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Effect of deep-breathing exercise training on reducing stress among maintenance hemodialysis patients: Quasi-experimental randomized trial study.

BACKGROUND: Dialysis is a stressful process and follows various psychological and social problems, which can lead to psychological disturbances. Patients on dialysis experience psychological distress, and the reduction of stress in patients provides psychological resources to cope with their physical condition. The study aimed to evaluate the effect of deep-breathing exercise training on the level of stress among maintenance hemodialysis patients. MATERIALS AND METHODS: This study is a randomized quasi-experimental design with parallel groups. A hundred eight hemodialysis patients participate…

Окончательные анализы OS на ТУРМАЛИНЕ-ММ3 и -ММ4 РТС ixazomib технического обслуживания в недавно диагностированном множестве миелом.

TOURMALINE-MM3 (В тыс.NCT02181413) и -ММ4 (NCT02312258) были фазы 3 :: исследования по обслуживанию ixazomib в течение длительного периода времени в период после трансплантации (TOURMALINE-MM3)/приемлемый для трансплантации (TOURMALINE-MM4) пациенты с недавно поставленным диагнозом множественной миеломы (NDMM), которые продемонстрировали улучшение среднего уровня выживаемости без прогрессирования (PFS) для ixazomib vs placebo. Мы представляем анализы окончательного общего выживания (ОС) по каждому исследованию отдельно. В обоих исследованиях пациенты, имеющие право на получение пособия, были с

Совпадение в аннотации оригинала
TOURMALINE-MM3 (NCT02181413) and -MM4 (NCT02312258) were phase 3 studies of fixed-duration, single-agent ixazomib maintenance in post-transplant (TOURMALINE-MM3)/transplant-ineligible (TOURMALINE-MM4) patients with newly diagnosed multiple myeloma (NDMM) that demonstrated improved median progression-free survival (PFS) for ixazomib vs placebo. We present the…

Long-term outcomes of refractory central venous occlusive disease treated by stent deployment in patients undergoing maintenance hemodialysis.

OBJECTIVES: To investigate the long-term outcomes of stent deployment in the treatment of refractory central venous occlusive disease (CVOD) in patients undergoing maintenance hemodialysis (MHD). METHODS: MHD patients who were successfully treated with stenting for symptomatic CVOD that was resistant to balloon angioplasty alone were consecutively included in this retrospective study. The primary (PPR) and assisted (APR) patency rates of the central vein and hemodialysis vascular access (VA), reintervention, and survival rates after stenting were followed. Multivariate logistic regression ana…

Electroacupuncture versus sham for insomnia in patients undergoing maintenance hemodialysis: study protocol for a pilot randomized controlled trial.

BACKGROUND: Insomnia causes severe health problems and poor quality of life in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD). Conventional therapies are limited due to the poor availability and opaque evidence, and electroacupuncture (EA) is considered an alternative for improving insomnia in patients with ESRD undergoing MHD. METHODS: This is a study protocol for a pilot randomized, sham-controlled, single-center, clinical trial. A total of 60 patients with insomnia in ESRD undergoing MHD will be randomly assigned to treatment group (EA, 3 sessions pe…

Circulating RIPK3 level predicts all-cause mortality in patients on maintenance hemodialysis: a 4-year prospective cohort study.

BACKGROUND: Maintenance hemodialysis (MHD) is a well-established modality of renal replacement treatment for patients with end-stage renal disease. Currently, receptor-interacting protein kinase-3 (RIPK3) is considered as a key regulator of inflammation. But its association with mortality in MHD patients remains unclear. Thus, the aim of the present study was to observe the predictive value of plasma RIPK3 for all-cause mortality in patients undergoing MHD with a 4-year follow-up. METHODS: 148 patients undergoing MHD treatment during June 2020 were enrolled. The plasma RIPK3 levels were measu…

Correlation between vascular access satisfaction and demoralization syndrome in elderly patients with maintenance hemodialysis: a multi-center study.

OBJECTIVE: This multi-center study aimed to investigate the correlation between vascular access satisfaction (VAS) and demoralization syndrome (DS) in elderly patients undergoing maintenance hemodialysis (MHD). Secondary objectives included identifying predictors of VAS and comparing DS severity between patients with high and low VAS scores. METHODS: A retrospective analysis was conducted from April 2024 to October 2024, involving 350 elderly MHD patients from three tertiary hospitals in China. Participants were stratified into two groups based on VAS scores: the VA dissatisfaction group (n =…

Haemodynamically irrelevant pericardial effusion is associated with increased mortality in maintenance hemodialysis patients with end-stage renal disease.

