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A Multi-step Approach to Adapting a Mind-Body Resiliency Intervention for Fear of Cancer Recurrence and Uncertainty in Survivorship (IN FOCUS).

BackgroundFor cancer survivors, there is a paucity of fear of recurrence (FOR) interventions that integrate empirically supported mind-body and psychological skills for managing FOR and are delivered in scalable formats.ObjectiveTo adapt an evidence-based resiliency intervention to address FOR among cancer survivors.MethodsA multidisciplinary team of researchers, clinicians, and patient stakeholders followed an iterative intervention adaptation process (ORBIT). In Step 1, we sought to define key FOR management skills through a literature review and feedback from stakeholders. In Step 2, we int

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… J Natl Compr Cancer Netw . 2017 ; 15 ( 9 ): 1140 - 1163 . 10.6004/jnccn.2017.0146 PMC5865602 28874599 50 Park ER Chiles C Cinciripini PM , et al. Impact of the COVID-19 pandemic on telehealth research in cancer prevention and care: A call to sustain telehealth advances . …

Impact of maintenance therapy on survival after autologous stem cell transplant for multiple myeloma regardless of response: a global analysis.

The effect of different maintenance therapies on outcome after autologous hematopoietic cell transplantation (AHCT) was analyzed in newly diagnosed multiple myeloma (NDMM) patients using global real-world data. NDMM patients transplanted between 2013 and 2017 were selected from the Worldwide Network for Blood and Marrow Transplantation (WBMT) registry. Overall survival (OS) was evaluated as primary and progression-free survival (PFS), non-relapse mortality and relapse/progression incidence as secondary endpoints. Multivariable 6- month landmark analyses were performed using Cox proportional ha

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… Leiden Study Unit, Leiden, Netherlands; 3 Department of Medicine, University of Pisa, Italy 4 Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan; 4 Aichi Medical University School of Medicine, Nagakute, Japan; 5 Intensive Hematology Unit, Hospital del Salvador, Santiago, Chile …

Risk of cancer in patients with thalassemia and sickle cell disease: a systematic review.

BACKGROUND: Individuals with thalassemia or sickle cell disease (SCD) are at an elevated risk of developing cancer, yet the full extent of this risk remains inadequately characterised. METHODS: We conducted a systematic review using three databases (MEDLINE, EMBASE and Scopus) to compare the cancer risk in patients with thalassemia and SCD with that of the general population. Secondly, we assessed the impact of other putative risk factors in patients with thalassemia and SCD on cancer risk. RESULTS: Five studies from four countries were included, encompassing a total of 24,439 individuals ov

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… Poverty, reproductive health and public health policies in Chile . In: Empowering Midwives and Obstetric Nurses. 2021 ; IntechOpen Limited (London, UK). doi: 10.5772/intechopen.96100 . …

Change in Neurocognitive Function in Patients Who Receive CAR-T Cell Therapies: A Steep Hill to Climb.

Immunotherapy with chimeric antigen receptor T (CAR-T) cell therapies has brought substantial improvement in clinical outcomes in patients with relapsed/refractory B cell neoplasms. However, complications such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) limit the therapeutic efficacy of this treatment approach. ICANS can have a broad range of clinical manifestations, while various scoring systems have been developed for its grading. Cognitive decline is prevalent in CAR-T therapy recipients including impaired attention, difficulty in it

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… Utility of the Neuropsychiatric Inventory Questionnaire (NPI-Q) in the Assessment of a Sample of Patients with Alzheimer’s Disease in Chile. Dement. Neuropsychol. 2017;11:129–136. doi: 10.1590/1980-57642016dn11-020005. 90. …

Recommendations for influenza and Streptococcus pneumoniae vaccination in elderly people in China.

Influenza and pneumonia can be prevented by vaccination, but they remain major causes of morbidity and mortality in age-related diseases. In most areas of China, the rates of influenza and pneumococcal vaccination are relatively low and public awareness of vaccination remains insufficient. Thus, it is essential to recommend influenza and Streptococcus pneumoniae vaccination to elderly people in clinical practice. Based on recently published studies and related documents issued by several vaccination authorities, such as the World Health Organization, the National Health and Wellness Committee,

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… PCV13 was first approved in Chile in 2009 and was subsequently licensed by the FDA to prevent pneumococcal disease in young children. 58 In December 2011 the FDA expanded the use of PCV13 to people aged ≥ 50 years. 59 In September 2014, the ACIP recommended the use of PCV13 in all adults aged > 65 years …

Использование микробиомных средств для совершенствования методов лечения нейродегенеративных заболеваний: данные о воздействии вдоль оси микробиота-гут-мозгов.

