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Coronary lesions in patients with COPD (Global Initiative for Obstructive Lung Disease stages I-III) and suspected or confirmed coronary arterial disease.

BackgroundSystemic inflammation is the pathophysiological link between coronary artery disease (CAD) and COPD. However, the influence of subclinical COPD on patients with suspected or diagnosed CAD is largely unknown. Thus, this study was designed to evaluate the degree of coronary involvement in patients with COPD and suspected or confirmed CAD.MethodsIn this cross-sectional study, carried out between March 2015 and June 2017, 210 outpatients with suspected or confirmed CAD were examined by both spirometry and coronary angiography or multidetector computed tomography. These patients were divi

Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?

BACKGROUND: Macroglossia due to amyloid depositions can cause cosmetic problems and functional disability, and can lead to life-threatening airway obstruction. Management of macroglossia in systemic amyloidosis is controversial, and the role of surgery is unclear. CASE DESCRIPTION: We present a case of a 66-year-old woman affected by macroglossia due to light chain amyloidosis who presented with eating and breathing difficulties. Because of prior successful results of radiotherapy for localized amyloid disease, our patient was treated with external beam radiation therapy (20 Gy in 10 fraction

Crosslink between atrial fibrillation and cancer: a therapeutic conundrum.

Atrial fibrillation (AF) is more common in patients with malignancies than in general population. The pathophysiological processes include the pro-inflammatory condition and the exaggerated inflammatory reaction to chemotherapy, radiotherapy, and surgery interventions. Thus, it is pivotal to decrease morbidity and mortality in this group by providing appropriate care and prevention. In this subset, the risk of thromboembolic and bleeding events is high and the common risk score such as CHA2DS2-VASc and HAS-BLED employed in non-oncologic patients have limited evidence in cancer patients. A pauc

Cardiovascular health: an important component of cancer survivorship.

Advances in the detection and treatment of cancer have translated into improved cancer survival rates and a growing population of cancer survivors. These include those living with cancer and individuals free of the disease following treatment. Epidemiological studies demonstrate that cancer survivors are at an increased risk of cardiovascular disease (CVD), with cardiovascular (CV) mortality overtaking cancer mortality in some tumour types. Cancer and CVD share common aetiological risk factors, for example, age, tobacco use and obesity, as well as a shared inflammatory pathogenesis. The CV ris

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… infrequency, late occurrence or population differences, for example, in performance status or comorbid conditions. 117 CV health in cancer survivorship Treatment-related CV toxicity and the safe delivery of cancer treatment to patients with CVD have been the focus of long-standing collaborations between cardiologists … impair the quality of life of cancer survivors, which studies of patient priorities suggest is often valued equally to length of life. 123 Table 1 Summary of key recommendations for asymptomatic cancer survivors after completion of anticancer therapy in guidelines produced by the European Society of Cardiologists …

Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies.

Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and pr

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… In case of HM patients and concomitant CVD or those commencing anti-cancer therapy characterized by high cardiotoxicity risk (e.g., high-dose of anthracyclines), cardiologists should be proactive by prescribing cardioprotective drugs. … The collaboration among hematologists, cardiologists and oncologists is of paramount importance in optimizing patients’ care. Data Availability Statement Data sharing not applicable. Conflicts of Interest The authors declare no conflict of interest. …

Частота и факторы риска в случае вновь диагностированной гиперкалемии после выписки из больницы пациентов, не зависящих от диализа, которые лечатся ингибиторами RAS.

ВВЕДЕНИЕ: Ингибиторы системы " ренин-ангиотенсин " (РАС) все чаще предписываются в силу их позитивного воздействия на систему " конечная организация " . Иатрогенная гиперкалемия представляет собой хорошо известное опасное для жизни осложнение использования ингибитора RAS у пациентов, страдающих хроническим заболеванием почек (CKD). Мы предположили, что у пациентов, проходящих курс лечения с помощью ингибиторов RAS, часто возникает гиперкалемия после выписки из больницы, даже если во время госпитализации у них была нормальная оклемия, так как их образ жизни существенно измен

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… Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs), which are both RAS inhibitors, are commonly used to treat hypertension, and nephrologists and cardiologists are not the only physicians prescribing RAS inhibitors. …

Cancer Prevalence among Physicians in Korea: A Single Center Study.

