Результаты поиска

Haematological Diseases in the Tropics

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

Совпадение в полном тексте источника
… The main topics are results from transcranial cerebral oximetry in the hyperbaric environment and the non-invasive assessment of oxygen metabolism using NIRS technology during high altitude trekking in the Nepal Himalayas. …

Chromatin modifiers in human disease: from functional roles to regulatory mechanisms.

The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional exploration to the process of participating in many types of disease regulatory mechanisms. Chromatin modifiers are a class of enzymes that can catalyze the chemical conversion of pyrimidine residues or amino acid residues, including histone modifiers, DNA methyltransferases, and chromatin remodeling complexes. Chromatin modifiers assist in the formation of transcriptional regulatory circuits between transcription factors, enhancers, and promoters by reg

Алгоритмы машинного обучения для виртуального раннего обнаружения и выявления нейродегенеративных и нейрокогнитивных расстройств: систематический обзор.

Происхождение и аналоговые расстройства (например, болезнь Альцгеймера, болезнь Паркинсона) приводят к нейронной потере; нейрокогнитивные расстройства (например, бред, слабоумие) свидетельствуют о когнитивном упадке. Раннее обнаружение имеет решающее значение для эффективного управления. Машинное обучение помогает в более точном выявлении заболеваний, потенциально преобразуя медицинское обслуживание. В рамках этого всеобъемлющего систематического обзора обсуждается вопрос о том, каким образом машинное обучение (ML) может способствовать раннему выявлению этих расстройств, превосходя при этом тр

Совпадение в полном тексте источника
… Adhikari et al. ( 61 ) | 2021 | Nepal | The transcripts of AD patients and control normal people were combined to build a novel dataset on low-resource language, namely Nepali, for this work and also provided baselines for the early identification of AD by utilizing a variety of machine learning (ML) …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

Совпадение в полном тексте источника
… Further, the 2015 Nepal earthquake resulted in forces of nature being its leading cause of DALYs that year. …

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was condu

Электронные постеры

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

Совпадение в полном тексте источника
… India is the biggest producer, consumer, and supplier, but it is also cultivated extensively in Cambodia, Bangladesh, Nepal, Indonesia, Thailand, Cambodia, Malaysia, West Bengal, Madagascar, Tamil Nadu, Maharashtra, Madras Indonesia, and Philippines ( Royal Botanic Gardens Kew, 2021 ). …

Harnessing CAR-Extracellular Vesicles for Next-Generation Cancer Immunotherapy.

Cancer immunotherapy has experienced substantial progress in recent years, particularly with the advancement of chimeric antigen receptor (CAR) technology, which enables immune cells to selectively target tumor-associated antigens. CARs, now in their fifth generation, are engineered by combining monoclonal antibody fragments with signaling and co-stimulatory domains and have been successfully applied to T cell, natural killer (NK) cell, and macrophage-based therapies. Notable clinical successes, such as tisagenlecleucel and lisocabtagene maraleucel underscore the therapeutic potential of CAR-T

Совпадение в полном тексте источника
… For example, the Centre for Regenerative Medicine in Nepal is pursuing the development of cost-effective CAR-T cell therapy by evaluating the feasibility of local production using regionally and internationally sourced reagents [ 49 ]. …

Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval.

The global research and pharmaceutical community rapidly mobilized to develop treatments for coronavirus disease 2019 (COVID-19). Existing treatments have been repurposed and new drugs have emerged. Here we summarize mechanisms and clinical trials of COVID-19 therapeutics approved or in development. Two reviewers, working independently, reviewed published data for approved COVID-19 vaccines and drugs, as well as developmental pipelines, using databases from the following organizations: United States Food and Drug Administration (US-FDA), European Medicines Agency (EMA), Japanese Pharmaceutical

PARP Inhibitors and Haematological Malignancies-Friend or Foe?

