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Bilateral multifocal water-clear cell parathyroid adenoma: A case report with literature review.

Water-clear cell parathyroid adenoma (WCCPA) is an exceptionally rare subtype of parathyroid adenoma characterized by large, clear, glycogen-rich cells. A small number of cases have been reported in the literature. This report presents a rare case of bilateral multifocal WCCPA in a young female. A 34-year-old female presented with generalized bone pain and fatigue. Laboratory evaluation revealed hypercalcemia (12.9 mg/dL) and markedly elevated PTH (488 pg/mL), consistent with primary hyperparathyroidism (PHPT). Neck ultrasonography and computed tomography identified bilateral inferior parathyr…

Diabetic and Nondiabetic Endocrine Emergencies: Clinical Spectrum and Outcomes From a Tertiary Care Center in North India.

ObjectiveEndocrine emergencies, although uncommon, are potentially life-threatening and require prompt diagnosis and timely intervention. Al … f 1.82 per 1000 emergency visits annually. DKA was the most frequent diagnosis (69.3%), followed by hypercalcemia (11.3%) and hypoglycemia (7.1%). HHS accounted for 3.8% of cases and had the highest mortality (50%). All patients with thyroid storm (n = 3) succumbed. Myxedema coma had a mortality rate of 33.3%. In DKA, older age, reduced estimated glomerular fil …

Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk.

Colorectal cancer (CRC) ranks as the third most common malignancy globally and represents one of the main causes of cancer-related death. Th … riggers skeletal-related events (SREs) such as pathological fractures, spinal cord compression, and hypercalcemia, which severely compromise patients' quality of life and survival. Although the molecular mechanisms of CRC and its bone metastasis have been extensively studied, the exact mechanisms underlying its initiation and progression remain incompletely elu …

Клинические и лабораторные характеристики и методы лечения пациентов, у которых диагностирована миелома: реальная группа пациентов в перуанской поликлинике.

Множественная миелома (ММ) — злокачественное распространение клеток клональной плазмы, вызывающее повреждения костей, почечную недостаточность, анемию и гиперкальцемию. Реальные данные о клинических характеристиках, методах лечения и результатах лечения пациентов с ММ в Латинской Америке, особенно в Перу, по-прежнему являются недостаточными. Цель этого исследования состояла в том, чтобы описать клинические и лабораторные характеристики, характеристики, методы и методы лечения. 5-year Выживание пациентов ММ в перуанской клинике. Мы провели ретроспективное когортное исследование с участием взрос

Совпадение в аннотации оригинала
BACKGROUND: Multiple myeloma (MM) is a malignant proliferation of clonal plasma cells causing bone lesions, renal impairment, anemia and hypercalcemia. Real-world data on the clinical characteristics, treatment patterns and outcomes of patients with MM in Latin America, particularly in Peru, remain scarce. This study aimed to describe the clinical and labora…

New-Onset Sarcoidosis During B-cell Maturation Antigen (BCMA)-Directed T-cell Engager Therapy With Teclistamab in Relapsed/Refractory High-Risk Multiple Myeloma: A Case Report and Mechanistic Insight.

Teclistamab is a bispecific T-cell engager targeting the B-cell maturation antigen (BCMA) on myeloma cells and CD3 on T cells, leading to po … normal pulmonary function, borderline-elevated angiotensin-converting enzyme (ACE) levels, and mild hypercalcemia. Lymph node biopsy revealed nonnecrotizing granulomas without evidence of myeloma or infection. Extensive evaluation excluded fungal, mycobacterial, and opportunistic pathogens. Given clinical stability and sustained myeloma remission, teclistamab w …

A novel PTH1R missense variant in a patient with early-onset primary hyperparathyroidism.