BackgroundThere is little research regarding whether working as a physician affects cancer risk. Moreover, there is no research on cancer prevalence among physicians in Korea. This study utilized the Korea National Cancer Incidence Database to determine whether the prevalence of cancer among physicians differs from the prevalence of cancer within the general population.MethodsWe analyzed the medical records of a representative sample of 382 doctors who underwent a health examination between 2010 and 2013 at a health examination center in a Ewha Womans University Medical Center.Cancer incidence

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… Finland, the risk of cancer in specific sites, particularly the risk of breast cancer, was found to be slightly increased in female physicians (standardized incidence ratio, 1.7; 95% CI 1.0 to 3.1). 29) In particular, orthopedic surgeons, neurosurgeons, interventional radiologists, and interventional cardiologists …

Cardiac Amyloidosis in Older Adults With a Focus on Frailty: JACC: Advances Expert Consensus.

Amyloidosis, which is caused by misfolded proteins that form amyloid fibrils, is predominantly diagnosed in older adults. Although previously considered a rare disease, increased awareness and noninvasive diagnostic methods have resulted in a rise in diagnoses. As a multisystem disease that affects multiple organ systems (cardiac, gastrointestinal, renal, and neurological), there is significant overlap with both geriatric conditions and common conditions in heart failure. Frailty is recognized as a distinct biological syndrome of declines across multiple physiological systems, which prevents m

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… Employing a multidisciplinary team approach to the management of frail patients with ATTR-CM is recommended, and in addition to the HF cardiologist, should include physical and occupational therapy, pharmacy, speech/language therapy, nutrition, genetic counseling, geriatric medicine, psychologists, social … assessment of symptoms of both HF and comorbidities (such as pain, anxiety, depression), nonessential medications, access to psychological and spiritual support for both patient and caregivers, and advanced care planning. 86 Unfortunately, access to palliative care specialists is not universal, so HF cardiologists …

Catch the Calcium: T-Cell Histiocyte-Rich B-Cell Lymphoma Presenting as Hypercalcemia.

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is an extremely rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL) that typically presents in middle-aged patients and carries a poor prognosis. Hypercalcemia presenting as the initial manifestation of the disease is rare, with only one other case reported in the literature. We report a case of a 90-year-old male who presented with progressive lethargy and unintentional weight loss. Initial workup showed elevated serum calcium of 14.6 mg/dL, corrected for albumin, and creatinine of 1.51 mg/dL. He had a suppressed iPTH of

Bridging the Gap in AL and ATTR Cardiac Amyloidosis: Integrating Histopathology, Biomarkers, and Multimodal Imaging for Subtype-Specific Diagnosis.

Cardiac amyloidosis (CA) represents an increasingly recognized but historically underdiagnosed cause of restrictive cardiomyopathy and heart failure. CA is now understood to be more prevalent, particularly in older adults, as advancements in imaging and biomarker technologies have improved detection. The disease results from the misfolding of precursor proteins, primarily immunoglobulin light chains (in light chain (AL) amyloidosis) or transthyretin (in transthyretin (ATTR) amyloidosis), into insoluble fibrils that deposit in myocardial tissue. These deposits cause structural and functional ca

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… Although cardiologists were consulted the most, they were only responsible for the diagnosis in 18.7% of cases. … Similar trends were observed in ATTR-CA, albeit in smaller sample sizes, where fewer than half of patients were diagnosed within six months, with cardiologists making the diagnosis in most cases [ 1 ]. …

Cardiogenic shock among cancer patients.

Sophisticated cancer treatments, cardiovascular risk factors, and aging trigger acute cardiovascular diseases in an increasing number of cancer patients. Among acute cardiovascular diseases, cancer treatment, as well as the cancer disease itself, may induce a cardiogenic shock. Although increasing, these cardiogenic shocks are still relatively limited, and their management is a matter of debate in cancer patients. Etiologies that cause cardiogenic shock are slightly different from those of non-cancer patients, and management has some specific features always requiring a multidisciplinary appro

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… Given the specificities of different cancers or their treatments, management of CS in this particular setting requires a comprehensive knowledge of the various determinants in addition to a multidisciplinary collaboration between intensivists, cardiologists, cardiac surgeons, and oncologists. … Multidisciplinary collaboration between intensivists, cardiologists, cardiac surgeons, and oncologists is essential in these critical situations. Author contributions AC, FM, and HM wrote the manuscript, reviewed, and edited the article before submission. …

Leveraging stories of cardiac amyloidosis patients of African ancestry or descent to support patient-derived data elements for efficient diagnosis and treatment.

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… Best practices in specialized amyloidosis centers in the United States: a survey of cardiologists, Nurses, patients, and patient advocates. Clin. Med. Insights Cardiol. 15, 11795468211015230. Available at:. 10.1177/11795468211015230 Nativi-Nicolau J. N., Karam C., Khella S., Maurer M. S. (2022). …

Chemotherapy Related Cardiotoxicity Evaluation-A Contemporary Review with a Focus on Cardiac Imaging.

