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Disparity in survival benefits of pembrolizumab between Asian and non-Asian patients with advanced cancers: A systematic review and meta-regression analysis.

BackgroundImmune checkpoint inhibitors have revolutionized the treatment of malignancies. However, disproportionate enrollment among races and ethnicities places the generalizability of global trial results in doubt.MethodsIn this systematic review, phase 3 randomized controlled trials investigating pembrolizumab in advanced cancers and providing subgroup analyses of Asian and non-Asian participants were included. The primary and secondary effect measures were the mean differences (MDs) in the natural logarithms of the hazard ratios (HRs) for overall survival (OS) and progression-free survival

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… The non‐Asian countries for global trials were in North America (Canada and the United States), Europe (mainly France, Germany, Spain, and the United Kingdom), Oceania (Australia and New Zealand), Africa (South Africa), the Middle East (Israel and Turkey), and Latin America (mainly Argentina and Chile …

Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect.

Bisphosphonates (BPs) reduce bone pain and fractures by balancing the osteoblast/osteoclast ratio. The behavior of ion channels in the presence of BPs is not known. To investigate this, the effect of zoledronic acid BP (ZOL) (3 × 10-8 to 5 × 10-4 M) treatment, on ion channels, cell proliferation, and mineralization, has been investigated on preosteoclast-like cells, RAW264.7, preosteoblast-like cells MC3T3-E1, and rat/mouse native bone marrow-derived osteoblasts. In whole-cell patch clamp on cell line- and bone marrow-derived osteoblasts, ZOL potentiated outward currents. On RAW264.7, ZOL (10-

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… Patch clamp experiments on Xenopus laevis oocytes were performed at Centro Interdisciplinario de Neurociencia de Valparaíso (CINV) (Chile) in accordance with NIH “Guidelines for Egg and Oocyte Harvesting in Xenopus laevis ” [ 38 ]. 4.4. …

A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies.

Adult T-cell leukemia-lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidel

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… A recent study reported that ATL accounts for 5.5% of non-Hodgkin lymphoma (NHL) in Peru, 0.5% in Chile, and 1.1% in Central and South America overall [ 15 ]. …

COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network.

Patients with multiple myeloma frequently present with substantial immune impairment and an increased risk for infections and infection-related mortality. The risk for infection with SARS-CoV-2 virus and resulting mortality is also increased, emphasising the importance of protecting patients by vaccination. Available data in patients with multiple myeloma suggest a suboptimal anti-SARS-CoV-2 immune response, meaning a proportion of patients are unprotected. Factors associated with poor response are uncontrolled disease, immunosuppression, concomitant therapy, more lines of therapy, and CD38 an

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… apart | 91·6% at 21 days after first dose (day of dose two) 19 | Russia, Belarus, Argentina, Serbia, UAE, Algeria, Palestine, and Egypt CoronaVac | Sinovac Biontech (China) | Inactivated virus | Two doses 14 days apart | 83·5% at 14 days or more after dose two 20 | China, Brazil, Columbia, Bolivia, Chile …

Cancer prevention programmes in Mexico: are we doing enough?

Cancer has increased in all the countries of the world and Mexico is no exception. The recognised risk factors for the main types of cancer are reviewed and searched through the Mexican government web pages and cancer prevention programmes to tackle the risk factors in the population. The Mexican government, a member of the World Health Organization, shows that the main approach is an early diagnosis rather than prevention, forgetting that an ounce of prevention is better than a pound of cure. Effective public programmes should be promoted to reduce preventable risk factors in the population (

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… Factores asociados al estilo de vida en pacientes diagnosticados con cáncer colorrectal en un hospital de Chile. [27/06/19];Perspectivas en nutrición humana. 2018 20:39–48. doi: 10.17533/udea.penh.v20n1a04. 88. Hardikar S, Newcomb PA, Campbell PT, et al. …

Diagnostic imaging for spinal disorders in the elderly: a narrative review.

