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Abstracts for NAPCON 2025

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… Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogenous lung condition characterised by chronic respiratory symptoms (dyspnea, cough, sputum production and/exacerbation) due to abnormalities in airways (bronchitis, bronchiolitis …

GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation.

We present the largest prospective real-world experience in 159 patients who received the triple combination of tacrolimus/sirolimus/mycophenolate mofetil after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) from matched-related (MRD), matched-unrelated (MUD) or mismatched-unrelated donors (MMURD). Despite the high-risk and elderly population, non-relapse mortality (NRM) at day +100 and 1 year was 5.1% and 8.6%. Grades 2-4 and 3-4 acute Graft-versus-host disease (GvHD) at day +180 was 30.3% and 13%, respectively. Chronic GvHD at 1 and 3 years w

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… Only 1 patient developed bronchiolitis obliterans. The CuIn of patients off immunosuppresive therapy at 3 years was 62.72% (95% CI: 43.8–76.9). …

Long-term outcomes of children after solid organ transplantation.

Solid organ transplantation has transformed the lives of many children and adults by providing treatment for patients with organ failure who would have otherwise succumbed to their disease. The first successful transplant in 1954 was a kidney transplant between identical twins, which circumvented the problem of rejection from MHC incompatibility. Further progress in solid organ transplantation was enabled by the discovery of immunosuppressive agents such as corticosteroids and azathioprine in the 1950s and ciclosporin in 1970. Today, solid organ transplantation is a conventional treatment with

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… In lung transplant recipients, early phase respiratory viral infections are linked to worsened allograft outcomes, and CMV has been implicated in bronchiolitis obliterans. …

Community-acquired pneumonia

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… to consider infection with a drug-resistant or unusual pathogen (tuberculosis, anthrax, Coxiella burnetii, Burkholderia pseudomallei, Pasteurella multocida , endemic fungi or hantavirus), a pneumonic complication (lung abscess, endocarditis, empyema) or a noninfectious process that mimics pneumonia (bronchiolitis …

Prevention, diagnosis and management of community acquired respiratory virus infections including COVID-19 in patients with cancer: 2025 updated evidence-based guideline of the infectious diseases working party (AGIHO) of the German society for hematology and medical oncology (DGHO).

Community-acquired respiratory viruses (CARV), such as influenza-, parainfluenza- or respiratory syncytial virus, pose a significant threat to immunocompromised patients with cancer. Following the COVID-19 pandemic, SARS-CoV-2 has now joined the ranks of endemic respiratory viruses and continues to be a cause of significant morbidity and mortality in patients with cancer. Strategies to protect this vulnerable patient population both by prevention of infection and by early therapeutic intervention in case of infectious disease are therefore of utmost importance. This guideline provides updated

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… Furthermore, the affection of the terminal bronchioles may manifest as “tree in bud” sign [ 60 ], bronchiolitis may further be visible as air-trapping, especially on image sets in expiration [ 59 ]. …

Р

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Замена иммуноглобулина: Понятия управления несколькими миеломами.

Immunoglobulin (Ig) - заместительная терапия (IGRT) - состоит из применения низкодозированных поликлонных иг человека для лечения первичной и вторичной гипогаммаглобулинемии, которая связана с периодическими инфекциями и иммунной дисфункцией. ИГРТ восстанавливает физиологические уровни антител и вызывает иммуномумудуляторный эффект путем укрепления клеток иммунного эффекта, тем самым уменьшая инфекцию. Здесь мы описываем фармакологию различных составов иг с уделением особого внимания их механизму действий как низкодозированный ИГРТ, включая прямой антимикробный эффект и иммунодуляторную функци

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… Main clinical manifestations of hypogammaglobulinemia involve the respiratory tract (e.g., pneumonia, bronchitis, bronchiolitis), otitis or urinary infections, chronic diarrhea due to gastrointestinal immunodeficiency, and consequent bacterial, viral, and fungal proliferation, enlarged lymph nodes, and …

Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies.

With the increasing use of targeted anticancer drugs and immunotherapies, there have been a substantial number of reports concerning life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, and acute generalized exanthematous pustulosis. Although the potential risks and characteristics for targeted anticancer agent- and immunotherapy-induced SCAR were not well understood, these serious adverse reactions usually result in morb

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… ). 59 PNP is a fatal mucocutaneous blistering disorder associated with hematologic malignancies. 60 PNP shares overlapping clinical features with SJS, including severe mucositis, flaccid sloughing bullae, keratinocyte necrosis histopathologically, and possible pulmonary involvement with features of bronchiolitis …

Hematopoietic stem cell transplantation.

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is performed using the patient's own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem

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… The clinical findings may overlap with aGvHD, as both disorders affect similar organs. cGvHD has other features that resemble autoimmune disorders, such as systemic lupus erythematosus, scleroderma, sicca syndrome, eosinophilic fasciitis, rheumatoid arthritis, primary biliary sclerosis, bronchiolitis …

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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агитационные рамки ИИ, связывающие языковые модели с электронными медицинскими записями, и график биомедицинских знаний для реальных доказательств.

Доступ к крупномасштабным клиническим и биомедицинским базам данных по-прежнему является серьезным препятствием для клинических и научных работников, требующим значительных вычислительных знаний. Агентские системы искусственного интеллекта, в которых крупные языковые модели (МПМ) организуют многоэтапное рассмотрение и выполнение запросов под интерактивным контролем человека, открывают возможности для демократизации доступа к данным и ускорения процесса получения доказательств. MethodsWe применяли Типовой контекстный протокол (МКП) для интеграции в рамках одного агентского рабочего процесса ста

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… For bronchiolitis, select one supportive care medication and show how often it appears in pediatric charts. 3 Event rates after a new exposure using routine outcomes. For new loop-diuretic users, what proportion has potassium < 3.5 mmol/L within 30 days? 4 Temporal trends and epoch comparisons. …

Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients - case series and literature review.

