago del Chile, May 3, 2019). Louis Abinander & Jorge Contreras, supra note 35 at 718–721. See also Björn Jürgens & Nigel Clarke, Evolution of CAR T-Cell Immunotherapy in Terms of Patenting Activity , 37 Nat Biotechnol 370 (2019). …