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Repetitive transcranial magnetic stimulation to alleviate fatigue in multiple sclerosis-study protocol for a randomized sham-controlled double-blinded clinical trial.

BACKGROUND: Fatigue is a common and disabling symptom in multiple sclerosis (MS), quantifiable by patient reported outcome instruments such as the Fatigue Scale for Motor and Cognitive Functions (FSMC). The pathophysiology of fatigue remains poorly understood, and effective treatments are limited. Emerging evidence implicates disrupted excitation-inhibition balance in the premotor cortex as a potential culprit of fatigue in MS. Converging evidence now show that such network imbalance can be modulated with repetitive transcranial magnetic stimulation (TMS). The efficacy of premotor rTMS retunin…

Effects of Acute and Repeated Ischemic Preconditioning on Recovery from Muscle Fatigue after High-Intensity Swim Training in Male Amateur Swimmers.

This study investigated the effects of acute and repeated ischemic preconditioning (IPC) on recovery following high-intensity swim training. Thirty male amateur freestyle swimmers (21 ± 1 years, with at least 2 years of training experience) were randomly assigned to one of three groups: sham IPC (SHAM, n = 10, 4×5 min, 20 mmHg), acute IPC (AIPC, n = 10, 4×5 min, 220 mmHg), or repeated IPC (RIPC, n = 10, 7 days×4×5 min, 220 mmHg). A 7×200m swim incremental load training was conducted 20 minutes after the intervention. External load measures (grip strength, upper limb work, lower limb relative p

A 16-year follow-up of walking function, fatigue, and pain in adults aged 34-65 years with spastic cerebral palsy.

OBJECTIVE: This study aimed to describe the long-term changes in walking function, fatigue, and pain in adults with cerebral palsy. DESIGN: A 16-year follow-up study with paired comparisons. SUBJECTS: Adults with spastic cerebral palsy (n = 29) from a baseline study in 2008. METHODS: The mean age at follow-up was 50 (standard deviation 10) years. PRIMARY OUTCOMES: Gait Deviation Index, 6 Minute Walk Test, Timed-Up-and-Go test, walking speed, Fatigue Severity Scale, and bodily pain (visual analogue scale, 0-100). Paired samples t-test (Wilcoxon signed rank test for non-parametric data) was …

Language Matters: What Not to Say to Patients with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, and Other Complex Chronic Disorders.

People with Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other complex chronic disorders consistently report having difficulty obtaining effective and compassionate medical care and being disbelieved, judged, gaslighted, and even dismissed by healthcare professionals. We believe that these adversarial interactions and language are more likely to arise when healthcare professionals are confronting complex chronic illnesses without proper training, diagnostic biomarkers, or FDA-approved therapies. These problematic conversations between practitioners and patients …

Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry.

BACKGROUND: Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a multisystem disorder characterised by unrelenting fatigue, post-exertional malaise, and dysfunction across immune, nervous, metabolism, and endocrine systems. Given the broad role of steroid hormones in regulating these systems, this study investigated differences in the steroid metabolome and network dynamics between ME/CFS patients and matched controls. METHODS: Blood plasma steroid levels were quantified using Ultra-Performance Supercritical Fluid Chromatography- Tandem Mass Spectrometry (UPSFC-MS/MS) in ME/CFS …

Effects of simultaneous aerobic and inspiratory muscle training on diaphragm function, respiratory muscle strength, endurance, and fatigue index: randomized-controlled trial.

PURPOSE: This study aims to investigate the effects of Walking-Specific Inspiratory Muscle Training (W-SIMT) on diaphragm thickness-stiffness, pulmonary and respiratory muscle functions, and fatigue index. RESEARCH QUESTION: Do individuals who performed W-SIMT have better diaphragm functions, respiratory muscle strength, endurance, and performance? METHODS: Twenty-seven healthy participants were included in the randomized-controlled study. The simultaneous inspiratory and aerobic exercise training (60-80% of maximal heart rate; 3 days/weeks; 4 weeks) was performed in the W-SIMT group (n = 14…

Impact of Metabolic Dysfunction-Associated Steatotic Liver Disease on Fatigue and Pruritus in Primary Sclerosing Cholangitis: A U.S. Single-Center Study.

Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of liver disease in the United States and frequently coexists with other liver diseases. Despite growing interest, the presence of MASLD in patients with primary sclerosing cholangitis (PSC) remains underexplored. This study aimed to assess the prevalence and characteristics of the MASLD-PSC overlap syndrome, with a specific focus on patient-reported outcomes such as pruritus and fatigue. Methods: A cross-sectional analysis was performed within a prospective cohort of patients with PS…

Effects of Multisession High-Definition Transcranial Direct Current Stimulation on Resting-State Brain Network Connectivity and Efficiency Under Running-Induced Fatigue.

