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The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021.

Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease-modifying treatments (DMTs) are now available. However, most DMTs are associated with adverse events, the most frequent of which being infections. Consideration of all DMT-associated risks facilitates development of risk mitigation strategies. An international focused workshop with expert-led discussions was sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and was held in April 202…

[Modern methods of rehabilitation of patients with different degrees of multiple sclerosis. (Literature review)].

Multiple sclerosis is a chronic autoimmune disease that causes damage to the myelin sheath of the nerve fibers, which leads to various neurological symptoms. Over the past 30 years, a significant advance in studying the pathogenesis of multiple sclerosis has been achieved and progress in symptomatic treatment of the disease, including control of secondary manifestations, has been noted. Rehabilitation plays an important role in the management of this disease. Physical rehabilitation, which includes physiotherapy and therapeutic exercise, is the main part of rehabilitation. Psychological rehabi…

Retraction Notice to "New relapse of multiple sclerosis and neuromyelitis optica as a potential adverse event of AstraZeneca AZD1222 vaccination for COVID-19" [Multiple Sclerosis and Related Disorders 57 (2022) 103321].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the authors. The authors would like to express their deepest apologies for the error contained in their article and for any concerns or misunderstandings it may have caused. Specifically, the article mistakenly mentioned the presence of the MF59 adjuvant in the AZD1222 vaccine formulation, which is incorrect.

How is and how should healthcare for people with multiple sclerosis in Germany be designed?-The rationale and protocol for the mixed-methods study Multiple Sclerosis-Patient-Oriented Care in Lower Saxony (MS-PoV).

BackgroundMultiple sclerosis (MS) is the most common autoimmune inflammatory disease of the central nervous system in Europe, often causing severe physical, cognitive and emotional impairments. Currently, it is unclear whether the healthcare provisions of people with MS (PwMS) are in line with the recommendations for treatment based on guidelines or patients' needs. The main objectives of the study are as follows: (a) to investigate how well PwMS are treated; and (b) to develop a needs-oriented, patient-centred care model.MethodsThis mixed-methods study focuses on adult PwMS living in Lower Sa…

[Secretion of tumor necrosis factor alpha (TNF-alpha) by peripheral blood monocytes in patients with multiple sclerosis and subacute sclerosis panencephalitis].

TNF alpha production by peripheral blood monocytes was studied in seventeen patients with a recent exacerbation of MS, thirteen with remission of MS and fourteen patients with SSPE. Monocytes from both MS groups spontaneously secreted high amounts of TNF alpha in vitro. Addition of lipopolisaccharide could not stimulate further synthesis of TNF alpha. In SSPE spontaneous and stimulated TNF alpha release did not differ from that in the control group. The observed changes in TNF alpha release in MS patients could play a role in the pathogenesis of the disease.

Multidomain Cognitive Decline and Motor Disability in Multiple Sclerosis: A Retrospective Cohort Study.

Background: Multiple sclerosis (MS) is characterized by heterogeneous trajectories of motor and cognitive disability. This study aimed to characterize longitudinal cognitive and motor trajectories across MS phenotypes and to identify baseline predictors of subsequent worsening. Methods: This retrospective cohort included 68 adults with MS followed for approximately six years. Cognitive performance was assessed at baseline (T0) and follow-up (T1) using the Rao's Brief Repeatable Battery (BRB-N) and quantified using the Cognitive Impairment Index (CII). Clinical, demographic, neuropsychological,…

Chronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact.

BACKGROUND: Chronic lower limb edema (CLLE) is a feature of advanced multiple sclerosis (MS) but its prevalence and causative factors are not clearly established. The aims of the study were to determine the prevalence and possible causative factors of CLLE in people with MS, and to examine the impact of CLLE on participants' quality of life. METHODS AND RESULTS: The prevalence of CLLE was determined by questionnaire (i.e., self-reported) and by clinical examination. Possible causative factors were recorded including level of disability using Expanded Disability Status Scale (EDSS) and the imp…

Neural stem cell transplantation in progressive multiple sclerosis: STEMS study long-term outcomes.

BACKGROUND: To evaluate the long-term safety and potential neuroprotective effects of human fetal neural precursor cell transplantation in individuals with progressive multiple sclerosis. METHODS: This retrospective observational study assessed long-term follow-up data (median 5.7 years) from participants in a first-in-human phase I trial (NCT03269071) investigating neural cell transplantation in progressive multiple sclerosis. Clinical and radiological available data were collected and compared to baseline values and reference populations. RESULTS: Long-term follow-up data were available fo…

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis.

OBJECTIVE: Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively. We asked how these ratios differ between early relapsing and established non-relapsing disease, change with early treatment, and relate to disability, and secondarily, whether lesions form reproducible microstructural subtypes. METHODS: Thirty-seven participants underwent multi-shell diffusion MRI: 11…

Training effects in oculography in multiple sclerosis patients: a one-year longitudinal study.

