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IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.

Chronic graft-versus-host disease (cGvHD) remains the most relevant factor affecting survival after allogeneic hematopoietic stem cell transplantation (alloHSCT). Besides corticosteroids (and ibrutinib in the USA), there is no established therapy for cGvHD. Tocilizumab, a humanized IgG1 IL6-receptor antibody, has shown efficacy in acute GvHD and cGvHD. We retrospectively analyzed the efficacy and safety of tocilizumab for the treatment of advanced cGvHD. Eleven patients with severe steroid refractory cGvHD (median age 49; range 21-62 years) that received at least two prior lines of therapy for

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… Donor B cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. 2012;119(6):1570–1580. doi: 10.1182/blood-2011-07-364414. 15. Nakagiri T, Inoue M, Minami M, Shintani Y, Okumura M. …

Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Intensive Care 2020, 10 (Suppl 1): CO-09 Rationale: Non Invasive Ventilation (NIV) and High Flow Nasal Cannula (HFNC) are the first-line therapies for the most severe patients with acute bronchiolitis. … The main objective of this study is to describe the weaning practices from NIV/HFNC in patients with acute bronchiolitis. Patients and methods: A single-center prospective study. Patients younger than 6 months with severe bronchiolitis and supported by NIV or HFNC were included. …

Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis.

BACKGROUND: Until recently, tumors of the clivus and the anterior region of the posterior cranial fossa were considered extremely difficult to access and often inoperable using standard transcranial approaches. With the introduction into the neurosurgical practice of minimally invasive methods utilizing endoscopic techniques, it became possible to effectively remove hard-to-reach tumors, including central tumors of the anterior region of the posterior cranial fossa. METHODS: From 2008 to the present time, the inpatient institution has operated on 140 patients with various tumors of the base o

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… Children who live with smokers are more likely to acquire respiratory illnesses, including bronchiolitis and pneumonia. They are also more likely to have middle ear illnesses and develop asthma, which can result in hospitalization. They are also more prone to death before turning five. …

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge.

The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may a

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… Pulmonary Rehabilitation for Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation Biol. Blood Marrow Transplant. 2012 18 1250 1254 10.1016/j.bbmt.2012.01.017 22300617 PMC3378799 60. El-Jawahri A. Fishman S.R. Vanderklish J. Dizon D.S. Pensak N. Traeger L. Greer J.A. …

Real-life data on safety and efficacy of autologous stem cell transplantation in elderly patients with multiple myeloma.

Autologous stem cell transplantation (ASCT) is still debatable in treatment of patients over 65 years with multiple myeloma (MM). We performed a retrospective analysis of newly diagnosed MM patients who underwent ASCT between January 2010 and July 2016. A non-transplanted group with similar clinical characteristics, aged 65-70 years old, diagnosed and treated in the same timeline was used for comparison. We analyzed a total of 155 patients, 132 of which underwent ASCT (≤ 65 years, n = 103, median 56 years; > 65 years, n = 29, median 67 years) and 23 non-transplanted (median 68 years). Conditio

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… Five patients had to be admitted to intensive care unit (3 under 65 years old and 2 over 65 years old), four of them due to septic shock, and one patient for stroke and bronchiolitis obliterans with organizing pneumonitis. …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Polymorphisms in PRRs is of importance in host–microbe interactions such as NOD2, originally described in Crohn’s disease, and TLRs have been implicated in the occurrence of GVHD, bronchiolitis obliterans, and treatment-related mortality [ 113 , 114 ]. …

Effects of pre-transplant chest physical therapy on spirometric values and respiratory muscle strength in patients waiting for allogeneic hematopoietic stem cell transplantation: a randomized controlled trial.

IntroductionMany noninfectious pulmonary complications occur immediately within the first few weeks after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to evaluate the efficacy of chest physical therapy (CPT) performed during the pre-transplant period in terms of spirometric values and respiratory muscle strength (RMS) in patients waiting for allo-HSCT.Material and methodsFifty patients aged 40 to 55 years who were scheduled for allo-HSCT were randomly allocated into two equal-sized groups, a CPT group and a control group. The CPT group (n = 25) received CPT

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… Bronchiolitis obliterans and other late-onset non-infectious pulmonary complications in hematopoietic stem cell transplantation . Bone Marrow Transplant 2001 ; 28 : 425 – 34 . 11593314 10.1038/sj.bmt.1703142 10 Wah TM , Moss HA , Robertson RJH , Barnard DL . …

Оценка спроса на паллиативный уход у пациентов, не имеющих онкологов, в Чили.

