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The perioperative management of geriatric patients in transplantation surgery-clinical, immunological, and translational considerations.

Transplant surgery encompasses two primary branches: solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA). As the global population ages, elderly transplant patients become a more pressing clinical challenge. Elderly transplant recipients require specialized care that addresses their unique needs, including increased comorbidities and frailty. Despite the growing recognition of these challenges, there is a paucity of studies that synthesize the current knowledge on this patient cohort, from immunological changes over translational challenges to tailored clinic

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… Lungs Older lung transplant recipients have a markedly increased risk of chronic lung allograft dysfunction (CLAD), particularly bronchiolitis obliterans syndrome (BOS) ( 116 , 117 ). … Bronchiolitis Obliterans. Tripoli: StatPearls Publishing; (2025). Available online at: http://www.ncbi.nlm.nih.gov/books/NBK441865/ ( Accessed April 29, 2025). 118. Paraskeva MA, Borg BM, Paul E, Fuller J, Westall GP, Snell GI. …

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment.

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

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… Ultrasound-guided thoracentesis can be an important test in RA patients with pleural effusion. 3.1.3 Airway involvement (bronchiolitis, bronchiectasis, and cricoarytenoid arthritis) The prevalence of airway disease is high in RA as it affects 39% to 60% of RA patients and may involve any part of the … Chronic inflammatory infection is the main cause of bronchiectasis in RA patients, and bronchiolitis is characterized by damage to the airway epithelium, which leads to airflow obstruction ( 81 ). …

Pregnancy Exposure to Anti-CD20 Monoclonal Antibodies in Patients With Multiple Sclerosis: Results From an Italian Multicenter Registry Study.

BACKGROUND AND OBJECTIVES: Although anti-CD20 monoclonal antibodies (anti-CD20s) theoretically represent an ideal treatment option for women with multiple sclerosis (wwMS) planning a pregnancy, the paucity of real-world data still limits their use in this context. Through our Italian registry "CD20-PREGNANCY," we aim to report pregnancy, infant, and maternal outcomes in wwMS treated with anti-CD20s. METHODS: In this observational study, wwMS having received rituximab (RTX), ocrelizumab (OCR), or ofatumumab (OFA) before and/or during pregnancy (≤12 months for RTX/OCR, ≤6 months for OFA) were i

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… Only one serious perinatal infection was reported (“exposed” group), in a woman treated with OCR, and consisted of bronchiolitis and blood cultures positivity for staphylococcus and enterococcus faecalis. General health status of the infant at FU was good. … Finally, only one serious perinatal infection was reported: a case of bronchiolitis in an “exposed” pregnancy, without consequences on long-term health status of the infant and which could still be due to chance. …

CRP patterns and clinical associations in febrile patients undergoing autologous bone marrow transplant: experience from the sole transplant center in the West Bank, Palestine.

Autologous bone marrow transplantation (auto-BMT) is frequently complicated by febrile episodes and systemic inflammation, particularly during the neutropenic phase, making inflammatory markers such as C-reactive protein (CRP) valuable for monitoring recovery and guiding clinical decisions. In this descriptive, retrospective study of 244 febrile auto-BMT patients in the West Bank, data on demographics, CRP levels (days 1–14), fever onset and duration, and white blood cell (WBC) engraftment were analyzed using non-parametric tests and Spearman correlation. Fever typically began around day 6.7,

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… Paz HL, Crilley P, Patchefsky A, Schiffman RL, Brodsky B (1992) Bronchiolitis obliterans after autologous bone marrow transplantation. Chest 101(3):775–778 8. …

Курсы по болезням, результатам и осложнениям у беременных женщин и кормящих матерей с множественным склерозом, обработанных ритуксимабом или окрилизумабом: обзор нарации.

