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Congestive heart failure associated with POEMS syndrome that was adequately distinguished from cardiac amyloidosis: a case report and literature review.

Congestive heart failure (CHF) is a common complication in patients with AL amyloidosis but is rare in another plasma cell dyscrasia, POEMS syndrome. A 52-year-old man developed POEMS syndrome with a solitary plasmacytoma complicated by CHF mimicking cardiac amyloidosis (CA). His neurological symptoms and CHF did not improve after radiotherapy (50 Gy) targeting the plasmacytoma. Based on typical findings of noninvasive examinations such as elevated serum NT-proBNP (12,631 pg/mL), a pseudo-infarct pattern on electrocardiography, interventricular septal thickening with a granular sparkling appea

Листерия моноцитогены и ауреат ауреуса Staphylococus у пациента с множественной миеломой: отчет по делу.

ВВЕДЕНИЕ: Listeria monocitogenes представляет собой грозный патоген, который представляет собой значительную угрозу для иммунокомпромизации и может вызвать редкие нетипичные формы заболевания, особенно осложненные при кондиционировании Staphylococcus aureus. КАСЕ: Мы представляем случай пациента с моноцитогенесом менингоэнцефалитом, эндокардитом, сепсисом и С. ауреусом остеомиелитом, высветив сложность лечения распространяемой полимикробной инфекции. A 64-year-old Женщина с множественной миеломой лечится химиотерапией с температурой, изменившимся психическим состоянием, тошнотой и диареей в от

Гипертрофическая кардиомиопатия, открывающая множественные миеломы: диагностический вызов.

Гипертрофическая кардиомиопатия может быть редкой иллюстрацией гематологических магнатов, таких, как множественная миелома, вызванная неконтролируемым клональным распространением плазменных клеток. Мы сообщаем о случае 65-year-old человек, показывая с заточенной сердечной недостаточностью, в которой EKJ и эхокардиография указывают на сердечный амилоидоз, и этиологическая оценка выявила множественные миеломы в качестве основной причины. В этом случае мы показываем, что сердечный амилоидоз в качестве вторичной амилоидозной миеломы может появиться в качестве недавно диагностированной и быстро про

Delayed Diagnosis of Cardiac Amyloidosis Masked by Chronic Coronary Artery Disease and Ischemic Cardiomyopathy: A Case Report of an Overlooked and Underdiagnosed Etiology.

Cardiac amyloidosis (CA) is an infiltrative disease of the heart characterized by the deposition of insoluble protein aggregates in the myocardium. There are two subtypes of CA, and they are named after the misfolded protein. Transthyretin cardiac amyloidosis (ATTR-CA) is caused by the accumulation of the tetrameric transthyretin protein produced in the liver, and light-chain cardiac amyloidosis (AL-CA) occurs due to circulating abnormal light-chain deposition. Disease manifestation can be very non-specific, and there can be overlap with other cardiac processes. This often leads to a delay in

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… Early detection and appropriate therapy can help halt the progression of cardiac damage, but delayed diagnosis is frequent and may require multiple visits to different subspecialty physicians, including interventional cardiologists, electrophysiologists, neurologists, and hematology oncologists for an …

An unexpected cause of a swollen pacemaker pocket: a case report.

BACKGROUND: A complication originating from the pacemaker pocket after device implantation can most often be explained by a post-operative pocket haematoma, or, less frequently, by a pocket infection. Both conditions need immediate assessment, dedicated treatment, and specialized follow-up. In rare cases, however, a swollen pacemaker pocket has an alternative diagnosis, which is exemplified by the following case. CASE SUMMARY: A 70-year-old male patient had a-specific symptoms of fatigue, dyspnoea, and coughing for some weeks. He also noted an evident, new swelling of his pacemaker pocket sev

Cardiovascular toxicities associated with novel cellular immune therapies.

AbstractOver the past decade, T-cell-directed therapies, including chimeric antigen receptor T-cell (CAR-T) and bispecific T-cell engager (BTE) therapies, have reshaped the treatment of an expanding number of hematologic malignancies, whereas tumor-infiltrating lymphocytes, a recently approved cellular therapy, targets solid tumor malignancies. Emerging data suggest that these therapies may be associated with a high incidence of serious cardiovascular toxicities, including atrial fibrillation, heart failure, ventricular arrhythmias, and other cardiovascular toxicities. The development of these

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… Multidisciplinary collaboration between cardiologists and oncologists and the strengthening of pharmacovigilance reporting are essential to fully evaluate cardiovascular outcomes. … Multidisciplinary strategies inclusive of cardio-oncologic assessments and shared decision-making with patients, cardiologists, and oncologists are needed to facilitate increased applications of these impactful therapies. …

Recent advances in the diagnosis and management of amyloid cardiomyopathy.