Доступ к паллиативному уходу представляет собой новую глобальную проблему в области здравоохранения. В Чили недавно был принят закон о паллиативном уходе, предусматривающий охват паллиативным уходом неонологического населения. Таким образом, для надлежащего планирования политики в области здравоохранения необходима надежная и законная оценка спроса на паллиативную помощь. Годовая смертность от выявленных заболеваний оценивалась за периоды 2018-2020. Оценка спроса соответствует определению доли умерших пациентов, нуждающихся в паллиативном уходе, исходя из тяжести тяжелых страданий, связанных с

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… Pneumonia due to Streptococcus pneumonia, Pneumonia due to Haemophilus influenzae, Bacterial pneumonia, not elsewhere classified, Pneumonia due to other infectious organisms not elsewhere classified, Pneumonia in diseases classified elsewhere, Pneumonia, organism unspecified Acute bronchitis, Acute bronchiolitis …

Proceedings of Reanimation 2022, the French Intensive Care Society International Congress.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… -08 Rationale: High flow oxygen nasal cannula therapy (HFNC) is a non-invasive respiratory support increasingly used to treat bronchiolitis induced respiratory failure. … Reference 1: The New England Journal of Medicine 2018 “A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.” Donna Franklin. Reference 2: Eur Respir J 2020 “A randomised trial of high-flow nasal cannula in infants with moderate bronchiolitis” Philippe Durand. …

Extracorporeal Photopheresis in Pediatric and Adult Patients with Graft-Versus-Host Disease.

Background/Objectives: Graft-versus-host disease (GVHD) is a severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) resulting from histocompatibility differences between donor and host cells leading to inflammation, tissue damage, and compromised patient outcome. Extracorporeal photopheresis (ECP) is considered as a second-line treatment administered to patients with GVHD who do not respond to corticosteroid treatment or who experience a relapse after an initial response and are therefore classified as steroid refractory (SR). The aim of this study is to evaluate

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… Effect of extracorporeal photopheresis on lung function decline for severe bronchiolitis obliterans syndrome following allogeneic stem cell transplantation J. Clin. Apher. 2016 31 347 352 Epub 2015 May 29 10.1002/jca.21404 26031713 32. Weisdorf D. Zhang M.J. Arora M. Horowitz M.M. Rizzo J.D. …

Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients.

Chronic graft-versus-host-disease (cGvHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Among various organ-specific cGvHD, the cGvHD of liver is less well-characterized. In this study, we applied the National Institutes of Health 2014 scoring criteria of cGvHD to analyze a retrospective cohort of 362 allo-HSCT recipients focusing on cGvHD of liver. The overall incidence of liver cGvHD with a score of 3 by 1.5 years post-transplant was 5.8% (21/362). Poor outcome, in terms of overall survival (OS), were observed in patients with scores of 3 liver

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… Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation. 2003;9(10):657–66. doi: 10.1016/S1083 . 10. …

Роль врожденных иммунных клеток в множественном склерозе.

Множественный склероз (MS) — хроническое аутоиммунное, воспалительное и нейродегенеративное заболевание, затрагивающее центральную нервную систему (КНС). MS ассоциируется со сложным взаимодействием между нейродегенеративными и воспалительными процессами, в основном связанными с патогенными Т и В клетками. Однако все большее количество доклинических и клинических данных свидетельствует о том, что врожденный иммунитет играет ключевую роль в поощрении и развитии НР. В этой связи в настоящее время изучаются доклинические и клинические исследования, ориентированные на различные врожденные иммунные

Feasibility and safety of the discontinuation of systemic immunosuppressive treatment after single-unit cord blood transplantation in adults.

We retrospectively evaluated the incidence, factors, and clinical outcomes of the discontinuation of immunosuppressive treatment (IST) after single-unit unrelated cord blood transplantation (CBT) in adults receiving cyclosporine-based graft-versus-host disease (GVHD) prophylaxis at our institute. Among the 309 patients who achieved engraftment, 247 were able to discontinue IST with a median follow-up of 121 months for survivors. The cumulative incidence of the discontinuation of IST was 46.2% at 180 days, 72.8% at 2 years, and 79.3% at 5 years post-CBT. In the multivariate analysis, discontinu

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… The main causes of the re-initiation of IST were the development of chronic GVHD ( n = 24), cryptogenic organizing pneumonia or bronchiolitis obliterans organizing pneumonia ( n = 4), and pneumonia caused by infections ( n = 3). …

Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications.

Recent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led to introducing the term autoinflammatory keratinization diseases encompassing entities in which monogenic mutations cause spontaneous activation of the innate immunity and subsequent disruption of the keratinization process. Originally, autoinflammatory keratinization diseases were attributed to pathogenic variants of CARD14 (generalized pustular psoriasis with concomitant psoriasis vulgaris, palmoplantar pustulosis

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… in the arm folds and on the wrists | POMP | Autosomal recessive | 601952 Epidermal growth factor receptor deficiency | • Papulo-pustular rash, loss of scalp hair, trichomegaly • Possible systemic involvement (gastrointestinal and respiratory symptoms (watery diarrhea, respiratory difficulties, and bronchiolitis … The child also suffered from gastrointestinal and respiratory symptoms (watery diarrhea, respiratory difficulties, and bronchiolitis) and died of infection and electrolyte imbalance at the age of 2.5 years [ 171 ]. …

Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation - a registry study on behalf of the EBMT Acute Leukemia Working Party.