PURPOSE: Longitudinal quantitative data on eye movement abnormalities in people with multiple sclerosis (PwMS) are scarce, and the impact of repeated oculomotor testing on these measures is unknown. We aimed to use infrared oculography to characterise one-year changes in oculomotor metrics in PwMS and to determine whether frequent exposure to eye movement tasks influences these measurements. METHODS: At baseline, 3- and 12 months 86 PwMS and 22 healthy controls (HCs, baseline, and 3 months only) were prospectively assessed using infrared oculography (DEMoNS protocol), including fixation, pro-…

Fatigue, depressive symptoms, and Mediterranean diet adherence among Greek adults with multiple sclerosis.

Fatigue and depressive symptoms are common among individuals with multiple sclerosis (MS) and impose a substantial burden on daily functioning and overall well-being. Lifestyle factors, including dietary patterns, may contribute to symptom burden, although evidence remains inconsistent. This cross-sectional study aimed to examine fatigue and depressive symptoms in adults with MS and explore their associations with adherence to the Mediterranean diet and individual dietary components. Mediterranean diet adherence was assessed using the Mediterranean Diet Adherence Screener (MEDAS). Fatigue seve…

Use of patient reported outcomes in multiple sclerosis clinical management: Scoping literature review.

BACKGROUND: Patient-reported outcomes (PROs) are collected in some multiple sclerosis (MS) care settings, yet their uses in MS clinical care are unclear. OBJECTIVES: To determine how PROs are used in MS clinical care and gain insights into instruments, purposes, facilitators/barriers, and impact. METHODS: Scoping review of studies reporting PRO use in MS clinical practice (January 2012-June 2025) across seven electronic databases. RESULTS: Of 6797 records screened, 21 articles (10 countries; 43 instruments) met review criteria. Frequently assessed domains were health-related quality of life…

Автономная гематопоэтическая трансплантация уменьшает воспаление мозга и аксоглиальные повреждения биомаркеров при множественном склерозе.

Аутологическая трансплантация стволовых клеток (AHSCT) может вызвать долгосрочную иммунную терпимость и остроту болезней у пациентов с сильным множественным склерозом (MS), однако основные механизмы не вполне понятны. Мы гипотезуем, что AHSCT вызовет постоянное снижение в провокационных цитокинах, хемокинах и аксолиальных повреждениях биомаркеров в сыворотке и CSF.МЕТОДЫ: Продольная сыворотка и пробы CSF были получены из 24 :: участники процесса по делу HALT-MS с сильными MS, проходящими через AHSCT ( < < AHSCT > > )NCT00288626), с сывороткой, собираемой в 9 период времени с момент

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Autologous hematopoietic stem cell transplantation (AHSCT) can induce long-lasting immune tolerance and disease quiescence in patients with severe multiple sclerosis (MS), but the underlying mechanisms are not well understood. We hypothesized that AHSCT would induce persistent decreases in inflammatory cytokines, chemokines, and ax…

Доверие, информационная оценка и общение между людьми, живущими с множественным склерозом.

Справочная информация: Люди, страдающие множественным склерозом (МС), все чаще обращаются в Интернет за информацией о своем состоянии и лечении. Вместе с тем информация о состоянии здоровья в онлайновом режиме существенно варьируется по качеству, и пациенты часто не имеют грамотности в области электронного здравоохранения, необходимой для проведения различия между надежными и ненадежными источниками. Цель: В этом исследовании рассматривается вопрос о том, каким образом лица, имеющие НР в Соединенном Королевстве, стремятся получить, оценить и оценить качество онлайновой информации по вопросам з

Совпадение в аннотации оригинала
Background: People living with multiple sclerosis (MS) are increasingly turning to the Internet for information about their condition and its treatment. However, online health information varies widely in quality, and patients often lack the eHealth literacy needed to distinguish reliable from unreliable sources. Objective: This study examined how people wit…

Interleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain.

BACKGROUND AND OBJECTIVES: Interleukin-9 (IL-9) is an immune molecule with multiple roles in a variety of cell types. IL-9-induced cell responses are mediated by the IL-9 receptor (IL-9R). Recent evidence demonstrates that expression of IL-9R in post mortem brain tissues of patients with multiple sclerosis (MS) is associated with a protective, anti-inflammatory role of IL-9 in MS. In this study, we investigated the expression of IL-9R in cells resident in the CNS of patients with MS. We found that astrocytes express IL-9R, indicating their expected responsiveness to IL-9. Astrocytes play a cri…

EAE models of neuropathic pain in multiple sclerosis do not require pertussis toxin.

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) is a preclinical model of multiple sclerosis (MS), typically induced with two inoculations of myelin oligodendrocyte glycoprotein (MOG35-55) emulsified in complete Freund's adjuvant (CFA), and supplemented with pertussis toxin (PTX). Although PTX has been considered essential, recent studies suggest that EAE pathology can develop without it. OBJECTIVES: Indices of clinical disease and neuropathic pain were evaluated in a conventional model of EAE that included PTX (EAE-PTX) and one that lacked PTX (EAE-nPTX), as well as in multiple c…