BACKGROUND: Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis. METHODS: Three patients with calciphylaxis and metastatic pulmonary calcification (MPC) were treated with human amnion-derived mesenchymal stem cells (hAMSCs). Effects were evaluated using the Visual Analogue Scale (VAS), modified Bates-Jensen Wound Assessment Tool for CUA (BWAT-CUA), wound quality of life questionnaire (Wound-QoL), and histological analysis. MPC was assessed by high-resolution

Describing financial toxicity among cancer patients in different income countries: a systematic review and meta-analysis.

BackgroundThere is limited evidence of financial toxicity (FT) among cancer patients from countries of various income levels. Hence, this study aimed to determine the prevalence of objective and subjective FT and their measurements in relation to cancer treatment.MethodsPubMed, Science Direct, Scopus, and CINAHL databases were searched to find studies that examined FT. There was no limit on the design or setting of the study. Random-effects meta-analysis was utilized to obtain the pooled prevalence of objective FT.ResultsOut of 244 identified studies during the initial screening, only 64 studi

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases.

Cutaneous manifestations occur in the course of hematologic malignancies and precede, accompany or occur late in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, immunosuppression resulting from the hematologic disease itself or its treatment. The dermatologist must be aware of these conditions that may be helpful both in the diagnosis of the underlying disease and in reducing patient morbidity. This review (part II) addresses the paraneoplastic dermatological changes associated with systemic hematologic malignancies.

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… Figure 5 Lichenoid lesions predominate in children and in East Asian populations and may have clinical and histopathological characteristics that are similar to erythema multiforme or graft-versus-host disease (GvHD). 59 , 63 Some patients develop bronchiolitis obliterans, which can lead to fatal respiratory …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome.

The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches are required. Intravenous (IV) Vitamin C (Vit-C) has emerged as one of the other alternatives for this purpose. Here we review the effects of IV Vit-C on the immune system response, the antiviral properties of IV Vit-C, and finally the antioxidant properties of IV Vit-C to specificall

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… Viral-mediated in hibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis. Am. J. Respir. Crit. Care Med. 2011;183:1550–1560. doi: 10.1164/rccm.201010-1755OC. 109. Castro S.M., Guerrero-Plata A., Suarez-Real G. …

Liver Disease Associated with Non-Hepatitis Viruses

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… Transaminase levels in ventilated children with respiratory syncytial virus bronchiolitis Intensive Care Medicine 30 2004 931 934 15024569 10.1007/s00134-004-2236-2 Finegold M.J. Carpenter R.J. …

Infections in Recipients of Hematopoietic Stem Cell Transplants

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… complications after HSCT, which can include pulmonary edema, pleural effusion, alveolar hemorrhage, radiation injury (pneumonitis or fibrosis), drug reactions, adult respiratory distress syndrome, idiopathic pneumonia syndrome, cytolytic thrombi (causing multiple peripheral lung nodules), obliterative bronchiolitis … , bronchiolitis obliterans with organizing pneumonia, and chronic GVHD. 54 Management of noninfectious pneumonias requires that lower respiratory tract infection be ruled out or recognition of its coexistence. …

NTP Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CAS No. 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies).

2,3-Dibromo-l-propanol, a colorless liquid, has been used as a flame retardant, as an intermediate in the preparation of the flame retardant tris(2,3-dibromopropyl) phosphate, and as an intermediate in the manufacture of pesticides and pharmaceutical preparations. Toxicology and carcinogenicity studies were conducted by applying 2,3-dibromo-1-propanol (approximately 98% pure) in ethanol to the subscapular area of the skin of male and female F344/N rats and B6C3F1 mice 5 days per week for 16 days, 13 weeks, 48 to 51 weeks (male rats), 52 to 55 weeks (female rats), 36 to 39 weeks (male mice), or

The anti-inflammatory effects of mesenchymal stem cells and their research progress in hematopoietic stem cell transplantation: A comprehensive review.

Hematopoietic stem cell transplantation (HSCT) is frequently accompanied by severe inflammation-related complications, among which graft-versus-host disease (GVHD) stands out as one of the most common and life-threatening. As a systemic inflammatory disorder, GVHD arises when donor T cells recognize the recipient's alloantigens and initiate an immune attack. Currently, effective second-line treatment options remain scarce for patients with antibiotic-resistant or steroid-refractory GVHD. Mesenchymal stem cells (MSCs) are non-hematopoietic cells widely distributed in fetal and adult tissues and

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… Unlike aGVHD, cGVHD mostly affects the oral mucosa (presenting with dryness and ulcers), lacrimal/salivary glands (manifesting as Sjögren’s syndrome-like features), and lungs (such as bronchiolitis obliterans) 65 . …

Interleukin-6: obstacles to targeting a complex cytokine in critical illness.

Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory distress syndrome. Elevations in serum IL-6 concentrations in patients with severe COVID-19 have led to renewed interest in the cytokine as a therapeutic target. However, although the pro-inflammatory properties of IL-6 are widely known, the cytokine also has a series of important physiological and anti-inflammatory functions. An adequate understanding of the complex processes by which IL-6 signalling occurs is c

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… Ruxolitinib | Oral | JAK1 and JAK2 | Myelofibrosis and polycythaemia rubra vera (approved); graft-versus-host disease, polycythaemia rubra vera, vitiligo, and atopic dermatitis (phase 3); acute myeloid leukaemia, chronic lymphocytic leukaemia, essential thrombocythaemia, haemophagocytic syndrome, and bronchiolitis …