Conditioning protocols for patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) are being developed continuously to improve their anti-leukemic efficacy and reduce their toxicity. In this study, we compared the conditioning protocol of fludarabine with melphalan 140 mg/m2 (FluMel) with conditioning protocols based on this same backbone but with an additional alkylating agent i.e., either fludarabine/BCNU (also known as carmustine)/melphalan (FBM), or fludarabine/thiotepa/melphalan (FTM) 110 mg/m2. We included 1272 adult patients (FluMel, n = 1002; FBM/FTM, n = 270) with

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… Impact of lung function on bronchiolitis obliterans syndrome and outcome after allogeneic hematopoietic cell transplantation with reduced-intensity conditioning. Biol Blood Marrow Transpl. 2018;24:2277–84. doi: 10.1016/j.bbmt.2018.06.024. 16. …

Real-world results with IgPro20 for hypo- or agammaglobulinemia in Japan.

BackgroundSubcutaneous immunoglobulin is one of the standard treatments for hypogammaglobulinemia in primary immunodeficiencies (PID) worldwide. In Japan, IgPro20 (Hizentra® ; l-proline-stabilized 20% human subcutaneous immunoglobulin) is approved for agammaglobulinemia or hypogammaglobulinemia due to PID or secondary immunodeficiency (SID); however, its safety and effectiveness has not previously been assessed in a real-world setting.MethodsThis multicenter, open label post-marketing surveillance study was conducted between January 2014 and March 2019. Patients who received IgPro20 due to PID

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… The reasons for treatment discontinuation were AEs – PID: n = 2 (injection site pain; n = 1, aseptic meningitis syndromes; n = 1); SID: n = 3 (aseptic meningitis syndromes; n = 1, hives; n = 1, bronchiolitis obliterans syndrome; n = 1); patients changed to a different hospital (PID: n = 1; SID: n = 1 …

When to investigate for secondary hyperhidrosis: data from a retrospective cohort of all causes of recurrent sweating.

Background: Identification of underlying diseases is crucial for secondary hyperhidrosis management, but data are lacking to guide appropriate investigation.Objective: To describe aetiologies of recurrent sweating in a hospital setting and the diagnostic performance parameters of their respective clinical/biological features.Patients and Methods: We performed a monocentric evaluative study in a tertiary care centre. Patients with recurrent generalised sweating were selected via the Clinical Data Warehouse (CDW) by screening all electronic hospital documents from the year 2018 using a keyword-b

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… Anxiety disorder | 10 | Withdrawal syndrome | 3 | Burn-out | 1 | Psychogenic non-epileptic seizure | 1 Respiratory | Obstructive sleep apnoea | 5 | 12 (2.9) | Asthma | 1 | Chronic obstructive pulmonary disease | 1 | Cystic fibrosis | 1 | Lymphocytic interstitial pneumonia | 1 | Post-infectious bronchiolitis …

Patients with type 1 Gaucher disease in South Florida, USA: demographics, genotypes, disease severity and treatment outcomes.

BackgroundGaucher disease, an autosomal recessive condition due to deficiency of lysosomal glucocerebrosidase, is a multisystemic disease, with variable age of onset, severity and progression. It is classified into subtypes delineated by the absence (type 1) or presence (type 2 and 3) of primary nervous system involvement. The ethnically diverse, largely immigrant population in South Florida has a spectrum of Gaucher disease phenotypes, creating a challenge for optimization of disease management and an opportunity to explore treatment patterns.MethodsNinety-three records from patients with Gau

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… Number of pts with splenectomy Parkinsonism* | 3 | 2 Chronic kidney disease | 3 | Acute myeloid leukemia and/or myelodysplasia | 3 | 1 Dementia without Parkinsonism | 2 | Non-Hodgkin’s lymphoma | 1 | 1 Lung cancer, metastatic | 1 | Cerebrovascular accident | 1 | Congestive heart failure | 1 | Bronchiolitis …

Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections.

BackgroundRespiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants (HCTs) are associated with increased morbidity and mortality. However, the hospital presentations and courses of these infections remain under-described.MethodsWe performed a multicenter retrospective cohort study of hospitalized patients with hematologic malignancy or HCT at 2 comprehensive cancer centers between January 2019 and June 2023. We included all patients with acute viral respiratory infection (identified based on a constellation of test results and objective physi

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… Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. Am J Respir Crit Care Med 2004; 170:181–7. 44. de Zwart A, Riezebos-Brilman A, Lunter G, et al. …

The Risk of Sarcoidosis Misdiagnosis and the Harmful Effect of Corticosteroids When the Disease Picture Is Incomplete.

Sarcoidosis is a complex granulomatous disease of unknown etiology. Due to the heterogeneity of the disease, the diagnosis remains challenging in many cases, often at the physician's discretion, requiring a thorough and complex investigation. Many other granulomatous diseases have the potential to mimic sarcoidosis, whether infectious, occupational, or autoimmune diseases and starting an unnecessary corticosteroid treatment can worsen the patient's prognosis, leading to side effects that can be harder to treat than the actual disease.