Множественный склероз (MS) в основном затрагивает женщин детородного возраста, и принятие решений в отношении методов лечения заболеваний во время беременности и кормления, особенно в отношении высокоэффективных методов лечения против CD20, таких, как ритуксимаб и окролизумаб, по-прежнему сопряжено с трудностями. Цель этого обзора состоит в обобщении имеющихся данных о ходе беременности, беременности и неонатальных исходах, осложнениях и соображениях безопасности у беременных и кормящих женщин, у которых цитусимаб или острелизумаб. Этот структурированный обзор описательной части был проведен в

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… Overall, no significant increase in severe neonatal infections or delays in growth and development has been reported to date.[ 16 ] Although some studies have noted that a proportion of infants with in utero exposure experienced common early-life infections (such as upper respiratory infections, bronchiolitis …

Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit?

Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy. By breaking down extracellular matrix (ECM) components and releasing the proteins composing the ECM and growth factors, as well as their receptors, MMPs affect tissue integrity and promote cancer cell invasion and metastasis. A vital pathophysiological characteristic of MM is the progress of osteolytic lesions, which are brought on by interactions between myeloma cells and the bone marrow mic

The use of high-flow nasal oxygen vs. standard oxygen therapy in hematological malignancy patients with acute respiratory failure in hematology wards

Background/aimHigh flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients.Materials and methodsThe study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC.ResultsOne hundred patients were included in the study. Median age was 58.5 (18–86) years and

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… G364(P) High flow nasal cannula (HFNC) oxygen therapy for bronchiolitis on a paediatric ward (including children with co-morbidities): two years’ experience. Archives of Disease in Childhood. 2017;102:143–143. Nicholson T Channon L Williams H Shahidi M. …

2019 ASCO Annual Meeting Highlights for the Advanced Practitioner: Hematologic Malignancies.

Amy Pierre, MSN, ANP-BC, of the Memorial Sloan Kettering Cancer Center, and Nancy M. Nix, PharmD, BCPS, BCOP of St. Joseph's/Candler Health System offer an advanced practitioner perspective on trials assessing the efficacy and safety of novel agents in smoldering and relapsed/refractory multiple myeloma, chronic lymphocytic leukemia, and acute myeloid leukemia.

Воздействие нефтеперерабатывающих и биотопливных заводов на здоровье человека: карта систематических доказательств и обзор скопирования.

ЦЕЛЬ ОБЗОРА: Нефтеперерабатывающие заводы являются важными источниками выбросов токсичных загрязнителей во всем мире, которые угрожают здоровью работников нефтеперерабатывающих предприятий и близлежащего населения. Мы провели обзор эпидемиологических данных об остром и хроническом воздействии нефтеперерабатывающих и биотопливных заводов на здоровье окружающих общин. Мы провели оценку доказательств с использованием оценок риска предубеждений и зафиксировали полученные результаты на карте доказательств для выявления пробелов в литературе. Мы систематически искали исследования, опубликованные к а

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… Case days were hospital admissions for asthma and bronchiolitis and control days were the same day of the week in the same month. … bronchiolitis hospital admission odds ratio decreases as NO 2 and SO 2 increases based on dispersion modeling of reported emissions Gnesi et al., 2020 [ 44 ] | Italy, 2002–2014 | Adults (age 20–64) within 4 km of one refinery matched by age, gender, and municipality. …

Cellular Therapy for Systemic Autoimmune Diseases: New Opportunities for Future Research and Interdisciplinary Collaboration.

Systemic autoimmune diseases (sAIDs) affect 1 in 10 people and represent a leading cause of death in women under the age of 65 years. Despite the emergence of targeted-biologic therapies, mortality rates for sAIDs have not improved. Emerging cellular therapies represent a promising therapeutic strategy for patients living with sAIDs given their potential to induce sustained remission and limit long-term exposure to glucocorticoids. Encouraging outcomes from a case series of patients with systemic lupus erythematosus, idiopathic inflammatory myopathy, and systemic sclerosis (SSc) have ignited c

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… Donor B‐cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans . Blood 2012 ; 119 ( 6 ): 1570 – 1580 . 22072556 10.1182/blood-2011-07-364414 PMC3286218 66 Hill GR , Olver SD , Kuns RD , et al. … The safety and tolerability of pirfenidone for bronchiolitis obliterans syndrome after hematopoietic cell transplant (STOP‐BOS) trial . Bone Marrow Transplant 2022 ; 57 ( 8 ): 1319 – 1326 . 35641662 10.1038/s41409-022-01716-4 PMC9357121 79 Rurik JG , Tombácz I , Yadegari A , et al. …

Fulminant hepatitis and multi-organ failure following varicella zoster virus infection in an adult with G6PD deficiency: a case report.