BACKGROUND: Pericardial effusion (PE) is common in patients with end-stage renal disease (ESRD) undergoing maintenance haemodialysis (MHD). The prognostic value of a small, haemodynamically non-compromising PE in patients with ESRD who undergo MHD, is currently lacking. OBJECTIVE: The purpose of this study was to determine the predictive significance of a small, haemodynamically non-compromising PE in MHD patients with ESRD. METHODS AND RESULTS: Patients with ESRD who received regular dialysis in the Hemodialysis Center of the Fifth Affiliated Hospital of Sun Yat-sen University from January …

An explainable machine learning framework for railway predictive maintenance using data streams from the metro operator of Portugal.

The public transportation sector generates large volumes of sensor data that, if analyzed adequately, can help anticipate failures and initiate maintenance actions, thereby enhancing quality and productivity. This work contributes to a real-time data-driven predictive maintenance solution for Intelligent Transportation Systems. The proposed method implements a processing pipeline comprised of sample pre-processing, incremental classification with Machine Learning models, and outcome explanation. This novel online processing pipeline has two main highlights: (i) a dedicated sample pre-processin…

Venetoclax Plus CyBorD Induction Therapy and Venetoclax Maintenance Treatment for Immunoglobulin Light Chain Amyloidosis with t(11;14) Translocation.

Background: A total of 50% of patients with AL amyloidosis have t(11;14) translocation, allowing us to use the selective oral BCL-2 inhibito … T) was performed. At 100 days post-ASCT, the patient had complete hematologic remission. Venetoclax maintenance treatment was initiated. The follow-up examinations showed that the patient is in very good partial remission. Conclusions: In the case of our AL amyloidosis patient with t(11;14) translocation, the combined treatment with CyBorD and venetoclax was …

Stem Cell Transplantation for Ovarian Cancer Patient with Associated Myelodysplasia After Maintenance Therapy with Olaparib: A Case Report.

Ovarian cancer remains a significant cause of morbidity and mortality in women worldwide. Olaparib, a poly ADP-ribose polymerase (PARP) inhibitor, has been shown in studies to increase the time that people with cancer do not get worse. However, reports have indicated rare adverse effects, like myelodysplastic syndrome (MDS). In this report, we highlight the case of a 42-year-old female patient who was diagnosed with ovarian endometrioid carcinoma, FIGO Stage IIB. Following surgery and chemotherapy, the patient commenced maintenance therapy with Olaparib. After two years, she experienced abnorm…

Non-adherence to treatment and concurrent opioid use among people on methadone maintenance treatment using methamphetamine in Vietnam.

INTRODUCTION: The global rise of concurrent use of opioids and methamphetamine presents challenges to stable methadone maintenance treatment (MMT). We assessed non-adherence to treatment and concurrent opioid use, along with associated factors, among people on MMT using methamphetamine in Vietnam. METHODS: This analysis utilized baseline data from a randomized clinical trial designed to investigate the effectiveness of various combinations of behavioral evidence-based interventions for methamphetamine use among patients on MMT in Vietnam (STAR-OM R01DA050486). We used data from 498 participan…

Altered reward feedback processing in methadone maintenance treatment patients: An ERP study using the monetary incentive delay task.

Opioid use disorder (OUD) is a significant global health challenge marked by neurophysiological abnormalities affecting mood, motivation, memory, and reward processing. While methadone maintenance treatment (MMT) is widely employed to treat OUD, its impact on neural reward mechanisms remains poorly understood. In this study, we investigated the electrophysiological correlates of reward processing in 15 MMT patients and 21 healthy controls using the Monetary Incentive Delay (MID) task combined with electroencephalography (EEG). MMT patients performed the task both before and 30 min after the me…

Steroid Withdrawal Versus Maintenance in Simultaneous Pancreas-Kidney Transplantation: Long-Term Outcomes in a Single-Center Retrospective Cohort.