Amyloidosis is a disorder characterized by misfolded precursor proteins that form depositions of fibrillar aggregates with an abnormal cross-beta-sheet conformation, known as amyloid, in the extracellular space of several tissues. Although there are more than 30 known amyloidogenic proteins, both hereditary and non-hereditary, cardiac amyloidosis (CA) typically arises from either misfolded transthyretin (ATTR amyloidosis) or immunoglobulin light-chain aggregation (AL amyloidosis). Its prevalence is more common than previously thought, especially among patients with heart failure and preserved

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… In general, though, cardiologists currently follow traditional ICD criteria for primary and secondary prevention, since the life expectancy of most CA patients now exceeds 1 year thanks to advancements in therapy 122 , 123 . Advanced heart failure therapies. … J Am Coll Cardiol. 2016 ; 67 ( 25 ): 2941 – 8 . 10.1016/j.jacc.2016.03.593 27339491 12 Witteles RM Liedtke M : AL Amyloidosis for the Cardiologist and Oncologist: Epidemiology, Diagnosis, and Management. …

Applications of Structural Expert Elicitations for Economic Evaluations: A Systematic Review Update.

BackgroundStructured expert elicitation (SEE) has become increasingly important in health technology assessment and economic evaluations. Complementing previous work, we aimed to synthesize recent developments in published SEE applications within health economics over the past 8 years.MethodsA systematic literature search was conducted in Medline and Embase databases from April 2017 to February 2026, supplemented with snowball sampling, to identify applications of SEE as part of economic evaluations. Data extraction and synthesis focused on expert selection, elicitation methods, and analytical

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… | NA Konidaris et al. (2021) [ 31 ] | Clinicians with expertise in oncology, specifically for advanced CSCC treatment; health economists | Purposive sampling | NR | VIM | Mode, median, UPL, LPL, and CIs via SHELF guidance | Mathematical | No | NA Petersohn et al. (2021) [ 30 ] | Vascular surgeons, cardiologists … Purposive sampling | 4 | FIM | Median, IQR, 95% CrIs | Mathematical | Yes | Equal weights van Hoeven et al. (2019) [ 42 ] | Hematologists (adult and pediatric), neonatologists, immunologists | Purposive sampling | NR | FIM | Median; 95% CIs | Mathematical | Yes | Equal weights Kip et al. (2018) [ 38 ] | Cardiologists …

Future Costs in Cost-Effectiveness Analyses: Past, Present, Future.

There has been considerable debate on the extent to which future costs should be included in cost-effectiveness analyses of health technologies. In this article, we summarize the theoretical debates and empirical research in this area and highlight the conclusions that can be drawn for current practice. For future related and future unrelated medical costs, the literature suggests that inclusion is required to obtain optimal outcomes from available resources. This conclusion does not depend on the perspective adopted by the decision maker. Future non-medical costs are only relevant when adopti

Cardiotoxicity Induced by Anticancer Therapies: A Call for Integrated Cardio-Oncology Practice.

The introduction of novel oncologic therapies, including targeted agents, immunotherapies, and antibody-drug conjugates, has transformed the therapeutic landscape of cancer care. This evolution has resulted in a dual clinical scenario; while survival outcomes have markedly improved, leading to a growing population of long-term cancer survivors, an increasing incidence of previously unrecognized treatment-related toxicities has emerged. Among these, cardiovascular adverse events represent some of the most prevalent and clinically significant complications observed in both conventional chemother

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… It delivers standardized activities—including ambulatory consultations, ECG and echocardiographic interpretation, bedside assessments, and cardiac imaging reviews—and relies on the collaboration of cardiologists, nurses, trainees, and clinical pharmacists. … As such, cardio-oncology must be embedded within a multidisciplinary network, fostering continuous dialogue between oncologists and cardiologists through regular meetings and shared protocols. …

Heart Failure in Older Patients: An Update.

Heart failure (HF) is a clinical syndrome with high incidence and prevalence and high morbidity and death rate, even in the short term, representing a serious public health issue, mainly in older people. It is a growing cause for hospital admission in this age group, being frequently associated with several comorbidities, further aggravating the disease's course. Moreover, older HF patients are usually affected by clinical conditions, like frailty, malnutrition, and cachexia, which significantly impact the overall management of HF and need to be properly identified and treated. Diagnosing and

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… In particular, the AHA/ACC/HFSA guidelines specify that a PC approach starts from every member of the patient’s primary care team (primary care physicians, cardiologists, other specialists, nurses, psychologists, and so on), targeted to satisfy a patient’s basic palliative needs, to communicate disease … It is necessary to build care networks [ 238 ] involving general practitioners, cardiologists, geriatricians, nurses, physiotherapists, and other specialists working synergistically to ensure comprehensive, coordinated, and personalized care. …

Practical recommendations for the implementation of shared decision-making in multiple myeloma care.

BackgroundMultiple myeloma (MM) is characterized by complex and evolving treatment pathways, involving multiple preference-sensitive decisions across the disease trajectory. Shared decision-making (SDM) is widely recognized as a best-practice approach for such decisions, yet practical, context-specific guidance for implementing SDM in MM care remains limited.ObjectiveTo develop a set of practical, stakeholder-informed recommendations to support the implementation of SDM in MM care.MethodsThis study was conducted as part of a European mixed-methods research project initiated by the patient orga

Screening for Cardiac Amyloidosis When Conducting Carpal Tunnel Surgery.