The high prevalence of neck and low back pain in the rapidly aging population is associated with significant increases in health care expenditure. While spinal imaging can be useful to identify less common causes of neck and back pain, overuse and misuse of imaging services has been widely reported. This narrative review aims to provide primary care providers with an overview of available imaging studies with associated potential benefits, adverse effects, and costs for the evaluation of neck and back pain disorders in the elderly population. While the prevalence of arthritis and degenerative

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… | MRI | CT Head | Abdomen | Head | Pelvis United Kingdom | $187 | $187 | $187 | $187 Spain | $234 | $117 | $117 | $117 Canada | $304 | $61 | $65 | $98 France | $398 | $179 | $179 | $215 Australia | $439 | $487 | $234 | $386 Chile | $505 | $249 | $220 | $179 New Zealand | $603 | $447 | $227 | $302 Germany …

ISEV2019 Abstract Book

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… OWP1.06=PS01.11 Extracellular vesicles from Fat-laden hypoxic hepatocytes activates pro-fibrogenic signals in Hepatic Stellate Cells Alejandra Hernandez a , Yana Geng b , Daniel Cabrera c , Nancy Solis d , Han Moshage e and Marco Arrese d a Pontificia Universidad Católica de Chile; University Medical … Center of Groningen, Groningen, Netherlands; b UMCG, Groningen, Netherlands; c Pontificia Universidad Católica de Chile/Universidad Bernardo O´Higgins, SANTIAGO, Chile; d Pontificia Universidad Católica de Chile, Santiago, Chile; e University Medical Center Groningen, Groningen, Netherlands Introduction …

Oral Presentations

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Электронные постеры

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Радиум - с момента открытия и до настоящего времени - обзор событий.

После его открытия радий первоначально пропагандировался в качестве терапевтического агента для широкого круга заболеваний, включая расстройства кожи, аллергию, проблемы зрения, боль в суставах и общее средство для укрепления здоровья. Однако последующие исследования продемонстрировали ее значительную радиологическую токсичность и вредное воздействие на здоровье человека. Несмотря на эти риски, более чем через сто лет после его открытия, некоторые радиевые изотопы по-прежнему имеют ограниченное применение в медицинских целях, особенно при лечении конкретных раковых заболеваний. После поглощени

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… The Radium Palace in Jáchymov, Czech Republic (opened in 1912) and other similar spas or radon-rich springs still exist in Austria, Germany, Romania, Bulgaria, Poland, Russia, Italy, France, Greece, Serbia, Chile, and Japan. …

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab.

Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the target of new biologic treatments for patients with eosinophilic asthma. Given the central role of interleukin (IL)-5 in the eosinophil lifecycle, several therapies directed against the IL-5 pathway have been developed, including the anti-IL-5 antibodies mepolizumab and reslizumab and the IL-5 receptor α (IL-5Rα)-directed cytolytic antibody benralizumab. Eosinophil-depleting therapies represent a relatively new class of asthma treatment, and it is important to understand their long-term efficacy and safet

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… be noted that such infections are uncommon in countries where IL-5–targeted therapies have generally been studied; however, the safety results for CALIMA/SIROCCO are based on results from 447 global sites, including representation beyond North America and Europe (Argentina, n = 269; Brazil, n = 36; Chile …

The needs of cancer patients during the COVID-19 pandemic-psychosocial, ethical and spiritual aspects-systematic review.

The COVID-19 pandemic resulted in unprecedented changes in the functioning of the health care system, which were connected with the occurrence of new challenges for both the health care system's employees and for the patients. The purpose of the present article is to analyze the needs of persons with oncological diseases. Taking into account the multiple aspects of the term health, psychological, social, and existential needs of the patients were analyzed. This article is directed mainly at persons who remain in a direct therapeutic relation with a patient. It is to facilitate recognizing the

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… Most citizens have been vaccinated in Israel—over 56% of the population, the United Arab Emirates—39.3%, Chile—34.1% and the USA—almost 30%. In Poland, 7.2% of the population has been vaccinated with a full dose ( Our World in Data, 2021 ). …

ISEV2020 Резюме

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Поэтапное сокращение сотрудничества между людьми.