We report a 30-year-old male with early-onset primary hyperparathyroidism (PHPT) and incidental papillary thyroid carcinoma. Biochemical tests showed hypercalcemia, hypophosphatemia, elevated PTH and normal renal function. Planar 99ᵐTc-MIBI scintigraphy projected a parathyroid lesion to the left thyroid inferior pole, while surgery revealed an ectopic solitary parathyroid adenoma in the left upper mediastinum; serum calcium, phosphate and PTH normalized two months postoperatively. Whole-exome sequencing detected a novel heterozygous PTH1R variant c.982G > A (p.Gly328Ser), classified as a varia…

Beyond Atrial Fibrillation: A Case of Thyrotoxicosis-Associated Ischemic Stroke in a Young Patient.

While it is presumed that thyrotoxicosis is a contributing factor for cardioembolic stroke secondary to atrial fibrillation (AF), cerebrovas … ne, and bisoprolol in addition to stress-dose glucocorticoids. Subsequent labs uncovered refractory hypercalcemia, prompting further evaluation that confirmed hyperparathyroidism. Notably, her presentation occurred in the absence of AF. The cardiovascular effects of hyperthyroidism are well-established, with sinus tachycardia and AF being the most common electr …

Complex Chromothripsis-like Features in Plasma Cell Myeloma: A Case Report and Review of the Literature.

Backgroundand Clinical Significance: Chromothripsis represents a catastrophic genomic event in plasma cell myeloma (PCM) associated with poor prognosis. We report a case of newly diagnosed PCM with complex cytogenetic abnormalities indicative of genomic instability. Case Presentation: A 67-year-old man presented with acute dyspnea and was found to have severe acute kidney injury, anemia, hypercalcemia, and IgG lambda monoclonal gammopathy. Bone marrow biopsy revealed plasma cell infiltration. Comprehensive FISH analysis demonstrated a complex pattern with gain of 1q, monosomy 13, and multiple …

Pharmacologic management of central giant cell granuloma of the jaws: a systematic review of effectiveness and safety.

OBJECTIVE: To evaluate the effectiveness, safety, and outcomes of pharmacologic therapies for CGCG of the jaws and their role relative to su … sive lesions, whereas denosumab produced rapid symptomatic improvement but carried risks of rebound hypercalcemia and recurrence after cessation. Calcitonin showed slower, less predictable responses, whereas interferon-α and bisphosphonates were mainly adjunctive or rescue therapies. Combined medical-surgical strategies generally reduced surgical morbidity and …

Extramedullary disease in multiple myeloma at diagnosis and over the course of the disease.

Extramedullary disease (EMD) is an aggressive manifestation of multiple myeloma (MM) and is categorized into two distinct types: extramedull … significantly shorter progression-free survival and overall survival than those with EM-B. Anemia, hypercalcemia, high LDH, EMD at relapse, ≥ 2 involved sites, and not receiving autologous stem cell transplantation were independent poor risk factors for survival. In conclusion, EMD is a heterogeneous entity, and this study demonstrated that patients with EM-E …

Novel approach to central giant cell granuloma of the Jaw: Low-dose intralesional denosumab treatment in a case series of nine patients.

Central giant cell granuloma (CGCG) is a rare non-neoplastic but locally destructive intraosseous lesion of the jaw. While surgical resectio … after ≥8 injections and is an alternative for CGCG treatment when surgery is harmful. Note rebound hypercalcemia in children.

Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold.

Vitamin D receptor (VDR) has emerged as a crucial target for the treatment of hepatic fibrosis, a condition characterized by excessive depos … oved serum liver function indices. Notably, E15 achieved these therapeutic effects without inducing hypercalcemia, a common adverse effect associated with VDR agonists such as calcipotriol. These findings underscore the potential of E15 as a potent and safe therapeutic agent for the treatment of liver fibrosis.

A Novel Pathogenic CDC73 Gene Variant in Hyperparathyroidism-jaw Tumor Syndrome.

Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a rare hereditary disorder caused by pathogenic CDC73 gene variants. We report the case of a patient with HPT-JT who carried a novel germline pathogenic CDC73 variant. A 27-year-old woman presented with thirst, polyuria, fatigue, constipation, and a history of fibro-osseous mandible lesions and endometrial polyps. Examination revealed hypercalcemia and grossly elevated PTH levels with hypercalciuria accompanied by a right lower parathyroid tumor with concordant imaging, suggesting primary hyperparathyroidism (PHPT). Given that she had early-on…

Therapeutic implications of vitamin D in leukemia: mechanistic and clinical perspectives.

Recent research has highlighted vitamin D's potential role in the development and treatment of hematological cancers, expanding its known im … production of inflammatory cytokines. While the doses required to achieve these effects may lead to hypercalcemia in humans, researchers have developed analogs and combination treatments to mitigate this side effect. These findings underscore the importance of continued research into the role of vitamin D in hematological cancers and its potential as a therapeu …

Pharmacovigilance analysis of polatuzumab plus bendamustine and rituximab treatment protocol: identifying comprehensive safety signals using FDA database.

BACKGROUND: The combination of polatuzumab, bendamustine and rituximab (pola+BR) was authorized for the treatment of relapsed or refractory … obstruction, epilepsy, deep vein thrombosis, haemorrhage, increased blood lactate dehydrogenase and hypercalcemia. CONCLUSION: Our study identified significant AE signals for pola+BR through realworld disproportionality analysis data and analyzed the severity and clinical priority of these signals, which can assist clinicians in managing related AEs.

Case Report: Bone Marrow Infiltration with Anemia and Thrombocytopenia, Rare Initial Symptoms of Breast Cancer.

INTRODUCTION: Bone metastasis is common in breast cancer, causing pain, myelosuppression, and hypercalcemia. However, bone marrow invasion leading to pancytopenia is exceedingly rare, and its optimal treatment remains a subject of debate. This report presents the first such case from Vietnam, where chemotherapy proved effective. CASE PRESENTATION: A 47-year-old female patient presented to the emergency department with cough, dyspnea, and back pain. Initial laboratory tests revealed WBC 21.83 G/L, neutrophil 10.97 G/L, Hct 27.3%, Hgb 87 g/L, and PLT 22 G/L. Further examination identified a lef…

Brown tumor mimicking giant cell tumor in primary hyperparathyroidism: a case report.

BACKGROUND: Differentiating brown tumor due to primary hyperparathyroidism from a giant cell tumor remains a clinical challenge. Misdiagnosi … t bone scintigraphy indicated metabolic bone disease. A full biochemical evaluation revealed severe hypercalcemia and elevated parathyroid hormone. Parathyroid scintigraphy confirmed a hyperfunctioning parathyroid adenoma. Retrospective review of previous pathology reports supported the diagnosis of brown tumor. The patient underwent successful parathyroidectom …

Rapid development of diffuse hepatic calcification in a patient with congenital hepatic fibrosis and secondary hyperparathyroidism.

A man in his 20 s with congenital hepatic fibrosis and polycystic kidney disease (PKD) presented with symptoms of anemia. Upper gastrointest … s for four months because of end-stage chronic kidney disease due to PKD. Laboratory tests revealed hypercalcemia (10.9 mg/dL), hyperphosphatemia (8.3 mg/dL), markedly elevated intact parathyroid hormone (1,640 pg/mL), and low 1,25-dihydroxy vitamin D (17.6 pg/mL), consistent with secondary hyperparathyroidism. Treatment with evocalcet and dialysis regimen adju …

Endocrine paraneoplastic syndromes in lung cancer: A call for clinical vigilance (Review).

Endocrine paraneoplastic syndromes (PNS) are uncommon but clinically impactful manifestations associated with malignancies, particularly lun … mmon endocrine PNS in lung cancer include syndrome of inappropriate antidiuretic hormone secretion, hypercalcemia, Cushing syndrome, carcinoid syndrome, and other hormonal imbalances such as non-islet cell tumor hypoglycemia, gynecomastia and acromegaly. The pathophysiology of these conditions involves ectopic secretion of bioactive substances such as hormones …