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Early Detection of Ductal Carcinoma in situ through Surveillance in a Patient with Peutz-Jeghers Syndrome: A Case Report.

INTRODUCTION: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and gastrointes … situ. Mammography showed widespread microcalcifications. She underwent right total mastectomy with sentinel lymph node biopsy, followed by immediate reconstruction with tissue expander and later implant exchange with fat grafting. No adjuvant radiotherapy or systemic therapy was administered. She has remained disease-free for 2.5 years postoperatively. CONCLUSION: …

Sebaceous carcinoma of the breast predominantly characterized by intraductal growth: a case report.

BACKGROUND: Sebaceous carcinoma (SC) is frequently classified as periocular or extraocular. Extraocular SC is rare and mainly occurs in the … t, and analysis of a core needle biopsy revealed noninvasive ductal carcinoma. Total mastectomy and sentinel lymph node biopsy were performed. Histopathology demonstrated that carcinoma in situ (CIS) represented a significant lesion, and the cytoplasm of tumor cells was clear with numerous minute vacuoles. Immunohistochemical analysis demonstrated that most tumor cel …

[Cancer of the Ascending Colon Diagnosed at the Same Time as Breast Cancer Following Leukemia Treatment for Which Laparoscopic Surgery Was Performed-A Case Report].

An 83-year-old woman received 8 courses of chemotherapy(mogamulizumab)for adult T cell leukemia in the hematolo- gy department of our hospit … tus of the patient was favorable; thus, right pectoral muscle-conserving mastectomy and concomitant sentinel lymph node biopsy were performed through laparoscope-assisted extended right hemicolectomy. The postoperative course was favorable, and she was discharged on hospital day 7. The excised tumors were pathologically diagnosed as stageⅠ breast cancer and stage Ⅲa …

A Very Rare Case: HPV-Negative Vulvar Cancer in an Adolescent.

Carcinoma of the vulva is usually regarded as a disease of older women, with the typical age of 65-85 years. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. Vulvar radical local excision and bilateral inguinal sentinel lymph node biopsies were performed. The clitoris was preserved during the surgery. Patient did not receive adjuvant therapy.…

Triple negative breast cancer and immunoglobulin A nephropathy: A case report and literature review.

The association between malignant tumors and the occurrence of glomerular disease has been well documented in previous studies. The most com … identified in the patient. Subsequently, the patient was administered breast-conserving surgery and sentinel lymph node biopsy, which validated the diagnosis of triple negative breast cancer at stage IA (T1cN0M0). The patient received chemotherapy and radiotherapy. Following the review of the relevant studies within the last 30 years, it was demonstrated that the pre …

Osteogenic Melanoma With Desmin Expression.

BACKGROUND: Osteogenic differentiation is rarely seen in melanomas, when it occurs it is mainly in acral lesions. METHODS: We report a case … genes were not present. The patient was submitted to an amputation of the left hallux with negative sentinel lymph node. CONCLUSION: The importance of recognizing osteogenic melanoma is based on difficulties for histologic recognition and its differentials diagnosis.

Engineering InAs(x)P(1-x)/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared.

Quantum dots with a core/shell/shell structure consisting of an alloyed core of InAs(x)P(1-x), an intermediate shell of InP, and an outer sh … nce imaging. These NIR-emitting core/shell/shell InAs(x)P(1-x)/InP/ZnSe were successfully used in a sentinel lymph node mapping experiment.

Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients.

PURPOSE: Detection of micrometastases in the regional tumor-draining lymph nodes is critical for accurate staging and prognosis in melanoma patients. We hypothesized that a multiple-mRNA marker (MM) reverse transcriptase-polymerase chain reaction (RT-PCR) assay would improve the detection of occult metastases in the sentinel node (SN), compared with hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC), and that MM expression is predictive of disease relapse. PATIENTS AND METHODS: Seventy-two consecutive patients with clinical early-stage melanoma underwent sentinel lymphadenect

A Novel Treatment Schedule for Rapid Completion of Surgery and Radiation in Early-Stage Breast Cancer.

BACKGROUND: Data support the use of accelerated partial-breast irradiation (APBI) for early-stage breast cancer. We initiated a prospective protocol for intraoperative APBI catheter placement using a multi-lumen strut-based device. We hypothesized that with intraoperative pathology assessment of margins and sentinel nodes, all locoregional treatment (surgery and APBI) could be completed within 10 days with acceptable complication rates and cosmesis. METHODS: Eligible patients included women age 50 years or older with clinical T1 estrogen receptor positive (ER+) sentinel lymph node (SLN)-negat…

Precision Nodal Staging in Intermediate-Risk Prostate Cancer: A Narrative Review of Molecular Imaging.

BACKGROUND: Lymph node (LN) staging remains critical for risk stratification and treatment selection in intermediate-risk prostate cancer (IR-PCa). Conventional imaging modalities have limited sensitivity, and extended pelvic LN dissection (ePLND) is associated with considerable morbidity. SUMMARY: This narrative review evaluates conventional imaging, molecular imaging, and intraoperative technologies for LN staging in IR-PCa. Conventional computed tomography and magnetic resonance imaging demonstrate low sensitivity for detecting LN metastasis. Prostate-specific membrane antigen (PSMA) posit

Co-existence of fibroadenoma, intraductal carcinoma and invasive ductal carcinoma in the unilateral breast mass: a case report and literature review.

BACKGROUND: Fibroadenoma is the most common benign breast tumor. However, the coexistence of ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) within single breast fibroadenomas is rare. CASE DESCRIPTION: A 71-year-old woman presented with a palpable mass in her left breast, and she had a history of right-side breast cancer, which had been treated 16 years ago. Invasive ductal carcinoma was confirmed through core needle biopsy. She subsequently underwent left breast mastectomy with sentinel lymph node biopsy. Postoperative pathological examination revealed two fibroadenomas:…

Primary endometrial squamous cell carcinoma with molecular Characterization: A case report.