Since their introduction several years ago, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have become the standard of care for breast and gynaecological cancers with BRCA gene mutations. Given that PARPi act by exploiting defective DNA repair mechanisms within tumour cells, they should be ideally suited to combatting haematological malignancies where these pathways are notoriously defective, even though BRCA mutations are rare. To date, despite promising results in vitro, few clinical trials in humans for haematological malignancies have been performed, and additional investigation is

Иммунотерапия Множественной миеломы: Текущий статус как пролог в будущее.

Площадь терапевтических мер по лечению множественной миеломы претерпела сейсмические изменения с начала нынешнего столетия. Это было обусловлено главным образом введением новых классов небольших молекул, таких, как протеазонные блокаторы (например, бортезомиб) и иммуноводители (например, линалидомид), а также иммунотерапевтическими агентами, начиная с anti-CD38 Моноклональная антитела Daratumumab 2015. В последнее время в арсенал лекарств, доступных для борьбы с этим злоумышленником, добавились и другие иммунотерапии. В их число входят продукты биконкретных теклистамб, талькетамаб и эльранатам

Совпадение в полном тексте источника
… Aiman W., Anwar A., Satti D.I., Hamza M., Perez A.M., Khan A.A., Nepal A., Supraja A., Yeesau M., Nanjundaiah N., et al. Addition of daratumumab to drug regimens in the treatment of multiple myeloma: A systematic review and meta-analysis of randomized clinical trials. Clin. …

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Совпадение в полном тексте источника
… Iron-deficiency anaemia was the first leading cause and lower back and neck pain was the second leading cause of YLDs in both India and Pakistan, whereas sensory disorders, other musculoskeletal disorders, and iron-deficiency anaemia ranked second for disability in Nepal, Bangladesh, and Bhutan, respectively …

Oral Presentations

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Устные доклады

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer.

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. The use of small molecule RTK inhibitors however, has been crippled by the emergence of resistance, highlighting the need for a pleiotropic anti-cancer agent that can replace or be used in combination with existing pharmacological agents to enhan

Совпадение в полном тексте источника
… Hutchins-Wolfbrandt and Mistry (2011) describe a few studies that have looked into daily turmeric consumption in India and Nepal, however, these studies did not examine how this affected the overall prevalence of cancer. …

Искусственные интеллектуальные технологии зондирования для борьбы с раком, диабетом и COVID-19.

Интеграция искусственного интеллекта (АИ) с износимыми сенсорными технологиями может привести к революции в мониторинге и лечении различных хронических заболеваний и острых заболеваний. Комбинированные износы АИ классифицируются по таким основополагающим методам зондирования, как электрохимическая, колориметрическая, химическая, оптическая, а также давление/стабильность. Алгоритмы АИ повышают эффективность изношенных датчиков, обеспечивая индивидуализированный, постоянный надзор и прогнозный анализ, помогая распознавать время и оптимизируя терапевтические методы. В этой рукописи рассматриваютс

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis.

Although it has long been recognized that inflammation, a consequence of immune-driven processes, significantly impacts bone turnover, the degree of centralization of skeletal and immune functions has begun to be dissected only recently. It is now recognized that formation of osteoclasts, the bone resorbing cells of the body, is centered on the key osteoclastogenic cytokine, receptor activator of NF- κ B ligand (RANKL). Although numerous inflammatory cytokines are now recognized to promote osteoclast formation and skeletal degradation, with just a few exceptions, RANKL is now considered to be

BREAST

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Approximately 50000 visceral infections occur annually with 90% in the five countries of Sudan, Bangladesh, Brazil, India and Nepal. In advanced cases if it is untreated it can lead to severe cachexia and severe anaemia can lead to heart failure in extreme cases. …

Breaking into HIV-1's Epigenetic Vault: Cure Strategies to Eliminate the Viral Reservoir.

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that integrates into the host cell's DNA as a provirus. Transcription from the provirus is regulated in large part by cellular proteins and epigenetic factors. These may be repressive or permissive to productive infection. The host factors that regulate this balance are therefore attractive targets for HIV-1 therapeutics. Indeed, proviral chromatin is the focus of two of the current HIV-1 cure strategies. "Shock and Kill" uses latency reversal agents to open the provirus's chromatin, promoting high levels of gene expression that induc