The long-term survivorship of patients diagnosed with cancer has improved due to accelerated detection and rapidly evolving cancer treatment strategies. As such, the evaluation and management of cancer therapy related complications has become increasingly important, including cardiovascular complications. These have been captured under the umbrella term "cardiotoxicity" and include left ventricular dysfunction and heart failure, acute coronary syndromes, valvular abnormalities, pericardial disease, arrhythmia, myocarditis, and vascular complications. These complications add to the burden of ca

Endodontics in Systemically Compromised Patients

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Скриншот аортального клапана как независимый клинический знак системных заболеваний, диастической дисфункции и риска смерти: большое эхокардиографическое коортовое исследование.

ВВЕДЕНИЕ: Склероз аортального клапана (AVS) широко распространен среди пожилых людей. Однако прогнозные последствия различных степеней эхокардиографической АВС и их связь с коморбидами, миокардной реконструкцией и фенотипами сердечной недостаточности остаются неполными. МЕТОДЫ: 42,959 - участники из крупной институциональной эхокардиографической базы данных. Жестокость AVS была классифицирована как нормальная (см.69%), толщиной (или толстой)16%), калькуляция ()13%), или сильно перекалиброванной (2%). Исключаются лица с аортальным стенозом, превышающим мягкий.РЕЗУЛЬТАТЫ: Усиливающаяся острота А

Cardiac Amyloidosis: A Rare TTR Mutation Found in an Asian Female.

BACKGROUND: Transthyretin cardiac amyloidosis (ATTR) is a life-threatening, debilitating disease caused by abnormal formation and deposit of transthyretin (TTR) protein in multiple tissues, including myocardial extracellular matrix. It can be challenging to diagnose due to the myriad of presenting signs and symptoms. Additionally, numerous TTR mutations exist in certain ethnicities. Interestingly, our patient was discovered to have a very rare Gly67Ala TTR mutation typically not found in individuals of Asian descent. Recent advances in cardiovascular imaging techniques have allowed for earlier

BRAF V600E-Mutant Acute Myeloid Leukemia: A Case Series and Literature Review of a Rare Entity.

Background: Although BRAF V600E mutations are common in solid tumors and select hematologic neoplasms, they are reported less frequently in myeloid malignancies. Of the cases of BRAF V600E-mutant acute myeloid leukemia (AML) that have been described, most display monocytic morphology and concurrent KMT2A rearrangement. Strikingly, all cases have been associated with poor survival. Case Presentation: Here, we report two cases of AML, one diagnosed in an elderly male with metastatic lung adenocarcinoma and hepatocellular carcinoma and the other diagnosed in a young boy previously treated for B-c

Arrhythmia in tumor lysis syndrome and associated in-hospital mortality: A nationwide inpatient analysis.

BackgroundTumor lysis syndrome (TLS) is a life-threatening oncologic emergency associated with fatal complications including arrhythmia. The epidemiology and mortality outcomes of arrhythmia in TLS are scarcely studied in the literature.MethodsWe used the National Inpatient Sample (NIS) to study the prevalence and outcome of arrhythmia in patients hospitalized with TLS (ICD-9 code 277.88) from 2009 to 2014. Baseline characteristics, burden of arrhythmia, and pertinent outcomes were analyzed. Multivariable regression analysis was performed to identify the impact of underlying malignancy in pred

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… Risk stratification of cancer patients is very important and there should be increased collaboration between oncologists and cardiologists under cardio‐oncology specialty. …

CSI position statement on management of heart failure in India.

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… Since our resources are limited and the vast majority of the population spend out-of-pocket for treatment, it is an important responsibility of the cardiologists and all concerned stakeholders to provide the best available therapeutic options in an affordable manner, based on the latest available medical …

Arrhythmias, conduction disorders and sudden cardiac death in cancer patients and survivors: expert opinion of the working groups on cardio-oncology and on electrophysiology of the hellenic cardiac society.

Advances in cancer therapeutics have significantly improved patient survival; however, cardiotoxic effects-including arrhythmias-have emerged as a growing clinical concern. This expert opinion, developed by the Working Groups on Cardio-Oncology and Electrophysiology of the Hellenic Cardiological Society, aims to raise awareness of the increasing burden of arrhythmias in cancer patients and survivors. This document explores the multifactorial etiology of arrhythmias in this population, including patient-related factors, the direct effects of malignancy, and the arrhythmogenic potential of thera

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… Fig. 2 A thorough baseline assessment prior to therapy initiation can detect risk factors associated with an increased risk for arrhythmias Monitoring during treatment During treatment with potentially cardiotoxic agents, an expert consultation with a cardiologist with specific expertise in managing … This evolving field also calls for collaborative care models that integrate oncologists, cardiologists, and electrophysiologists to optimize CV outcomes across the cancer continuum. …