This study aimed to investigate the effects of five-session high-definition transcranial direct current stimulation (HD-tDCS) on resting-state brain network connectivity and efficiency under running-induced fatigue. This double-masked, randomized, and sham-controlled study involved 24 male adults randomly assigned to the HD-tDCS or sham-tDCS group. Participants completed a running-induced fatigue protocol at a personalized running speed before and after the intervention, and heart rate (HR) and Borg rating of perceived exertion (RPE) were monitored. Resting-state electroencephalography (EEG) s…

Effects of High Intensity Interval Training in Normobaric Hypoxia on Aerobic Performance and Exercise-Induced Motor Performance Fatigue in Young Biathletes.

This study investigated the effect of high-intensity interval training (HIIT) in normobaric hypoxia on aerobic performance in young biathlon athletes. In addition, the study aimed to assess the impact of training in hypoxia on the mechanisms of exercise-induced motor performance fatigue. In a randomized, controlled crossover study twelve athletes (age 15.7 ± 1.0 years) completed a HIIT in normobaric hypoxia (hypoxia training) (fraction of inspired oxygen, FiO2 = 15.2%) and normoxia (normoxia training) in a randomized order. The HIIT was performed 3 days/week for 6 weeks (3 weeks in hypoxia and…

Evaluating Ma-ol-asal Syrup for Chemotherapy-induced Fatigue in Gastrointestinal Cancer Patients: A Randomized Double-blinded Placebo-controlled Clinical Trial :

BACKGROUND: Chemotherapy-induced fatigue (CIF) is a common and debilitating side effect in cancer patients, particularly those with gastrointestinal cancers. This study explores the potential of Ma-ol-asal, a traditional Persian herbal syrup, as a holistic, supportive approach to alleviate CIF's physical and psychological burdens. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial involved 120 gastrointestinal cancer patients with fatigue, randomly assigned to receive 10 mL of Ma-ol-asal (compound honey syrup) or placebo thrice daily for four weeks. Fatigue was ass…

Clinician perspectives on cognitive behavioral therapy and health education for sleep disturbance and fatigue after acquired brain injury: A qualitative study.

Sleep disturbance and fatigue are persistent, clinically significant problems for many with acquired brain injury (ABI). A recent randomized controlled trial (RCT) demonstrated that cognitive and behavioral therapy tailored for post-ABI sleep and fatigue (CBT-SF) produced larger and faster effects compared to an active health education (HE) control intervention. The current study aimed to qualitatively explore the perspectives of the six clinicians, all clinical neuropsychologists, who delivered the CBT-SF and HE interventions to 126 individuals with ABI in the RCT. One-on-one semi-structured …

Усталость, депрессия и связанное со здоровьем качество жизни в педиатрическом многоразовом склерозе: сравнительное исследование из центра третичной медицинской помощи.

Усталость, депрессия и снижение качества жизни в связи со здоровьем (HRQOL), как правило, отмечаются среди пациентов с педиатрическим множественным склерозом (POMS). Однако их взаимодействие и различные проявления по-прежнему недостаточно понятны. ЦЕЛЬ: Данное исследование было направлено на оценку усталости, депрессивных симптомов и HRQOL в хорошо отождествленной группе пациентов ПОМС в сравнении с методами контроля за здоровым здоровьем в возрасте и по половому признаку. МЕТОДЫ: Участники закончили работу над шкалой утомления (СФС), обследованием по 36 позициям в краткой форме (SF-36), а так

Совпадение в аннотации оригинала
BACKGROUND: Fatigue, depression, and decreased health-related quality of life (HRQoL) are commonly reported among patients with pediatric-onset multiple sclerosis (POMS). However, their interplay and distinct manifestations remain insufficiently understood. OBJECTIVE: This study aimed to assess fatigue, depressive symptoms, and HRQoL in a well-characterized…

Relationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study.

BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease causing sensory and motor impairments due to central nervous system demyelination. Sensory feedback, essential for balance and gait, is often disrupted in people with MS (PwMS). However, its relationship with fatigue, physical activity, cognitive function, and body awareness remains unclear. AIM: To investigate the relationship between plantar sensation, knee position sense, and clinical factors in PwMS compared to healthy controls (HC). METHODS: Thirty-three PwMS and 11 HC participated in this study. Foot sensations includi…

Effects of stretching exercises on muscle tension, fatigue, strength, and lactic acid accumulation: A pre-experimental study among fish transport workers.