BACKGROUND: Simultaneous pancreas and kidney (SPK) transplants using steroid-free regimens are a frequently used immunosuppressive strategy in low immunologic risk recipients. The long-term effect on recipient outcomes remains incompletely understood. METHODS: We analyzed post-transplant outcomes in 307 SPK recipients from a single center, comparing early steroid withdrawal (after completion of Thymoglobulin) with maintenance steroids. Steroid withdrawal was primarily utilized in low immunologic risk patients. RESULTS: In total, 170 SPK recipients underwent steroid withdrawal, and 137 receiv…

Histone deacetylase 4 in limb mesenchyme is essential for chondrocyte proliferation, growth plate maintenance and proper bone formation.

PURPOSE/AIM: Dysregulation of well-ordered chondrocyte proliferation and differentiation leads to distorted architecture of the growth plate … CLUSIONS: Hdac4 in limb mesenchymal cells plays an indispensable role in chondrocyte proliferation, maintenance of the growth plate and formation of secondary ossification centers, its pro-osteogenic role was accomplished through premature differentiation of chondrocytes, along with accelerated cartilage-to-bone conversion.

Real world effectiveness of maintenance ketamine infusions for treatment-resistant depression in major depressive disorder and bipolar disorder.

Antidepressant effects with sub-anesthetic doses of intravenous ketamine have been previously demonstrated. However, previous studies have primarily evaluated the efficacy of acute treatment protocols, with limited research on maintenance treatment. Moreover, controlled maintenance studies have only included patients with treatment-resistant Major Depressive Disorder (TRD), with no maintenance studies evaluating effects in bipolar disorder. Herein, we report the first study to evaluate maintenance ketamine infusions in patients with treatment-resistant bipolar depression (TRBD), in addition to…

Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4+ Tregs.

Maintenance of pregnancy is highly dependent on the maternal immune system. High levels of regulatory T cells (Tregs) accumulate in the maternal placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate immunoreactivity and thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In AsR-exposed mice, total Tregs were significantly increased, whereas cytotoxic T lymphocyte antigen 4 (CTLA-4)-positive Tregs were decreased in AsR-exposed mice. Tregs…

Cross-frequency coupling in cortico-hippocampal networks supports the maintenance of sequential auditory information in short-term memory.

It has been suggested that cross-frequency coupling in cortico-hippocampal networks enables the maintenance of multiple visuo-spatial items in working memory. However, whether this mechanism acts as a global neural code for memory retention across sensory modalities remains to be demonstrated. Intracranial EEG data were recorded while drug-resistant patients with epilepsy performed a delayed matched-to-sample task with tone sequences. We manipulated task difficulty by varying the memory load and the duration of the silent retention period between the to-be-compared sequences. We show that the …

Maintenance infusion rate of oxytocin after initial 1-IU bolus for elective Cesarean delivery: a dose-finding study.

PURPOSE: The purpose of our study was to determine the minimum effective dose of oxytocin maintenance infusion required to maintain adequate uterine tone in 90% of patients (ED90) after administration of the initial bolus at elective Cesarean delivery (CD) under spinal anesthesia. METHODS: We conducted a prospective, double-blind dose-finding study with biased coin up-down design. Immediately after delivery, a 1-IU oxytocin bolus was administered, followed by a maintenance infusion. The obstetrician assessed the uterine tone by palpation as satisfactory or unsatisfactory. In case of unsatisfa…

Effects of Visualized Health Education Based on Health Belief Model on Self-Management of Patients Undergoing Maintenance Hemodialysis.

BACKGROUND: Patients with end-stage renal disease often require maintenance hemodialysis (MHD). Effective self-management is crucial for the prognosis of patients undergoing MHD; however, their self-management practices remain suboptimal. OBJECTIVE: This study aimed to explore the effects of visualized health education based on health belief model on self-management, self-efficacy, quality of life, and quality of dialysis in patients undergoing MHD. METHODS: A total of 93 patients undergoing MHD from a tertiary hospital in Guangzhou were recruited between December 2021 and June 2022 and divi…

Assessing lifetime occupational chrysotile inhalation exposure, respiratory symptoms, and lung cancer risk among brake maintenance workers in Malaysia.

This study aimed to estimate workers' occupational lifetime exposure to chrysotile and examine the respiratory symptoms and lung cancer risk. A total of 112 workers were interviewed about their occupational histories. Exposure modeling using information on the determinants of exposure was used to estimate chrysotile emissions. The cumulative lifetime exposure was then assessed for each worker. Respiratory symptoms were obtained using a validated questionnaire. Lung cancer mortality rate was also predicted using a model. Almost all the workers were male and young (mean age = 30 years, SD = 7).