Недавно в качестве полезной модели для понимания возникновения и развития нейродегенеративных заболеваний (НДД) появилась ось микробиота-гут-мозгов (МГБА). Меры воздействия на основе микробиома с использованием биотических добавок (пробиотики, предбиотики, синдиотики, постбиотики) могут модифицировать MGBA и служить подходящими решениями для снижения риска неврологических изменений, связанных с НИЗ, и регулирования симптомов. В настоящем описательном обзоре содержится резюме функционирования МГБС и его взаимодействия с заболеваниями, связанными с началом и развитием НИЗ. Проводится обзор мероп

TLN1: an oncogene associated with tumorigenesis and progression.

Talin-1 (TLN1), encoded by the TLN1 gene, is a focal adhesion-related protein capable of binding various proteins in the cytoskeleton. It is also expressed at high levels in many cancers wherein it influences cellular adhesion and the activation of integrins. TLN1 is also capable of promoting tumor cell invasivity, proliferation, and metastatic progression, in addition to being a relevant biomarker and therapeutic target in certain cancers. The present review offers a comprehensive overview of current knowledge regarding TLN1 with respect to its structural properties, functions, and role in tu

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… Chiles C. Lung cancer screening with low-dose computed tomography. Radiol Clin North Am. 2014;52(1):27. 101. Wu Y, et al. Driver and novel genes correlated with metastasis of non-small cell lung cancer: a comprehensive analysis. Pathol Res Practice. 2021;224:153321. 102. Novikova SE, et al. …

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

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… Today, there are similar rises in colorectal cancer incidence rates in many transitioning countries. 116 Particularly rapid increases have been observed in parts of Latin America and the Caribbean (e.g., Chile, Costa Rica, Ecuador) and across several African countries. 86 , 117 A recent analysis of 12 … Prostate cancer is the leading cause of cancer death among men in 68 countries, including many in the Caribbean and sub‐Saharan Africa, as well as several in Central and South America (e.g., Colombia, Peru, Venezuela, and Chile) and Sweden in Europe (Figure 5A ). …

Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective.

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, representing a major global health concern, particularly in developing countries. This review provides an updated overview of the epidemiology, diagnosis, prognosis, treatment, and a Brazilian perspective for ALL. Despite advances in chemotherapy and immunotherapy, survival disparities remain challenging, driven by socioeconomic and healthcare access inequalities. Present diagnosis incorporates immunophenotyping, cytogenetics, and molecular biology for precise stratification and treatment planning. Treatment has evolved fr

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… A different study involving patients from Argentina, Bulgaria, Cuba, Chile, Croatia, Greece, Hungary, Poland, Serbia, Slovakia, Slovenia, and Uruguay has shown that 84.1% of childhood patients had B-type ALL, and 11.1% were classified as T-type ALL ( 37 ). …

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review.

Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold and is also a cofactor of hydrolases that participate in the synthesis of collagen and catecholamines, and in the regulation of gene expression. In cancer, vitamin C is associated with prevention, progression, and treatment, due to its general properties or its role as a pro-oxidant at high concentration. This review explores the role of vitamin C in cancer clinical trials and the aspects to consider in future studies, such as plasmatic vitamin C and metabolite excretion recording, and metabolism and tra

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… Chile. Conflicts of Interest The authors declare no conflict of interest. Footnotes Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. References 1. Lindblad M., Tveden-Nyborg P., Lykkesfeldt J. …

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

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… Alberto Fierro, Chile, was supported by “Fondecyt regular 1120731.” Appendix Presentations from the ISN Nexus 2016 Berlin meeting, Berlin, Germany—April 14–17, 2016 are available at http://www.theisn.org/education/education-topics/general-nephrology/itemlist/tag/Nexus%202016%20Berlin . …

Электронные постеры

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Information-Seeking Patterns and Communication Preferences Among Japanese Survivors With Cancer: Cross-Sectional Analysis.

BackgroundWith increasing numbers of survivors with cancer, the importance of patient-centered information provision and communication to alleviate psychological burdens, such as anxiety and depression, is growing. However, substantial individual differences exist in patients with cancer information-seeking behaviors and use of support services, and few studies have comprehensively examined cognitive and psychological factors such as treatment status, sex, trust in information sources, and patient-provider relationships.ObjectiveThis study aimed to integrate the theory of planned behavior and

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… Moore P Vargas A Núñez S Macchiavello S A study of hospital complaints and the role of the doctor-patient communication Revista médica de Chile 07 2011 139 7 880 885 doi 10.4067/S0034-98872011000700008 Medline 22051825 14. …

Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… Chiles C. Handbook of Psychiatric Drug Therapy, 5th Ed J. Clin. Psychiatry 2007 68 339 10.4088/JCP.v68n0222a 30. Abdul M. Logothetis C.J. Hoosein N.M. Growth-Inhibitory Effects of Serotonin Uptake Inhibitors on Human Prostate Carcinoma Cell Lines J. …

Comparative Analysis of Aging-related Metabolic and Biological Markers between Cancer Survivors and Healthy Populations: A Systematic Review.