Fish transport workers in Indonesia lift loads more than the specified limits, both in weight and frequency. This could cause lactic acid accumulation, fatigue and reduced physical performance. The aim of this study was to assess the effect of stretching intervention on muscle tension, fatigue, strength, and lactic acid level in fish transport workers in Indonesia. A pre-experimental study design with one group (pre- and post-test) design was conducted among male fish transport workers at the Tawang fish auction, Weleri, Central Java, Indonesia, in June 2022 for two weeks. We created a 1.5-min…

Methylphenidate for treating fatigue in palliative cancer care - effect and side effects in real-world data from a palliative care unit.

BACKGROUND: Methylphenidate can be used for the treatment of cancer-related fatigue (CRF), although randomized controlled trials have shown conflicting results. The aim of this study was to use 'real-world' data to evaluate the effect and side effects of using methylphenidate in palliative cancer care with a focus on the late palliative phase and dose-response. METHOD: A retrospective review of medical records from a palliative care unit in Sweden was performed to evaluate the effect and adverse events (AEs) of using methylphenidate to treat CRF. Univariable and multivariable regression was p…

How do different intraoral scanners and milling machines affect the fit and fatigue behavior of lithium disilicate and resin composite endocrowns?

The aim of this in vitro study was to evaluate the effect of the combinations of two different intraoral scanners (IOS), two milling machines, and two restorative materials on the marginal/internal fit and fatigue behavior of endocrowns produced by CAD-CAM. Eight groups (n= 10) were considered through the combination of TRIOS 3 (TR) or Primescan (PS) IOS; 4-axes (CR; CEREC MC XL) or 5-axes (PM; PrograMill PM7) milling machines; and lithium disilicate (LD; IPS e.max CAD) or resin composite (RC; Tetric CAD) restorative materials. Specific surface treatments were applied to each material, and the…

Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain.

High disease activity, cognitive dysfunction (CD), fatigue and pain negatively affect the quality of life in patients with systemic lupus erythematosus (SLE). However, the impact on brain perfusion and blood-brain barrier (BBB) permeability remains incompletely understood. Therefore, we utilized 3 T dynamic susceptibility contrast magnetic resonance imaging to investigate these factors in a cohort of 66 female SLE patients. Normalized leakage corrected cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and the BBB leakage parameter K2, were compared within the coh…

Influence of Continuous Rotation and Optimal Torque Reverse Kinematics on the Cyclic Fatigue Strength of Endodontic NiTi Clockwise Cutting Rotary Instruments.

Objectives: The objective of the present study was to evaluate the cyclic fatigue strength of clockwise cutting rotary endodontic instruments when subjected to two different kinematics: continuous clockwise rotation and clockwise reciprocation movement under optimum torque reverse (OTR) motion. Methods: New ProTaper Next X1 (n = 20) and X2 (n = 20) instruments were randomly divided into two subgroups (n = 10) based on kinematics (continuous rotation or OTR). The specimens were tested using a custom-made device with a non-tapered stainless-steel artificial canal measuring 19 mm in length, featu…

Chronic thyrotoxic myopathy development is associated with thyroid hormone sensitivity index, predicted by lower-limb fatigue and the squat-up test.

Thyroid hormones (THs) may affect chronic thyrotoxic myopathy (CTM). The relationship between TH sensitivity and CTM is inconsistent. We aimed to investigate the associations between TH sensitivity and the risk of CTM and to screen potential CTMs with strength and function tests. A total of 162 Chinese patients (36.58% men) with Graves' disease were enrolled and divided into CTM and non-CTM groups. TH and sensitivity indices were measured. Muscle power and function were assessed by grip, upper-limb fatigue (ULFT), lower-limb fatigue (LLFT), and squat-up (SUT) tests, and walking pace. Associati…

Exploring Guolin Qigong (Mind-Body Exercise) for Improving Cancer Related Fatigue in Cancer Survivors: A Mixed Method Randomized Controlled Trial Protocol.

BACKGROUND: Cancer-related fatigue and its associated symptoms of sleep disorder and depression are prevalent in cancer survivors especially among breast, lung, and colorectal cancer survivors. While there is no gold standard for treating cancer-related fatigue currently, studies of mind-body exercises such as Qigong have reported promise in reducing symptoms. This study was designed to evaluate the feasibility and effect of Guolin Qigong on cancer-related fatigue and other symptoms in breast, lung and colorectal cancer survivors while exploring their perceptions and experiences of Guolin Qigo…