BACKGROUND: Primary endometrial squamous cell carcinoma (PESCC) is an extremely rare malignancy and represents a diagnostic challenge due to … dometrial origin. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy and sentinel lymph node mapping. Final pathology confirmed moderately differentiated PESCC with superficial myometrial invasion. Immunohistochemistry demonstrated diffuse squamous marker expression and limited hormone receptor positivity. Molecular testing showed microsate …

Сочетание Пембролизумаба и Офатумумаба в трехразовом негативном раке груди и множественном склерозе: доклад по делу.

ВВЕДЕНИЕ: Пембролизумаб широко используется с момента его утверждения в качестве периоперационной терапии для лечения трехотрицательного рака груди. Хотя появление различных антителных препаратов в последние годы расширило возможности лечения, сообщения о совокупном использовании иммунных антител у пациентов с другими заболеваниями остаются ограниченными. СООБЩЕНИЕ: 42-летняя женщина с массой 5 см в правой груди. Биопсия игл подтверждает инвазивную индукционную карциному (cT2N0M0, кStatge IIB, трехотрицательный рак груди). Рассматривалась терапия на основе Пембролизумаба, но пациент уже получа

Совпадение в аннотации оригинала
INTRODUCTION: Pembrolizumab has been widely used since its approval as perioperative therapy for triple-negative breast cancer. While the em … erative imaging indicated a clinical complete response. She underwent right partial mastectomy with sentinel lymph node biopsy, and postoperative pathology confirmed a pathologic complete response. No exacerbation of MS has been observed to date. CONCLUSIONS: This case demonstrates that pembrolizumab can be safely administered for triple-negative breast cancer in a …

Case Report: Efficacy of Multiparameter MRI in Diagnosis of Chronic Breast Inflammation Complicated with Invasive Ductal Carcinoma and Ductal Carcinoma in situ.

INTRODUCTION: Incidental Enhancement Lesions (IELs) complicate patient management but may be detected through multiparameter MRI including d … or to ultrasound-guided biopsy of the right breast lesion. Resection of the right breast lesion and sentinel lymph node was performed 2 days later. Chronic inflammation, locally invasive ductal carcinoma and high-grade ductal carcinoma in situ were found by pathological examination. DISCUSSION: Differentiation between benign and malignant breast IELs was facilitated …

Multimodal Ultrasound Imaging in the Diagnosis of Primary Giant Cell Tumor of the Breast: A Case Report and Literature Review.

Giant cell tumor of soft tissue (GCT-ST) is an extremely rare phenomenon in the breast. Herein, a case involving a 75-year-old female with a … stopathology and immunohistochemistry. Accordingly, the patient underwent left-sided mastectomy and sentinel lymph node biopsy. This case emphasizes the complexity of the clinical and pathological diagnosis of GCT-ST in the breast and may raise the awareness of clinicians and sonographers to the advantages of multimodal ultrasound imaging in the diagnosis of GCT-ST i …

Merkel cell carcinoma and the eye.

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor with a poor five-year survival rate. Yearly cases have risen nearly 350 … be assessed clinically through physical examination findings and imaging and/or pathologically with sentinel lymph node biopsy or fine-needle aspiration. Pathologic staging more accurately predicts the prognosis. Eyelid MCC treatments include Mohs micrographic surgery to allow for complete clearance and adequate reconstruction of lost tissue, followed by adjuvant rad …

Distress, Pain, and Nausea on Postoperative Days 1 and 14 in Women Recovering From Breast-Conserving Surgery: A Repeated-Measures Study.

OBJECTIVES: To determine the incidence and trajectory of distress, pain, and nausea and vomiting at postoperative day (POD) 1 and at POD 14 following breast-conserving surgery. SAMPLE & SETTING: 75 women aged 18 years or older receiving breast-conserving surgery with sentinel lymph node biopsy for treatment of early-stage primary breast cancer at an ambulatory surgery center. METHODS & VARIABLES: This prospective, repeated-measures study assessed distress, pain, and nausea and vomiting using the National Comprehensive Cancer Network Distress Thermometer and Problem List on POD 1 and POD 14. …

Breast Metastasis of Lung Cancer After Computed Tomography-Guided Core Needle Biopsy: A Case Report.

BACKGROUND: Needle tract metastasis is a rare complication following percutaneous procedures for malignancy. CASE SUMMARY: This report describes a 49-year-old female with a lump on her right breast. Mass core needle biopsy showed the specimen was an invasive carcinoma, and mastectomy with sentinel lymph node biopsy was performed. What is special about this case was that the patient reported a history of lung cancer and the position of the breast mass was the puncture site of computed tomography-guided core needle biopsy for lung cancer. Immunostaining of paraffin specimen findings indicated t…

Secretory carcinoma of the breast limited to the dermis: Cutaneous or breast primary?

We offer a case of a 22-year-old woman who presented with a painless breast mass. Physical examination of the breast was unrevealing other t … ast parenchyma or skin tissue was not clearly discernable. Therefore, the patient was scheduled for sentinel lymph node biopsy with plans for axillary dissection if positive. While the overall prognosis for secretory carcinoma is good, with a low chance of metastasis, any ambiguity in breast mass diagnosis should be discussed in a multidisciplinary tumor board and sh …

[Choice of function-preserving gastrectomy].

As the diagnosis rate of early gastric cancer is increasing annually, the current hot spot in the treatment of early gastric cancer is how t … ally gaining attention. The application of laparoscopic and endoscopic hybrid surgery combined with sentinel lymph node navigation is anticipated in the treatment of early gastric cancer.