Cancer survivors may exhibit biological and metabolic changes linked to both cancer and its treatment. This systematic review aimed to compare metabolic and biological aging-related biomarkers between cancer survivors and healthy individuals. The primary electronic databases utilized to search papers from 2019 to 2024 were PubMed, Scopus, and Web of Science. Boolean operators were combined with specific keywords and MESH terms in searching the articles. After excluding protocol papers, studies with incorrect designs or populations, and animal studies, 27 articles were selected for data extract

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… 32 ], five in India [ 7 , 11 , 12 , 33 , 34 ], three in the United States of America (USA) [ 5 , 6 , 35 ], two in Iran [ 36 , 37 ], one each in Egypt [ 38 ], Italy [ 39 ], Greece [ 40 ], Canada [ 10 ], Thailand [ 41 ], Japan [ 42 ], Russia [ 43 ], and another study conducted in multiple countries of Chile …

Novel therapeutic approaches for pulmonary fibrosis.

Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is characterized by the excessive deposition of extracellular matrix proteins within the pulmonary interstitium leading to the obliteration of functional alveolar units and in many cases, respiratory failure. While a small number of interstitial lung diseases have known aetiologies, most are idiopathic in nature, and of these, idiopathic pulmonary fibrosis is the most common and carries with it an appalling prognosis - med

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… Etanercept therapy resulted in a non-significant reduction in disease progression in several physiological, functional and QoL end points Azathioprine/prednisolone | As above | Thorax National Institute, Chile | Prospective, double-blinded, randomized placebo-controlled trial; currently recruiting patients … The AZAPRED trial (Thorax National Institute, Chile) is a randomized double-blinded placebo-controlled trial evaluating the efficacy of azathioprine/prednisolone, while the PANTHER trial (NHLBI, USA) will assess the efficacy of the current recommended ‘gold-standard triple therapy’ of azathioprine/prednisolone …

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside.

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its' very nature, epigenetics is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of num

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… Deoxyribonucleosides; Pyrimidine nucleosides DNMT inhibitors 2006 for MDS MDS, AML and CML T-ALL, T-LBL, T/M-MPAL Malignant melanoma; OC 07 Dec 2019 Pharmacodynamics data from a preclinical study in acute myeloid leukemia Vorinostat Vorinostat has been launched in the USA, Canada, Japan, Argentina, Chile … Deoxyribonucleosides; Pyrimidine nucleosides | DNMT inhibitors | 2006 for MDS | MDS, AML and CML | T-ALL, T-LBL, T/M-MPAL | | Malignant melanoma; OC | 07 Dec 2019 Pharmacodynamics data from a preclinical study in acute myeloid leukemia Vorinostat | Vorinostat has been launched in the USA, Canada, Japan, Argentina, Chile …

Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics.

Background and objectivesOsteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people worldwide suffer from OA, which shows a high incidence in middle-aged and elderly populations, with a prevalence of 50% among individuals aged over 60 years. Its core clinical symptoms consist of joint pain, swelling, and dysfunction. Studies have shown that arginine and proline metabolism play an important role in the pathogenesis and progression of OA, but the specific mechanism is still unclear. This study aimed to identify biomarkers and drug therapeutic targets for OA ass

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… Edited by: Felipe Eltit Guersetti , Vancouver Prostate Centre, Canada Reviewed by: Robyn Birch , University of British Columbia, Canada Mauricio Quezada , Finis Terrae University, Chile Data availability statement The datasets presented in this study can be found in online repositories. …

A comprehensive economic assessment of the burden of obesity in Kuwait.

BackgroundObesity is a complex public health issue that has risen to epidemic proportions globally. The aim of this study was to estimate the economic costs associated with obesity from governmental and societal perspectives in the State of Kuwait in 2024.MethodsA disease-specific prevalence-based cost-of-illness framework was applied. Key parameters include prevalence of obesity and its related comorbidities, relative risks, healthcare resources, income rate and growth, and lost workdays for patients and relatives, all were derived from literature. The outcomes measured were total healthcare

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… An evaluation of Chile’s Law of Food Labeling and Advertising on sugar-sweetened beverage purchases from 2015 to 2017: A before-and-after study . PLoS Med . 2020 ; 17 ( 2 ):e1003015. doi: 10.1371/journal.pmed.1003015 32045424 PMC7012389 55 Tham KW , Lim AYL , Baur LA . …

Re-estimation of the burden of serious fungal diseases in Uganda.

BACKGROUND: It is of utmost importance to monitor any change in the epidemiology of fungal diseases that may arise from a change in the number of the at-risk population or the availability of local data. OBJECTIVE: We sought to update the 2015 publication on the incidence and prevalence of serious fungal diseases in Uganda. METHODS: Using the Leading International Fungal Education methodology, we reviewed published data on fungal diseases and drivers of fungal diseases in Uganda. Regional or global data were used where there were no Ugandan data. RESULTS: With a population of ~45 million, w

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… High prevalence of Pneumocystis Jirovecii dihydropteroate synthase gene mutations in patients with a first episode of Pneumocystis pneumonia in Santiago, Chile, and clinical response to trimethoprim-sulfamethoxazole therapy . …