BACKGROUND: Varicella zoster virus (VZV) infection in adults can lead to severe complications, particularly in those with underlying comorbidities. This case report presents a rare instance of VZV-associated fulminant hepatitis progressing to multi-organ failure in a 27-year-old female with glucose-6-phosphate dehydrogenase (G6PD) deficiency. CASE PRESENTATION: The patient presented with a generalized rash and rapidly developed acute liver failure, coagulopathy, and renal dysfunction. Despite aggressive management, including intravenous immunoglobulin therapy and supportive care, the patient'

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… Table 2 Summary of reported cases of varicella hepatitis in adults and children ARDS: Acute Respiratory Distress Syndrome, BOOP: Bronchiolitis Obliterans Organizing Pneumonia, DM: Diabetes Mellitus, G6PD: Glucose-6-Phosphate Dehydrogenase, HSCT: Hematopoietic Stem Cell Transplantation (autologous = from …

Pharyngeal-Esophageal Malignancies with Dermatologic Paraneoplastic Syndrome.

Systemic changes often send signals to the skin, and certain neoplastic diseases of the internal organs can also trigger skin manifestations. In this article, the authors make clinical photography presentations of the patients seen at our clinic with dermatologic paraneoplastic syndromes within pharyngeal-esophageal malignancies, describe several paraneoplastic dermatoses, and also review high-quality scientific literature in order to be able to highlight the dermatological signs of pharyngoesophageal malignant tumors. The majority of our patients with paraneoplastic dermatoses, filtering for

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… Some patients develop respiratory complications such as bronchiolitis obliterans, which can lead to respiratory failure. Sepsis, hemorrhage, and respiratory failure are all associated with a high mortality rate in patients with paraneoplastic pemphigus [ 54 ]. 4.3. …

Pegylated Liposomal Doxorubicin in Vindesine-Based and Bortezomib-Based Regimens for Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study of Efficacy and Safety.

PurposeAlthough pegylated liposomal doxorubicin (PLD) has been approved in combination with bortezomib for relapsed/refractory multiple myeloma (MM), the antitumor efficacy and tolerability of PLD in different regimens for patients with newly diagnosed MM (NDMM) have not been fully defined.MethodsA total of 249 NDMM patients diagnosed between January 2008 and October 2019 were included in this retrospective study. Among them, 112 patients received vindesine-based chemotherapy (35 vDD and 77 vAD) and 137 received bortezomib-based chemotherapy (58 VDD and 79 VD).ResultsIn bortezomib-containing r

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… This combination treatment was prematurely discontinued in all three Japanese patients with RRMM in a phase I study due to adverse events (AEs) including Grade 3 bronchiolitis, Grade 3 peripheral sensory neuropathy, and Grade 2 stomatitis with all achieved partial response (PR). …

Beyond CAR T-Cell Therapy: Continued Monitoring and Management of Complications.

Chimeric antigen receptor (CAR) T-cell therapy has recently emerged as a groundbreaking treatment for CD19-expressing hematologic malignancies and received rapid approval by the U.S. Food & Drug Administration. Tisagenlecleucel and axicabtagene ciloleucel are now widely available at CAR T-cell therapy centers around the United States. Many patients have achieved complete response or remission despite failing multiple previous lines of therapy, but some patients endure the severe risks of cytokine release syndrome, neurotoxicity, and other immunologic effects. As more patients receive this ther

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… Auscultation and percussion for adventitious or absence of lung sounds is paramount for detecting signs or symptoms of pneumonia, bronchiolitis, or pleural effusion. The provider should take note of oxygenation, exertional dyspnea, and overall conditioning. …

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury.