Background: Carpal tunnel syndrome (CTS) has emerged as an early indicator of cardiac amyloidosis (CA) caused by transthyretin-associated (ATTR) mutations, possibly linked to adverse cardiovascular outcomes. This case series examines the relationship between idiopathic CTS and CA imaging diagnosis. Methods: Twenty-two patients from the cross-sectional study CarPoS (NCT05409833) were included. These patients underwent physical evaluation, laboratory exams, electrocardiography, echocardiography, cardiac magnetic resonance (CMR) imaging, and scintigraphy with 99mTc-3,3-diphosphono-1,2-propanodica

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… Multidisciplinary collaboration between orthopedic surgeons, hand surgeons, primary care physicians, rheumatologists, cardiologists, and amyloidosis specialists is crucial in order to optimize the identification and management of patients with CTS who may have or be at risk of developing cardiac amyloidosis …

Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study.

Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba (CCMB) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the CLL clinic influences patient outcome. Overall survival (OS) was assessed for all CLL/SLL patients diagnosed in Manitoba between 2007 and 2011. Of 555 patients, 281 (51%) were referred to the CLL clinic. Patients seen in this clinic had a twofold increased OS compared to patients who were managed by other hematologists a

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… Treatment and outcomes of acute myocardial infarction among patients of cardiologists and generalist physicians. Arch. Intern. Med. 157:2570–2576. 7. Collette, L. , Sylvester R. J., Stenning S. P., Fossa S. D., Mead G. M., de Wit R., et al. 1999. …

Иммуноглобулин А лямбда, связанный с миеломой, легкий сердечный амилоидоз с постепенной сердечной недостаточностью с консервируемой фракцией выброса: отчет о мультимодальной съемке.

Участие в кардиологической деятельности является основным фактором, определяющим прогноз иммуноглобулиновой световой цепи (AL) амилоидоз, но может быть недооценено у пациентов с множественной миеломой (MM), особенно в тех случаях, когда отсутствуют классические электрокардиографические или сердечные магнитные резонансные характеристики. Таким образом, раннее признание зависит от интеграции сердечных биомаркеров и мультимодальных изображений в тех случаях, когда биопсия тканей или синтиграфическая подстилка непрактична.Резюме дела: A 74-year-old - у человека с иммуноглобулином Алямбда ММ и имму

Легкомерный амилоидоз диагностируется Branbronchial Lung Biopsy: Three-Case Series with Divide Radiodial Provisions.

Легкий амилоидоз является редким заболеванием с различными радиологическими проявлениями, которое может имитировать злокачественную или диффузную межстициальную болезнь легких. Хотя традиционные щипцы трансбронхиальной биопсии легких (ТБЛБ) являются установленным менее инвазивным диагностическим методом, его клиническая роль может различаться в зависимости от вида заболевания. Мы сообщали о трех пациентах с легочным амилоидозом, диагностированным обычными щипцами ТББ. Двое из них были поражены носовыми повреждениями, имитирующими злокачественность; ТББ установил диагноз, и системная оценка пок

Сопоставимая смертность в результате пери-трансплантации и распространенность фебриловой нейтропении после высоких доз Мелфалана и автологической трансплантации стволовых клеток у пациентов с плазменными клеточными дискразиями, которые рассматривались как амбулаторные или стационарные.

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Аэробная способность смягчает связь между атрофией шейного мозга и клинической инвалидностью у слабобольных пациентов с множественным склерозом.

Утрата объема спинного мозга связана с клинической инвалидностью при множественном склерозе (MS). Аэробная способность может смягчать воздействие накопления повреждений центральной нервной системы (СНС), оказывая благотворное воздействие на инвалидность, связанную с НР. ЦЕЛИ: Мы изучили вопрос о том, может ли аэробная способность смягчать связь между атрофией спинного мозга и клинической инвалидностью в MS. МЕТОДЫ: В ходе такого перекрестного анализа были собраны данные об увеличении шкалы инвалидности (EDSS), пике потребления кислорода (VO2peak), объемных показателях мозга и нормализованной с

When tissue is not the only issue: Poorly differentiated lung squamous-cell carcinoma with adrenal, costochondral, and cardiac metastases - case report.

Nonmelanoma skin cancer is the most common cancer in the world, and lung cancer is the leading cause of death from cancer. Histologically, squamous cell carcinoma (SCC) is the second most prevalent type of both skin and lung cancers. We report the case of a 38-year-old female with metastatic, poorly differentiated lung SCC detected on chest X-ray after she presented to the hospital with cough and dyspnea. She had had a 7.5 cm moderately differentiated well-circumscribed posterior scalp SCC completely excised eight years earlier. CT scan showed a large right lung mass, nodular filling defect in

Idiopathic osteoporosis, Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder in a 27-year-old male patient: A unique case presentation.

A young male patient presents with widespread pain and varying chronic inflammatory symptoms for three years and idiopathic low bone density for more than ten years. Based on the patient's clinical history, the patient has been diagnosed with an hypermobile Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder trifecta with affiliated inflammation-induced osteoporosis.