Сотрудничество между людьми носит динамичный характер и зачастую сокращается даже при наличии благоприятных условий conditions1-4. Многие из существующих теорий объясняют уменьшение масштабов сотрудничества с точки зрения стратегического поведения или обучения, сформулированного как свидетельство рационального поведения или продвижения в направлении rationality5-9. Здесь мы показываем, что одним из ключевых источников долгосрочного спада являются отклонения от рационального поведения, которые систематически меняются с течением времени. Мы анализируем естественную социальную дилемму на местах,

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… We acknowledge funding from the Departamento de Administración, Facultad de Administración y Economía, Universidad de Santiago de Chile (to N.S.); ANID FONDECYT de Iniciación en Investigación 2020 folio (grant no. 11200781 to N.S.); the European Commission, through the 7th Framework FET-Open Project …

A scoping review of the literature on the application and usefulness of the Problem Management Plus (PM+) intervention around the world.

BackgroundGiven the high rates of common mental disorders and limited resources, task-shifting psychosocial interventions are needed to provide adequate care. One such intervention developed by the World Health Organization is Problem Management Plus (PM+).AimsThis review maps the evidence regarding the extent of application and usefulness of the PM+ intervention, i.e. adaptability, feasibility, effectiveness and scalability, since it was introduced in 2016.MethodWe conducted a scoping review of seven literature databases and grey literature from January 2015 to February 2024, to identify peer

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… Cost-effectiveness of a primary care treatment program for depression in low-income women in Santiago, Chile . Am J Psychiatry 2006 ; 163 ( 8 ): 1379 –87. 16877650 10.1176/ajp.2006.163.8.1379 129 Levin C , Chisholm D . …

Proceedings from the First Onco Summit: LATAM Chapter, 19-20 May 2023, Rio de Janeiro, Brazil.

The Onco Summit 2023: The Latin American (LATAM) Chapter took place over two days, from 19-20 May 2023, in Brazil. The event aimed to share the latest updates across various oncology disciplines, address critical clinical challenges, and exchange best practices to ensure optimal patient treatment. More than 30 international and regional speakers and more than 300 oncology specialists participated in the Summit. The Summit discussions centered on common challenges and therapeutic advances in cancer care, with a specific focus on the unique obstacles faced in LATAM and examples of adaptable stra

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… Most attendees were from Argentina, Brazil, Chile, Colombia, and Mexico. …

Frailty in Aging and the Search for the Optimal Biomarker: A Review.

In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of fra

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… Aging and Health Policies in Chile: New Agendas for Research Health Syst. Reform 2017 3 253 260 10.1080/23288604.2017.1353844 30359182 3. Michel J.-P. Sadana R. “Healthy aging” concepts and measures J. Am. Med. Dir. Assoc. 2017 18 460 464 10.1016/j.jamda.2017.03.008 28479271 4. Veronese N. …

Extracellular Vesicle-Associated miRNAs and Chemoresistance: A Systematic Review.

Cancer is a leading public health issue globally, and diagnosis is often associated with poor outcomes and reduced patient survival. One of the major contributors to the fatality resultant of cancer is the development of resistance to chemotherapy, known as chemoresistance. Furthermore, there are limitations in our ability to identify patients that will respond to therapy, versus patients that will develop relapse, and display limited or no response to treatment. This often leads to patients being subjected to multiple futile treatment cycles, and results in a reduction in their quality of lif

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… research was supported by The Lion Medical Research Foundation (2015001964), The Medical Research Future Fund (MRF1199984), National Health and Medical Research Council (NHMRC 1195451), The Donald & Joan Wilson Foundation Ltd. (2020000323), Ovarian Cancer Research Foundation (OCRF, 2018001167), and Becas Chile …

Oral Presentations

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ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

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