BACKGROUND: Acute lung injury (ALI) is a serious respiratory disorder for which therapy is primarily supportive once infection is excluded. Surgical lung biopsy may rule out other diagnoses, but has not been generally useful for therapy decisions or prognosis in this setting. Importantly, tissue and peripheral blood eosinophilia, the hallmarks of steroid-responsive acute eosinophilic pneumonia, are not commonly linked with ALI. We hypothesized that occult eosinophilic pneumonia may explain better outcomes for some patients with ALI. METHODS: Immunohistochemistry using a novel monoclonal antib

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… Acute Lung Injury Patterns: Diffuse Alveolar Damage and Bronchiolitis Obliterans- Organizing Pneumonia; p. 477. 34. Protheroe CA, Woodruff SA, DePetris G, Mukkada V, Ochkur SI, Janarthanan S, Lewis JC, Pasha S, Lunsford T, Harris L, et al. …

Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.

Transplant recipients have an increased risk of complications, including graft dysfunction and infections, which can be life-threatening if not recognized early. Pneumonia ranks as one of the most frequent complications in both solid organ and hematopoietic stem cell transplants. Clinical symptoms manifest late during infections in immunocompromised patients. An aggressive approach centered on early confirmatory diagnosis and a low threshold for empiric therapy is often the most effective strategy. The isolation of a pathogen in an upper airway sample does not necessarily mean the same organis

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… Non-infectious pulmonary complications can include chronic GVHD, presenting as bronchiolitis obliterans syndrome, and pulmonary veno-occlusive disease from pulmonary cytolytic thrombi. … In lung transplant patients, CMV infection is often the risk factor for bronchiolitis obliterans syndrome. CMV can emerge as either reactivation or disease, primarily presenting as pneumonia. …

Role of Cardio-Oncology Rehabilitation in Hematopoietic Stem Cell Transplantation and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chimeric antigen receptor T-cell (CAR-T) therapy often lead to severe sarcopenia and cachexia during treatment, making it difficult to maintain exercise tolerance. Consequently, "cancer rehabilitation" programs have been implemented to sustain and improve physical activity and motor function. Hematologic malignancies often involve the use of cardiotoxic drugs. Moreover, graft-vs.-host disease associated with allo-HSCT and the cytokine release syndrome in CAR-T therapy elevate the risk of cardiovascular complications. Thus, esta

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… injuries caused by GVHD, radiation therapy, or conditioning regimens have also been reported, including cryptogenic organizing pneumonia due to small airway epithelial damage, diffuse alveolar hemorrhage from vascular endothelial injury, and interstitial pneumonia affecting the lung parenchyma. 47 Bronchiolitis …

Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience.

BackgroundMalignancy is a significant, life-limiting complication after lung transplantation (LuTx) and the second common long-term cause of death. We aimed to investigate its incidence and effect on the outcome.MethodsThis is a retrospective observational study. Between 1996 and 2022, n = 627 lung transplantations (LuTx) were performed in our department. We used our institutional database to identify recipients with malignancies after LuTx and examined the malignancies' incidence and mortality.ResultsN = 59 malignancies occurred in n = 55 (8.8%) LuTx recipients. The post-LTx malignancies inci

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… 18–34 | 2 (3.6) 35–49 | 15 (27.3) 50–64 | 32 (58.2) ≥65 | 6 (10.9) Gender Female | 25 (40) Male | 33 (60) Underlying primary lung disorder COPD/A1AT | 25 (45.5) IPF | 13 (23.6) CF | 4 (7.3) Fibrotic lung disease | 4 (7.3) Exogenous allergic alveolitis | 3 (5.5) Sarcoidosis | 1 (1.8) CPFE | 1 (1.8) Bronchiolitis …

Abstracts of the Cell Therapy Transplant Canada 2024 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2024 Annual Conference. The conference was held on 1-3 May 2024 in beautiful Victoria, British Columbia, at the Victoria Conference Centre, and attracted 293 in-person delegates and five virtual attendees. Several plenary sessions were held on topics such as gene therapy for hemoglobin disorders, optimizing donor selection, graft-versus-host disease (GvHD) strategies, collaborative care, survivorship, graft failure, and CAR-T therapy. Poster authors presented their work during a lively and e

Advanced Diagnostic Techniques

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